scholarly journals Influenza and morbidity and mortality risk in patients in Mexico with systemic arterial hypertension alone or with comorbidities: a retrospective, observational, cross-sectional study from 2014 to 2020

BMJ Open ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. e057225
Author(s):  
Alejandrina Malacara-Villaseñor ◽  
Hermes Ilaraza-Lomeli ◽  
Roberto Tapia-Conyer ◽  
Elsa Sarti
Keyword(s):  
Arterial Hypertension ◽  
Influenza Vaccination ◽  
Case Fatality ◽  
Cross Sectional Study ◽  
Morbidity And Mortality ◽  
Secondary Outcome ◽  
Sectional Study ◽  
Cross Sectional ◽  
Systemic Arterial Hypertension ◽  
The Impact

ObjectivesIn Mexico, patients with systemic arterial hypertension (SAH) are excluded from the influenza vaccination programme despite their risk of cardiovascular events as influenza-related complications. We investigated the impact of influenza on morbidity and mortality in patients with SAH.DesignThis was a retrospective cross-sectional study that analysed data from early 2014 to mid-2020.SettingData were obtained from the Influenza Epidemiological Surveillance System in Mexico database.Participants32 663 cases of influenza in people aged ≥20 years with a confirmed case of influenza-like illness, severe respiratory infection and/or influenza death were investigated.Primary and secondary outcome measuresInfluenza deaths, hospitalisation frequency and the impact on hospitalisation and/or death due to influenza by the SAH variate alone and in combination with diabetes, obesity, chronic obstructive pulmonary disease, cardiovascular disease and/or smoking, and by vaccination status were assessed.ResultsThe hospitalisation frequency increased with age. Notably, 46.0% (15 033/32 663) of confirmed influenza cases had at least one comorbidity, with SAH (19.2%; 6260/32 663) and obesity (18.7%; 6106/32 663) being the most prevalent. Most confirmed SAH cases (80.8%; 5057/6260) were in those who had not been vaccinated against influenza. There were 3496 deaths due to influenza (mortality rate, 0.69×1 00 000 inhabitants), with the highest rates seen in those aged ≥80 years (80–89 years, 2.0%; ≥90 years, 3.6%). The case fatality rate due to influenza and SAH was significantly higher than those due to influenza without SAH in those aged <50 years, but not in the other age groups (20–29 years, 9.8%, p<0.0005; 30–39 years, 8.2%, p<0.035; 40–49 years, 17.8%, p<0.0005; vs 15.1%–20.0%, p=0.31–0.99 for those aged ≥50 years).ConclusionsOur findings support the need to include SAH in public policies of influenza vaccination as a secondary prevention measure to avoid fatal outcomes.

scholarly journals B Part of It School Leaver protocol: an observational repeat cross-sectional study to assess the impact of a meningococcal serogroup B (4CMenB) vaccine programme on carriage ofNeisseria meningitidis

BMJ Open ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. e027233 ◽  
Author(s):  
Helen S Marshall ◽  
Mark McMillan ◽  
Ann Koehler ◽  
Andrew Lawrence ◽  
Jenny MacLennan ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Age Groups ◽  
Case Fatality ◽  
Cluster Randomised Controlled Trial ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
School Students ◽  
Cross Sectional ◽  
The Impact ◽  
Carriage Prevalence

IntroductionInvasive meningococcal disease is uncommon but associated with a high-case fatality rate. Carriage prevalence of the causative bacteria,Neisseria meningitidis, is high in adolescents. A large (n=34 500) cluster randomised controlled trial (RCT) to assess the impact of a meningococcal B (MenB) vaccine on meningococcal carriage was implemented in the state of South Australia (SA) for year 10, 11 and 12 senior school students in 2017–2018. This study will assess the impact of MenB vaccine (4CMenB) on carriage prevalence in school leavers in SA, 1 and 2 years after implementation of the cluster RCT in adolescents. Measuring the impact of population programmes on carriage can assist in informing future meningococcal immunisation programmes such as targeted age groups and use of catch-up campaigns.Methods and analysisThis repeat cross-sectional study will assess carriage prevalence in 2018 and 2019. All school leavers who attended year 12 in any school in SA in 2018 or 2019 will be invited to participate in this study. An oropharyngeal swab will be taken from each participating student and a risk factor questionnaire completed by the student following informed consent. Students will attend clinics at SA universities, technical colleges, and metropolitan, rural and remote government council clinics. Confirmed vaccination history will allow a comparison in carriage prevalence between vaccinated and unvaccinated school leavers. A sample size of 4096 students per year will provide 80% power to detect a 20% difference in carriage prevalence of disease-causing meningococci (defined as genogroup A, B, C, W, X or Y) between years.Ethics and disseminationThe study was approved by the Women’s and Children’s Health Network Human Research Ethics Committee. Results will be published in international peer review journals and presented at national and international conferences.Trial registration numberNCT03419533; Pre-results

scholarly journals Case Fatality Rate of COVID-19 and Association With Sociodemographic Characteristics of Populations in Ecuador, 2020

2021 ◽  
Author(s):  
Karla Flores Sacoto ◽  
Galo Sánchez Del Hierro ◽  
Xavier Jarrín Estupiñan ◽  
Felipe Moreno-Piedrahita Hernandez
Keyword(s):  
Death Rate ◽  
Case Fatality Rate ◽  
Case Fatality ◽  
Sociodemographic Factors ◽  
Cross Sectional Study ◽  
Secondary Outcome ◽  
Morbidity Rate ◽  
Fatality Rate ◽  
Cross Sectional ◽  
The Impact

Abstract Background COVID-19 has caused deaths worldwide affecting the most vulnerable population with different case fatality rates. Socioeconomic conditions have demonstrated a role regarding the spread of infections and mortality. Socioeconomic characteristics of Ecuador related to poverty, ethnicity and demographic characteristics increase the impact of COVID-19 in certain populations. Methods Objective To analyze the influence of demographic factors on the COVID-19 case fatality rate (CFR) in Ecuador. Design: cross sectional study. Setting 24 provinces in Ecuador-221 cantons. Population: data including 233.277 confirmed COVID-19 cases of Ecuador. Primary and secondary outcome measures COVID-19 CFR and crude cause-specific death rate weight calculated using province-country level data from health ministry of Ecuador in data website. Results Ecuadors CFR is 4,03%, analyzed by cantons the CFR increases to a median of 5,75%, with cantons like Playas with a CFR of 32,39%. The morbidity rate has a median of 795,31 per 100 000 hab. with the highest rate in Isabela-Galápagos (10185,49), Aguarico-Orellana (9506,75) and Baños-Tungurahua (4156,85). And the crude COVID-19 death rate has a median of 39,73 per 100 000 hab. with the highest rate in Penipe-Chimborazo (201,29), 24 de Mayo-Manabí (143,79) and San Pedro de Huaca-Carchi (134,36). The correlations show relations with sociodemographic factors like poverty, ethnicity and scholarity. Conclusion The CFR is the proxy indicator of COVID-19 impact in Ecuador and the analysis made by location give us new information about the specific impact of this disease.

scholarly journals Continued medication use in dentistry: the importance of dental records

2017 ◽  
Vol 4 (3) ◽  
pp. 81
Author(s):  
Glaucia Helena Faraco De Medeiros ◽  
Vanessa Brüning
Keyword(s):  
Arterial Hypertension ◽  
Chronic Diseases ◽  
Heart Diseases ◽  
Medication Use ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Systemic Arterial Hypertension ◽  
Dental Records ◽  
School Of Dentistry

Aim: Appoint the main chronic diseases and the most frequent medications used by the patients by the graduation students of Dentistry between 2012 and 2014/A,through patients’dentistry records.Material and Methods: Two studies were performed: one retrospective in patients’ dentistry records, attended at the Clinical School of Dentistry and a cross-sectional study with the students enrolled between the 6th and 9th semester in 2014/B. After the record, the data were inserted on an Excel® spreadsheet to posterior analysis by simple frequency.Results: Eighty-eight charts were evaluated and applied a questionnaire to 61 students. The most prevalence disease in the attended patients at the clinic and mentioned by the students was the systemic arterial hypertension, 77.25% and 60.66% respectively. Fifty-eight students (95%) affirmed confirming the patients’ anamnesis with systemic arterial hypertension, mellitus diabetes and chronic disease. The most used medications by these patients are those to control the systemic arterial hypertension, mellitus diabetes and heart diseases. Seventy-two percent affirmed interest on the purpose of patients’ medication; 32.79% say to research about their interaction. By dentistry records analyzed we found that only 5.6% took notes about the time of use of the medications.Conclusions: The chronic diseases most found in patients were the arterial hypertension, mellitus diabetes and heart diseases. The main medications are used to control diseases previously mentioned. One update of anamnesis record is suggested by the students.

scholarly journals Difficulty in taking medication and stroke among older adults with systemic arterial hypertension: the Fibra Study

2021 ◽  
Vol 26 (suppl 3) ◽  
pp. 5089-5098
Author(s):  
Juliana Lustosa Torres ◽  
Anita Liberalesso Neri ◽  
Eduardo Ferrioli ◽  
Roberto Alves Lourenço ◽  
Lygia Paccini Lustosa
Keyword(s):  
Older Adults ◽  
Arterial Hypertension ◽  
Living Arrangements ◽  
Medical Diagnosis ◽  
Cross Sectional Study ◽  
Living Alone ◽  
Financial Difficulty ◽  
Sectional Study ◽  
Cross Sectional ◽  
Systemic Arterial Hypertension

Abstract This article aims to investigate whether difficulty in taking medication is associated with stroke among older adults with Systemic Arterial Hypertension (SAH) and to explore their association with living arrangements. Cross-sectional study was based on 3,502 older adults with SAH from the four universities pole of Frailty in Brazilian Older People (Fibra) Study, Brazil, including 14 municipalities of the five Brazilian regions. We used the medical diagnosis of stroke and difficulty in taking medications (self-reported difficulty and financial difficulty affording prescribed medications). Multivariate analysis was performed using logistic regression. Differently from women, older men with SAH, which report difficulty in taking medication (unintentional non-adherence), have higher odds of stroke. When stratified by living arrangements, those living with a partner have even higher odds of stroke compared to those without difficulty in taking medication and living alone. None association was found for difficulty affording prescribed medication for both men and women. Unintentional difficulty in taking medication plays a role in SAH treatment among men. Primary care strategies for controlling blood pressure should not be focus only on patients but targeting spouses as well.

scholarly journals Identification of the most vulnerable populations in the psychosocial sphere: a cross-sectional study conducted in Catalonia during the strict lockdown imposed against the COVID-19 pandemic

BMJ Open ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. e052140
Author(s):  
Judith Farrés ◽  
Jose Luis Ruiz ◽  
Jose Manuel Mas ◽  
Lilibeth Arias ◽  
Maria-Rosa Sarrias ◽  
...  
Keyword(s):  
Ethical Issues ◽  
Negative Impact ◽  
Psychological Impact ◽  
Cross Sectional Study ◽  
Secondary Outcome ◽  
Snowball Sampling ◽  
Sectional Study ◽  
Post Traumatic Stress ◽  
Cross Sectional ◽  
The Impact

Design and objectivesA cross-sectional study to evaluate the impact of COVID-19 on the psychosocial sphere in both the general population and healthcare workers (HCWs).MethodsThe study was conducted in Catalonia (Spain) during the first wave of the COVID-19 pandemic when strict lockdown was in force. The study population included all people aged over 16 years who consented to participate in the study and completed the survey, in this case a 74-question questionnaire shared via social media using snowball sampling. A total of 56 656 completed survey questionnaires were obtained between 3 and 19 April 2020.The primary and secondary outcome measures included descriptive statistics for the non-psychological questions and the psychological impact of the pandemic, such as depression, anxiety, stress and post-traumatic stress disorder question scores.ResultsA n early and markedly negative impact on family finances, fear of working with COVID-19 patients and ethical issues related to COVID-19 care among HCWs was observed. A total of seven target groups at higher risk of impaired mental health and which may therefore benefit from an intervention were identified, namely women, subjects aged less than 42 years, people with a care burden, socioeconomically deprived groups, people with unskilled or unqualified jobs, patients with COVID-19 and HCWs working with patients with COVID-19.ConclusionsActive implementation of specific strategies to increase resilience and to prepare an adequate organisational response should be encouraged for the seven groups identified as high risk and susceptible to benefit from an intervention.Trial registration numberNCT04378452.

scholarly journals Primary outcome switching among drug trials with and without principal investigator financial ties to industry: a cross-sectional study

BMJ Open ◽  
2018 ◽  
Vol 8 (2) ◽  
pp. e019831 ◽  
Author(s):  
Christopher W Jones ◽  
Benjamin S Misemer ◽  
Timothy F Platts-Mills ◽  
Rosa Ahn ◽  
Alexandra Woodbridge ◽  
...  
Keyword(s):  
Primary Outcome ◽  
Statistical Significance ◽  
Cross Sectional Study ◽  
Study Endpoint ◽  
Secondary Outcome ◽  
Primary Study ◽  
Drug Trials ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Impact

ObjectivesTo determine the relationship between manufacturer-related financial ties among investigators of published drug trials and rates of discrepant registered and published primary trial outcomes.DesignCross-sectional study.SettingHuman subjects drug trials published in ‘core clinical’ MEDLINE journals in 2013.Primary and secondary outcome measuresThe primary study endpoint was the presence of a prospectively registered, clearly defined primary outcome that matched the published primary outcome for each included trial. Secondary outcomes included assessments of registration timing and quality, and the impact of outcome discrepancies between registration and publication on the statistical significance of the included trials.ResultsOf 192 included trials, 134 (70%) were positive and 58 (30%) were negative. Financial ties were present between first or last authors and drug manufacturers for 130 trials (68%), of which 78% were positive, versus 53% of trials with no financial ties that were positive. Clearly defined, prospectively registered outcomes that matched the published outcomes were present in just 76 of the 192 trials (40%). After adjusting for study start date and sample size, the observed relationship between investigator financial ties and the presence of a match between prospectively registered and published primary outcomes was of borderline statistical significance (OR 2.12, 95% CI 0.998 to 4.50). Studies with financial ties present were more likely than studies without ties to have been prospectively registered (78%vs48%, P<0.001) and were more likely to have prospectively registered a clearly defined primary outcome(62%vs35%, P<0.001).ConclusionsLess than half of the trials in this cohort were prospectively registered with a clear primary outcome that was consistent with the primary outcome reported in the published manuscript. The presence of investigator financial ties was associated with higher quality registration practices, though this association diminished after adjusting for factors that impact registration quality.

The impact of the use of a footrest on the quality of chest compressions. A prospective, randomized, cross-sectional study

2018 ◽  
Vol 31 (3) ◽  
Author(s):  
Jolanta Majer ◽  
Sandra Pyda ◽  
Jerzy Robert Ladny ◽  
Antonio Rodriguez-Nunez ◽  
Lukasz Szarpak
Keyword(s):  
Cross Sectional Study ◽  
Sectional Study ◽  
Chest Compressions ◽  
Cross Sectional ◽  
The Impact

scholarly journals Impact of Community-Led Total Sanitation and Hygiene on Prevalence of Diarrheal Disease and Associated Factors among Under-Five Children: A Comparative Cross-Sectional Study in Selected Woredas of Gamo Gofa Zone, Southern Ethiopia

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Agune Ashole Alto ◽  
Wanzahun Godana ◽  
Genet Gedamu
Keyword(s):  
Drinking Water ◽  
Diarrheal Disease ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Under Five ◽  
Under Five Children ◽  
Sanitation And Hygiene ◽  
The Impact ◽  
Gamo Gofa

Background. Diarrheal diseases are still one of the major causes of morbidity in under-five children in sub-Saharan Africa. In Ethiopia, diarrhea is responsible for 9% of all deaths and is the major cause of under-five mortality. Objective. To assess the impact of community-led total sanitation and hygiene on the prevalence of diarrheal disease and factors associated among under-five children in Gamo Gofa Zone. Methods. Community-based comparative cross-sectional study design was used to compare the impact of community-led total sanitation and hygiene intervention on under-five diarrheal disease. Multistage sampling method was employed. The data were collected by using pretested structured questionnaires. Data quality was ensured by daily supervision completeness and consistency. The data were coded, entered, and cleaned by using Epi Info version 7 and were analyzed by using SPSS version 20. Bivariate and multivariable analyses were carried out by using binary logistic regression. Significance was declared by using p value of <0.05 and AOR with 95% confidence intervals. Results. The response rate of this study was 93.3%. The overall diarrhea prevalence was 27.5% (CI = (24.06, 30.97)) which was 18.9% (CI = (14.94, 23.2)) in implemented and 36.2%. (CI = (30.41, 41.59)) in nonimplemented woredas. Children whose age was between 12 and 23 months (AOR = 1.6) and greater than 24 months (AOR = 5), availability of handwashing facilities (AOR = 4), disposal of waste in open field (AOR = 9.7), unimproved source of drinking water (AOR = 6.5), using only water for handwashing (AOR = 6), children who started complementary feeding less than 6 months (AOR = 5.6) and greater than 6 months (AOR = 5.2), and utensils used to feed children such as bottle (AOR = 3.9) were the factors positively associated with diarrhea. Conclusion. The overall prevalence of under-five diarrhea was 27.5%. The prevalence was low in CLTSH woredas as compared with non-CLTSH woredas. The study showed that handwashing facility, using only water for handwashing, open refuse disposal, and unimproved source of drinking water among under-five had a statistically significant association with diarrhea occurrence in CLTSH nonimplemented areas. Integrated efforts are needed from the Ministry of Health together with the WASH Project in improving drinking water, handwashing facilities, and solid waste disposal practices.

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