Neonatal respiratory morbidity at / near term in relation to planned mode of delivery: a retrospective observational study

2012 ◽  
Vol 97 (Suppl 1) ◽  
pp. A109.1-A109
Author(s):  
F Memon ◽  
P Ayuk
2008 ◽  
Vol 199 (6) ◽  
pp. S62
Author(s):  
Caitlin Saint-Aubin ◽  
Sarah Hopkins ◽  
Deborah Feldman ◽  
Victor Fang ◽  
Charles Ingardia ◽  
...  

Author(s):  
Fouzia Rasool Memon ◽  
Asma Naz ◽  
Nusrat Fozia Pathan ◽  
Shahida Baloch ◽  
Ameer Ali Jamali ◽  
...  

Introduction: Antenatal corticosteroids are recommended by Royal College of Obstetrics and Gynaecology for caesarean section planned before thirty-eight plus six weeks gestation. However, these steroids are, not suggested for labour induced electively after thirty four weeks. Objective: This study’s aim is to enumerate the possibility of respiratory morbidity in neonates for various deliberated approaches of delivery between thirty-five and thirty eight weeks gestation. Methodology: This study was carried out during June 2018 and December 2020 at a tertiary obstetric unit and analysed 3796 neonates delivered between thirty-five and thirty eight weeks gestation for neonatal admission due to respiratory morbidity. Results: The risk for respiratory problems in spontaneous labour was 9.9% (16/161), 5.0% (12/238), 1.2% (5/426) and 0.64% (6/930) at thirty five, thirty six, thirty seven and thirty eight weeks of gestation respectively. For induced labour, it was 25% (4/16), 4.8% (5/104), 4.1% (13/318) and 0.82% (4/485) at thirty-five, thirty six, thirty seven and thirty eight weeks respectively. While the risk of respiratory morbidity in elective caesarean section, was 13.8% (4/29), 27.1% (13/48), 4.1% (5/122) and 2.8% (9/318) at thirty-five, thirty six, thirty seven and thirty eight weeks respectively. Overall chance of respiratory morbidity in neonates was 6% after elective caesarean section, 2.8% after labour induction and 2.2% after spontaneous labour (p< 0.0001). The number of neonates with respiratory problems born by elective C-section was only 31 out of total 132 (23.5%). Whereas this risk was 2.8% at 35-38 weeks and 5.0% at 35-37 weeks after induced labour. Conclusion: Elective delivery at 35-38 weeks is linked to respiratory morbidity in new born babies. More research is required to assess the role of prophylactic corticosteroids preceding elective induction of labour.


Neonatology ◽  
2021 ◽  
pp. 1-8
Author(s):  
Vincent D. Gaertner ◽  
Dirk Bassler ◽  
Roland Zimmermann ◽  
Jehudith R. Fontijn

<b><i>Introduction:</i></b> Umbilical artery cord blood provides information about the intrauterine metabolism during labor. Umbilical artery lactate is a useful parameter in predicting neonatal morbidity, but data on normal values are limited. We aimed to provide reference ranges of umbilical artery lactate values across the combination of gestational age and mode of delivery. <b><i>Methods:</i></b> A single-center retrospective observational study of liveborn infants born between 23 and 42 completed weeks gestation was conducted. Lactate, base deficit (BD), and pH from arterial cord blood were assessed between June 2018 and November 2020 and compared across gestational ages and modes of delivery. <b><i>Results:</i></b> Overall, there were 3,353 infants with evaluable data. Lactate values at the 50th, 90th, and 97th percentile were 3.4, 7.0, and 9.0 mmol/L. Lactate was inversely correlated with pH (<i>r</i> = −0.77, <i>p</i> &#x3c; 0.001) and positively correlated with BD (<i>r</i> = 0.63, <i>p</i> &#x3c; 0.001). Lactate values changed significantly across gestational age (Kruskal-Wallis test, <i>p</i> &#x3c; 0.001) which was attributable to an increase in lactate at 39–41 weeks gestational age. Also, lactate values were different across modes of delivery (Kruskal-Wallis test, <i>p</i> &#x3c; 0.001) with lowest values in elective CS and highest values in vaginal instrumental deliveries. Comprehensive reference ranges across modes of delivery and gestational ages could be established. <b><i>Discussion:</i></b> Mode of delivery and gestational age contribute to lactate levels with highest values occurring in vaginal instrumental deliveries and between 39 and 41 weeks gestational age. Based on these observations, we provide detailed reference ranges for clinical use.


Author(s):  
Shreetoma Datta ◽  
Sonali Jitendra Ingole ◽  
Jitendra R Ingole

Introduction: Pregnant women have also been affected globally due to the Coronavirus Disease 2019 (COVID-19) pandemic. As foeto-maternal unit is involved, hence it is important to know possible manifestations and outcome of COVID-19 affected pregnant women. The findings of the study can be a guide for betterment of COVID-19 affected antenatal patients care. Aim: To find the outcome of pregnancies affected by the COVID- 19 infection of the Antenatal care (ANC) patients who presented to the tertiary care hospital in terms of laboratory parameters, treatment of the infection, mode of delivery, adverse outcome if and presence of documented infection in newborn. Materials and Methods: This was a retrospective observational study done from May 2020 to December 2020 conducted on the admitted pregnant women to the tertiary care hospital who tested positive for the COVID-19 virus were included in the study. Data collection (symptoms, reports and treatment) from these pregnant COVID-19 positive patients was done. Patients who were discharged before delivery were contacted telephonically and were asked the relevant information. Results: During the study period, total 1150 COVID-19 positive patients were admitted to the hospital. Amongst these, there were 441 female patients including pregnant and non pregnant women. Amongst the 441 COVID-19 infected female patients, 20 were pregnant. Majority of the patients were in the age group of 21-30 years. An 85% of women were in their third trimester at the time of admission. Pre-eclampsia and Hypothyroidism were the major co-morbidities observed. Six maternal Intensive Care Unit (ICU) admissions were noted. Breathlessness was the main symptom seen followed by sore throat, fever and cough. Previous Lower Segment Caesarean Section (LSCS) and foetal distress were cited as the main reasons for undergoing LSCS. No vertical transmission of virus was seen in the study. There were two neonatal ICU admission. Low Molecular Weight Heparin (LMWH) was administered to 33% patients. Fifty percent of the patients were prescribed steroids. Conclusion: Advanced gestational age, pre-eclampsia, hypothyroidism, elevated levels of d-dimer, Neutrophil/Lymphocyte (NL) ratio and C-reactive protein were seen as the main findings. Mother to child transmission was not observed in this study.


2012 ◽  
Vol 32 (S 01) ◽  
pp. S39-S42 ◽  
Author(s):  
S. Kocher ◽  
G. Asmelash ◽  
V. Makki ◽  
S. Müller ◽  
S. Krekeler ◽  
...  

SummaryThe retrospective observational study surveys the relationship between development of inhibitors in the treatment of haemophilia patients and risk factors such as changing FVIII products. A total of 119 patients were included in this study, 198 changes of FVIII products were evaluated. Results: During the observation period of 12 months none of the patients developed an inhibitor, which was temporally associated with a change of FVIII products. A frequent change of FVIII products didn’t lead to an increase in inhibitor risk. The change between plasmatic and recombinant preparations could not be confirmed as a risk factor. Furthermore, no correlation between treatment regimens, severity, patient age and comorbidities of the patients could be found.


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