Vaginal malignant melanoma: a case report and literature review

2004 ◽  
Vol 14 (4) ◽  
pp. 687-689
Author(s):  
M. Moodley ◽  
M. Daya ◽  
J. Moodley
Keyword(s):  
Case Report ◽  
Adjuvant Chemotherapy ◽  
Malignant Melanoma ◽  
Local Excision ◽  
Adjuvant Radiotherapy ◽  
Pelvic Surgery ◽  
Treatment Modalities ◽  
High Dose ◽  
The Past ◽  
Worse Prognosis

Vaginal melanomas are rare genital malignancies occurring mainly in the 6th and 7th decades of life. In general, they have a worse prognosis than cutaneous melanomas. In the past, various treatment modalities have been recommended including radical pelvic surgery. However, the prognosis is poor in spite of such radical approaches. More recently, more conservative treatment in the form of wide local excision combined with adjuvant chemotherapy, high-dose radiotherapy, and immunotherapy seem to have promising results. We describe a patient with vaginal malignant melanoma treated with conservative local excision as well as adjuvant radiotherapy, chemotherapy, and interferon.

scholarly journals Malignant Fibrous Histiocytoma of the Kidney Treated with Nephrectomy and Adjuvant Radiotherapy: A Case Report

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Rita Marchese ◽  
Pantaleo Bufo ◽  
Giuseppe Carrieri ◽  
Giuseppe Bove
Keyword(s):  
Case Report ◽  
High Risk ◽  
Adjuvant Chemotherapy ◽  
Local Recurrence ◽  
Malignant Fibrous Histiocytoma ◽  
Adjuvant Radiotherapy ◽  
Poor Prognosis ◽  
Fibrous Histiocytoma ◽  
Distant Metastases ◽  
Survival Outcome

Malignant fibrous histiocytoma (MFH) usually presents in the extremities or retroperitoneum. Cases involving the kidney are rare and portend a poor prognosis. Although radical nephrectomy is the most beneficial curative choice for this neoplasm, patients are often treated with adjuvant chemotherapy due to high risk of local recurrence and distant metastases. We describe a case of a 68-year-old woman affected by MFH, treated with both nephrectomy and radiotherapy without systemic therapy showing an unexpected twenty-four-month postsurgery survival outcome.

scholarly journals Breast sarcomas. A review of the possible treatment modalities

2017 ◽  
Vol 12 (2) ◽  
pp. 23-27
Author(s):  
Nicolae BACALBASA ◽  
◽  
Olivia IONESCU ◽  
Keyword(s):  
Surgical Treatment ◽  
Adjuvant Chemotherapy ◽  
Connective Tissue ◽  
Adjuvant Radiotherapy ◽  
De Novo ◽  
The Body ◽  
Treatment Modalities ◽  
R0 Resection ◽  
Axillary Lymph ◽  
Tumor Type

Background. Breast sarcomas (BS) are rare tumors which origin within the connective tissue of the breast. A clear delimitation from breast carcinoma should be established because the management and evolution and prognosis are different. BS can develop “de novo” – primary BS or can be related to a previously treated malignant breast tumor – for example after breast conservative surgery and adjuvant radiotherapy. Aim. Owing to the rarity of this tumor type, there is limited evidence with regard to the optimal treatment possibilities. The information comes primary from small retrospective studies so that the treatment principles resemble that of primary mesenchymal malignancies arising in other parts of the body (e.g. leiomyosarcoma, angiosarcoma or liposarcoma). We aimed to make a review of the current treatment possibilities of the BS emphasizing on the type and extent of the surgical treatment, the utility of the axillary lymph node (LN) dissection and the feasibility and benefit of an adjuvant chemotherapy. Method. We performed an online research on Pubmed using the following key words: “sarcoma”, “radiotherapy”, “surgery”, “chemotherapy”. We tried to select the data referring to sarcoma developing with the connective tissue of the breast as well as the information of BS developing after irradiation of the breast in women previously diagnosed with breast cancer (BC) who received adjuvant radiotherapy. We further looked for reports about the role of an adjuvant treatment, namely chemotherapy. Conclusion. The only treatment proved to have a benefit on the prognosis is the surgical treatment with the achievement of a wide, radical, complete resection (R0-resection). For angiosarcomas, either primary or therapy-related, the margins of resection should be more than 1 cm for small tumors and more than 3 cm for larger tumors. Adjuvant chemotherapy has limited benefits and should be applied in selected cases.

scholarly journals Primary malignant mucosal melanoma of the larynx: A case report and literature review

2015 ◽  
Vol 5 (10) ◽  
pp. 872-874
Author(s):  
S Shrestha Khadka ◽  
MC Lee ◽  
AB Karki
Keyword(s):  
Case Report ◽  
Adjuvant Chemotherapy ◽  
Malignant Melanoma ◽  
Literature Review ◽  
Head And Neck ◽  
Radical Surgery ◽  
Mucosal Melanoma ◽  
Rare Entity ◽  
Mucous Membranes ◽  
Female Genital

Malignant mucosal melanoma is very rare entity. It comprises about 1% of all malignant melanoma and exhibit more aggressive behaviour than that of skin melanomas. Mucosal melanoma arises mainly from the mucous membranes of head and neck, the female genital organs or the anorectal and the urinary tracts.  Laryngeal malignant melanoma constitutes 3.8% to 7.4% of all cases of malignant mucosal melanoma of head and neck. In this article we report a case of primary malignant mucosal melanoma of larynx in 27 years old male who was treated with radical surgery and adjuvant chemotherapy in BPKM Cancer Hospital, Chitwan.

scholarly journals A Rare Case of Dissemination of Primary Spinal Glioblastoma

2021 ◽  
Author(s):  
Deniz Sirinoglu ◽  
Buse Sarigul ◽  
Ozan Baskurt ◽  
Mehmet Volkan Aydin
Keyword(s):  
Spinal Cord ◽  
Case Report ◽  
Adjuvant Radiotherapy ◽  
Poor Prognosis ◽  
Spinal Tumors ◽  
Optimal Management ◽  
First Case ◽  
Cranial Mri ◽  
Rare Lesion ◽  
Worse Prognosis

Abstract Background Primary spinal glioblastoma is a rare lesion which constitutes only 1.5% of all spinal tumors. Diagnosis is challenging due to absence of any radiological hallmark of the disease. Even though surgery combined with chemoradiotherapy is the optimal management for these tumors, prognosis is still poor. Dissemination of glioblastoma is reported several times in the literature, which is correlated with worse prognosis and outcome. This case report that we are presenting is the first case where dissemination of primary spinal glioblastoma dissemination is limited only to spinal cord, without intracranial invasion, and regression was achieved with chemoradiotherapy. Case Report In this article, a patient with primary spinal glioblastoma who presented with paraparesia is presented. Patient underwent surgery for resection of the tumor and received adjuvant radiotherapy. However, 9 months postoperatively, dissemination was detected in epidural and subdural spaces of spinal canal, with concomitant compression of spinal cord. There was no radiographically detected lesion in cranial MRI. He underwent second session of radiotherapy, combined with chemotherapy and steroid. Five months later, regression of metastatic disseminated lesions was observed. Conclusion Primary spinal glioblastoma is a rare pathology and known to have a poor prognosis, notably with dissemination of the disease. Even though further biomolecular studies are necessary to explain the pathophysiology better, chemotherapy and radiotherapy may be effective in regression of disseminated lesions.

scholarly journals Recurrence of uveal malignant melanoma: a case report

2013 ◽  
Vol 5 (2) ◽  
pp. 275-278
Author(s):  
Madhu Thapa ◽  
GB Shrestha ◽  
AK Sharma ◽  
S Karki ◽  
S Khanal
Keyword(s):  
Case Report ◽  
Adjuvant Chemotherapy ◽  
Malignant Melanoma ◽  
Early Diagnosis ◽  
Uveal Melanoma ◽  
Unusual Case ◽  
Uveal Tract ◽  
Uveal Malignant Melanoma ◽  
Ocular Morbidity

Background: Malignant melanoma of uveal tract is a rare ocular malignancy. It is one of the significant causes of ocular morbidity and mortality which is less commonly seen in children. Case: We report an unusual case of orbital recurrence of malignant melanoma in a 14-yearold boy who had previously undergone enucleation of the left painful blind eye 8 months ago. He was diagnosed to have uveal malignant melanoma elsewhere which was confirmed by histopathology. Orbital recurrence was managed with modified exenteration with adjuvant chemotherapy and radiotherapy. Conclusion: In all treated cases of uveal melanoma, close follow up examination and monitoring is necessary for early diagnosis of the recurrence and to plan for further management. Nepal J Ophthalmol 2013; 5(10): 275-278 DOI: http://dx.doi.org/10.3126/nepjoph.v5i2.8744

scholarly journals Immune Suppression in Head and Neck Cancers: A Review

2010 ◽  
Vol 2010 ◽  
pp. 1-15 ◽  
Author(s):  
Anaëlle Duray ◽  
Stéphanie Demoulin ◽  
Pascale Hubert ◽  
Philippe Delvenne ◽  
Sven Saussez
Keyword(s):  
Head And Neck ◽  
Hla Class I ◽  
Squamous Cell Carcinomas ◽  
Treatment Modalities ◽  
Host Immune System ◽  
Concomitant Chemoradiotherapy ◽  
The Past ◽  
Common Cancer ◽  
Invasive Carcinomas ◽  
Worse Prognosis

Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common cancer in the world. Despite significant advances in the treatment modalities involving surgery, radiotherapy, and concomitant chemoradiotherapy, the 5-year survival rate remained below 50% for the past 30 years. The worse prognosis of these cancers must certainly be link to the fact that HNSCCs strongly influence the host immune system. We present a critical review of our understanding of the HNSCC escape to the antitumor immune response such as a downregulation of HLA class I and/or components of APM. Antitumor responses of HNSCC patients are compromised in the presence of functional defects or apoptosis of T-cells, both circulating and tumor-infiltrating. Langerhans cells are increased in the first steps of the carcinogenesis but decreased in invasive carcinomas. The accumulation of macrophages in the peritumoral areas seems to play a protumoral role by secreting VEGF and stimulating the neoangiogenesis.

scholarly journals Abdominal perineal resection or wilde local excision in primary anorectal malignant melanoma. Case report and review

2017 ◽  
Vol 19 ◽  
pp. 74-77 ◽  
Author(s):  
Saverio Latteri ◽  
Michele Teodoro ◽  
Michele Malaguarnera ◽  
Maurizio Mannino ◽  
Giuseppe Currò ◽  
...  
Keyword(s):  
Case Report ◽  
Malignant Melanoma ◽  
Local Excision ◽  
Perineal Resection ◽  
Anorectal Malignant Melanoma ◽  
Abdominal Perineal Resection ◽  
Melanoma Case

scholarly journals Malignant Melanoma of Left Sole Metastasis to Brain: A Case Report

2019 ◽  
Vol 20 (1) ◽  
pp. 32-33
Author(s):  
Nabir Hossain ◽  
Avisak Bhattacharjee
Keyword(s):  
Case Report ◽  
Malignant Melanoma ◽  
Ct Scan ◽  
Local Excision ◽  
Wide Local Excision ◽  
Primary Lesion ◽  
Cerebral Metastasis ◽  
Lymphnode Metastasis ◽  
Neurological Features

A 60-year-old man presented with malignant melanoma on left heel with left inguinal lymphnode metastasis. He developed right hemiparesis on the 3rd POD of wide local excision of anulcerated lesion of the left sole. CT scan showed multiple cerebral metastasis in the bothparietal lobes. No neurological features also manifested before operation of the primary lesion. Journal of Surgical Sciences (2016) Vol. 20 (1) : 32-33

scholarly journals Malignant Melanoma of the Parotid Gland – Primary or Metastatic ?

2004 ◽  
Vol 43 (155) ◽  
Author(s):  
Usha Rani Singh ◽  
KU Chaturvedi ◽  
S Bhatta ◽  
S Karki ◽  
B Kumar
Keyword(s):  
Malignant Melanoma ◽  
Parotid Gland ◽  
Spontaneous Regression ◽  
Primary Melanoma ◽  
Detailed History ◽  
The Past ◽  
Pigmented Lesion ◽  
High Incidence ◽  
Distant Spread ◽  
Worse Prognosis

Involvement of the parotid gland by malignant melanoma is rare. Parotid Metastasis from cutaneous melanoma is uncommon. Primary melanoma of the parotid gland is a controversial entity. A diagnosis of parotid gland malignant melanoma should herald a search for a primary skin neoplasm & this may be exceptionally difficult because of the well recognised though uncommon phenomenon of spontaneous regression of the primary melanoma. A 39 years old male presented with progressive painless enlargement of the parotid gland over the past seven months. Removal of the parotid gland was possible only on the second attempt. A detailed history revealed excision of a pigmented lesion on the contralateral cheek 20 years back. The tumour  was  a  black  heavily  pigmented  lesion  with  varied  morphology.  In spite of low mitotic count there was vascular embolisation. The margins were infiltrative. Patients with parotid gland melanoma have a high incidence of distant spread & significantly worse prognosis, requiring  medical  surgery.Key Words: Melanoma, Parotid gland.

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