scholarly journals 1064 Role of CA 125, HE4 and IOTA simple rules in differentiating benign and malignant ovarian tumour

2021 ◽  
Author(s):  
A Bahadur ◽  
R Mundhra ◽  
N Bhattacharya
Keyword(s):  
Ovarian Tumour ◽  
Ca 125 ◽  
Simple Rules ◽  
Malignant Ovarian Tumour

scholarly journals Meigs’ Syndrome Associated With Elevated Ca 125 Level – A Rare Case

2016 ◽  
Vol 24 (1) ◽  
pp. 76-78
Author(s):  
Tabassum Ghani ◽  
Nilufar Sultana ◽  
Taufiqua Hussain ◽  
Afrina Begum ◽  
Subinoy Krisno Paul ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Postmenopausal Women ◽  
Rare Case ◽  
Ovarian Tumour ◽  
Ca 125 ◽  
Adnexal Masses ◽  
Ovarian Fibroma ◽  
Medical College ◽  
Ca125 Level ◽  
Malignant Ovarian Tumour

Meigs’ syndrome is a rare but well known syndrome. It is a triad of ovarian fibroma with ascites and pleural effusion that resolves after resection of the tumour. Postmenopausal women with solid adnexal masses, ascites and pleural effusion with elevated CA125 level are highly suggestive for malignant ovarian tumour. Only few cases of Meigs, syndrome with elevated CA 125 have been reported in different literatures. Here we report a case of Meigs syndrome due to right sided ovarian fibroma with elevated CA 125 level in postmenopausal woman.J Dhaka Medical College, Vol. 24, No.1, April, 2015, Page 76-78

TO DETERMINE THE ROLE OF CA125 IN THE DIAGNOSIS OF ACUTE APPENDICITIS

2020 ◽  
Vol 4 (7) ◽  
Author(s):  
Vinod Kumar ◽  
Bhupen Songra ◽  
Richa Jain ◽  
Deeksha Mehta
Keyword(s):  
Acute Appendicitis ◽  
Clinical Diagnosis ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Ca 125 ◽  
Care Hospital ◽  
Serum Samples ◽  
Roc Curve Analysis ◽  
Surgery Department

Background: the present study was under taken to determine the role of CA-125 in the diagnosis of acute appendicitis (AA), to prevent its complications and also in preventing negative appendicectomies in tertiary care hospital. Methods: The study was conducted at a tertiary care and research center between 01/03/2018 to 30/06/2019. Patients admitted to the surgery department with diagnosis of AA were considered for the study. After informed consent, a, standardized history was obtained as a case Performa. Serum samples from all the cases with clinical diagnosis of AA were obtained and stored. Only the cases with histopathologically approved AA were included in the study. Cases operated for clinical diagnosis of AA, but not histopathologically proven AA was not included in the study. CA125 levels in cases with definitive diagnosis of AA were measured. Results: In present study, ROC curve analysis revealed the sensitivity of 87.27 % and specificity of 90.91 % when the CA 125 cut-off value of > 16.8 was taken to diagnose acute appendicitis. AUC was 0.911 with a standard error of 0.0292. Conclusion: In this study we have observed that CA125 showed a positive correlation with acute appendicitis, that was statistically not significant (P>0.05). We didn’t evaluate the correlation with the disease severity. We consider that CA125 can be used as a marker in acute appendicitis cases although further research is still needed. Keywords: CA125, Acute Appendicitis, Surgery.

1097 Role of PD-L1 in In-vitro Interaction Between T-cells and Ovarian Tumour Cells

2012 ◽  
Vol 48 ◽  
pp. S264
Author(s):  
J. Chatterjee ◽  
N. Haslinda Abdul Aziz ◽  
C. Maine ◽  
C. Hayford ◽  
L. Whilding ◽  
...  
Keyword(s):  
T Cells ◽  
Ovarian Tumour ◽  
Tumour Cells ◽  
In Vitro Interaction

ESGO Statement on the Role of CA‐125 Measurement in Follow-Up of Epithelial Ovarian Cancer

2012 ◽  
Vol 22 (1) ◽  
pp. 175-175 ◽  
Author(s):  
Nicoletta Colombo ◽  
Gerald Gitsch ◽  
Nicolas Reed ◽  
Frederic Amant ◽  
David Cibula ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Ca 125

scholarly journals Menstrual Cycle Dependent Variability for Serum Tumor Markers CEA, AFP, CA 19-9, CA 125 and CA 15-3 in Healthy Women

1999 ◽  
Vol 15 (4) ◽  
pp. 259-267 ◽  
Author(s):  
Ayşe Binnur Erbağci ◽  
Necat Yilmaz ◽  
Irfan Kutlar
Keyword(s):  
Menstrual Cycle ◽  
Tumor Markers ◽  
Normal Function ◽  
Ca 125 ◽  
Diagnostic Efficiency ◽  
Healthy Women ◽  
Healthy Female ◽  
Serum Cea ◽  
Cycle Dependent

Information on menstrual cycle dependent variation of tumor markers in healthy women is a subject of diagnostic efficiency and has an impact in elucidating the normal function of these markers. In this study midfollicular and midluteal concentrations of serum CEA, AFP, CA 19-9, CA 125, CA 15-3 and their relations with LH, FSH, prolactin, estradiol and progesterone were evaluated during ovulatory cycles in a group of 23 healthy female individuals. Samples were collected on the 7th and 21st day of the same menstrual cycle. Tumor marker and hormone concentrations were determined with chemiluminescence or electrochemiluminescence EIA methods. A significant phase-dependent difference was observed for CA 15-3, midluteal concentrations (mean ± SEM; 26.33 ± 1.56 U/ml) higher than the midfollicular (mean ± SEM; 19.27 ± 1.49 U/ml) concentrations (p < 0.001). But an obvious difference for other tumor markers investigated did not exist. Significant correlations of follicular and luteal CA 125 levels with body mass index of the subjects were observed (r:0.52, p < 0.05 and r:0.57, p < 0.005, respectively).CA 15-3 antigen is a product of the MUC-1 gene which is expressed in abundance by endometrial epithelial cells in the secretory phase of the menstrual cycle which may be the potential source of variability. The association of CA 125 levels with obesity suggests a possible role of adipose tissue in CA 125 metabolism. In conclusion our data suggest that in healthy women serum CA 15-3 levels are significantly elevated in the midluteal phase of the menstrual cycle compared to midfollicular phase. Therefore, consideration of menstrual cycle dependent variability for CA 15-3 appears indicated in interpretation of individual results.

scholarly journals The Role of CA‐125 in the Management of Ovarian Cancer

1997 ◽  
Vol 2 (1) ◽  
pp. 6-9 ◽  
Author(s):  
Maurie Markman
Keyword(s):  
Ovarian Cancer ◽  
Ca 125

Spurious Elevation of Ca-125 in Benign Ovarian Tumour

2017 ◽  
Vol 6 (2(Part-1)) ◽  
pp. 327-329
Author(s):  
Vincy T.M. ◽  
◽  
Kanchana M.P. ◽  
Keyword(s):  
Ovarian Tumour ◽  
Ca 125 ◽  
Benign Ovarian Tumour

The role of progesterone-induced blocking factor (PIBF) in invasion of primary ovarian tumour cells

2017 ◽  
Vol 122 ◽  
pp. 46
Author(s):  
T. Balassa ◽  
G. Berta ◽  
N. Bohonyi ◽  
J. Szekeres-Barthó
Keyword(s):  
Ovarian Tumour ◽  
Tumour Cells ◽  
Blocking Factor

scholarly journals The Role of Cathepsin B in Peritoneal Fibrosis due to Peritoneal Dialysis

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Su Ah Sung ◽  
Dong Hee Kim ◽  
Kook-Hwan Oh ◽  
Sang Youb Han ◽  
Kum Hyun Han
Keyword(s):  
Peritoneal Dialysis ◽  
Cystatin C ◽  
Cathepsin B ◽  
Ca 125 ◽  
Peritoneal Fibrosis ◽  
Peritoneal Mesothelial Cells ◽  
Type Plasminogen Activator ◽  
Lysosomal Cysteine Protease ◽  
Human Peritoneal Mesothelial Cells

Glucose-containing peritoneal dialysis (PD) solution causes peritoneal fibrosis (PF) characterized by accumulation of extracellular matrix (ECM) in the submesothelial layer. Cathepsin B is a lysosomal cysteine protease that degrades ECM, but its role in the PF remains unclear. Thus, we investigated the role of cathepsin B in PF. Procathepsin B was measured in the 73 PD effluents of 68 patients. Procathepsin B and cathepsin B after exposure of glucose and the effects of cathepsin B on the expression of matrix metalloproteinases (MMPs), tissue inhibitor of metalloproteinases (TIMPs), and urokinase-type plasminogen activator (uPA) were measured in the supernatant of cultured human peritoneal mesothelial cells (HPMCs). The effect of cathepsin B and its inhibitor, cystatin C, on PF was investigated in the murine model. Procathepsin B was measured at 3.6 μg/L in serum and 5.4 μg/L in PD effluent and positively correlated to the cancer antigen (CA) 125. The treatment with 4.25% glucose increased procathepsin B by 3.1-fold and cathepsin B by 5.9-fold in the HPMCs. Cathepsin B induced the secretion of MMP-1, -2, and -3 and TIMP-1 in the HPMCs, but uPA was not excreted. In the PF murine models, cathepsin B reduced the thickness of the submesothelial layer and cystatin C attenuated the effect of cathepsin B. HPMCs secrete cathepsin B with exposure of PD solution, and cathepsin B might help protect against PF.

Sign in / Sign up

Export Citation Format

Share Document