Body size, non-occupational physical activity and the chance of reaching longevity in men and women: findings from the Netherlands Cohort Study

2019 ◽  
Vol 73 (3) ◽  
pp. 239-249 ◽  
Author(s):  
Lloyd Brandts ◽  
Piet A van den Brandt
Keyword(s):  
Physical Activity ◽  
Cohort Study ◽  
Body Size ◽  
The Netherlands ◽  
Cox Regression ◽  
Occupational Physical Activity ◽  
Vital Status ◽  
Human Lifespan ◽  
Using Data ◽  
Study Participants

IntroductionThe rising number of obese and/or physically inactive individuals might negatively impact human lifespan. This study assessed the association between height, body mass index (BMI) and non-occupational physical activity and the likelihood of reaching 90 years of age, in both sexes separately.MethodsAnalyses were conducted using data from the Netherlands Cohort Study. Participants born in 1916–1917 (n=7807) completed a questionnaire in 1986 (at age 68–70 years) and were followed up for vital status information until the age of 90 years (2006–2007). Cox regression analyses were based on 5479 participants with complete data to calculate risk ratios (RRs) of reaching longevity (age 90 years).ResultsIn women, we observed significant associations between reaching longevity and height (RR: 1.05 per 5 cm increment; 95% CI 1.00 to 1.09), BMI at baseline (≥30vs18.5–<25 kg/m2; RR: 0.68; 95% CI 0.54 to 0.86) and BMI change since age 20 years (≥8vs0–<4 kg/m2; RR: 0.81; 95% CI 0.66 to 0.98). In men, height and BMI were not associated with reaching longevity. In women, non-occupational physical activity showed an inverse U-shaped association with reaching longevity, with the highest RR around 60 min of physical activity per day. In men, a positive linear association was observed between physical activity and reaching longevity.ConclusionThis study indicates that body size and physical activity are related to the likelihood of reaching 90 years of age and that these associations differ by sex.

scholarly journals Alcohol consumption in later life and reaching longevity: the Netherlands Cohort Study

2020 ◽  
Vol 49 (3) ◽  
pp. 395-402 ◽  
Author(s):  
Piet A van den Brandt ◽  
Lloyd Brandts
Keyword(s):  
Cohort Study ◽  
The Netherlands ◽  
Binge Drinking ◽  
Alcohol Intake ◽  
Cox Regression ◽  
Later Life ◽  
History Of ◽  
Using Data ◽  
Moderate Alcohol Intake ◽  
Study Participants

Abstract Background whether light-to-moderate alcohol intake is related to reduced mortality remains a subject of intense research and controversy. There are very few studies available on alcohol and reaching longevity. Methods we investigated the relationship of alcohol drinking characteristics with the probability to reach 90 years of age. Analyses were conducted using data from the Netherlands Cohort Study. Participants born in 1916–1917 (n = 7,807) completed a questionnaire in 1986 (age 68–70 years) and were followed up for vital status until the age of 90 years (2006–07). Multivariable Cox regression analyses with fixed follow-up time were based on 5,479 participants with complete data to calculate risk ratios (RRs) of reaching longevity (age 90 years). Results we found statistically significant positive associations between baseline alcohol intake and the probability of reaching 90 years in both men and women. Overall, the highest probability of reaching 90 was found in those consuming 5– &lt; 15 g/d alcohol, with RR = 1.36 (95% CI, 1.20–1.55) when compared with abstainers. The exposure-response relationship was significantly non-linear in women, but not in men. Wine intake was positively associated with longevity (notably in women), whereas liquor was positively associated with longevity in men and inversely in women. Binge drinking pointed towards an inverse relationship with longevity. Alcohol intake was associated with longevity in those without and with a history of selected diseases. Conclusions the highest probability of reaching 90 years was found for those drinking 5– &lt; 15 g alcohol/day. Although not significant, the risk estimates also indicate to avoid binge drinking.

scholarly journals Adherence to the Mediterranean diet and risk of lung cancer in the Netherlands Cohort Study

2018 ◽  
Vol 119 (6) ◽  
pp. 674-684 ◽  
Author(s):  
Maya Schulpen ◽  
Piet A. van den Brandt
Keyword(s):  
Lung Cancer ◽  
Cancer Research ◽  
Cohort Study ◽  
Cancer Risk ◽  
The Netherlands ◽  
Mediterranean Diet ◽  
Dietary Habits ◽  
Lung Cancer Risk ◽  
Cox Regression ◽  
The Mediterranean

AbstractThe evidence on a cancer-protective effect of the Mediterranean diet (MD) is still limited. Therefore, we investigated the association between MD adherence and lung cancer risk. Data were used from 120 852 participants of the Netherlands Cohort Study (NLCS), aged 55–69 years. Dietary habits were assessed at baseline (1986) using a validated FFQ and alternate and modified Mediterranean diet scores (aMED and mMED, respectively), including and excluding alcohol, were calculated. After 20·3 years of follow-up, 2861 lung cancer cases and 3720 subcohort members (case-cohort design) could be included in multivariable Cox regression analyses. High (6–8) v. low (0–3) aMED excluding alcohol was associated with non-significantly reduced lung cancer risks in men and women with hazard ratios of 0·91 (95 % CI 0·72, 1·15) and 0·73 (95 % CI 0·49, 1·09), respectively. aMED-containing models generally fitted better than mMED-containing models. In never smokers, a borderline significant decreasing trend in lung cancer risk was observed with increasing aMED excluding alcohol. Analyses stratified by the histological lung cancer subtypes did not identify subtypes with a particularly strong inverse relation with MD adherence. Generally, the performance of aMED and World Cancer Research Fund/American Institute for Cancer Research dietary score variants without alcohol was comparable. In conclusion, MD adherence was non-significantly inversely associated with lung cancer risk in the NLCS. Future studies should focus on differences in associations across the sexes and histological subtypes. Furthermore, exclusion of alcohol from MD scores should be investigated more extensively, primarily with respect to a potential role of the MD in cancer prevention.

scholarly journals Physical Activity and Risk of Ovarian Cancer: Results from the Netherlands Cohort Study (The Netherlands)

2006 ◽  
Vol 17 (1) ◽  
pp. 109-115 ◽  
Author(s):  
Regien G. Biesma ◽  
Leo J. Schouten ◽  
Miranda J.M. Dirx ◽  
R. Alexandra Goldbohm ◽  
Piet A. van den Brandt
Keyword(s):  
Physical Activity ◽  
Ovarian Cancer ◽  
Cohort Study ◽  
The Netherlands

415 OCCUPATIONAL PHYSICAL ACTIVITY AND THE RISK OF GORD, BARRETT’S OESOPHAGUS AND OESOPHAGEAL ADENOCARCINOMA A PROSPECTIVE COHORT STUDY IN UK BIOBANK

2020 ◽  
Vol 33 (Supplement_1) ◽  
Author(s):  
S Lam ◽  
G Savva ◽  
L Alexandre ◽  
B Kumar ◽  
A Hart
Keyword(s):  
Physical Activity ◽  
Cohort Study ◽  
Gastroesophageal Reflux Disease ◽  
Reflux Oesophagitis ◽  
Barrett’S Oesophagus ◽  
Oesophageal Adenocarcinoma ◽  
Occupational Physical Activity ◽  
Barrett's Oesophagus ◽  
Manual Activity ◽  
Reflux Œsophagitis

Abstract   Recreational physical activity has been shown to protect against the development of oesophageal adenocarcinoma as well as gastroesophageal reflux disease (GORD), but such effects have not been demonstrated for non-recreational activity. We examined whether high levels of occupational physical activity (heavy manual labour or physical work) were associated with the risk of oesophageal adenocarcinoma as well as its sequential precursor diseases; gastroesophageal reflux disease (GORD), reflux oesophagitis and Barrett’s oesophagus. Methods In this population-based prospective cohort study, participants aged between 37 to 73 years were recruited from 22 regions across the United Kingdom. Baseline occupational information of job type and levels of heavy manual activity was assessed using both questionnaires and verbal interviews. Incident cases were identified by linkage with routinely collected hospital inpatient and cancer registry data for England, Scotland and Wales. Primary clinical outcomes were GORD without oesophagitis, GORD with oesophagitis (reflux oesophagitis), Barrett’s oesophagus and oesophageal adenocarcinoma. The effects of heavy manual activity on disease risk were estimated using Cox proportional hazard regression. Results Between 2006 and 2010, 502 524 men and women were enrolled. Main analyses were limited to the working population with a full set of variables of interest (n = 266 453). Compared to jobs with low levels of heavy manual activity, high level jobs had increased hazard ratios (HRs) for GORD (1.20, 95% CI 1.11–1.30), reflux oesophagitis (1.17, 95% CI 1.04–1.31) and Barrett’s oesophagus (1.13, 95% CI 0.98–1.32), but not oesophageal adenocarcinoma (0.91 95% CI 0.54–1.56). Conclusion High levels of occupational heavy manual activity could be used as a risk factor for GORD and reflux oesophagitis, the precursor diseases of Barrett’s oesophagus and oesophageal adenocarcinoma.

scholarly journals Body Size and Colorectal Cancer Risk After 16.3 Years of Follow-up: An Analysis From the Netherlands Cohort Study

2011 ◽  
Vol 174 (10) ◽  
pp. 1127-1139 ◽  
Author(s):  
L. A. E. Hughes ◽  
C. C. J. M. Simons ◽  
P. A. van den Brandt ◽  
R. A. Goldbohm ◽  
M. van Engeland ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cohort Study ◽  
Body Size ◽  
Cancer Risk ◽  
The Netherlands ◽  
Colorectal Cancer Risk
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