Exposure to occupational hazards and risk of sinonasal epithelial cancer: results from an extended Italian case–control study

2020 ◽  
pp. oemed-2020-106738
Author(s):  
Angelo d’Errico ◽  
Jana Zajacova ◽  
Anna Cacciatore ◽  
Santo Alfonzo ◽  
Fabio Beatrice ◽  
...  
Keyword(s):  
Organic Solvents ◽  
Smoking Habit ◽  
Cumulative Exposure ◽  
Sufficient Evidence ◽  
Wood Dust ◽  
Expert Assessment ◽  
Welding Fumes ◽  
Occupational Hazards ◽  
Sinonasal Cancer ◽  
Alcohol Production

ObjectivesThere is sufficient evidence for a causal association of sinonasal epithelial cancers (SNEC) only for exposure to wood and leather dusts, nickel compounds and employment in isopropyl alcohol production. The aim of this study was to assess whether other occupational hazards are associated with the risk of SNEC for the main histologic types, namely adenocarcinoma (AD) and squamous cell carcinoma (SCC).MethodsThe study population included 375 incident SNEC cases collected from 1996 to 2014 (79% of all diagnosed SNEC) throughout the Piedmont region by the regional Sinonasal Cancer Registry, and 408 hospital controls. Exposure to 17 occupational agents was assigned through expert assessment based on interviews to the subjects on jobs held throughout their working life. The relationship of SNEC with ever and cumulative exposure to the hazards was assessed through unconditional logistic regression models adjusted for age, sex, area of residence, smoking habit, year of enrolment and coexposures.ResultsAD was associated with both ever and cumulative exposure to wood dust, leather dust and organic solvents, and with cumulative exposure to textiles dusts. SCC risk was significantly increased by ever exposure to nickel, chromium and welding fumes, as well as by cumulative exposure to welding fumes, arsenic and organic solvents. A mixed group of other histological types was associated with both ever and cumulative exposure to wood dust and textile dusts.ConclusionsThe associations of SNEC with wood dust, leather dust and nickel were confirmed, while some new associations were observed for other hazards, which merit further investigation.

scholarly journals Prevalence of occupational hazards in patients with different types of epithelial sinonasal cancers

2013 ◽  
Vol 51 (1) ◽  
pp. 31-36
Author(s):  
M. Bonzini ◽  
P. Battaglia ◽  
D. Parassoni ◽  
M. Casa ◽  
N. Facchinetti ◽  
...  
Keyword(s):  
Risk Factors ◽  
Occupational Exposure ◽  
Case Series ◽  
Occupational Exposures ◽  
Wood Dust ◽  
Occupational Hazards ◽  
Sinonasal Cancer ◽  
Occupational Risk Factors ◽  
Case Series Study ◽  
Wide Range

Background: Occupational exposure to carcinogens contributes greatly to the etiology of sinonasal cancer (SNC), but the role of different risk factors in determining different histological subtypes is disputed. Methodology: All consecutive surgical epithelial SNC cases (case-series study) underwent a systematic occupational medicine examination to determine previous exposure to a wide range of work-related chemical hazards. Results: We investigated 65 SNC cases including intestinal-type adenocarcinoma [ITAC] squamous-cell carcinoma [SCC], and others. Occupational exposure was recognized for 39 cases. Occupational exposures were sensibly more frequent among ITAC than among SCC or other histotypes. Occupational exposure in ITAC cases was to leather or wood dust only, while among non-ITAC cases, we recognised exposure to formaldehyde, solvents and metal fumes. A high proportion of SNC with occupational exposure originated in the ethmoidal epithelium. Conclusion: In our case-series of SNC, a very high frequency of previous occupational exposure to carcinogens was detected, suggesting that occupational hazards may be associated to the aetiopathogenesis, primarily for ITAC, but also for other histotypes. Besides leather or wood, other chemical agents must be recognized as occupational risk factors.

scholarly journals Worker Characteristics and Dust Exposure to Pulmonary Function Status in Jumping Saw Division Of Wood Industry At Banyuwangi: An Association Study

2019 ◽  
Vol 11 (2) ◽  
pp. 99
Author(s):  
Desy Tri Wulansari
Keyword(s):  
Pulmonary Function ◽  
Smoking Habit ◽  
Dust Exposure ◽  
Wood Dust ◽  
Wood Industry ◽  
Chi Square ◽  
Cross Sectional ◽  
Lung Physiology ◽  
Dust Level ◽  
Worker Characteristics

Wood dust in the air will bring serious health problems if it is prolonged. Wood Dust has effect for health due to  its effect on , pulmonary function via respiratory system entrance. The aim of this study was to analyze the  association of worker characteristics and dust exposure to pulmonary function status in jumping saw division workers in wood industry Sempu, Banyuwangi. The research was observasional with cross sectional desain. Research data was obtained by giving questionnaire to respondent, measurement of dust level by using HVAS and lung physiology examination using spirometry tool. The sampel in this research was 7 workers in the part of jumping saw and 6 worker in the part of office. Data were analyzed with chi square statistical test  to analyzing the association and statistical t-test to analyzing difference  pulmonary function status between to 2 groups. The result showed that dust level in the exposure groups of jumping saw workers was 19,90 mg/m3 and non-exposure group  (office) was 0,089 mg/m3, suitable with Permenakertrans No. 13/MEN/X/2011 is 5 mg/m3. Results of lung function measurement showed that normal 15,38% and impairment 84,62%. It is concluded that no associoation between age, length of employment, smoking habit, respiratory ptotective equipment usage habit, respiratory diseases history and  dust exposure to pulmonary function status, except association between nutrion status with pulmonary function status. The company should monitor the levels of wood dust, to ensure that it does not exceed the NAB and regular lung physiological health checks.

scholarly journals Sinonasal Cancer and Occupational Exposure in a Population-Based Registry

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Carolina Mensi ◽  
Dario Consonni ◽  
Claudia Sieno ◽  
Sara De Matteis ◽  
Luciano Riboldi ◽  
...  
Keyword(s):  
Clinical Information ◽  
Occupational Exposures ◽  
Population Based ◽  
Dust Exposure ◽  
Wood Dust ◽  
Sinonasal Cancer ◽  
Complete Collection ◽  
Lombardy Region ◽  
Industrial Sectors ◽  
Population Based Registry

We examined occupational exposures among subjects with sinonasal cancer (SNC) recorded in a population-based registry in the Lombardy Region, the most populated and industrialized Italian region. The registry collects complete clinical information and exposure to carcinogens regarding all SNC cases occurring in the population of the region. In the period 2008–2011, we recorded 210 SNC cases (137 men, 73 women). The most frequent occupational exposures were to wood (44 cases, 21.0%) and leather dust (29 cases, 13.8%), especially among men: 39 cases (28.5%) to wood and 23 cases (16.8%) to leather dust. Exposure to other agents was infrequent (<2%). Among 62 subjects with adenocarcinoma, 50% had been exposed to wood dust and 30.7% to leather dust. The proportions were around 10% in subjects with squamous cell carcinoma and about 20% for tumors with another histology. The age-standardized rates (×100,000 person-years) were 0.7 in men and 0.3 in women. Complete collection of cases and their occupational history through a specialized cancer registry is fundamental to accurately monitor SNC occurrence in a population and to uncover exposure to carcinogens in different industrial sectors, even those not considered as posing a high risk of SNC, and also in extraoccupational settings.

Toward Understanding of Environmental Risk Factors in Systemic Sclerosis

2020 ◽  
pp. 120347542095795
Author(s):  
Lydia Ouchene ◽  
Anastasiya Muntyanu ◽  
Jérôme Lavoué ◽  
Murray Baron ◽  
Ivan V. Litvinov ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Systemic Sclerosis ◽  
Organic Solvents ◽  
Epoxy Resins ◽  
Twin Studies ◽  
Breast Implants ◽  
Welding Fumes ◽  
Increased Risk ◽  
Vitamin D Levels

Importance Systemic sclerosis (SSc) is a severe, chronic, and incurable autoimmune fibrotic skin disease with significant extracutaneous involvement. Low concordance rate in twin studies and unequal geographic distribution of SSc argues for importance of environment in disease initiation and progression. Objective In this manuscript we provide a summary of all investigated potential external risk factors for SSc. Data sources A literature search in PubMed and EMBASE database was performed for studies published until January 1, 2020 by 2 reviewers (EN and LO) independently. Findings Occupational and/or environmental exposures to silica and organic solvents are associated with increased incidence and severity of SSc. Exposure to epoxy resins, asbestos, and particulate air pollution favors increased risk of SSc, but data are based on limited number of observational studies. There is insufficient evidence to conclude an association between SSc development and other occupational (eg, welding fumes) or personal exposures (eg, smoking, vitamin D deficiency). Association of SSc with silicone breast implants has been disproven. Infectious pathogens (eg, Helicobacter pylori and angiotropic viruses) and dysbiosis seem to play a role in SSc development and severity, but their role remains to be clarified. Conclusions and relevance It may be prudent to counsel our patients with SSc (or those at risk of SSc) to avoid occupations with exposure to silica, organic solvents, asbestos and epoxy resins; restraint from smoking, using cocaine or drugs with pro-fibrotic potential. While the association between low vitamin D and SSc remains to be confirmed, we believe that SSc patients should be encouraged to maintain healthy vitamin D levels as benefits outweigh the risks.

scholarly journals Exposure to Welding Fumes, Hexavalent Chromium, or Nickel and Risk of Lung Cancer

2019 ◽  
Vol 188 (11) ◽  
pp. 1984-1993 ◽  
Author(s):  
Beate Pesch ◽  
Benjamin Kendzia ◽  
Hermann Pohlabeln ◽  
Wolfgang Ahrens ◽  
Heinz-Erich Wichmann ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Hexavalent Chromium ◽  
Regression Models ◽  
Welding Process ◽  
Cumulative Exposure ◽  
Welding Fumes ◽  
Odds Ratios ◽  
Case Control Studies ◽  
High Exposure ◽  
Logistic Regression Models

Abstract To investigate the risk of lung cancer after exposure to welding fumes, hexavalent chromium (Cr(VI)), and nickel, we analyzed 3,418 lung cancer cases and 3,488 controls among men from 2 German case-control studies (1988–1996). We developed a welding-process exposure matrix from measurements of these agents, and this was linked with welding histories from a job-specific questionnaire to calculate cumulative exposure variables. Logistic regression models were fitted to estimate odds ratios with confidence intervals conditional on study, and they adjusted for age, smoking, and working in other at-risk occupations. Additionally, we mutually adjusted for the other exposure variables under study. Overall, 800 cases and 645 controls ever worked as regular or occasional welders. Odds ratios for lung cancer with high exposure were 1.55 (95% confidence interval (CI): 1.17, 2.05; median, 1.8 mg/m3 × years) for welding fumes, 1.85 (95% CI: 1.35, 2.54; median, 1.4 μg/m3 × years) for Cr(VI), and 1.60 (95% CI: 1.21, 2.12; median, 9 μg/m3 × years) for nickel. Risk estimates increased with increasing cumulative exposure to welding fumes and with increasing exposure duration for Cr(VI) and nickel. Our results showed that welding fumes, Cr(VI), and nickel might contribute independently to the excess lung cancer risk associated with welding. However, quantitative exposure assessment remains challenging.

scholarly journals Literature Review : Risk Factors Wood Dust Exposure on Workers Lung Status

2020 ◽  
Vol 12 (3) ◽  
pp. 200
Author(s):  
Faradilla Nikmah
Keyword(s):  
Risk Factors ◽  
Respiratory Tract ◽  
Smoking Habit ◽  
Dust Exposure ◽  
Wood Dust ◽  
Organic Dust ◽  
Literature Study ◽  
Wood Industry ◽  
Cross Sectional ◽  
The Status

Introduction: Health problems caused by environmental factors are still one of the main things to note. One of the dangers in the work environment is the presence of organic dust including wood dust. Organic dust flying in the air is able to interfere with the health of the workers through the respiratory tract. The resulting wood dust is at risk causing lung faal status disorders in workers. This article aims to explore risks factors for wood dust exposure to the status of lung faal in wood industry workers based on the previously performed research from published journals. Discussion: This research used a method of literature study with a comparative study approach. The selected research should be in appropriated with the topic and through the protocols that have been set to become secondary data. The results of data analysis indicated that almost all research use observational analytic types with cross sectional approaches. Wood dust that has entered through the respiratory tract worker is influenced by several variables. The most often used risk factors as a research variable are dust levels, age, use of PPE, and smoking habit. Conclusion: The research can be concluded that independent variables of selected research are less varied. The selected research variables already existed in previous research. Upcoming researchers are expected to be able display new variables that are suspected to affect the status of the lung Faal on wood industry workers.

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