Septic epiphysitis and sequestrum formation in the glenoid of the scapula in a five-month-old foal diagnosed by computed tomography

2019 ◽  
Vol 7 (3) ◽  
pp. e000837
Author(s):  
Peter E Clements ◽  
Becky Jones ◽  
Richard Coomer
Keyword(s):  
Poor Prognosis ◽  
Serum Amyloid A ◽  
Proximal Humerus ◽  
Treatment Options ◽  
Elevated Serum ◽  
Acute Onset ◽  
Subchondral Bone Plate ◽  
Large Defect ◽  
Amyloid A ◽  
Bony Fragment

A five-month-old Connemara foal presented for acute-onset, severe left forelimb lameness with fever, neutrophilia and an elevated serum amyloid A concentration. Radiographs were suspicious of septic physitis of the proximal humerus. CT identified a large defect involving the central portion of the subchondral bone plate of the glenoid and a sequestered bony fragment within the defect, which were not seen radiographically. CT findings were consistent with septic epiphysitis and sequestrum formation, which had significant implications on available treatment options. The foal was given a poor prognosis for returning to soundness so was subject to humane euthanasia.

scholarly journals Serum Amyloid A is a biomarker of severe Coronavirus Disease and poor prognosis

2020 ◽  
Vol 80 (6) ◽  
pp. 646-655 ◽  
Author(s):  
Huan Li ◽  
Xiaochen Xiang ◽  
Hongwei Ren ◽  
Lingli Xu ◽  
Lisha Zhao ◽  
...  
Keyword(s):  
Poor Prognosis ◽  
Serum Amyloid A ◽  
Serum Amyloid ◽  
Amyloid A

scholarly journals Serum amyloid A (AA) type amyloidosis of the kidney and immune complex-mediated glomerulopathy in the setting of hyperimmunoglobulin E (Job’s) syndrome

2019 ◽  
Author(s):  
Miroslav Sekulic ◽  
Helmut G Rennke ◽  
Arash Rashidi
Keyword(s):  
Immune Complex ◽  
Serum Amyloid A ◽  
Kidney Biopsy ◽  
Elevated Serum ◽  
Pulmonary Infections ◽  
Amyloid A ◽  
Characteristic Features ◽  
Immunodeficiency Syndrome ◽  
Nephrotic Range Proteinuria ◽  
Insight Into

Abstract Hyperimmunoglobulin E syndrome (HIES) is a rare immunodeficiency syndrome with characteristic features of pulmonary infections, eczema, recurrent skin abscesses and elevated serum IgE. We present a case of an HIES patient referred for nephrology consultation with elevated serum creatinine and nephrotic-range proteinuria. The subsequent kidney biopsy revealed AA-type amyloidosis and a separate and distinct inactive immune complex-mediated glomerulopathy with frequent glomerular capillary wall and mesangial polyclonal deposits. Potential kidney pathology in the setting of HIES has not been well described previously, and this case provides insight into associated renal comorbidities faced by patients with this rare syndrome.

scholarly journals Elevated Serum Amyloid a Levels Are not Specific for Sarcoidosis but Associate with a Fibrotic Pulmonary Phenotype

Cells ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 585
Author(s):  
Els Beijer ◽  
Claudia Roodenburg-Benschop ◽  
Milou C. Schimmelpennink ◽  
Jan C. Grutters ◽  
Bob Meek ◽  
...  
Keyword(s):  
Serum Amyloid A ◽  
Inflammatory Diseases ◽  
Elevated Serum ◽  
Serum Levels ◽  
Serum Amyloid ◽  
Eosinophilic Granulomatosis With Polyangiitis ◽  
Amyloid A ◽  
Underlying Mechanisms ◽  
Granulomatous Diseases

Elevated Serum Amyloid A (SAA) levels have been found in several inflammatory diseases, including sarcoidosis. SAA is suggested to be involved in sarcoidosis pathogenesis by involvement in granuloma formation and maintenance. We hypothesized that SAA serum levels would be higher in sarcoidosis compared to other non-infectious granulomatous and non-granulomatous diseases. SAA levels were measured in serum from sarcoidosis, Hypersensitivity pneumonitis (HP), and (eosinophilic) granulomatosis with polyangiitis ((E)GPA) patients. Idiopathic pulmonary fibrosis (IPF) patients were included as non-granulomatous disease group. SAA levels of patients with sarcoidosis (31.0 µg/mL), HP (23.4 µg/mL), (E)GPA (36.9 µg/mL), and IPF (22.1 µg/mL) were all higher than SAA levels of healthy controls (10.1 µg/mL). SAA levels did not differ between the diagnostic groups. When SAA serum levels were analyzed in sarcoidosis subgroups, fibrotic sarcoidosis patients showed higher SAA levels than sarcoidosis patients without fibrosis (47.8 µg/mL vs. 29.4 µg/mL, p = 0.005). To conclude, the observation that fibrotic sarcoidosis patients have higher SAA levels, together with our finding that SAA levels were also increased in IPF patients, suggests that SAA may next to granulomatous processes also reflect the process of fibrogenesis. Further studies should clarify the exact role of SAA in fibrosis and the underlying mechanisms involved.

scholarly journals Elevated serum amyloid A is associated with venous thromboembolism

2013 ◽  
Vol 109 (02) ◽  
pp. 358-359 ◽  
Author(s):  
Darlene Elias ◽  
Silvia Navarro ◽  
Francisco España ◽  
John Griffin ◽  
Hiroshi Deguchi
Keyword(s):  
Venous Thromboembolism ◽  
Serum Amyloid A ◽  
Elevated Serum ◽  
Serum Amyloid ◽  
Amyloid A

scholarly journals Multiple papular lesions in a patient with HIV and/or AIDS and coinfected with hepatitis B virus: Amyloidosis

2017 ◽  
Vol 18 (1) ◽  
Author(s):  
Hayati Demiraslan ◽  
Kemal Deniz ◽  
Mehmet Doganay
Keyword(s):  
Hepatitis B Virus ◽  
Antiretroviral Therapy ◽  
Hepatitis B ◽  
Serum Amyloid A ◽  
Elevated Serum ◽  
Serum Amyloid ◽  
Biopsy Material ◽  
Hiv Rna ◽  
Amyloid A ◽  
B Virus

Introduction: The most common form of systemic amyloidosis is amyloid A induced by a chronic inflammation. In HIV-infected patients, elevated serum amyloid A levels might be associated with chronic inflammation.Patient presentation: A 43-year-old male patient was admitted to hospital with a complaint of papular lesions around his eyes, existing for four months. The patient is receiving antiretroviral therapy. HIV RNA was undetectable, and the CD4 count was 770 cells/mm3. He suffered from a bladder carcinoma for four years. On examination, periocular, perioral and anogenital papules, papular lesions in the meatus of external auditory canal, and intranasal polyps were observed.Management: Microscopic examination of the biopsy material taken from the periocular lesion and then from perianal polyps revealed eosinophilic deposition, and stained positively by Congo red. Serum amyloid A level was negative. Antiretroviral therapy was continued.Conclusion: A rare form of amyloidosis in a patient with HIV and/or AIDS and coinfected with hepatitis B virus (HBV) was presented here with cutaneous and mucosal lesions.

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