scholarly journals Current treatment for Wilms tumor: COG and SIOP standards

2019 ◽  
Vol 2 (3) ◽  
pp. e000038 ◽  
Author(s):  
Jinhu Wang ◽  
Minju Li ◽  
Daxing Tang ◽  
Weizhong Gu ◽  
Junqing Mao ◽  
...  
Keyword(s):  
Wilms Tumor ◽  
Current Treatment ◽  
Paediatric Oncology ◽  
Preschool Age ◽  
Diagnosis And Treatment ◽  
Postoperative Treatment ◽  
Current Management ◽  
Collaborative Groups ◽  
Primary Surgery ◽  
Tumor Study

BackgroundWilms tumor (WT) is the most common renal malignant tumor in children. It occurs primarily at preschool age. The purpose of this review is to present current standards of diagnosis and treatment of WT around the world.Data sourcesAll the recent literature on diagnosis and treatment of WT were searched and reviewed.ResultsMost cases with WT are sporadic. The current survival in patients with WT is high (90%). Involvement of mutidisciplinary collaborative groups in the diagnosis and treatment of WT. National Wilms Tumor Study Group (NWTSG)/Children’s Oncology Group (COG) and The International Society of Paediatric Oncology (SIOP) are two major guidelines used for the current management of WT worldwide. The major difference exists in the two guidelines is the timing of surgery: SIOP recommends using preoperative chemotherapy, and NWTSG/COG prefers using primary surgery before any adjuvant treatments.ConclusionsMost patients with WT have good overall survival outcomes. Further studies should be highlighted on how to use chemotherapy and radiotherapy under more accurate risk-stratified strategies. Surgeons must be more focusing on how to maximize preoperative and postoperative treatment possibilities for achieving optimal results of patients with WT.

scholarly journals Treatment of Wilms Tumor in Sub-Saharan Africa: Results of the Second French African Pediatric Oncology Group Study

2019 ◽  
pp. 1-8 ◽  
Author(s):  
Atteby Jean-Jacques Yao ◽  
Claude Moreira ◽  
Fousseyni Traoré ◽  
Sonia Kaboret ◽  
Angele Pondy ◽  
...  
Keyword(s):  
Wilms Tumor ◽  
Stage Iv ◽  
Paediatric Oncology ◽  
Sub Saharan Africa ◽  
Stage Iii ◽  
Postoperative Treatment ◽  
Pediatric Oncology Group ◽  
Localized Disease ◽  
Sub Saharan ◽  
Chemotherapy Patients

PURPOSE Multidisciplinary management of Wilms tumor has been defined through multicenter prospective studies and an average expected patient cure rate of 90%. In sub-Saharan Africa, such studies are uncommon. After the encouraging results of the first Groupe Franco-Africain d'Oncologie Pédiatrique (GFAOP) study, we report the results of the GFAOP-NEPHRO-02 study using an adaptation of the International Society of Paediatric Oncology 2001 protocol. PATIENTS AND METHODS From April 1, 2005, to March 31, 2011, seven African units participated in a nonrandomized prospective study. All patients who were referred with a clinical and radiologic diagnosis of renal tumor were screened. Those older than age 6 months and younger than 18 years with a unilateral tumor previously untreated were pre-included and received preoperative chemotherapy. Patients with unfavorable histology or with a tumor other than Wilms, or with a nonresponding stage IV tumor were excluded secondarily. RESULTS Three hundred thirteen patients were initially screened. Two hundred fifty-seven patients were pre-included and 169 with histologic confirmation of intermediate-risk nephroblastoma were registered in the study and administered postoperative treatment. Thirty-one percent of patients were classified as stage I, 38% stage II, 24% stage III, and 7% stage IV. Radiotherapy was not available for any stage III patients. Three-year overall survival rate was 72% for all study patients and 73% for those with localized disease. CONCLUSION It was possible to conduct sub-Saharan African multicenter therapeutic studies within the framework of GFAOP. Survival results were satisfactory. Improvements in procedure, data collection, and outcome are expected in a new study. Radiotherapy is needed to reduce the relapse rate in patients with stage III disease.

Nephroblastome

2003 ◽  
Vol 03 (01) ◽  
pp. 39-49 ◽  
Author(s):  
Harald Reinhard ◽  
Norbert Graf
Keyword(s):  
Wilms Tumor ◽  
Bildgebende Verfahren ◽  
Paediatric Oncology ◽  
Wird Eine ◽  
Präoperative Chemotherapie ◽  
Tumor Study ◽  
Prognostische Gruppen

ZusammenfassungDas Nephroblastom ist der häufigste bösartige Nierentumor im Kindesalter mit einem Altersgipfel um das 2.–3. Lebensjahr. Die Kinder fallen meistens durch eine schmerzlose Tumorschwellung auf. Die Diagnose wird primär durch bildgebende Verfahren (Ultraschall, CT, MRT) gestellt. Nach präoperativer Chemotherapie wird der Tumor operiert. Eine primäre Operation sollte nur bei unklarer bildgebender Diagnose und Kindern unter 6 Monaten oder über 16 Jahren erfolgen. Der Tumor muss immer histologisch aufgearbeitet und molekulargenetisch untersucht werden. Durch Chemotherapie, Operation und bei wenigen Patienten durch zusätzliche Strahlenbehandlung werden heute 90% der Kinder mit einem Nephroblastom geheilt. Dieser Fortschritt ist in erster Linie durch die verschiedenen prospektiven und randomisierten multizentrischen Studien erzielt worden. Dabei werden zwei unterschiedliche Konzepte verfolgt. Im Rahmen der SIOP (Society of Paediatric Oncology) wird eine präoperative Chemotherapie der Tumoroperation vorangestellt, während in Nordamerika (NWTS – National Wilms Tumor Study) jedes Kind mit einem Nephroblastom primär operiert wird. Postoperativ richtet sich die weitere Behandlung sowohl bei der SIOP als auch bei der NWTS nach dem erzielten lokalen Stadium und dem histologischen Befund des Tumors. In beiden großen Studiengruppen wird bei definierten Patientengruppen durch randomisierte Fragestellungen geprüft, inwieweit die Therapieintensität reduziert werden kann, ohne die sehr gute Prognose dieses Tumors zu verschlechtern. Hierdurch sollen akute Toxizitäten und Spätfolgen minimiert als auch Therapiekosten gesenkt werden. Neben dem postoperativ erzielten lokalen Stadium und dem histologischen Subtyp des Tumors werden zukünftig weitere Parameter benötigt, um eine individuellere Stratifizierung der Patienten in unterschiedliche prognostische Gruppen zu gewährleisten. So kann der in vivo response auf eine präoperative Chemotherapie als prognostischer Parameter herangezogen werden. Nach Beendigung der Behandlung ist mit dem Auftreten eines Rezidivs fast ausschließlich innerhalb der ersten beiden Jahre zu rechnen. Nach Tumornephrektomie als auch durch die Gabe nephrotoxischer und kardiotoxischer Zytostatika und der Bestrahlung sind im Langzeitverlauf entsprechende Spätfolgen zu beachten. Die Zweitmalignomrate liegt bei ca. 1%.

919: Ureteral Extension in Childhood Renal Tumors: A Report From the National Wilms Tumor Study Group (NWTSG)

2007 ◽  
Vol 177 (4S) ◽  
pp. 305-305
Author(s):  
Shane Daley ◽  
Michael Ritchey ◽  
Robert Shamberger ◽  
Robert Sawin ◽  
Thomas Hamilton ◽  
...  
Keyword(s):  
Wilms Tumor ◽  
Renal Tumors ◽  
Study Group ◽  
Tumor Study ◽  
Tumor Study Group

PERANAN RADIOLOGI PADA KASUS TUMOR WILMS’

2020 ◽  
Vol 4 (1) ◽  
pp. 26-33
Author(s):  
Galuh Ayu Treswari ◽  
Bambang Soeprijanto ◽  
Indrastuti Normahayu ◽  
Lenny Violetta
Keyword(s):  
Differential Diagnosis ◽  
Distant Metastasis ◽  
Wilms Tumor ◽  
Diagnosis And Treatment ◽  
Tumor Extension ◽  
Abdominal Tumors ◽  
Pathology Reports

Wilms’ tumor is the most frequent renal malignancy in childhood with the highest incidence per year, approximately 7,8 cases per 1.000.000in children under 15 years-old and frequently occurred in 2-5 years of age (highest incidences in 3 years-old). There are many differential diagnosis of intra-abdominal tumors and the correct differential diagnosis are detrimental to the prescribed treatments for the patients.Medical imaging along with pathology reports is a precise way to determine the appropriate diagnosis and treatment. Imaging gives information about tumor extension and distant metastasis, especially useful for indicating pre-operative chemotherapy.

scholarly journals The Application of Dynamic Uncertain Causality Graph Based Diagnosis and Treatment Unification Model in the Intelligent Diagnosis and Treatment of Hepatitis B

Symmetry ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1185
Author(s):  
Nan Deng ◽  
Qin Zhang
Keyword(s):  
Hepatitis B ◽  
Response Probability ◽  
Logic Gates ◽  
Current Treatment ◽  
Subsequent Treatment ◽  
Diagnosis And Treatment ◽  
Treatment Model ◽  
Treatment Scheme ◽  
Treatment Plans ◽  
Dynamic Uncertain Causality Graph

Although hepatitis B is widespread, it is hard to cure. This paper presents a new and more accurate model for the diagnosis and treatment of hepatitis B. Based on previous research, the diagnosis and treatment modes were combined into one. By adding more influencing factors and risk factors, the overall diagnosis and treatment model will be further expanded, and a richer and more detailed overall diagnosis and treatment model will be constructed. Reverse logic gates are used in the model to improve the accuracy of the treatment planning. The new unified model is more accurate in subdividing diagnosis results, and it is more flexible and accurate in providing dynamic treatment plans. The prediction process and the static diagnosis process of the model are symmetric, and the related sub-graph is symmetric in structure. In addition, an algorithm for predicting the response probability of treatment scheme is developed, so as to predict the subsequent treatment effects of the current treatment scheme, such as the probability of drug resistance. The results show that this method is more accurate than other available systems, and it has encouraging diagnostic accuracy and effectiveness, which provides a promising help for doctors in diagnosing hepatitis B.

Anaplasia in unilateral Wilms' tumor: A report from the National Wilms' Tumor Study Pathology Center

1988 ◽  
Vol 19 (10) ◽  
pp. 1199-1209 ◽  
Author(s):  
Craig W. Zuppan ◽  
J. Bruce Beckwith ◽  
Dennis W. Luckey
Keyword(s):  
Wilms Tumor ◽  
Tumor Study

Wilms' tumor in the neonate: A report from the national Wilms' tumor study

1986 ◽  
Vol 21 (5) ◽  
pp. 385-387 ◽  
Author(s):  
Ellen E. Hrabovsky ◽  
H. Biemann Othersen ◽  
Alfred deLorimier ◽  
Panoyotis Kelalis ◽  
J. Bruce Beckwith ◽  
...  
Keyword(s):  
Wilms Tumor ◽  
Tumor Study

Therapy and outcome in 51 children with mesoblastic nephroma: A report of the national Wilms' tumor study

1982 ◽  
Vol 17 (6) ◽  
pp. 826-831 ◽  
Author(s):  
C.G. Howell ◽  
H.B. Othersen ◽  
N.E. Kiviat ◽  
P. Norkool ◽  
J.B. Beckwith ◽  
...  
Keyword(s):  
Wilms Tumor ◽  
Mesoblastic Nephroma ◽  
Tumor Study

Silencing of lncRNA MEG8 Represses the Viability, Migration, and Invasion of Wilms’ Tumor Cells through Mediating miR-23a-3p/CRK Axis

2021 ◽  
pp. 1-13
Author(s):  
Jing Shen ◽  
Qiang Shu
Keyword(s):  
Cell Viability ◽  
Wilms Tumor ◽  
Luciferase Reporter ◽  
Migration And Invasion ◽  
Transwell Assay ◽  
Reaction Cell ◽  
Tumor Study ◽  
Polymerase Chain ◽  
Dual Luciferase Reporter Assay

<b><i>Purpose:</i></b> Compelling evidence has unveiled the importance of long noncoding RNAs (lncRNAs) in malignant behavior of Wilms’ tumor (WT). Hereon, we intend to assess the function and associated molecular mechanism of lncRNA maternally expressed gene 8 (MEG8) in WT cells. <b><i>Methods:</i></b> Expression levels of MEG8, miR-23a-3p, and CT10 regulator of kinase (CRK) were determined by quantitative real-time polymerase chain reaction. Cell viability was assessed by MTT assay. Besides, wound healing assay and transwell assay were applied to examine abilities of cell migration and invasion, respectively. Dual-luciferase reporter assay was employed to test the interplay among MEG8, miR-23a-3p, and CRK. Western blot was used to detect relative protein expression of CRK. <b><i>Results:</i></b> MEG8 and CRK expression was elevated, while miR-23a-3p expression was decreased in WT tissues and cells. The histologic type, lymphatic metastasis, and National Wilms Tumor Study (NWTS) stage were associated with the expression of MEG8, miR-23a-3p, and CRK in WT patients. MEG8 knockdown or miR-23a-3p overexpression restrained WT cells in cell viability, migration, and invasiveness in vitro. As to mechanism exploration, MEG8 could directly bind to miR-23a-3p and then miR-23a-3p targeted CRK. MEG8 was inversely correlated with miR-23a-3p and positively correlated with CRK in WT tissues. Meantime, miR-23a-3p was inversely correlated with CRK in WT tissues. Additionally, MEG8 knockdown-mediated suppressive impacts on cell viability, migration, and invasiveness were reversed by overexpression of CRK or repression of miR-23a-3p in WT cells. <b><i>Conclusions:</i></b> The cell viability, migration, and invasiveness of WT cells were repressed by MEG8 knockdown via targeting the miR-23a-3p/CRK axis.

scholarly journals Postoperative use of somatostatin analogs and mortality in patients with acromegaly

2019 ◽  
Vol 180 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Mark R Postma ◽  
Thalijn L C Wolters ◽  
Gerrit van den Berg ◽  
Antonius E van Herwaarden ◽  
Anneke C Muller Kobold ◽  
...  
Keyword(s):  
Disease Control ◽  
Univariate Analysis ◽  
Standard Deviation Score ◽  
Somatostatin Analogs ◽  
Pituitary Surgery ◽  
Postoperative Treatment ◽  
Primary Therapy ◽  
Strong Trend ◽  
Primary Surgery ◽  
Standardized Mortality Ratios

Objective To assess the effect of somatostatin analogs (SSAs) on mortality in relation to disease control of acromegaly after pituitary surgery. Design A retrospective study in two large tertiary referral centers in The Netherlands. Methods Overall, 319 patients with acromegaly in whom pituitary surgery was performed as primary therapy between January 1980 and July 2017 were included. Postoperative treatment with SSA was prescribed to 174 (55%) patients because of persistent or recurrent disease. Disease control at last visit was assessed by IGF1 standard deviation score (SDS). Adequate disease control was defined as IGF1 SDS ≤2. Univariate determinants of mortality and standardized mortality ratios (SMRs) were calculated for groups with and without SSA at any moment postoperatively and at last visit. Results In total, 27 deaths were observed. In univariate analysis, determinants of mortality were inadequate disease control (relative risk (RR): 3.41, P = 0.005), surgery by craniotomy (RR: 3.53, P = 0.013) and glucocorticoid substitution (RR: 2.11, P = 0.047). There was a strong trend toward increased mortality for patients who used SSA (RR: 2.01, P = 0.067) and/or dopamine agonists (RR: 2.54, P = 0.052) at last visit. The SMR of patients with adequate disease control who used SSA at any moment postoperatively (1.07, P = 0.785) and at last visit (1.19; P = 0.600) was not increased. Insufficiently controlled patients had a significantly raised SMR (3.92, P = 0.006). Conclusions Postoperative use of SSA is not associated with increased mortality in patients with acromegaly who attain adequate disease control. In contrast, inadequate disease control, primary surgery by craniotomy and glucocorticoid substitution are associated with increased mortality.

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