Adrenergic control of the human cutaneous circulation

2009 ◽  
Vol 34 (5) ◽  
pp. 829-839 ◽  
Author(s):  
Gary J. Hodges ◽  
John M. Johnson
Keyword(s):  
Local Heating ◽  
Whole Body ◽  
Local Cooling ◽  
Vascular Responses ◽  
Heating And Cooling ◽  
Sympathetic Function ◽  
Adrenergic Control ◽  
Flow Through ◽  
Sympathetic Nervous ◽  
Cutaneous Circulation

The cutaneous circulation is influenced by a variety of thermoregulatory (skin and internal temperature-driven) and nonthermoregulatory (e.g., baroreflex, exercise-associated reflexes) challenges. The responses to these stimuli are brought about through vasoconstrictor nerves, vasodilator nerves, and changes in the local temperature of the vessels themselves. In this review, we examine how thermoregulatory influences mediate changes in skin blood flow through the sympathetic nervous system. We discuss cutaneous vascular responses to both local and whole-body heating and cooling and the mechanisms underlying these responses, with the overarching conclusion that sympathetic function plays significant roles in reflex vasoconstriction and vasodilatation and in the responses to both local cooling and local heating of the skin.

In vivo mechanisms of cutaneous vasodilation and vasoconstriction in humans during thermoregulatory challenges

2006 ◽  
Vol 100 (5) ◽  
pp. 1709-1718 ◽  
Author(s):  
D. L. Kellogg
Keyword(s):  
Local Heating ◽  
Whole Body ◽  
Temperature Sensitive ◽  
Vascular Responses ◽  
Heating And Cooling ◽  
Cutaneous Vasodilation ◽  
Heat And Cold Stress ◽  
Y1 Receptors ◽  
Whole Body Cooling

This review focuses on the neural and local mechanisms that have been demonstrated to effect cutaneous vasodilation and vasoconstriction in response to heat and cold stress in vivo in humans. First, our present understanding of the mechanisms by which sympathetic cholinergic nerves mediate cutaneous active vasodilation during reflex responses to whole body heating is discussed. These mechanisms include roles for cotransmission as well as nitric oxide (NO). Next, the mechanisms by which sympathetic noradrenergic nerves mediate cutaneous active vasoconstriction during whole body cooling are reviewed, including cotransmission by neuropeptide Y (NPY) acting through NPY Y1 receptors. Subsequently, current concepts for the mechanisms that effect local cutaneous vascular responses to direct skin warming are examined. These mechanisms include the roles of temperature-sensitive afferent neurons as well as NO in causing vasodilation during local heating of skin. This section is followed by a review of the mechanisms that cause local cutaneous vasoconstriction in response to direct cooling of the skin, including the dependence of these responses on intact sensory and sympathetic, noradrenergic innervation as well as roles for nonneural mechanisms. Finally, unresolved issues that warrant further research on mechanisms that control cutaneous vascular responses to heating and cooling are discussed.

Measurement of the cutaneous circulation

1965 ◽  
Vol 20 (4) ◽  
pp. 696-702 ◽  
Author(s):  
Harry M. Wright
Keyword(s):  
Blood Flow ◽  
Skin Temperature ◽  
Circulatory Arrest ◽  
Thermal Conductance ◽  
Venous Occlusion ◽  
Indirect Methods ◽  
Blood Content ◽  
Heating And Cooling ◽  
Flow Through ◽  
Cutaneous Circulation

Relationships between four commonly used indirect methods for study of the cutaneous circulation in intact, unanesthetized man were examined. Skin temperature, thermal conductance, volume plethysmography and the light absorption of the skin (as related to hemoglobin content) were simultaneously recorded on the upper extremities of normal young men as blood flow and blood content of the skin were changed by circulatory arrest, venous occlusion, indirect heating and cooling, and changes in position. Skin temperature and thermal conductance changed along parallel courses as blood flow was changed, while finger volume and reflectance of the skin to light of wavelength 550 mμ both changed in expected directions although along different courses, following passive congestion and de-congestion and changes in level of the hand relative to the heart. The advantages, disadvantages, and limitations of each of the methods in the study of cutaneous circulation in man are discussed and compared. measurement of circulation of skin; methods for measurement of cutaneous circulation; blood flow through skin; blood content of skin; skin Submitted on March 12, 1964

scholarly journals On the heating and cooling of the body by local application of heat and cold

1922 ◽  
Vol 93 (651) ◽  
pp. 207-212
Keyword(s):  
Body Temperature ◽  
Beneficial Effect ◽  
Cold Water ◽  
The Body ◽  
Hot Water ◽  
Local Application ◽  
Whole Body ◽  
Local Cooling ◽  
Heating And Cooling ◽  
Stimulation Of

The object of this enquiry is to find out how much heat can be gained, or cold lost from the body, by the local cooling or warming of a small part, by cooling the hands in a stream of cold water, warming the feet in a hot foot­ bath, or by a foot-warmer. In order to secure the beneficial effect of open windows, the breathing of cool air of low-vapour tension, and stimulation of body metabolism by such air ventilating the clothed and naked parts of the skin, the general heating of rooms by hot-water coils might be replaced by small heaters kept a few degrees above body temperature and locally applied to each individual, and each under the individual’s control. Electric heaters have been used by aeroplanists placed beneath their outer garments. One of us(l) recently published results showing that heating or cooling the hands can effectively heat or cool the whole body. We record further experiments of a like nature.

The role of baseline in the cutaneous vasoconstrictor responses during combined local and whole body cooling in humans

2007 ◽  
Vol 293 (5) ◽  
pp. H3187-H3192 ◽  
Author(s):  
Gary J. Hodges ◽  
Wojciech A. Kosiba ◽  
Kun Zhao ◽  
Guy E. Alvarez ◽  
John M. Johnson
Keyword(s):  
Blood Flow ◽  
Skin Blood Flow ◽  
Local Heating ◽  
Laser Doppler ◽  
Whole Body ◽  
Local Cooling ◽  
Doppler Flowmetry ◽  
Vasoconstrictor Response ◽  
Body Cooling ◽  
Whole Body Cooling

Previous work showed that local cooling (LC) attenuates the vasoconstrictor response to whole body cooling (WBC). We tested the extent to which this attenuation was due to the decreased baseline skin blood flow following LC. In eight subjects, skin blood flow was assessed using laser-Doppler flowmetry (LDF). Cutaneous vascular conductance (CVC) was expressed as LDF divided by blood pressure. Subjects were dressed in water-perfused suits to control WBC. Four forearm sites were prepared with microdialysis fibers, local heating/cooling probe holders, and laser-Doppler probes. Three sites were locally cooled from 34 to 28°C, reducing CVC to 45.9 ± 3.9, 42 ± 3.9, and 44.5 ± 4.8% of baseline ( P < 0.05 vs. baseline; P > 0.05 among sites). At two sites, CVC was restored to precooling baseline levels with sodium nitroprusside (SNP) or isoproterenol (Iso), increasing CVC to 106.4 ± 12.4 and 98.9 ± 10.1% of baseline, respectively ( P > 0.05 vs. precooling). Whole body skin temperature, apart from the area of blood flow measurement, was reduced from 34 to 31°C. Relative to the original baseline, CVC decreased ( P < 0.05) by 44.9 ± 2.8 (control), 11.3 ± 2.4 (LC only), 29 ± 3.7 (SNP), and 45.8 ± 8.7% (Iso). The reductions at LC only and SNP sites were less than at control or Iso sites ( P < 0.05); the responses at those latter sites were not different ( P > 0.05), suggesting that the baseline change in CVC with LC is important in the attenuation of reflex vasoconstrictor responses to WBC.

scholarly journals Contribution of regional vascular responses to whole body autoregulation in conscious areflexic rats.

Hypertension ◽  
1991 ◽  
Vol 17 (6_pt_2) ◽  
pp. 1078-1084 ◽  
Author(s):  
C Hinojosa-Laborde ◽  
B H Frohlich ◽  
A W Cowley
Keyword(s):  
Whole Body ◽  
Vascular Responses

Direct observation of three-dimensional transient temperature distribution in SiC Schottky barrier diode under operation by optical-interference contactless thermometry (OICT) imaging

2022 ◽  
Author(s):  
Keiya Fujimoto ◽  
Hiroaki Hanafusa ◽  
Takuma Sato ◽  
Seiichiro HIGASHI
Keyword(s):  
Temperature Distribution ◽  
Schottky Barrier ◽  
Hot Spot ◽  
Local Heating ◽  
Three Dimensional ◽  
Schottky Barrier Diode ◽  
Transient Temperature ◽  
Optical Interference ◽  
Transient Temperature Distribution ◽  
Heating And Cooling

Abstract We have developed optical-interference contactless thermometry (OICT) imaging technique to visualize three-dimensional transient temperature distribution in 4H-SiC Schottky barrier diode (SBD) under operation. When a 1 ms forward pulse bias was applied, clear variation of optical interference fringes induced by self-heating and cooling were observed. Thermal diffusion and optical analysis revealed three-dimensional temperature distribution with high spatial (≤ 10 μm) and temporal (≤ 100 μs) resolutions. A hot spot that signals breakdown of the SBD was successfully captured as an anormal interference, which indicated a local heating to a temperature as high as 805 K at the time of failure.

scholarly journals Hip Range of Motion and Strength and Energy Flow During Windmill Softball Pitching

2021 ◽  
Author(s):  
Gretchen D. Oliver ◽  
Kyle Wasserberger ◽  
Anne de Swart ◽  
Kenzie Friesen ◽  
Jessica Downs ◽  
...  
Keyword(s):  
Range Of Motion ◽  
Energy Flow ◽  
Injury Risk ◽  
External Rotation ◽  
Whole Body ◽  
Net Energy ◽  
Acceleration Phase ◽  
Hip Range Of Motion ◽  
Flow Through ◽  
The Relationship

Context Inadequate hip range of motion (ROM) and isometric strength (ISO) may interfere with energy flow through the kinetic chain and result in increased injury susceptibility. Objective To examine the relationship of hip ROM and ISO with energy flow through the trunk and pitching-arm segments during the windmill softball pitch in youth athletes. A subsequent purpose was to examine the relationship between energy flow and pitch speed. Design Descriptive laboratory study. Setting University research laboratory. Patients or Other Participants A sample of 29 youth softball pitchers (age = 11.2 ± 1.3 years, height = 155.0 ± 10.4 cm, mass = 53.2 ± 12.6 kg). Main Outcome Measure(s) Bilateral hip internal-rotation and external-rotation (ER) ROM and ISO were measured. Net energy outflow and peak rates of energy outflow from the distal ends of the trunk, humerus, and forearm were calculated for the acceleration phase of the windmill softball pitch, and pitch speed was measured. Results Regression analysis revealed an effect of drive-hip ER ISO on the net energy flow out of the distal ends of the trunk (P = .045) and humerus (P = .002). Specifically, increased drive-hip ER ISO was associated with increased net energy outflow from the trunk to the humerus and from the humerus to the forearm. No significant effects of hip ROM or other hip ISO measures were observed. Additionally, pitchers who achieved higher peak rates of distal outflow tended to achieve higher pitch speeds. Conclusions An association was present between drive-hip ER ISO and the net energy flow out of the distal ends of the trunk and humerus during the acceleration phase of the windmill softball pitch, emphasizing the importance of hip and lower body strength in executing the whole-body windmill pitch. Overall, energy-flow analysis is an interesting new way to analyze pitching mechanics and will aid in furthering our understanding of performance and injury risk in windmill softball pitching.

Effects of Hip Range of Motion and Isometric Strength on Energy Flow during Windmill Softball Pitching

2021 ◽  
Author(s):  
Gretchen D. Oliver ◽  
Kyle Wasserberger ◽  
Anne de Swart ◽  
Kenzie Friesen ◽  
Jessica Downs ◽  
...  
Keyword(s):  
Range Of Motion ◽  
Energy Flow ◽  
External Rotation ◽  
Isometric Strength ◽  
Whole Body ◽  
Net Energy ◽  
Acceleration Phase ◽  
Hip Range Of Motion ◽  
Flow Through ◽  
The Relationship

Abstract Context:Inadequate hip range of motion (ROM) and isometric strength (ISO) may interfere with energy flow through the kinetic chain and result in increased injury susceptibility. Objective:To examine the relationship of hip ROM and ISO with energy flow through the trunk and pitching arm segments during the windmill softball pitch in youth athletes. A subsequent purpose was to examine the relationship between energy flow and pitch speed. Design:Descriptive laboratory study. Setting:University research laboratory. Participants:A sample of 29 youth softball pitchers (11.2±1.3 yrs.; 155.0±10.4 cm; 53.2±12.6 kg). Main Outcome Measure(s):Bilateral hip internal rotation (IR) and external rotation (ER) ROM and ISO were measured. Net energy outflow and peak rates of energy outflow from the distal ends of the trunk, humerus, and forearm were calculated for the acceleration phase of the windmill softball pitch, and pitch speed was measured. Results:Regression analysis revealed a significant effect of drive hip ER ISO on the net energy flow out of the distal ends of the trunk (p=0.045) and humerus (p=0.002). Specifically, increased drive hip ER ISO was associated with increased net energy outflow from the trunk to the humerus and from the humerus to the forearm. No significant effects of hip ROM or other hip ISO measures were observed. Additionally, pitchers who achieved higher peak rates of distal outflow tended to also achieve higher pitch speeds. Conclusions:There is an association between drive hip ER ISO and the net energy flow out of the distal ends of the trunk and humerus during the acceleration phase of the windmill softball pitch, emphasizing the importance of hip and lower body strength in the execution of the whole-body windmill pitch. Overall, energy flow analysis is an interesting new way to analyze pitching mechanics and will aid in further understanding of performance and injury risk in windmill softball pitching.

scholarly journals The nitric oxide dependence of cutaneous microvascular function to independent and combined hypoxic cold exposure

2020 ◽  
Vol 129 (4) ◽  
pp. 947-956
Author(s):  
Josh T. Arnold ◽  
Alex B. Lloyd ◽  
Stephen J. Bailey ◽  
Tomomi Fujimoto ◽  
Ryoko Matsutake ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Nitrite Reduction ◽  
Whole Body ◽  
Local Cooling ◽  
Cutaneous Reflex ◽  
Body Cooling ◽  
Whole Body Cooling ◽  
Oxide Removal ◽  
Oxide Synthase

When separated from local cooling, whole body cooling elicited cutaneous reflex vasoconstriction via mechanisms independent of nitric oxide removal. Hypoxia elicited cutaneous vasodilatation via mechanisms mediated primarily by nitric oxide synthase, rather than xanthine oxidase-mediated nitrite reduction. Cold-induced vasoconstriction was blunted by the opposing effect of hypoxic vasodilatation, whereas the underpinning mechanisms did not interrelate in the absence of local cooling. Full vasoconstriction was restored with nitric oxide synthase inhibition.

Norepinephrine spillover from skeletal muscle during exercise in humans: role of muscle mass

1989 ◽  
Vol 257 (6) ◽  
pp. H1812-H1818 ◽  
Author(s):  
G. K. Savard ◽  
E. A. Richter ◽  
S. Strange ◽  
B. Kiens ◽  
N. J. Christensen ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Muscle Mass ◽  
Nervous Activity ◽  
Plasma Concentrations ◽  
Whole Body ◽  
Knee Extensors ◽  
Sympathetic Nervous Activity ◽  
Leg Blood Flow ◽  
Sympathetic Nervous

The purpose of this study was to determine the effect of increasing muscle mass involvement in dynamic exercise on both sympathetic nervous activation and local hemodynamic variables of individual active and inactive skeletal muscle groups. Six male subjects performed 15-min bouts of one-legged knee extension either alone or in combination with the knee extensors of the other leg and/or with the arms. The range of work intensities varied between 24 and 71% (mean) of subjects' maximal aerobic capacity (% VO2max). Leg blood flow, measured in the femoral vein by thermodilution, was determined in both legs. Arterial and venous plasma concentrations of norepinephrine (NE) and epinephrine were analyzed, and the calculated NE spillover was used as an index of sympathetic nervous activity to the limb. NE spillover increased gradually both in the resting, and to a larger extent in the exercising legs, with a steeper rise occurring approximately 70% VO2max. These increases were not associated with any significant changes in leg blood flow or leg vascular conductance at the exercise intensities examined. These results suggest that, as the total active muscle mass increases, the rise in sympathetic nervous activity to skeletal muscle, either resting or working at a constant load, is not associated with any significant neurogenic vasoconstriction and reduction in flow or conductance through the muscle vascular bed, during whole body exercise demanding up to 71% VO2max.

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