Alkaline Hydrolysis of 1-Iodomethyl-1,2,5-triphenylphospholium Iodide, a New Route to the 4-Phosphabicyclo[3.1.0]hex-2-ene System

1971 ◽  
Vol 49 (6) ◽  
pp. 879-884 ◽  
Author(s):  
A. N. Hughes ◽  
Chit Srivanavit
Keyword(s):  
Alkaline Hydrolysis ◽  
High Yield ◽  
Hydroxide Ion ◽  
Compound C ◽  
Hydrolysis Of ◽  
Very High

Alkaline hydrolysis of 1-iodomethyl-1,2,5-triphenylphospholium iodide gives 3,4,5-triphenyl-4-phosphabicyclo[3.1.0]hex-2-ene-4-oxide in very high yield. Three possible mechanisms are discussed and isolation of a key intermediate allows one of these mechanisms to be discarded. Alkaline hydrolysis of 1-allyl-1,2,5-triphenylphospholium bromide in methanol gives 1,2,5-triphenylphosphole and small quantities of a compound C26H27O2P which is an adduct of the original phospholium ion, hydroxide ion, and methanol.

Thiohydantoins. XI Kinetic Studies of the Alkaline Hydrolysis of 1-Acyl-2-thiohydantoins

1972 ◽  
Vol 50 (23) ◽  
pp. 3780-3788 ◽  
Author(s):  
Wayne I. Congdon ◽  
John T. Edward
Keyword(s):  
Carboxylic Acid ◽  
Alkaline Solution ◽  
Alkaline Hydrolysis ◽  
Ground State ◽  
Kinetic Studies ◽  
Steric Effects ◽  
Hydroxide Ion ◽  
Entropy Of Activation ◽  
Hydrolysis Of ◽  
Conjugate Base

1-Acyl-2-thiohydantoins ionize in alkaline solution (pK ∼ 7). In solutions more alkaline than pH > 11 they are rapidly hydrolyzed to 2-thiohydantoin and a carboxylic acid, by attack of a hydroxide ion on the conjugate base of the 1-acyl-2-thiohydantoin. Possible mechanisms to accord with the entropy of activation, which is less negative than usual for base-catalyzed amide hydrolyses, are discussed. 1-Benzoyl-2-thiohydantoin hydrolyzes more rapidly than 1-acetyl-2-thiohydantoin, possibly because the ground state of the former molecule is destabilized by steric effects.

scholarly journals 2-(5-Fluoro-3-isopropylsulfanyl-7-methyl-1-benzofuran-2-yl)acetic acid

2012 ◽  
Vol 68 (4) ◽  
pp. o946-o946
Author(s):  
Hong Dae Choi ◽  
Pil Ja Seo ◽  
Uk Lee
Keyword(s):  
Acetic Acid ◽  
Hydrogen Bonds ◽  
Alkaline Hydrolysis ◽  
Title Compound ◽  
Compound C ◽  
Hydrolysis Of

The title compound, C14H15FO3S, was prepared by alkaline hydrolysis of ethyl 2-(5-fluoro-3-isopropylsulfanyl-7-methyl-1-benzofuran-2-yl)acetate. In the crystal, molecules are linkedviapairs of O—H...O hydrogen bonds, forming inversion dimers. These dimers are connected by weak C—H...O hydrogen bonds.

THE ALKALINE HYDROLYSIS OF N-ACYLTHIOUREAS

1974 ◽  
Vol 52 (5) ◽  
pp. 697-701 ◽  
Author(s):  
Wayne I. Congdon ◽  
John T. Edward
Keyword(s):  
Carboxylic Acid ◽  
Sodium Hydroxide ◽  
Alkaline Solution ◽  
Alkaline Hydrolysis ◽  
Potassium Hydroxide ◽  
Ion Concentration ◽  
Hydroxide Ion ◽  
Arrhenius Parameters ◽  
Hydrolysis Of

N-Benzoylthiourea (pKHA 10.9) and other N-acylthioureas ionize in alkaline solution, and then are rapidly hydrolyzed to thiourea and a carboxylic acid. The rates become independent of hydroxide ion concentration when this exceeds about 0.1 M and point to a mechanism in which hydrolysis takes place by attack of an hydroxide ion on the un-ionized molecule of N-acylthiourea. This mechanism accords with the Arrhenius parameters for the hydrolysis of N-benzoylthiourea in 0.2 N sodium hydroxide, and with the Hammett ρ value of 0.10 for the hydrolysis of m- and p-substituted N-benzoylthioureas in 1.0 N potassium hydroxide.

THE STRUCTURE OF RYANODINE. I

1951 ◽  
Vol 29 (11) ◽  
pp. 905-910 ◽  
Author(s):  
R. B. Kelly ◽  
D. J. Whittingham ◽  
K. Wiesner
Keyword(s):  
Carboxylic Acid ◽  
Alkaline Hydrolysis ◽  
Periodic Acid ◽  
Crystalline Substance ◽  
Alkaline Fusion ◽  
Compound C ◽  
Hydrolysis Of

Ryanodine consumes one mole of periodic acid and gives oxoryanodine C25H33O9N. Splitting off water from ryanodine gives anhydroryanodine C25H33O8N. The analyses of these two derivatives are therefore in agreement with the formula for ryanodine C25H35O9N. Alkaline hydrolysis of ryanodine gives pyrrole-α-carboxylic acid and an alcohol C20H32O8. This alcohol splits off water to give a compound C20H30O7. Alkaline hydrolysis of oxoryanodine consumes three moles of alkali and gives a mixture of low molecular acidic products. Alkaline fusion of oxoryanodine gives a neutral aromatic nitrogen-free crystalline substance.

scholarly journals An Optimal Designed Experiment for the Alkaline Hydrolysis of Feather Keratin

2021 ◽  
Author(s):  
Małgorzata Dąbrowska ◽  
Agata Sommer ◽  
Izabela Sinkiewicz ◽  
Antoni Taraszkiewicz ◽  
Hanna Staroszczyk
Keyword(s):  
Molecular Weight ◽  
Alkaline Hydrolysis ◽  
Volume Ratio ◽  
High Yield ◽  
Hydrolysis Time ◽  
Process Yield ◽  
Feather Keratin ◽  
Wide Ph Range ◽  
Input Variables ◽  
Hydrolysis Of

Abstract Feathers, burdensome waste from the poultry industry, can be a cheap source of keratin, a protein with excellent physicochemical, biological and mechanical properties. The high yield of the keratin isolation is ensured by alkaline hydrolysis. This study aimed at assessing the statistically significant effect of input variables in the alkaline hydrolysis of keratin from chicken feathers on the process yield and on the molecular weight of peptides obtained. The volume ratio of 1M NaOH to the feathers mass, the hydrolysis time and the shaking speed of the reaction mixture were analyzed. The use of statistical analysis at the design step of experiment allowed to reduce of the trials number from 27 to 9. Among the input variables analyzed, only the volume ratio of 1M NaOH to the feathers mass had a significant effect on the process yield, while none of them significantly affected the molecular weight of the peptides obtained. All hydrolysates were dominated by two peptides fractions, with molecular weights of ca. 130 and 250 kDa, and mixture of many peptides of weight close to 10 kDa and smaller. Alkaline hydrolysis of feather keratin yielded protein hydrolysates soluble over a wide pH range.

DURIMPHY

Alloy Digest ◽  
2007 ◽  
Vol 56 (2) ◽  
Keyword(s):  
Tensile Strength ◽  
Corrosion Resistance ◽  
Yield Strength ◽  
Physical Properties ◽  
Precipitation Hardening ◽  
Heat Treating ◽  
High Yield ◽  
High Yield Strength ◽  
Precision Alloys ◽  
Very High

Abstract Durimphy is a maraging steel with 1724 MPa (250 ksi) tensile strength and a very high yield strength due to precipitation hardening. This datasheet provides information on composition, physical properties, hardness, and tensile properties. It also includes information on corrosion resistance as well as forming, heat treating, machining, and joining. Filing Code: FE-140. Producer or source: Metalimphy Precision Alloys.

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