Plasma corticosterone, hemoglobin, creatinine and blood urea nitrogen levels, and urinary corticosteroid amounts in mice made hypothermic by exposure to −10 °C

1971 ◽  
Vol 49 (7) ◽  
pp. 657-665
Author(s):  
Bernard Grad ◽  
Firouz Rafizadeh
Keyword(s):  
Renal Function ◽  
Renal Impairment ◽  
Adrenal Cortex ◽  
Blood Urea Nitrogen ◽  
Plasma Corticosterone ◽  
Hemoglobin Level ◽  
Plasma Creatinine ◽  
Urea Nitrogen ◽  
Nitrogen Levels ◽  
Lower Urinary

The plasma corticosterone (PC) levels of mice adapted to 27–28 °C rose significantly when they were exposed to the cold at −10 °C until they became comatose, the increase being significantly less during a second similar exposure a week later. The PC elevations which occurred at −10 °C before the mice became comatose could be due in some degree to renal impairment, as indicated by increases in blood urea nitrogen and plasma creatinine levels during the first and second exposures, respectively. However, hemoconcentration as indicated by changes in the hemoglobin level could not account for the increase in the PC level. Mice that became comatose at −10 °C also had significantly elevated PC levels which were probably not primarily due to hemoconcentration or renal impairment. Mice recovering from coma in the warmth also had elevated PC levels for 6 h after the first exposure and for 1 day after the second one. At 1 and 7 days following exposure to the cold, the adrenal cortex no longer appeared to be hyperfunctional. Renal function appeared to have been impaired for 4 h following the first exposure and for at least 7 days after the second one. This impairment could account for the elevated PC levels and lower urinary corticosteroid amounts observed on the first day following the second exposure.

GROWTH-DEPENDENT CHANGES IN BLOOD UREA NITROGEN LEVELS IN LINCOLN AND SOUTHDOWN LAMBS

1969 ◽  
Vol 49 (2) ◽  
pp. 197-204 ◽  
Author(s):  
H. Mukhoty ◽  
W. Combs ◽  
T. D. D. Groves
Keyword(s):  
Body Weight ◽  
Blood Plasma ◽  
Blood Urea Nitrogen ◽  
Growth Period ◽  
Urea Nitrogen ◽  
Plasma Urea ◽  
Nitrogen Levels ◽  
Rate Of Increase

The concentration of blood plasma urea nitrogen (BUN) was measured at bi-weekly intervals in four groups of growing Lincoln and Southdown lambs which received the same ration throughout their growth period. BUN increased with age and weight in each group. Although all groups showed similar changes in BUN with age, BUN concentration increased at 0.73 × 10−2, 0.88 × 10−2, 0.91 × 10−2, and 1.23 × 10−2 mg per kg of body weight gained in the case of Lincoln males, Lincoln females, Southdown males, and Southdown females, respectively. The average rates of gain for these groups were 0.33, 0.28, 0.26 and 0.20 kg per day, respectively. It appeared from these studies that at any given weight, the more mature animals at that weight tended to have higher BUN concentrations and a higher rate of increase of BUN with weight.

Aqueous and Blood Urea Nitrogen Levels After Intravenous Urea Administration

1961 ◽  
Vol 65 (6) ◽  
pp. 805-807 ◽  
Author(s):  
M. A. GALIN ◽  
H. D. NANO ◽  
R. A. DAVIDSON
Keyword(s):  
Blood Urea Nitrogen ◽  
Urea Nitrogen ◽  
Nitrogen Levels

scholarly journals KADAR KOLESTEROL, UREA, KREATININ DARAH DAN KOLESTEROL TELUR AYAM SENTUL DENGAN PENAMBAHAN EKSTRAK BUAH MENGKUDU YANG DISUPLEMENTASI Cu DAN Zn

2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Nai Nurazizah ◽  
Nai Nurazizah
Keyword(s):  
Blood Urea Nitrogen ◽  
Animal Husbandry ◽  
Egg Yolk ◽  
Blood Cholesterol ◽  
Fruit Extract ◽  
Urea Nitrogen ◽  
Nitrogen Levels ◽  
Randomized Design ◽  
Yolk Cholesterol ◽  
Cu And Zn

The research was conducted to know the effect of noni fruit extract supplemented by Cu and Zn on blood cholesterol and  egg yolk cholesterol, creatinin, and blood urea nitrogen of sentul chicken. The research was done from August until October 2019. Samples test was held in Physiology and Biochemistry Laboratory, Animal Husbandry Faculty, Padjadjaran University, Sumedang. The methods used experimental with a Completely Randomized Design (CRD) and the effect of treatment using Analysis of  Varience (ANOVA) followed by Orthogonal Polynomial. The treatment consisted of five kind with five repetitions, those are to =  without adding noni fruit extract and  Cu, Zn , t1= Ration + 60 mg/kg extract noni fruit suplemented Cu 0,06 mg and Zn 1,5 mg, t2= Ration+ 180 mg/kg extract fruit noni suplemented Cu 0,18 mg and Zn 3,0 m, t3= Ration + 240 mg/kg extract fruit noni suplemented Cu 0,24 mg and Zn 4,5 mg, t4= Ration + 360 mg/kg extract fruit noni suplemented Cu 0,36 and Zn 6,0 mg. The result showed that the effect of giving 360 mg/kg noni extract suplemented Cu 0,36 and Zn 6,0 mg was significant effect  decreasing blood cholesterol levet but non significant  decreasing egg yolk cholesterol, creatinin, and blood urea nitrogen levels of Sentul Chicken. Keywords:  noni fruit extract, cholesterol, urea, creatinin, blood, egg yolk              cholesterol, sentul chicken, mineral Cu and ZnThe research was conducted to know the effect of noni fruit extract supplemented by Cu and Zn on blood cholesterol and  egg yolk cholesterol, creatinin, and blood urea nitrogen of sentul chicken. The research was done from August until October 2019. Samples test was held in Physiology and Biochemistry Laboratory, Animal Husbandry Faculty, Padjadjaran University, Sumedang. The methods used experimental with a Completely Randomized Design (CRD) and the effect of treatment using Analysis of  Varience (ANOVA) followed by Orthogonal Polynomial. The treatment consisted of five kind with five repetitions, those are to =  without adding noni fruit extract and  Cu, Zn , t1= Ration + 60 mg/kg extract noni fruit suplemented Cu 0,06 mg and Zn 1,5 mg, t2= Ration+ 180 mg/kg extract fruit noni suplemented Cu 0,18 mg and Zn 3,0 m, t3= Ration + 240 mg/kg extract fruit noni suplemented Cu 0,24 mg and Zn 4,5 mg, t4= Ration + 360 mg/kg extract fruit noni suplemented Cu 0,36 and Zn 6,0 mg. The result showed that the effect of giving 360 mg/kg noni extract suplemented Cu 0,36 and Zn 6,0 mg was significant effect  decreasing blood cholesterol levet but non significant  decreasing egg yolk cholesterol, creatinin, and blood urea nitrogen levels of Sentul Chicken. Keywords:  noni fruit extract, cholesterol, urea, creatinin, blood, egg yolk              cholesterol, sentul chicken, mineral Cu and Zn

scholarly journals Protection of renal function by four selected plant extracts during Plasmodium berghei infection

2015 ◽  
Vol 5 (10) ◽  
pp. 339 ◽  
Author(s):  
Adewale Adetutu ◽  
Olubukola Sinbad Olorunnisola ◽  
Kazeem Iyanda
Keyword(s):  
Renal Function ◽  
Body Weight ◽  
Blood Urea Nitrogen ◽  
Aqueous Extract ◽  
Plant Extracts ◽  
Plasmodium Berghei ◽  
Malaria Infection ◽  
Renal Tissue ◽  
Untreated Group ◽  
Urea Nitrogen

Background: Weakening of renal function from reactive oxygen species generated during malaria infection is one of the prominent causes of death in prevalent regions. The potential toxicity of free radical generated by malaria parasites are counteracted by a large number of cytoprotective phytochemicals. Therefore, this study examined the influence of extracts of five selected antimalarial plants (Azadirachta indica, Parquetina nigrescens, Citrus paradisi, and Khaya senigalensis) on reduction of inflammation in renal tissue, blood urea nitrogen and creatinine levels during malaria infection using Plasmodium berghei infected Swiss albino mice. For in vivo assay, mice were inoculated with 1 × 107 parasitized erythrocytes and plant extracts were subsequently administered orally at 100 mg/kg body weight once a day for 17 consecutive days. The chemo-suppressive and prophylaxis effects of the plant extracts against P. berghei were investigated and compared with those of standard antimalarial drug, chloroquine. Tail bleeding was performed to check the percentage parasitaemia by making a thin film smear on a slide, stained in Giemsa. The numbers of parasited cells against the unparasitised cells were counted using a microscope. The effect of malaria infection on renal tissue was assessed by histological analysis and measurement of blood urea nitrogen and creatinine levels in plasma. At 100 mg/kg per body weight, aqueous extract of K. senegalensis, A. indica, C. paradisi and P. nigrescens exhibited significant (p<0.05) percentage inhibition and chemo-suppressive effects in comparison with the chloroquine treated mice. The result of the untreated group showed that there was a significant (p<0.05) increase in the level of plasma urea while the level of the groups treated with plants extract stabilized the level of urea and creatinine in the blood. Also there was a pathological lesion on the kidney tissue of untreated group whereas the group treated with aqueous extract of A. indica, Khaya senegalensis and C. paradisi showed no lesion. It can be established that the extracts can protect and preserve renal function during malaria infection. These findings justified the use of the extracts in traditional medicine practice, for the treatment of malaria infection.  Keywords: Plasmodium berghei, antimalarial plants, renal function, antiplasmodium

Pengaruh Pemberian Virgin Coconut Oil Terhadap Kadar Kreatinin dan Urea Nitrogen Darah Rattus Norvegicus Jantan

2020 ◽  
Vol 17 (2) ◽  
pp. 181
Author(s):  
NOVIANE ANGRELLA ◽  
ROOSTANTIA INDRAWATI ◽  
LESTARI DEWI
Keyword(s):  
Creatinine Level ◽  
Blood Urea Nitrogen ◽  
Coconut Oil ◽  
The Body ◽  
Virgin Coconut Oil ◽  
Urea Nitrogen ◽  
Waste Products ◽  
Nitrogen Levels ◽  
Functional Product ◽  
Male Wistar Rats

<p><strong>ABSTRACT</strong></p><p><strong>Background:</strong><em> </em><em>Virgin Coconut Oil </em>(VCO) is a functional product that is highly favored and have been widely applied in the everyday lives of society. The increase of the frequencies and duration of VCO consumption is suspected that VCO could negatively impact the target organ. The kidney is a vital organ in the human body, it is responsible for clearing out the residual waste products of metabolism in the body. The evalution of the kidney’s function can be done through the measurement of creatinine and blood urea nitrogen. The purpose of this study is to determine the effect of VCO administration on kidney function.</p><p><strong>Method</strong>: 24 male wistar rats that are divided into 4 groups, which are listed as follows, K(-) or a negative-controlled group, P(1) or the first group of rats that are given VCO with a dose of 2mL/200gr of the rats’ total BW/day, P(2) or the second group of rats that are given VCO with a dose of 3mL/200gr of the rats’ total BW/day,  and P(3) or the third group of rats that are given VCO with a dose of 4mL/200gr of the rats’ total BW/day for 28 day</p><p><strong>Results</strong>: Administrating<strong> </strong>VCO with a dose of 2mL/200gr and 3mL/200gr of the rats’ total BW/day does not affect the blood’s creatinine level while with a dose of 4mL/200gr of the rats’ total BW/day decreases the blood’s creatinine level. Administrating VCO with a dose of 2 mL/200gr, 3 mL/200gr, and 4 mL/200gr of the rats’ total BW/day does not affect the level of blood urea nitrogen.</p><p><strong>Conclusion: </strong>Administration of VCO dose of 4 mL / 200 g BW rat / day significantly decreased blood creatinine levels in experimental animals, while other doses did not affect the creatinine levels or blood urea nitrogen levels<strong></strong></p><p><strong>Keywords</strong><strong>:</strong> <em>Virgin Coconout Oil </em>(VCO), cretinine, blood urea nitrogen.</p>

INDICATION OF INTRINSIC RENAL DISEASE IN AZOTEMIC INFANTS WITH DIARRHEA AND DEHYDRATION

PEDIATRICS ◽  
1973 ◽  
Vol 52 (2) ◽  
pp. 197-205
Author(s):  
Charles B. Brill ◽  
Stanley Uretsky ◽  
Donald Gribetz
Keyword(s):  
Renal Impairment ◽  
Renal Disease ◽  
Blood Urea Nitrogen ◽  
Obstructive Uropathy ◽  
Half Time ◽  
Urea Nitrogen ◽  
Clinical Method ◽  
Serial Blood

In an effort to differentiate transient renal impairment from more serious forms of renal disease in infants presenting with diarrhea and dehydration, serial blood urea nitrogen (BUN) values were obtained during rehydration. These were plotted against time on semilogarithmic paper. It was found that the BUN fell linearly with time. The half time (HT) of the BUN fall off, the time taken for the admission BUN to fall by 50%, was estimated from the graph. In patients with no intrinsic renal disease the half time was between 6 and 24 hours, mean half time was 15 hours. Of nine children who had half times in excess of 24 hours, six had proven renal disease as manifested by oliguria, hematuria, or obstructive uropathy. This technique, the plotting of serial BUN values during rehydration, is suggested as a clinical method in evaluating the significance of azotemia in infants presenting with diarrhea and dehydration.

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