Pengaruh Pemberian Virgin Coconut Oil Terhadap Kadar Kreatinin dan Urea Nitrogen Darah Rattus Norvegicus Jantan

2020 ◽  
Vol 17 (2) ◽  
pp. 181
Author(s):  
NOVIANE ANGRELLA ◽  
ROOSTANTIA INDRAWATI ◽  
LESTARI DEWI
Keyword(s):  
Creatinine Level ◽  
Blood Urea Nitrogen ◽  
Coconut Oil ◽  
The Body ◽  
Virgin Coconut Oil ◽  
Urea Nitrogen ◽  
Waste Products ◽  
Nitrogen Levels ◽  
Functional Product ◽  
Male Wistar Rats

<p><strong>ABSTRACT</strong></p><p><strong>Background:</strong><em> </em><em>Virgin Coconut Oil </em>(VCO) is a functional product that is highly favored and have been widely applied in the everyday lives of society. The increase of the frequencies and duration of VCO consumption is suspected that VCO could negatively impact the target organ. The kidney is a vital organ in the human body, it is responsible for clearing out the residual waste products of metabolism in the body. The evalution of the kidney’s function can be done through the measurement of creatinine and blood urea nitrogen. The purpose of this study is to determine the effect of VCO administration on kidney function.</p><p><strong>Method</strong>: 24 male wistar rats that are divided into 4 groups, which are listed as follows, K(-) or a negative-controlled group, P(1) or the first group of rats that are given VCO with a dose of 2mL/200gr of the rats’ total BW/day, P(2) or the second group of rats that are given VCO with a dose of 3mL/200gr of the rats’ total BW/day,  and P(3) or the third group of rats that are given VCO with a dose of 4mL/200gr of the rats’ total BW/day for 28 day</p><p><strong>Results</strong>: Administrating<strong> </strong>VCO with a dose of 2mL/200gr and 3mL/200gr of the rats’ total BW/day does not affect the blood’s creatinine level while with a dose of 4mL/200gr of the rats’ total BW/day decreases the blood’s creatinine level. Administrating VCO with a dose of 2 mL/200gr, 3 mL/200gr, and 4 mL/200gr of the rats’ total BW/day does not affect the level of blood urea nitrogen.</p><p><strong>Conclusion: </strong>Administration of VCO dose of 4 mL / 200 g BW rat / day significantly decreased blood creatinine levels in experimental animals, while other doses did not affect the creatinine levels or blood urea nitrogen levels<strong></strong></p><p><strong>Keywords</strong><strong>:</strong> <em>Virgin Coconout Oil </em>(VCO), cretinine, blood urea nitrogen.</p>

scholarly journals The Effect of Avocado to the Profile of Blood Urea Nitrogen (BUN) and Creatinine in Rats (Rattus norvegicus) Induced with Meloxicam

2018 ◽  
Vol 2 (1) ◽  
Author(s):  
Amelia Ramadhani Anshar ◽  
Muhammad Akbar Bahar ◽  
Dini Kurnia Ikliptikawati
Keyword(s):  
Treatment Group ◽  
Creatinine Level ◽  
Blood Urea Nitrogen ◽  
Control Group ◽  
Urea Nitrogen ◽  
White Rats ◽  
Group I ◽  
Male Wistar Rats ◽  
Treatment Administration ◽  
The Mean

Incidence of drug overdose during treatment of acute disease consequently leads to serious renal damage. As supporting treatment, administration of herbal medicine and food dietary are frequently developed. This research aimed to prove how the administration of avocado juice could lower the BUN and creatinine level in white rats induced with toxic doses of meloxicam. Meloxicam is a non-steroidal anti-inflamatory drug (NSAID), which is effectively used as an anti-inflamatory, analgesic, and antipyretic. Twenty four (24) male Wistar rats were assigned to 4 groups of six rats each (n=6). 1 ml of CMC 1% was administered to Control Group I, 30 mg/kgBB meloxicam and 1 ml of CMC 1% to Control Grup II, 30 mg/kgBB meloxicam and avocado juice 5 g/kgBB/day to Treatment Group I, and 30 mg/kgBB meloxicam and avocado juice 10 g/kgBB/day to Treatment Group II. The study was conducted over 8 days, then the level of Blood Urea Nitrogen and creatinine of the white rats were examined on the 1st and 8th day. The results were analyzed by Anova Two Way With Replication, then followed by T-test (α = 0,05) if there were difference. The Anova Two Way With Replication test showed that the mean of the four groups either the levels of Blood Urea Nitrogen or creatinine was significantly decreased (p<0,05). The decrease of BUN in the treatment group I was 27,17 27,17mg/dl and 17,83mg/dl while the decrease of creatinine level was 0,983mg/dl and 0,713mg/dl. The conclusion of this study was that avocado juice decreases level of Blood Urea Nitrogen and creatinine in white rats which exposed toxic doses of meloxicam.

GROWTH-DEPENDENT CHANGES IN BLOOD UREA NITROGEN LEVELS IN LINCOLN AND SOUTHDOWN LAMBS

1969 ◽  
Vol 49 (2) ◽  
pp. 197-204 ◽  
Author(s):  
H. Mukhoty ◽  
W. Combs ◽  
T. D. D. Groves
Keyword(s):  
Body Weight ◽  
Blood Plasma ◽  
Blood Urea Nitrogen ◽  
Growth Period ◽  
Urea Nitrogen ◽  
Plasma Urea ◽  
Nitrogen Levels ◽  
Rate Of Increase

The concentration of blood plasma urea nitrogen (BUN) was measured at bi-weekly intervals in four groups of growing Lincoln and Southdown lambs which received the same ration throughout their growth period. BUN increased with age and weight in each group. Although all groups showed similar changes in BUN with age, BUN concentration increased at 0.73 × 10−2, 0.88 × 10−2, 0.91 × 10−2, and 1.23 × 10−2 mg per kg of body weight gained in the case of Lincoln males, Lincoln females, Southdown males, and Southdown females, respectively. The average rates of gain for these groups were 0.33, 0.28, 0.26 and 0.20 kg per day, respectively. It appeared from these studies that at any given weight, the more mature animals at that weight tended to have higher BUN concentrations and a higher rate of increase of BUN with weight.

Aqueous and Blood Urea Nitrogen Levels After Intravenous Urea Administration

1961 ◽  
Vol 65 (6) ◽  
pp. 805-807 ◽  
Author(s):  
M. A. GALIN ◽  
H. D. NANO ◽  
R. A. DAVIDSON
Keyword(s):  
Blood Urea Nitrogen ◽  
Urea Nitrogen ◽  
Nitrogen Levels

scholarly journals PENGARUH VCO MENGANDUNG EKSTRAK WORTEL TERHADAP PEROKSIDASI LIPID PLASMA

2011 ◽  
Vol 15 (1) ◽  
pp. 296 ◽  
Author(s):  
Lidya I Momuat ◽  
Meiske S Sangi ◽  
Ni Putu Purwati
Keyword(s):  
Lipid Oxidation ◽  
Corn Oil ◽  
Plasma Lipid ◽  
Coconut Oil ◽  
Control Group ◽  
Virgin Coconut Oil ◽  
Male Wistar Rats ◽  
Acid Test ◽  
Plasma Lipid Peroxidation ◽  
Carrot Extract

PENGARUH VCO MENGANDUNG EKSTRAK WORTEL TERHADAP PEROKSIDASI LIPID PLASMA Lidya Irma Momuat1), Meiske S. Sangi1), Ni Putu Purwati2) 1)Program Studi Kimia FMIPA Universitas Sam Ratulangi, Manado 95115; 2)Alumni Program Studi Kimia FMIPA Universitas Sam Ratulangi, Manado 95115 ABSTRAK Penelitian ini bertujuan untuk mengukur tingkat oksidasi lipid dalam plasma darah tikus yang diberi pakan VCO mengandung ekstrak wortel.  Tikus Wistar jantan pada penelitian ini dibagi menjadi empat kelompok, yaitu (I) pakan standar (kontrol), (II) 10% VCO tanpa ekstrak wortel, (III) 10% VCO mengandung ekstrak wortel dan (IV) 10% minyak jagung.  Setelah 4 minggu masa perlakuan, plasma darah dipisahkan dengan sentrifugasi untuk analisis tingkat oksidasi plasma dengan mengukur konsentrasi malondialdehida (MDA) menggunakan metode uji asam tiobarbiturat.  Hasil penelitian menunjukkan bahwa konsentrasi MDA tertinggi terdapat pada kelompok tikus yang diberi minyak jagung (11,253 mM), diikuti kelompok kontrol (10,167 mM), lalu kelompok tikus yang diberi VCO mengandung ekstrak wortel (8,656 mM) dan VCO (8,269 mM).  Penelitian ini menyimpulkan bahwa tingkat oksidasi lipid plasma tikus yang diberi VCO mengandung ekstrak wortel relatif sama dengan yang diberi VCO tanpa ekstrak wortel, tetapi lebih rendah daripada kontrol dan yang diberi minyak jagung. Kata kunci: malondialdehida, minyak kelapa, wortel EFFECT OF VIRGIN COCONUT OIL (VCO) CONTAINING CARROT EXTRACT ON PLASMA LIPID PEROXIDATION ABSTRACT The aim of this study was measure the level of lipid oxidation in the blood plasma of rats fed VCO containing carrot extracts. Male Wistar rats in this study were divided into four groups: (i) control, (II) 10% VCO without the carrot extract, (III) 10% VCO containing carrot extracts, and (IV) 10% corn oil. After 4 weeks of treatment, blood from each rat was taken by syringe.  Plasma is separated from whole blood by centrifugation for analysis of plasma oxidation levels by measuring the malondialdehyde (MDA) concentration using tiobarbituric acid test. The results showed that the highest concentration of MDA was found in rats fed corn oil (11.253 m M), followed by the control group (10.167 m M), then rats fed VCO containing carrot extract (8.656 m M) and VCO (8.269 m M). This study concluded that the level of plasma lipid oxidation in rats fed VCO containing carrot extracts is relatively similar to rats fed VCO without the carrot extract, but it is lower than the control and corn oil groups. Keywords: malondialdehyde, coconut oil, carrot

scholarly journals KADAR KOLESTEROL, UREA, KREATININ DARAH DAN KOLESTEROL TELUR AYAM SENTUL DENGAN PENAMBAHAN EKSTRAK BUAH MENGKUDU YANG DISUPLEMENTASI Cu DAN Zn

2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Nai Nurazizah ◽  
Nai Nurazizah
Keyword(s):  
Blood Urea Nitrogen ◽  
Animal Husbandry ◽  
Egg Yolk ◽  
Blood Cholesterol ◽  
Fruit Extract ◽  
Urea Nitrogen ◽  
Nitrogen Levels ◽  
Randomized Design ◽  
Yolk Cholesterol ◽  
Cu And Zn

The research was conducted to know the effect of noni fruit extract supplemented by Cu and Zn on blood cholesterol and  egg yolk cholesterol, creatinin, and blood urea nitrogen of sentul chicken. The research was done from August until October 2019. Samples test was held in Physiology and Biochemistry Laboratory, Animal Husbandry Faculty, Padjadjaran University, Sumedang. The methods used experimental with a Completely Randomized Design (CRD) and the effect of treatment using Analysis of  Varience (ANOVA) followed by Orthogonal Polynomial. The treatment consisted of five kind with five repetitions, those are to =  without adding noni fruit extract and  Cu, Zn , t1= Ration + 60 mg/kg extract noni fruit suplemented Cu 0,06 mg and Zn 1,5 mg, t2= Ration+ 180 mg/kg extract fruit noni suplemented Cu 0,18 mg and Zn 3,0 m, t3= Ration + 240 mg/kg extract fruit noni suplemented Cu 0,24 mg and Zn 4,5 mg, t4= Ration + 360 mg/kg extract fruit noni suplemented Cu 0,36 and Zn 6,0 mg. The result showed that the effect of giving 360 mg/kg noni extract suplemented Cu 0,36 and Zn 6,0 mg was significant effect  decreasing blood cholesterol levet but non significant  decreasing egg yolk cholesterol, creatinin, and blood urea nitrogen levels of Sentul Chicken. Keywords:  noni fruit extract, cholesterol, urea, creatinin, blood, egg yolk              cholesterol, sentul chicken, mineral Cu and ZnThe research was conducted to know the effect of noni fruit extract supplemented by Cu and Zn on blood cholesterol and  egg yolk cholesterol, creatinin, and blood urea nitrogen of sentul chicken. The research was done from August until October 2019. Samples test was held in Physiology and Biochemistry Laboratory, Animal Husbandry Faculty, Padjadjaran University, Sumedang. The methods used experimental with a Completely Randomized Design (CRD) and the effect of treatment using Analysis of  Varience (ANOVA) followed by Orthogonal Polynomial. The treatment consisted of five kind with five repetitions, those are to =  without adding noni fruit extract and  Cu, Zn , t1= Ration + 60 mg/kg extract noni fruit suplemented Cu 0,06 mg and Zn 1,5 mg, t2= Ration+ 180 mg/kg extract fruit noni suplemented Cu 0,18 mg and Zn 3,0 m, t3= Ration + 240 mg/kg extract fruit noni suplemented Cu 0,24 mg and Zn 4,5 mg, t4= Ration + 360 mg/kg extract fruit noni suplemented Cu 0,36 and Zn 6,0 mg. The result showed that the effect of giving 360 mg/kg noni extract suplemented Cu 0,36 and Zn 6,0 mg was significant effect  decreasing blood cholesterol levet but non significant  decreasing egg yolk cholesterol, creatinin, and blood urea nitrogen levels of Sentul Chicken. Keywords:  noni fruit extract, cholesterol, urea, creatinin, blood, egg yolk              cholesterol, sentul chicken, mineral Cu and Zn

Virgin coconut oil reverses hepatic steatosis by restoring redox homeostasis and lipid metabolism in male Wistar rats

2017 ◽  
Vol 98 (5) ◽  
pp. 1757-1764 ◽  
Author(s):  
Arunaksharan Narayanankutty ◽  
Devika Mukundan Palliyil ◽  
Kezia Kuruvilla ◽  
Achuthan C Raghavamenon
Keyword(s):  
Lipid Metabolism ◽  
Hepatic Steatosis ◽  
Wistar Rats ◽  
Redox Homeostasis ◽  
Coconut Oil ◽  
Virgin Coconut Oil ◽  
Male Wistar Rats

scholarly journals Probiotic Amelioration of Azotemia in 5/6th Nephrectomized Sprague-Dawley Rats

2005 ◽  
Vol 5 ◽  
pp. 652-660 ◽  
Author(s):  
Natarajan Ranganathan ◽  
Beena Patel ◽  
Pari Ranganathan ◽  
Joseph Marczely ◽  
Rahul Dheer ◽  
...  
Keyword(s):  
Renal Failure ◽  
Life Span ◽  
Blood Urea Nitrogen ◽  
Clinical Severity ◽  
Sprague Dawley ◽  
Bacillus Pasteurii ◽  
Urea Nitrogen ◽  
Blood Concentrations ◽  
Nitrogen Levels ◽  
Probiotic Treatment

The present study was to test the hypothesis that selected bacteria instilled into the gastrointestinal tract could help in converting nitrogenous wastes accumulated due to renal insufficiency into nontoxic compounds; thereby, ameliorating the biochemical imbalance. Herein we describe a prospective, blinded, placebo-controlled pilot study, using 5/6thnephrectomized Sprague Dawley rat as a chronic renal failure model. The study group consisted of 36 nephrectomized and 7 non-nephrectomized (control) rats. After two-week nephrectomy stabilization, cohorts of six nephrectomized rats were fed casein-based diet plus one of the following regimens: (A) Control, (B) Placebo (casein-based diet without probiotics), (C)Bacillus pasteurii, (D) Sporolac®, (E) Kibow cocktail, (F) CHR Hansen Cocktail, and (G) ECONORMTM. Subsequently, blood (retro-orbital) and urine (collected for measurements of blood urea-nitrogen and creatinine respectively), body weight and bacterial counts (feces) were obtained at regular intervals. The study end-points were to determine if any of the probiotic dietary supplements facilitated, (1) decreased blood concentrations of uremic toxins, (2) altered renal function, and (3) prolonged survival. After 16 weeks of treatment, regimens C and D significantly prolonged the life span of uremic rats, in addition to showing a reduction in blood urea-nitrogen levels, concluding that supplementation of probiotic formulation to uremic rats slows the progression of azotemia, which may correlate with prolonged life span of uremic rats. Derivative trials of probiotic treatment of larger animals and humans will further assess the potential role of probiotic formulations in delaying the onset and clinical severity of clinical illness at different stages of renal failure.

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