The Effect of Oxotremorine on the "Free" and "Bound" Brain Acetylcholine Concentrations and Motor Activity in Beri-Beri Pigeons

1971 ◽  
Vol 49 (11) ◽  
pp. 985-987 ◽  
Author(s):  
R. Igić ◽  
P. Stern
Keyword(s):  
Motor Activity ◽  
Significant Change ◽  
Brain Acetylcholine

Oxotremorine (0.125 mg/kg i.v.) did not produce a significant change in the "free" and "bound" brain acetylcholine in beri-beri pigeons, while in normal pigeons a significant increase was obtained. Oxotremorine caused tremor in normal pigeons. In beri-beri pigeons oxotremorine did not induce tremor but the compound potentiated beri-beri symptoms (opisthotonus and convulsions).

scholarly journals Влияние ультразвука на поведение серых крыс

2018 ◽  
Vol 8 (2) ◽  
pp. 1-4 ◽  
Author(s):  
A. V. Matsyura ◽  
T. V. Antonenko ◽  
O. M. Ulitina ◽  
Yu. A. Bondarchuk ◽  
I. I. Shakhmatov ◽  
...  
Keyword(s):  
Motor Activity ◽  
Open Field ◽  
Field Test ◽  
Rattus Norvegicus ◽  
Open Field Test ◽  
Before And After ◽  
Significant Change ◽  
The Individual

The influence of ultrasound on the behavior of Brwon Rats (Rattus norvegicus, Berkenhout, 1769) in the open field test is considered in the article. Animals were exposed to ultrasound at 22 kHz and simultaneously at 50-60 kHz for 24 hours. The indices of the activity of the individual in the open field were compared before and after the experiment. As a result of the tests, multidirectional changes in motor activity (number of columns and intersected squares), frequency of defecations and duration of grooming were revealed. The results obtained show that the behavior of most rats after exposure to ultrasound tended to change, but these data did not differ significantly. Thus, the use of the Quadblaster QB-4 and Filin ultrasound scanners at a frequency of 22 kHz and 50-60 kHz for 24 hours did not cause a significant change in the behavior of the animals, and therefore their use as repellents for gray rats appears to be ineffective.

Effects of Carisoprodol, Phenylbutazone and Antazoline

1971 ◽  
Vol 5 (12) ◽  
pp. 400-403
Author(s):  
Linda L. Lien ◽  
Eric J. Lien
Keyword(s):  
Motor Activity ◽  
Sex Difference ◽  
Dosage Level ◽  
Dose Increase ◽  
Sleeping Time ◽  
Female Mice ◽  
Significant Change ◽  
Dose Dependent

Carisoprodol at 100 mg/Kg dosage level was found to increase the pentobarbital induced sleeping time in mice significantly, while phenylbutazone at 14 mg/Kg did not cause a significant change. The sex difference of the pentobarbital sleeping time was found to be dose dependent. The female mice were found to be more sensitive to the dose increase than the male. Carisoprodol at 50 mg/Kg level did not reduce the motor activity significantly. Antazoline phosphate at 14 mg/Kg reduced the motor activity by 34 percent. When these two drugs were given together the motility was reduced by more than 50 percent (P<0.005).

Tachykinin-mediated increase in motility acts independently of vasoactive intestinal polypeptide release in the canine ileum

1994 ◽  
Vol 72 (2) ◽  
pp. 109-112 ◽  
Author(s):  
E. G. Watson ◽  
J. E. T. Fox-Threlkeld ◽  
E. E. Daniel
Keyword(s):  
Gastrointestinal Tract ◽  
Substance P ◽  
Motor Activity ◽  
Vasoactive Intestinal Polypeptide ◽  
Neurokinin A ◽  
Significant Change ◽  
Dose Dependent Increase ◽  
Dose Dependent ◽  
Intestinal Polypeptide

Tachykinins induce motor activity in the canine ileum, and their mechanism of excitation may include inhibition of the release of a nonadrenergic, noncholinergic inhibitor, for which vasoactive intestinal polypeptide (VIP) is a candidate. Both substance P and neurokinin A produced a dose-dependent increase in ileal contractility with no significant change in VIP output. The highly selective NK1 agonist [Sar9, Met(O2)11]substance P and the highly selective NK2 agonist [Nle10]neurokinin A (4–10) also increased motor activity in the absence of any change in VIP released. These data suggest that the tachykinins produce motor activity in the canine ileum via a mechanism that does not involve changes in VIP output but may involve excitation through both NK1 and NK2 receptors.Key words: vasoactive intestinal polypeptide, tachykinins, gastrointestinal tract, motility.

scholarly journals Hypocretin release in normal and narcoleptic dogs after food and sleep deprivation, eating, and movement

2002 ◽  
Vol 283 (5) ◽  
pp. R1079-R1086 ◽  
Author(s):  
M.-F. Wu ◽  
J. John ◽  
N. Maidment ◽  
H. A. Lam ◽  
J. M. Siegel
Keyword(s):  
Cerebrospinal Fluid ◽  
Motor Activity ◽  
Sleep Deprivation ◽  
Strong Correlation ◽  
Fasting Period ◽  
Hypothalamic Neuropeptides ◽  
Baseline Levels ◽  
Significant Change ◽  
Highly Correlated ◽  
Hypocretin 1

Hypocretins (orexins) are recently discovered hypothalamic neuropeptides that have been implicated in the etiology of narcolepsy. The normal behavioral functions of these peptides are unclear, although a role in feeding has been suggested. We measured hypocretin-1 (Hcrt-1) in the cerebrospinal fluid of dogs during a variety of behaviors. We found that 48 h without food (24 h beyond normal 24-h fasting period) produced no significant change in Hcrt-1 levels nor did feeding after the deprivation. In contrast, 24 h of sleep deprivation produced on average a 70% increase in Hcrt-1 level compared with baseline levels. The amount of increase was correlated with the level of motor activity during the sleep-deprivation procedure. A 2-h period of exercise in the same dogs produced a 57% increase in Hcrt-1 levels relative to quiet waking levels, with the magnitude of the increase being highly correlated with the level of motor activity. The strong correlation between motor activity and Hcrt-1 release may explain some of the previously reported behavioral, physiological, and pathological phenomena ascribed to the Hcrt system.

DYNAMICS OF INDEXES OF EXTERNAL BREATH AND BEHAVIOR ACTIVITIES OF WHITE RATS WHEN EXPOSED TO A SUBSTANCE OF THE CS TYPE

2018 ◽  
pp. 13-17
Author(s):  
L. P. Erdniev ◽  
D. V. Gorbunov ◽  
Y. A. Stepanov ◽  
E. Y. Andreeva ◽  
L. V. Gorbunova ◽  
...  
Keyword(s):  
Motor Activity ◽  
Respiratory Rate ◽  
Minute Volume ◽  
External Respiration ◽  
Respiratory Volume ◽  
White Rats ◽  
Respiratory Minute Volume ◽  
Significant Change ◽  
And Behavior

The indexes of external respiration of white rats exposed by inhalation to a substance of the CS type were estimated. Increase in the respiratory volume and respiratory minute volume as well as the absence of changes in respiratory rate when exposed to the formulation at the level of effective inhalation toxodosis has been found. It has been established that substance of the CS type causes a significant change in motor activity.

CCK-1 and CCK-2 receptors mediate differential effects of cholecystokinin on the motor activity of distal colon

2001 ◽  
Vol 120 (5) ◽  
pp. A173-A174
Author(s):  
F BASCHIERA ◽  
C BLANDIZZI ◽  
M FOMAI ◽  
M TACCA
Keyword(s):  
Motor Activity ◽  
Distal Colon ◽  
Differential Effects

Simultaneous recording of pseudoaffective reflexes and motor activity in the jejunum of the anesthetized rat

2001 ◽  
Vol 120 (5) ◽  
pp. A717-A717
Author(s):  
A TIMARPEREGRIN ◽  
K KUMANO ◽  
Z KHALIL ◽  
G SANGER ◽  
S BEECHAM ◽  
...  
Keyword(s):  
Motor Activity ◽  
Simultaneous Recording
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