Interaction of Local Anesthetics and Salicylate with Phospholipid Membranes
1973 ◽
Vol 51
(11)
◽
pp. 785-789
◽
Keyword(s):
Local anesthetics reduce both the surface charge and cation permeability of phosphatidylcholine (PC) liposomes containing the long chain anion dicetylphosphate. These agents also reduce the negative surface charge of PC vesicles dispersed in a salicylate solution, but in this case cation permeability is enhanced. It is proposed that the local anesthetic, by reducing the negative surface potential on the PC–salicylate liposome, permits the adsorption of more salicylate anions. The resultant higher salicylate surface concentration is responsible for the increased cation permeability.
Negative surface charge density near heart calcium channels. Relevance to block by dihydropyridines.
1987 ◽
Vol 89
(4)
◽
pp. 629-644
◽
1974 ◽
Vol 52
(5)
◽
pp. 930-941
◽
1996 ◽
Vol 34
(5-6)
◽
pp. 309-316
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Influence of negative surface charge on toxin binding to canine heart Na channels in planar bilayers
1989 ◽
Vol 55
(2)
◽
pp. 359-365
◽
Keyword(s):
2007 ◽
Vol 1
(1)
◽
pp. 60-63
Keyword(s):