ACCELERATION OF ANNUAL HIBERNATING CYCLE TO 6 WEEKS IN CAPTIVE DORMICE

1966 ◽  
Vol 44 (5) ◽  
pp. 903-910 ◽  
Author(s):  
N. Mrosovsky

Cycles of food intake and body weight lasting a few weeks occurred in dormice, Glis glis, kept in the laboratory in relatively constant conditions of temperature (about 25 °C) and photoperiod (about 12 hours light–dark schedule). These fluctuations appeared to be more marked in the winter months. Periods of reduced eating were associated with low body temperatures and lethargy. The frequent disturbance and arousal of the animals was probably an important factor in these short hibernating cycles. The influence of variation of the diet on body weight of dormice is described. Animals kept on ad libitum supplies of sunflower seed became obese and remained so for many months.

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3893 ◽  
Author(s):  
Desiree M. Sigala ◽  
Adrianne M. Widaman ◽  
Bettina Hieronimus ◽  
Marinelle V. Nunez ◽  
Vivien Lee ◽  
...  

Sugar-sweetened beverage (sugar-SB) consumption is associated with body weight gain. We investigated whether the changes of (Δ) circulating leptin contribute to weight gain and ad libitum food intake in young adults consuming sugar-SB for two weeks. In a parallel, double-blinded, intervention study, participants (n = 131; BMI 18–35 kg/m2; 18–40 years) consumed three beverages/day containing aspartame or 25% energy requirement as glucose, fructose, high fructose corn syrup (HFCS) or sucrose (n = 23–28/group). Body weight, ad libitum food intake and 24-h leptin area under the curve (AUC) were assessed at Week 0 and at the end of Week 2. The Δbody weight was not different among groups (p = 0.092), but the increases in subjects consuming HFCS- (p = 0.0008) and glucose-SB (p = 0.018) were significant compared with Week 0. Subjects consuming sucrose- (+14%, p < 0.0015), fructose- (+9%, p = 0.015) and HFCS-SB (+8%, p = 0.017) increased energy intake during the ad libitum food intake trial compared with subjects consuming aspartame-SB (−4%, p = 0.0037, effect of SB). Fructose-SB decreased (−14 ng/mL × 24 h, p = 0.0006) and sucrose-SB increased (+25 ng/mL × 24 h, p = 0.025 vs. Week 0; p = 0.0008 vs. fructose-SB) 24-h leptin AUC. The Δad libitum food intake and Δbody weight were not influenced by circulating leptin in young adults consuming sugar-SB for 2 weeks. Studies are needed to determine the mechanisms mediating increased energy intake in subjects consuming sugar-SB.


1988 ◽  
Vol 255 (4) ◽  
pp. R616-R621 ◽  
Author(s):  
J. O. Hill ◽  
J. C. Anderson ◽  
D. Lin ◽  
F. Yakubu

The effects of differences in meal frequency on body weight, body composition, and energy expenditure were studied in mildly food-restricted male rats. Two groups were fed approximately 80% of usual food intake (as periodically determined in a group of ad libitum fed controls) for 131 days. One group received all of its food in 2 meals/day and the other received all of its food in 10-12 meals/day. The two groups did not differ in food intake, body weight, body composition, food efficiency (carcass energy gain per amount of food eaten), or energy expenditure at any time during the study. Both food-restricted groups had a lower food intake, body weight gain, and energy expenditure than a group of ad libitum-fed controls. In conclusion, these results suggest that amount of food eaten, but not the pattern with which it is ingested, has a major influence on energy balance during mild food restriction.


Endocrinology ◽  
1999 ◽  
Vol 140 (1) ◽  
pp. 244-250 ◽  
Author(s):  
Karim Meeran ◽  
Donal O’Shea ◽  
C. Mark B. Edwards ◽  
Mandy D. Turton ◽  
Melanie M. Heath ◽  
...  

Abstract Central nervous system glucagon-like peptide-1-(7–36) amide (GLP-1) administration has been reported to acutely reduce food intake in the rat. We here report that repeated intracerebroventricular (icv) injection of GLP-1 or the GLP-1 receptor antagonist, exendin-(9–39), affects food intake and body weight. Daily icv injection of 3 nmol GLP-1 to schedule-fed rats for 6 days caused a reduction in food intake and a decrease in body weight of 16 ± 5 g (P &lt; 0.02 compared with saline-injected controls). Daily icv administration of 30 nmol exendin-(9–39) to schedule-fed rats for 3 days caused an increase in food intake and increased body weight by 7 ± 2 g (P &lt; 0.02 compared with saline-injected controls). Twice daily icv injections of 30 nmol exendin-(9–39) with 2.4 nmol neuropeptide Y to ad libitum-fed rats for 8 days increased food intake and increased body weight by 28 ± 4 g compared with 14 ± 3 g in neuropeptide Y-injected controls (P &lt; 0.02). There was no evidence of tachyphylaxis in response to icv GLP-1 or exendin-(9–39). GLP-1 may thus be involved in the regulation of body weight in the rat.


Parasitology ◽  
1981 ◽  
Vol 82 (1) ◽  
pp. 23-38 ◽  
Author(s):  
D. W. T. Crompton ◽  
D. E. Walters ◽  
Susan Arnold

SUMMARYThe daily food intake and related changes in body weight were measured in young rats which were fed on synthetic diets containing 1% (3 experiments), 2% (4 experiments) and 20% (1 experiment) casein respectively. Some rats were infected with Nippostrongylus brasiliensis and allowed to feed ad libitum, some remained uninfected and were allowed to feed ad libitum while others, which were matched by initial weight with rats from the infected group, remained uninfected and were given only the same amount of food as that consumed during the previous 24 h by their infected partners. No significant differences were detected between the rats before the start of the infection. Thereafter, the food intake of the infected undernourished rats was usually found to be significantly lower and the loss of body weight significantly greater than those of the uninfected rats. In infection periods of relatively long duration, the pair-fed uninfected rats did not lose as much weight as their infected partners even though their food intake (1% and 2% casein) was the same. Although the food intake, and consequently the weight, of infected rats fed on the diet containing 20% casein were significantly less than in their uninfected partners, no significant differences were observed between the weights of the infected and pair-fed rats fed on this diet.


1985 ◽  
Vol 40 (1) ◽  
pp. 23-32 ◽  
Author(s):  
R. B. Thiessen

ABSTRACTIn a multibreed experiment, 292 heifers from 25 British cattle breeds were fed a standard pelleted diet ad libitum from 12 to 72 weeks of age. Inter-age correlations involving body weight, weight gain, average daily food intake and cumulated food intake were measured across traits at the same age and within and across traits at ages separated by an interval of 12, 24, 36 and 48 weeks. Within-breed correlations were phenotypic but between-breed correlations were genetic.The between-breed inter-age correlations involving body weight, cumulated intake and average daily intake were all very high (range 104 to 0·94) and declined only gradually as the intervening age interval increased from 12 to 48 weeks. Inter-age correlations involving weight gain were lower but usually above 0·7. The within-breed correlations by contrast were invariably lower and declined much more rapidly as the age interval increased. Although the between-breed and within-breed correlations differed in magnitude there was a similarity in their overall pattern.For breed samples, body weight at young ages provided very accurate rankings at later ages for body weight, cumulated intake and average daily intake. Body weight was almost as reliable as food intake itself for predicting cumulated intake.For individuals within breeds predicted rankings at later ages were not very accurate for body weight or cumulated intake and they became worse as the age interval increased. Neither weight gain nor average daily intake could be predicted with any reliability.Inter-age correlations while dependant on age interval did not depend on age itself in the case of body weight and cumulated intake, although they were age-dependant for weight gain and to a lesser extent for average daily intake. Reciprocal correlations between body weight and cumulated intake were very symmetrical whereas those involving weight gain and daily intake were asymmetrical.


1973 ◽  
Vol 51 (12) ◽  
pp. 1604-1616 ◽  
Author(s):  
B. Szepesi

Starvation followed by refeeding a 65% glucose diet led to elevated levels of hepatic glucose-6-phosphate dehydrogenase and malic enzyme activity. A second starve–refeed episode led to even greater enzyme responses. Food intake and body weight gain were increased by one, and further increased by a second, starve–refeed episode. Prefeeding a 65% fructose or sucrose diet ad libitum (which results in elevated enzyme levels comparable with the effect of one starve–refeed episode) was not accompanied by increased food intake or body-weight gain, nor did such treatment increase the enzyme response to subsequent starvation–refeeding. Previous starvation, however, did increase the subsequent enzyme response to feeding ad libitum a diet containing sucrose or invert sugar. The enzyme response was greater when the sucrose-containing diet was fed, and the diet effect was independent of the treatment effect. The results suggest that: (1) the metabolic consequences of starvation–refeeding are longer lasting than the metabolic consequences of feeding fructose or sucrose, (2) the effect of dietary sucrose is greater than the effect of an equal amount of invert sugar, (3) the metabolic effects of dietary fructose and sucrose may be mediated by different mechanisms than the corresponding effects of starvation–refeeding.


1977 ◽  
Vol 24 (1) ◽  
pp. 91-101 ◽  
Author(s):  
J. M. Forbes

SUMMARYA model has been developed in which the voluntary food intake of sheep is related directly to metabolizable energy requirements unless physical or endocrine limitations intervene.Although no ‘set point’ for body weight or body fat is incorporated in the model, mature sheep offered food ad libitum are predicted to reach eventually a plateau of body weight due to progressive depression of gut capacity by the increasing volume of abdominal fat. The final body weight is proportional to the digestibility of the diet. During pregnancy and lactation metabolic, physical and endocrine factors interact in such a way as to give predicted patterns of feed intake similar to those observed in practice with several qualities of diet.


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