The Distribution of Yin-Deficient Symptoms and Their Relationship on Survival Rate in Cancer Patients with Yin-Deficiency

Yin-Deficiency (YD), representing a status of the human body under lack of nutrition and fluid in traditional Chinese medicine, is commonly seen in late stage of cancer patients. It is not known whether the severity of YD related symptoms/signs can predict the survival rate of cancer patients. This study evaluated the distribution of Yin-deficiency symptoms/signs (YDS) in cancer patients with YD, and investigated whether the severity of YDS can predict the survival rate of cancer patients with YD. From 5 January 2007 to 5 May 2007, we selected 43 cancer patients with diagnosis of YD from hospitalized patients and outpatients. The severity of YD was evaluated by a questionnaire. We further estimated the cumulative probabilities of the survival rates over 4 months since the start of study by the Kaplan-Meier product-limit method, and compared the differences among groups with various severities in each symptom/sign with the use of the log-rank test. The results revealed that, the 3 most common YDS were sleeplessness with annoyance, less or non-coated tongue with or without redness and dry mouth. In the survival rate analysis, only 2 parameters, rapidly small pulse (p = 0.002) and less-or non-coated tongue with paleness (p = 0.017), were found to be related to the decrease of cancer patients with YD. This suggests that, both rapidly small pulse and less-or non-coated tongue without redness may be used as predictors for the estimation of survival rate in cancer patients with YD.

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Survival of Patients With Testicular Cancer in Lithuania During 1999–2002

Medicina ◽

10.3390/medicina47010008 ◽

2011 ◽

Vol 47 (1) ◽

pp. 8 ◽

Cited By ~ 1

Author(s):

Agnius Juška ◽

Albertas Ulys ◽

Laura Kairevičė ◽

Giedrė Smailytė ◽

Edgaras Stankevičius ◽

...

Keyword(s):

Survival Rate ◽

Testicular Cancer ◽

Cancer Patients ◽

Cancer Registry ◽

Survival Rates ◽

Tumor Stage ◽

Rank Test ◽

Log Rank Test ◽

Kaplan Meier ◽

Younger Age

The aim of this study was to evaluate the survival of patients with testicular cancer in Lithuania during 1998–2002 and factors that influenced the survival.Material and methods. The survival rates of testicular cancer patients were evaluated using the data of the Lithuanian Cancer Registry for 1998–2002. The survival was evaluated using the Kaplan-Meier method and log-rank test in order to compare the survival rates. The observed survival rates were calculated.Results. The 5-year observed survival rate in Lithuania was 71.2% (95% CI, 64.4%–77.5%). The survival of testicular cancer patients depended on age at the time of diagnosis, histology of tumor, stage and extent of disease.Conclusions. The survival of patients with testicular cancer in Lithuania was substantially lower than in other European countries. The better survival was associated with younger age and lesser extent of metastases.

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12-Month Self-Ligating Bracket Failure Rate with a Self-Etching Primer

The Angle Orthodontist ◽

10.2319/112507-552.1 ◽

2008 ◽

Vol 78 (6) ◽

pp. 1095-1100 ◽

Cited By ~ 21

Author(s):

Selma Elekdag-Turk ◽

Fethiye Cakmak ◽

Devrim Isci ◽

Tamer Turk

Keyword(s):

Survival Rate ◽

Clinical Performance ◽

Survival Rates ◽

Rank Test ◽

Dental Arch ◽

Bond Failure ◽

Lower Survival Rate ◽

Log Rank Test ◽

Kaplan Meier ◽

Significant Difference

Abstract Objective: To compare the clinical performance of a self-etching primer (SEP) with a conventional two-step etch and primer method (CM). Materials and Methods: Study subjects were 39 patients with a mean age of 15 years 7 months. Six hundred and eighty-eight brackets were bonded by one operator with a split-mouth design, using Transbond Plus Self-Etching Primer or a conventional two-step etch and primer (Transbond XT). The survival rate of the brackets was estimated by the Kaplan-Meier analysis. Bracket survival distributions with respect to bonding procedure, dental arch, type of tooth (incisor, canine, and premolar) and patients' gender were compared using the log-rank test. Bond failure interface was determined using the Adhesive Remnant Index (ARI). Results: The bond failure rates of SEP and CM were 4.7% and 1.7%, respectively. A significant difference was found between the bonding procedures using the log-rank test (P < .05). Furthermore, canine and premolar teeth displayed a lower survival rate than incisor teeth (P < .05). Survival rates did not show significant differences between the upper and lower dental arches and patients' gender (P > .05). No significant difference was observed for ARI scores (P > .05). Conclusion: These findings indicate that the SEP (Transbond Plus) can be effectively used to bond orthodontic brackets.

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Survival of Cervical Cancer Patients in Brunei Darussalam: 2002-2017

10.21203/rs.3.rs-148839/v1 ◽

2021 ◽

Author(s):

Shirley Lee ◽

Nurlaylasahira Abdul Rahim ◽

Sok King Ong ◽

Hanif Abdul Rahman ◽

Lin Naing

Keyword(s):

Cervical Cancer ◽

Survival Rate ◽

Cancer Patients ◽

Cox Regression ◽

Survival Rates ◽

Rank Test ◽

Cox Regression Analysis ◽

Brunei Darussalam ◽

Kaplan Meier ◽

Risk Of Mortality

Abstract BACKGROUND: Cervical cancer is the fourth leading cause of cancer deaths among Bruneian women. This study aims to investigate the survival rate of cervical cancer patients in Brunei Darussalam between 2002 and 2017, to compare survival of cervical cancer patients between two periods: 2002-2009 and 2010-2017 and to identify prognostic factors of cervical cancer.METHODS: A retrospective cohort study on cervical cancer patients registered in Brunei Darussalam Cancer Registry between 2002 and 2017. De-identified data from the registry was extracted and survival analysis was performed using Kaplan-Meier estimator, log-rank test and multiple Cox regression analysis.RESULTS: The 1-, 3- and 5-year survival rates of cervical cancer patients in Brunei Darussalam were 88.2%, 78.9% and 74.1% respectively from 2002-2017. The 5-year survival rate for 2002-2009 and 2010-2017 were 77.5% and 72.1% respectively. The risk of mortality was significantly higher in 2010-2017 compared to 2002-2009 after adjusting for other variables (Adjusted HR=1.57; 95% CI: 1.06, 2.31; p=0.025). Cervical cancer patients ≥ 60 years (Adjusted HR=1.85; 95% CI: 1.11, 3.09; p=0.019), and patients with distant cancer (Adjusted HR=49.47; 95% CI: 6.64, 368.52; p<0.001) had the highest risk of mortality.CONCLUSION: The 5-year survival rate of cervical cancer patients in Brunei Darussalam was 74.1%, which ranks relatively high globally. However, increased mortality among elderly patients, and patients diagnosed with cervical cancers at the later stages, calls for raising awareness, early detection, and management.

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A prospective comparative analysis of the survival rates of conventional vs no-prep/minimally invasive veneers over a mean period of 9 years

Clinical Oral Investigations ◽

10.1007/s00784-021-04289-6 ◽

2021 ◽

Author(s):

Beata Smielak ◽

Oskar Armata ◽

Witold Bojar

Keyword(s):

Survival Rate ◽

Minimally Invasive ◽

Survival Rates ◽

United States Public Health ◽

Rank Test ◽

Log Rank Test ◽

Kaplan Meier ◽

The Mean ◽

Test Probability ◽

Observation Period

Abstract Objectives The present study compares the survival rates of 186 conventional and no-prep/minimally invasive porcelain veneers in 35 patients over a mean period of 9 years. Materials and methods The veneers were placed on the incisors, canines, and premolars in 35 patients between January 2009 and December 2010. Fourteen patients received 84 conventional veneers, and 21 patients received 102 no-prep/minimally invasive veneers. The restorations were evaluated at baseline and after every 6 months until June 2019 based on modified United States Public Health Service criteria. The data was analyzed by using Wilcoxon–Breslow–Gehan and Taron–Ware tests. Kaplan–Meier survival and success curves were plotted for two groups of veneers. The results were compared by using the log rank test. A test probability of P < .05 was regarded as significant, while a test probability of P < .01 was considered to be statistically significant. Results The mean survival rate, according to the Kaplan–Meier estimator, was 9.67% for conventional veneers and 100% for the no-prep or minimal prep veneers. A total of ten absolute failures were observed in six patients: eight restoration chipping/fractures, one debonding, and one fracturing of the tooth. Mean success rate time for conventional veneers without absolute or relative failures was 9.32 years, and 10.28 years for no-prep/minimally invasive veneers. Conclusions Over a mean observation period of 9 years, the survival rate of no-prep/minimally invasive veneers exceed that of conventional veneers. Clinical relevance No-prep/minimally invasive veneers appear very effective and should always be considered in certain clinical situations.

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Effect of body mass index (BMI) on outcomes after surgical resection and adjuvant therapy for pancreatic cancer patients.

Journal of Clinical Oncology ◽

10.1200/jco.2011.29.4_suppl.185 ◽

2011 ◽

Vol 29 (4_suppl) ◽

pp. 185-185

Author(s):

M. R. Khawaja ◽

N. Zyromski ◽

M. Yu ◽

H. R. Cardenes ◽

C. M. Schmidt ◽

...

Keyword(s):

Pancreatic Cancer ◽

Adjuvant Therapy ◽

Cancer Patients ◽

Surgical Resection ◽

Survival Rates ◽

Disease Free Survival ◽

University Hospital ◽

Rank Test ◽

Kaplan Meier ◽

Significant Difference

185 Background: Obesity is one of the factors commonly associated with pancreatic cancer risk, but its prognostic role for survival is debatable. This study aimed to determine the role of BMI in treatment outcomes of pancreatic cancer patients (pts) undergoing surgical resection followed by adjuvant therapy. Methods: We retrospectively reviewed 165 consecutive pts with pancreatic cancer undergoing pancreaticoduodenectomy at Indiana University Hospital between 2004 and 2008. Fifty-three pts who received adjuvant treatment [gemcitabine alone (C-group): n=19; gemcitabine + radiotherapy (CRT-group): n=34] at our institution were included in the analysis. The Kaplan-Meier method was used to estimate the disease-free survival (DFS) and overall survival (OS); log-rank test was used to compare these outcomes between BMI groups (normal 18.5-24.99 kg/m2 vs. overweight/obese ≥ 25 kg/m2). Results: The sample comprised 53 pts (28 males; median age 62 yrs) with a median follow-up of 18.6 months (mos). Thirty pts (56.6%) had their BMIs recorded before the date of surgery, and 23 pts prior to starting adjuvant therapy. Two (3.8%) pts were underweight, 21 (39.6%) had a normal BMI and 30 (56.6%) were overweight/obese. There was no statistically significant difference in the median DFS of obese/overweight and normal BMI pts irrespective of adjuvant therapy (C or CRT) (14.47 vs. 11.80 mos; p= 0.111). Obese/overweight pts had a better median OS [25.2 vs. 14.6 mos; p=0.045 overall (25.7 vs. 16.9 mos; p= 0.143 for the CRT-group and 17.3 vs. 13.4 mos; p= 0.050 for the C-group)], 1-year survival [96.7% vs. 61.9%; p < 0.0001 overall (95% vs. 64.3%; p= 0.001 for the CRT-group, and 90% vs. 57.1%; p=0.016 with C)], and 2-year survival [52.6% vs. 25.4%; p < 0.0001 overall (60.0% vs. 30.0%; p=0.0001 for the CRT-group and 37.5% vs. 14.3%; p=0.0002 for the C-group)] than patients with normal BMI. Conclusions: In our experience, overweight/obese pts undergoing surgery followed by adjuvant therapy have better survival rates than patients with normal BMI. [Table: see text] No significant financial relationships to disclose.

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Clinical Performance of Lithium Disilicate Glass-Ceramic Onlays For The Treatment of Tooth Defects

10.21203/rs.3.rs-840869/v1 ◽

2021 ◽

Author(s):

Shujiang Chen ◽

Meng Lu ◽

Zhimin Zhu ◽

Wenchuan C. Chen

Keyword(s):

Survival Rate ◽

Glass Ceramic ◽

Clinical Performance ◽

United States Public Health ◽

Lithium Disilicate ◽

Western China ◽

Rank Test ◽

Log Rank Test ◽

Kaplan Meier ◽

Chi Squared

Abstract BackgroundThe aim of this study was to assess the clinical performance of lithium disilicate glass-ceramic onlays for the treatment of tooth defects and to evaluate the clinical performance and whether they are worth more extensive use as that of the full crown. MethodsPatients who received treatment by lithium disilicate glass-ceramic onlays at the Western China Hospital of Stomatology were recalled after 1~4 years. The clinical performance and patients’ satisfaction of onlays for various tooth defects, cracked or uncracked teeth and endodontically treated or vital teeth were retrospectively evaluated with a combination of modified United States Public Health Service Criteria and questionnaire survey. Statistical analysis was performed by using the chi-squared test, Kaplan–Meier analysis and Log-rank test (a = 0.05) where appropriate. ResultsA total of 154 patients with 166 onlays were recalled for clinical examination. Of the 166 onlays examined, 65 (39.19%) were occlusal onlays, 92 (55.42%) were proximal-occlusive onlays and 9 (5.42%) were buccal-or lingual-occlusal onlays. The clinical performance of O and PO onlays was not significantly different (P > 0.05), according to USPHS Criteria. Kaplan-Meier analysis showed that the 4-year survival rate of O and PO onlays was 95.4% and 97.8%, respectively while there was no failure happened in buccal-or lingual-occlusal onlays. Log- rank test showed that the kinds of defects/onlays, tooth vitality and tooth crack had no influence on the survival rate (P > 0.05). The overall satisfaction rate was more than 98%.ConclusionsThis medium-term analysis indicated that lithium disilicate glass-ceramic onlays achieved satisfactory clinical performance for the restoration of different tooth defects. The survival rate of onlays was comparable to that of full crown. Different kinds of tooth defects, tooth vitality and tooth crack did not influence performance.Trial registrationThe study was approved by the Medical Ethics Committee of West China Hospital of Stomatology of Sichuan University with the approval number: WCHSIRB-D-2021-300. Consent to participate was not applicable.

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Determination of Affected Factor on Survival Rates In Referral Gastric Cancer Patients to Imam Khomeini Clinic in Hamadan Province from 2004-2017

Journal of Shahid Sadoughi University of Medical Sciences ◽

10.18502/ssu.v27i12.2832 ◽

2020 ◽

Author(s):

Fatemeh Gohari-Ensaf ◽

Zeinab Berangi ◽

Mohamad Abbasi ◽

Ghodratollah Roshanaei

Keyword(s):

Gastric Cancer ◽

Survival Rate ◽

Screening Program ◽

Survival Rates ◽

Tumor Stage ◽

Rank Test ◽

Significance Level ◽

Kaplan Meier ◽

One Year ◽

Gastric Cancer Patients

Introduction: Gastric cancer is the fourth most common cancer and the second leading cause of death in the world. Despite the recent advances in controlling and treating the disease, the survival rate of this cancer is relatively low. Various factors can affect the survival of the patients with gastric cancer. The aim of this study was to determine the survival rates and the effective factors in the patients with gastric cancer. Methods: The study population included all the patients diagnosed with gastric cancer in Hamadan Province who were referred to Hamadan Imam Khomeini Specialized Clinic between 2004 to 2017. Patients were followed up by periodical referrals and/or telephone contact. The survival rate of the patients was calculated using Kaplan-Meier method and effective survival factors with Cox proportional regression. Data were analyzed using SPSS 23 software at a significance level of 0.05. Results: Out of the 350 patients with gastric cancer, 74.3% were male and 25.7% were female. One-year, three-year and five-year survival rates were 67%, 36% and 27%, respectively. The log -rank test showed that age, type of tumor, stage of disease, type of Surgery and metastasis of the disease were effective on the survival of patients. In Cox's multivariate analysis, the only age variables at the time of diagnosis and chemotherapy were survival variables. (P<0.05). Conclusion: The results of this study showed that age variable is a strong factor in survival, so it is essential to diagnose the disease at the early age and early stages of the disease using a screening program.

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A comparison of the prognostic significance of changes in NT-proBNP levels in HFrEF and HFpEF.

10.22541/au.161978616.62769552/v1 ◽

2021 ◽

Author(s):

Nishant Sahni ◽

Umesh Sharma ◽

Rashi Arora

Keyword(s):

Regression Models ◽

Cox Regression ◽

Survival Rates ◽

Prognostic Significance ◽

Rank Test ◽

Log Rank Test ◽

Kaplan Meier ◽

Regional Health Care ◽

Comorbidity Scores ◽

Blood Pressures

Background: Rising NT-proBNP are associated with reduced survival patients with HFrEF. However, it remains to be conclusively and formally demonstrated that the temporal trend in NT-proBNP level carries prognostic significance in HFpEF. Objective: To determine whether there is an association between rising NT-proBNP levels and 6-month survival in patients with HFpEF and HFrEF. Methods: We examined a cohort of 5203 patients to 5 hospitals in a regional health care system — who had at least one admission to the hospital with diagnoses of heart failure over a 3-year period. Kaplan-Meier survival curves were constructed for patients with downtrending (>25% net decrease), stable or uptrending (>25% net increase) NT-proBNP levels in HF, HFpEF and HFrEF patients. The log-rank test was used to test for differences in 6-month survival amongst the groups. Multivariate extended Cox regression models were constructed for 6-month survival with NT-proBNP as a time-varying covariate. Age, albumin, sex, race, serum creatinine, systolic and diastolic blood pressures and Charlson comorbidity scores at baseline were used as covariates in the model. Separate analyses were done for HFpEF and HFrEF patients. Results: HFpEF and HFrEF patients with up-trending levels had significantly lower 6-month survival rates than patients with downtrending or stable NT-proBNP levels. A doubling of the NT-proBNP level in patients was significantly associated with reduced 6-month survival in patients with in both subgroups of HF, HFpEF and HFrEF (HFpEF-HR: 1.53(1.49-2.57), HFrEF HR: 1.45(1.43-1.48) after adjusting for covariates.

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Copy Number Analysis Reveal Genetic Risks of Penile Cancer

Frontiers in Oncology ◽

10.3389/fonc.2020.596261 ◽

2020 ◽

Vol 10 ◽

Author(s):

Yongbo Yu ◽

Chengwen Gao ◽

Yuanbin Chen ◽

Meilan Wang ◽

Jianfeng Zhang ◽

...

Keyword(s):

Survival Rate ◽

Copy Number ◽

Penile Cancer ◽

Survival Rates ◽

Rank Test ◽

Cancer Specific Survival ◽

Functional Roles ◽

Kaplan Meier ◽

Genome Analysis Toolkit ◽

Penile Squamous Cell Carcinoma

ObjectivesTo evaluate copy number alterations (CNAs) in genes associated with penile cancer (PeC) and determine their correlation and prognostic ability with PeC.MethodsWhole-exome sequencing was performed for tumor tissue and matched normal DNA of 35 patients diagnosed with penile squamous cell carcinoma from 2011 to 2016. Somatic CNAs were detected using the Genome Analysis Toolkit (GATK). Retrospective clinical data were collected and analyzed. All the data were statistically analyzed using SPSS 16.0 software. The cancer-specific survival rates were estimated by Kaplan-Meier curves and compared with the log-rank test.ResultsCNAs in the MYCN gene was detected in 19 (amplification: 54.29%) patients. Other CNAs gene targets were FAK (amplification: 45.72%, deletion: 8.57%), TP53 (amplification: 2.86%, deletion: 51.43%), TRKA (amplification: 34.29%, deletion: 2.86%), p75NTR (amplification: 5.71%, deletion: 42.86%), Miz-1 (amplification: 14.29%, deletion: 20.00%), Max (amplification: 17.14%, deletion: 2.86%), Bmi1 (amplification:14.29%, deletion: 48.57%), and MDM2 (amplification: 5.71%, deletion: 45.72%). The CNAs in MYCN and FAK correlated significantly with patient prognosis (P<0.05). The 3-year Recurrence-free survival rate was 87.10% among patients followed up. The 5-year survival rate of patients with MYCN amplification was 69.2%, compared to 94.4% in the non-amplification group. The 5-year survival rate of patients with FAK amplification was 65.6%, compared to 94.7% in the non-amplification group. The PPI network showed that TP53 and MYCN might play meaningful functional roles in PeC.ConclusionMYCN and FAK amplification and TP53 deletion were apparent in PeC. MYCN and TP53 were hub genes in PeC. MYCN and FAK amplification was also detected and analyzed, and the findings indicated that these two genes are predictors of poor prognosis in PeC.

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Midterm Survivorship of an Uncemented Hydroxyapatite-Coated Titanium Femoral Component and Clinically Meaningful Outcomes in Patients Older Than 75 Years

Journal of Clinical Medicine ◽

10.3390/jcm10051019 ◽

2021 ◽

Vol 10 (5) ◽

pp. 1019

Author(s):

Alexander Zimmerer ◽

Luis Navas ◽

Stefan Kinkel ◽

Stefan Weiss ◽

Matthias Hauschild ◽

...

Keyword(s):

Survival Rate ◽

Femoral Component ◽

Survival Rates ◽

Femoral Stem ◽

Harris Hip Score ◽

Rank Test ◽

Kaplan Meier ◽

Clinically Meaningful Outcomes ◽

Modified Harris Hip Score

Purpose: It remains controversial whether cementless femoral components are safe in elderly patients. The aim of this study was (1) to determine the stem survival rate in patients >75 years of age who were treated with an uncemented femoral component and (2) to report clinically significant results on a mid-term follow-up. Methods: 107 total hip arthroplasties (THA) were retrospectively evaluated in 97 patients over 75 years of age (mean age 78 years, range 75–87) treated with an uncemented femoral stem. The minimum follow-up was five years (mean 6.4 years, range 5–8). Stem survival rates, clinically meaningful outcomes, and incidence of complications were evaluated. Results: Kaplan-Meier survival analysis, with the endpoint revision for any reason, showed a 6.4-year survival rate of 98% (95% CI, 95–99%; 63 hips at risk). The survival rates were comparable for male and female patients (log-rank test, p = 0.58). The modified Harris Hip Score (mHHS) improved from 42.2 (12 to 85) points to 81.1 (22 to 97) points (p < 0.0001). Mid-term minimal clinically important difference (MCID), substantial clinical benefit (SCB), and patient acceptable symptomatic state (PASS) were 25, 84, and 70, respectively. Conclusion: An uncemented stem is a viable option in patients over 75 years with good clinical outcomes and survivorship. Periprosthetic fractures were not a relevant failure mechanism with the stem used.

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