THE ROLE OF UNBOUNDED TIME-SCALES IN GENERATING LONG-RANGE MEMORY IN ADDITIVE MARKOVIAN PROCESSES

2013 ◽  
Vol 12 (02) ◽  
pp. 1340002 ◽  
Author(s):  
SALVATORE MICCICHÈ ◽  
FABRIZIO LILLO ◽  
ROSARIO N. MANTEGNA

Any additive stationary and continuous Markovian process described by a Fokker–Planck equation can also be described in terms of a Schrödinger equation with an appropriate quantum potential. By using such analogy, it has been proved that a power-law correlated stationary Markovian process can stem from a quantum potential that (i) shows an x-2 decay for large x values and (ii) whose eigenvalue spectrum admits a null eigenvalue and a continuum part of positive eigenvalues attached to it. In this paper we show that such two features are both necessary. Specifically, we show that a potential with tails decaying like x-μ with μ < 2 gives rise to a stationary Markovian process which is not power-law autocorrelated, despite the fact that the process has an unbounded set of time scales. Moreover, we present an exactly solvable example where the potential decays as x-2 but there is a gap between the continuum spectrum of eigenvalues and the null eigenvalue. We show that the process is not power law autocorrelated, but by decreasing the gap one can arbitrarily well approximate it. A crucial role in obtaining a power-law autocorrelated process is played by the weights [Formula: see text] giving the contribution of each time-scale contribute to the autocorrelation function. In fact, we will see that such weights must behave like a power-law for small energy values λ. This is only possible if the potential VS(x) shows a x-2 decay to zero for large x values.

Author(s):  
Partha Basu ◽  
Richa Tripathi ◽  
Ravi Mehrotra ◽  
Koninika Ray ◽  
Anurag Srivastava ◽  
...  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yafei Wang ◽  
Erik Brodin ◽  
Kenichiro Nishii ◽  
Hermann B. Frieboes ◽  
Shannon M. Mumenthaler ◽  
...  

AbstractColorectal cancer and other cancers often metastasize to the liver in later stages of the disease, contributing significantly to patient death. While the biomechanical properties of the liver parenchyma (normal liver tissue) are known to affect tumor cell behavior in primary and metastatic tumors, the role of these properties in driving or inhibiting metastatic inception remains poorly understood, as are the longer-term multicellular dynamics. This study adopts a multi-model approach to study the dynamics of tumor-parenchyma biomechanical interactions during metastatic seeding and growth. We employ a detailed poroviscoelastic model of a liver lobule to study how micrometastases disrupt flow and pressure on short time scales. Results from short-time simulations in detailed single hepatic lobules motivate constitutive relations and biological hypotheses for a minimal agent-based model of metastatic growth in centimeter-scale tissue over months-long time scales. After a parameter space investigation, we find that the balance of basic tumor-parenchyma biomechanical interactions on shorter time scales (adhesion, repulsion, and elastic tissue deformation over minutes) and longer time scales (plastic tissue relaxation over hours) can explain a broad range of behaviors of micrometastases, without the need for complex molecular-scale signaling. These interactions may arrest the growth of micrometastases in a dormant state and prevent newly arriving cancer cells from establishing successful metastatic foci. Moreover, the simulations indicate ways in which dormant tumors could “reawaken” after changes in parenchymal tissue mechanical properties, as may arise during aging or following acute liver illness or injury. We conclude that the proposed modeling approach yields insight into the role of tumor-parenchyma biomechanics in promoting liver metastatic growth, and advances the longer term goal of identifying conditions to clinically arrest and reverse the course of late-stage cancer.


Proceedings ◽  
2019 ◽  
Vol 10 (1) ◽  
pp. 11
Author(s):  
Fabio Dominguez ◽  
Jose Guilherme Milhano ◽  
Carlos A. Salgado ◽  
Konrad Tywoniuk ◽  
Victor Vila

In the first part of this work we study the color coherence phenomenon by considering the well-known quark-antiquark antenna with an in-medium hard gluon emission and an extra very soft emission outside it—double antenna. By discussing the coherence effects in terms of the survival probability, we generalize previous studies of the antenna radiation to the case of more than two emitters. After providing support to the jet quenching picture with effective emitters in the QCD cascade, we present a novel setup of an antenna splitting inside the medium taking into account the finite formation time of the dipole, which turns out to be an important scale. We read into the role of coherence and the relevant time scales which control the scenario, while also providing theoretical support for vacuum-like emissions early in the medium. Finally, by mapping the spectrum of in-medium splittings through the corresponding kinematical Lund diagram, we appreciate regimes of a close correspondence to a semi-classical description.


Entropy ◽  
2021 ◽  
Vol 23 (4) ◽  
pp. 450
Author(s):  
Chao Wang ◽  
Ravi P. Agarwal

As an effective tool to unify discrete and continuous analysis, time scale calculus have been widely applied to study dynamic systems in both theoretical and practical aspects. In addition to such a classical role of unification, the dynamic equations on time scales have their own unique features which the difference and differential equations do not possess and these advantages have been highlighted in describing some complicated dynamical behavior in the hybrid time process. In this review article, we conduct a survey of abstract analysis and applied dynamic equations on hybrid time scales, some recent main results and the related developments on hybrid time scales will be reported and the future research related to this research field is discussed. The results presented in this article can be extended and generalized to study both pure mathematical analysis and real applications such as mathematical physics, biological dynamical models and neural networks, etc.


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