ONE-STEP SYNTHESIS OF BIOCOMPATIBLE CHITOSAN/NaGdF4:Eu3+ NANOCOMPOSITE WITH FLUORESCENT AND MAGNETIC PROPERTIES FOR BIOIMAGING

NANO ◽  
2014 ◽  
Vol 09 (01) ◽  
pp. 1450007 ◽  
Author(s):  
HUI LI ◽  
CHUANXI WANG ◽  
YINGNAN JIANG ◽  
ZHANCHEN CUI ◽  
QUAN LIN
Keyword(s):  
Hexagonal Phase ◽  
Mri Contrast Agent ◽  
Uniform Size ◽  
Mri Contrast ◽  
Potential Applications ◽  
One Step ◽  
Ft Ir ◽  
Good Biocompatibility ◽  
Amine Groups ◽  
Magnetic Resonance Imaging Mri

Lanthanide-doped luminescent nanoscale materials have great potential applications in biological researches. Herein, we reported a novel and mild method for one-step synthesis of chitosan/ NaGdF 4: Eu 3+ nanocomposites. The luminescent Eu 3+ ions and magnetic resonance imaging (MRI) contrast agent Gd 3+ ions were incorporated to these biocompatible nanocomposites. The resultant nanocomposites exhibited strong fluorescence and attractive magnetic features. The nanocomposites also have pure hexagonal phase with uniform size of about 65 nm. FT-IR spectra revealed that these nanocomposites were successfully coated by hydrophilic chitosan, whose amine groups conferred the nanocomposites excellent dispensability in aqueous solution. Besides, the MTT assay and laser confocal microscopy images have confirmed the good biocompatibility of the nanocomposites. These results indicated that the as-prepared nanocomposites could be used as an excellent targeted imaging agent in biological fields.

Switchable 19F MRI polymer theranostics: towards in situ quantifiable drug release

2017 ◽  
Vol 8 (34) ◽  
pp. 5157-5166 ◽  
Author(s):  
A. V. Fuchs ◽  
A. P. Bapat ◽  
G. J. Cowin ◽  
K. J. Thurecht
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Hyperbranched Polymer ◽  
Relaxation Times ◽  
Mri Contrast Agent ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
19F Mri ◽  
Magnetic Resonance Imaging Mri

A switchable polymeric 19F magnetic resonance imaging (MRI) contrast agent was synthesised whereby the transverse (T2) relaxation times increased as a therapeutic was released from a hyperbranched polymer (HBP) scaffold.

Preparation of Magnetic Resonance Nano Contrast Agent and Its Adoption in Diagnosis of Breast Cancer

2021 ◽  
Vol 13 (9) ◽  
pp. 1611-1621
Author(s):  
Rong Guo ◽  
Binbin Ma ◽  
Jiaqiu Nie
Keyword(s):  
Breast Cancer ◽  
Differential Diagnosis ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Malignant Tumors ◽  
Nipple Discharge ◽  
Mri Contrast Agent ◽  
Cytotoxicity Test ◽  
Mri Contrast ◽  
Magnetic Resonance Imaging Mri

This study aimed to explore the value of preoperative mammography in the differential diagnosis of benign and malignant tumors of nipple discharge. A biocompatible T1 contrast agent KMnF3 nanoparticle was first developed in the research, and then RGD-coupled KMnF3 nanoparticles were further synthesized as a highly sensitive tumor-targeted magnetic resonance imaging (MRI) contrast agent. While the nanoparticle was characterized physically, cytotoxicity test and MRI test in breast cancer mice were performed, and the excised tumors were subjected to immunostaining and tumor electron microscope section processing. At the same time, 60 patients with nipple discharge were screened to participate in the research, and the prepared MRI nano contrast agent was used for the differential diagnosis of breast benign/malignant tumors of nipple discharge. In the experiment, the synthetic nanoparticles were tested by Fourier transformed infrared (FTIR), which proved that the designed RGDtu/KMnF3 nanoparticles were successfully synthesized. The quantitative analysis of the synthesized nanoparticles showed that the relaxation efficiency reached 23.12 mM−1s−1, and there was no obvious toxicity. After staining, the microscope showed that the tumor was proliferating. After intravenous injection of low-dose RGDtu/KMnF3 contrast agent, nanoparticles were found in the tumor tissue. It was found that the synthesized nanoparticles enhanced the contrast of tumors with a volume of less than 50 mm3 by observing tumor slices. The imaging of the patient’s breast showed that the X-ray classification of galactography based on this contrast agent was statistically significant in distinguishing benign/malignant lesions of nipple discharge (X2 = 58.700, P < 0.01).

scholarly journals Luminophore and Magnetic Multicore Nanoassemblies for Dual-Mode MRI and Fluorescence Imaging

Nanomaterials ◽  
2019 ◽  
Vol 10 (1) ◽  
pp. 28 ◽  
Author(s):  
Lénaïc Lartigue ◽  
Marina Coupeau ◽  
Mélanie Lesault
Keyword(s):  
Magnetic Interaction ◽  
Fluorescent Imaging ◽  
Mri Contrast Agent ◽  
Dual Mode ◽  
Mri Contrast ◽  
Additional Information ◽  
Clinical Procedures ◽  
Magnetic Resonance Imaging Mri ◽  
Biological Entities ◽  
Nanometric Size

Nanoassemblies encompass a large variety of systems (organic, crystalline, amorphous and porous). The nanometric size enables these systems to interact with biological entities and cellular organelles of similar dimensions (proteins, cells, …). Over the past 20 years, the exploitation of their singular properties as contrast agents has led to the improvement of medical imaging. The use of nanoprobes also allows the combination of several active units within the same nanostructure, paving the way to multi-imaging. Thus, the nano-object provides various additional information which helps simplify the number of clinical procedures required. In this review, we are interested in the combination between fluorescent units and magnetic nanoparticles to perform dual-mode magnetic resonance imaging (MRI) and fluorescent imaging. The effect of magnetic interaction in multicore iron oxide nanoparticles on the MRI contrast agent properties is highlighted.

Cobalt ferrite nanowhiskers as T2 MRI contrast agent

RSC Advances ◽  
2015 ◽  
Vol 5 (22) ◽  
pp. 17223-17227 ◽  
Author(s):  
M. Ravichandran ◽  
Goldie Oza ◽  
S. Velumani ◽  
Jose Tapia Ramirez ◽  
Francisco Garcia-Sierra ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Cobalt Ferrite ◽  
Mri Contrast Agent ◽  
Mri Contrast ◽  
One Dimensional ◽  
One Step ◽  
T2 Mri

A novel, one-step synthesis of one-dimensional cobalt ferrite nanowhiskers (CfW) is reported.

scholarly journals Highly water-dispersible calcium lignosulfonate-capped MnO nanoparticles as a T1 MRI contrast agent with exceptional colloidal stability, low toxicity and remarkable relaxivity

RSC Advances ◽  
2019 ◽  
Vol 9 (69) ◽  
pp. 40498-40506
Author(s):  
Mahdi Arian ◽  
Ali Zamanian ◽  
Salman Taheri
Keyword(s):  
Colloidal Stability ◽  
Mri Contrast Agent ◽  
Oxide Nanoparticles ◽  
Potential Candidate ◽  
Resonance Imaging ◽  
Manganese Oxide Nanoparticles ◽  
Mri Contrast ◽  
Water Dispersible ◽  
Low Toxicity ◽  
Magnetic Resonance Imaging Mri

A simple and efficient method to synthesize highly water-dispersible calcium lignosulfonate-coated manganese oxide nanoparticles as a potential candidate for the current magnetic resonance imaging (MRI) T1 contrast agents was reported.

Room Temperature Synthesis and Characterization of Au Nanoparticles

2010 ◽  
Vol 159 ◽  
pp. 303-306
Author(s):  
Sharmin Haq ◽  
Tasnuva Ashrafee ◽  
Mahmuda Begum ◽  
Tasmia Sharmin ◽  
Nirban Bhowmick ◽  
...  
Keyword(s):  
Room Temperature ◽  
Cost Effective ◽  
Nano Particles ◽  
Emergent Properties ◽  
Temperature Synthesis ◽  
Room Temperature Synthesis ◽  
Potential Applications ◽  
One Step ◽  
Ft Ir ◽  
Photo Detection

The new emergent properties of nanoparticles include quantam size effect, nonlinear optical properties and thus the nanomaterials have extensive applications in microelectronic, bacteriostatic and catalytic or magnetic recording materials. Nanoparticles find potential applications in DNA detection and photo detection. Gold nano particles (AuNPs) are useful in nanoscale devices and systems due to its resistance to oxidation. In this paper a cost effective, versatile and simple one step room temperature synthesis of highly stable and freestanding Au quantum dots capped by TTAB (Tetradecyltrimethyl Amonium Bromide) in the range of 10-90 nm is reported. Ultraviolet- visible spectroscopy (UV-VIS), Fourier transformation infrared spectroscopy (FT-IR) was carried out to characterize these samples. Scanning Electron Microscopy (SEM) confirms the AuNPs sizes of about 80 and 88 nm.

Sign in / Sign up

Export Citation Format

Share Document