Fabrication of Small Multifunctional CuS Nanoclusters for Fluorescence Imaging and Chemo-Photothermal Therapy of Cancer

NANO ◽  
2020 ◽  
Vol 15 (09) ◽  
pp. 2050123
Author(s):  
Yanqiu Zhao ◽  
Yang Zou ◽  
Xunxun Deng ◽  
Hanwen Wang ◽  
Shuo Wu
Keyword(s):  
Hyaluronic Acid ◽  
Real Time ◽  
Tumor Cells ◽  
Fluorescence Imaging ◽  
Photothermal Therapy ◽  
Colloid Stability ◽  
Ph Responsive ◽  
Ha Coating ◽  
Promising Application ◽  
Real Time Tracking

A multifunctional nanodrug, PAMAM@CuS-HA-RB/DOX, was prepared for the real time tracking and chemo-photothermal therapy of tumor cells. The CuS nanoclusters with diameter less than 10[Formula: see text]nm could be easily ingested by tumor cells and showed good colloid stability and high photothermal conversion efficiency. The hyaluronic acid (HA) coating and rhodamine B (RB) labeling endowed the nanocomposite with low cytotoxity and real time fluorescence imaging ability. In the acidic tumor microenvironment, the doxorubicin linked via the pH-responsive hydrazone bonds was released and worked synergistically with CuS to kill the tumor cells, which showed a high chemo-photothermal therapy capacity. All these properties indicated the PAMAM@CuS-HA-RB/DOX have promising application for the therapy of cancers and tracking of nanodrugs.

scholarly journals Cyclometalated iridium(iii) complexes as lysosome-targeted photodynamic anticancer and real-time tracking agents

2015 ◽  
Vol 6 (10) ◽  
pp. 5409-5418 ◽  
Author(s):  
Liang He ◽  
Yi Li ◽  
Cai-Ping Tan ◽  
Rui-Rong Ye ◽  
Mu-He Chen ◽  
...  
Keyword(s):  
Singlet Oxygen ◽  
Real Time ◽  
Rational Design ◽  
Ph Responsive ◽  
Anticancer Mechanism ◽  
Real Time Tracking ◽  
Imaging Properties

We report the rational design and photodynamic anticancer mechanism studies of iridium(iii) complexes with pH-responsive singlet oxygen (1O2) production and lysosome-specific imaging properties.

scholarly journals Endosomal pH-Responsive Fe-Based Hyaluronate Nanoparticles for Doxorubicin Delivery

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3547
Author(s):  
Yangmun Bae ◽  
Yoonyoung Kim ◽  
Eun Seong Lee
Keyword(s):  
Hyaluronic Acid ◽  
Tumor Cells ◽  
Tumor Targeting ◽  
Drug Carriers ◽  
Acidic Environment ◽  
Ph Responsive ◽  
Ferrous Chloride ◽  
Endosomal Ph ◽  
Dimethylmaleic Anhydride ◽  
Positively Charged

In this study, we report pH-responsive metal-based biopolymer nanoparticles (NPs) for tumor-specific chemotherapy. Here, aminated hyaluronic acid (aHA) coupled with 2,3-dimethylmaleic anhydride (DMA, as a pH-responsive moiety) (aHA-DMA) was electrostatically complexed with ferrous chloride tetrahydrate (FeCl2/4H2O, as a chelating metal) and doxorubicin (DOX, as an antitumor drug model), producing DOX-loaded Fe-based hyaluronate nanoparticles (DOX@aHA-DMA/Fe NPs). Importantly, the DOX@aHA-DMA/Fe NPs improved tumor cellular uptake due to HA-mediated endocytosis for tumor cells overexpressing CD44 receptors. As a result, the average fluorescent DOX intensity observed in MDA-MB-231 cells (with CD44 receptors) was ~7.9 × 102 (DOX@HA/Fe NPs, without DMA), ~8.1 × 102 ([email protected]/Fe NPs), and ~9.3 × 102 ([email protected]/Fe NPs). Furthermore, the DOX@aHA-DMA/Fe NPs were destabilized due to ionic repulsion between Fe2+ and DMA-detached aHA (i.e., positively charged free aHA) in the acidic environment of tumor cells. This event accelerated the release of DOX from the destabilized NPs. Our results suggest that these NPs can be promising tumor-targeting drug carriers responding to acidic endosomal pH.

scholarly journals Oxygenated graphene quantum dots (GQDs) synthesized using laser ablation for long-term real-time tracking and imaging

RSC Advances ◽  
2017 ◽  
Vol 7 (85) ◽  
pp. 53822-53829 ◽  
Author(s):  
Ashwin Kumar Narasimhan ◽  
Swathi Lakshmi B ◽  
Tuhin Subhra Santra ◽  
M. S. Ramachandra Rao ◽  
Ganapathy Krishnamurthi
Keyword(s):  
Quantum Dots ◽  
Laser Ablation ◽  
Real Time ◽  
Fluorescence Imaging ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Graphene Quantum Dots ◽  
Real Time Tracking

Synthesis of graphene quantom dots for single live cell imaging andin vivofluorescence imaging.

Methacrylated gellan gum and hyaluronic acid hydrogel blends for image-guided neurointerventions

2020 ◽  
Vol 8 (27) ◽  
pp. 5928-5937 ◽  
Author(s):  
Sílvia Vieira ◽  
Paulina Strymecka ◽  
Luiza Stanaszek ◽  
Joana Silva-Correia ◽  
Katarzyna Drela ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Real Time ◽  
Gellan Gum ◽  
Cell Delivery ◽  
Image Guided ◽  
Real Time Tracking ◽  
Hyaluronic Acid Hydrogel

Mn-Based gellan gum hydrogels for cell delivery and real-time tracking on image-guided neuro-procedures.

Real-time, non-invasive monitoring of hydrogel degradation using LiYF4:Yb3+/Tm3+ NIR-to-NIR upconverting nanoparticles

Nanoscale ◽  
2015 ◽  
Vol 7 (26) ◽  
pp. 11255-11262 ◽  
Author(s):  
Ghulam Jalani ◽  
Rafik Naccache ◽  
Derek H. Rosenzweig ◽  
Sophie Lerouge ◽  
Lisbet Haglund ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Real Time ◽  
Intervertebral Discs ◽  
Photoluminescence Spectroscopy ◽  
Invasive Monitoring ◽  
Non Invasive ◽  
Nir Imaging ◽  
Real Time Tracking

LiYF4:Yb3+/Tm3+ upconverting nanoparticles are used for real-time tracking of degradation of chitosan-hyaluronic acid gels in live intervertebral discs using photoluminescence spectroscopy and NIR imaging.

Developing a pH-sensitive Al(OH)3 layer-mediated UCNP@Al(OH)3/Au nanohybrid for photothermal therapy and fluorescence imaging in vivo

2018 ◽  
Vol 6 (47) ◽  
pp. 7862-7870 ◽  
Author(s):  
Jian Chen ◽  
Dongya Zhang ◽  
Yan Zou ◽  
Zhongjie Wang ◽  
Mingcong Hao ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Photothermal Therapy ◽  
Ph Sensitive ◽  
Upconversion Nanoparticles ◽  
Ph Responsive

A pH-responsive and hydrophilic Al(OH)3 mediating layer makes possible the promising integration of photothermal therapy and fluorescence imaging based on upconversion nanoparticles (UCNPs).

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