Developing a pH-sensitive Al(OH)3 layer-mediated UCNP@Al(OH)3/Au nanohybrid for photothermal therapy and fluorescence imaging in vivo

2018 ◽  
Vol 6 (47) ◽  
pp. 7862-7870 ◽  
Author(s):  
Jian Chen ◽  
Dongya Zhang ◽  
Yan Zou ◽  
Zhongjie Wang ◽  
Mingcong Hao ◽  
...  

A pH-responsive and hydrophilic Al(OH)3 mediating layer makes possible the promising integration of photothermal therapy and fluorescence imaging based on upconversion nanoparticles (UCNPs).

2018 ◽  
Vol 6 (4) ◽  
pp. 877-884 ◽  
Author(s):  
Po Li ◽  
Yue Yan ◽  
Binlong Chen ◽  
Pan Zhang ◽  
Siling Wang ◽  
...  

In recent years, multifunctional nanoparticles have attracted much research interest in various biomedical applications such as biosensors, diagnosis, and drug delivery systems.


RSC Advances ◽  
2018 ◽  
Vol 8 (65) ◽  
pp. 37433-37440 ◽  
Author(s):  
Huicong Zhang ◽  
Xuandong Wang ◽  
Peiyuan Wang ◽  
Rong Liu ◽  
Xuemei Hou ◽  
...  

Polydopamine-doped mesoporous silica nanocomposites (PMSNs) were controllably synthesized by a one-pot approach. They were demonstrated to be good biodegradability, pH-responsive drug release and targeting synergistic chemo-photothermal therapy.


Nanoscale ◽  
2014 ◽  
Vol 6 (15) ◽  
pp. 9279-9292 ◽  
Author(s):  
Qianqian Yu ◽  
Yanan Liu ◽  
Chengwen Cao ◽  
Fangling Le ◽  
Xiuying Qin ◽  
...  

The pH-sensitive delivery system G2/PAH-Cit/SeNPs@siRNA enhances anti-tumor effects through VEGF gene silencing and reduces angiogenesis, with no side effects in organs.


ACS Nano ◽  
2011 ◽  
Vol 5 (2) ◽  
pp. 1086-1094 ◽  
Author(s):  
Boseung Jang ◽  
Jin-Young Park ◽  
Ching-Hsuan Tung ◽  
In-Hoo Kim ◽  
Yongdoo Choi

Nanoscale ◽  
2017 ◽  
Vol 9 (35) ◽  
pp. 12885-12896 ◽  
Author(s):  
Ruoyan Wei ◽  
Wensong Xi ◽  
Haifang Wang ◽  
Jinliang Liu ◽  
Torsten Mayr ◽  
...  

A multifunctional nanocomposite was synthesized by linking pH-responsive prodrug onto gold nanocrystals that were grown in situ on the surface of upconversion nanoparticles, which is bioimaging-guided multifunctional synergistic therapy agent.


2018 ◽  
Vol 6 (23) ◽  
pp. 3914-3921 ◽  
Author(s):  
Tianzheng Wang ◽  
Siqi Li ◽  
Zhen Zou ◽  
Luo Hai ◽  
Xue Yang ◽  
...  

A zeolitic imidazolate framework-8-based indocyanine green theranostic agent was constructed for fluorescence imaging and photothermal therapy of tumors in vivo.


Nanoscale ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 1067-1074 ◽  
Author(s):  
Krishan Kumar ◽  
Parikshit Moitra ◽  
Mohsin Bashir ◽  
Paturu Kondaiah ◽  
Santanu Bhattacharya

AuNPs capped with a natural pH-responsive short tripeptide sequence are presented herein for the successful delivery of doxorubicin both in vitro and in vivo. Efficacy of the system has also been evaluated in drug resistant cancer cell line.


2015 ◽  
Vol 3 (22) ◽  
pp. 4514-4523 ◽  
Author(s):  
Zeng-Ying Qiao ◽  
Di Zhang ◽  
Chun-Yuan Hou ◽  
Si-Meng Zhao ◽  
Ya Liu ◽  
...  

The co-encapsulation of RA-V cyclopeptide and SQ molecules in pH-sensitive PAE micelles for efficient tumor therapy and imaging in vitro and in vivo.


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