GOLD NANOPARTICLES-BASED BIOSENSORS FOR BIOMEDICAL APPLICATION

Gold nanoparticles are the most extensively studied nanomaterials for biomedical application due to their unique properties, such as rapid and simple synthesis, large surface area, strong adsorption ability and facile conjugation to various biomolecules. The remarkable photophysical properties of gold nanoparticles have provided plenty of opportunities for the preparation of gold nanoparticles-based optical biosensors, while the excellent biocompatibility, conductivity, catalytic properties and large surface-to-volume ratio have facilitated the application of gold nanoparticles in the construction of electrochemical biosensors. In this review, we mainly detail the gold nanoparticles-based optical and electrochemical biosensors for biomedical application in the recent two years, which have exhibited greatly enhanced analytical performances in the detection of DNA, proteins and some important small molecules.

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Applications of Gold Nanoparticles in Non-Optical Biosensors

Nanomaterials ◽

10.3390/nano8120977 ◽

2018 ◽

Vol 8 (12) ◽

pp. 977 ◽

Cited By ~ 14

Author(s):

Pengfei Jiang ◽

Yulin Wang ◽

Lan Zhao ◽

Chenyang Ji ◽

Dongchu Chen ◽

...

Keyword(s):

Gold Nanoparticles ◽

Inductively Coupled Plasma ◽

Electrochemical Biosensor ◽

High Surface ◽

Volume Ratio ◽

Optical Biosensors ◽

Inductively Coupled ◽

Icp Ms ◽

Plasma Mass Spectrometry ◽

Good Biocompatibility

Due to their unique properties, such as good biocompatibility, excellent conductivity, effective catalysis, high density, and high surface-to-volume ratio, gold nanoparticles (AuNPs) are widely used in the field of bioassay. Mainly, AuNPs used in optical biosensors have been described in some reviews. In this review, we highlight recent advances in AuNP-based non-optical bioassays, including piezoelectric biosensor, electrochemical biosensor, and inductively coupled plasma mass spectrometry (ICP-MS) bio-detection. Some representative examples are presented to illustrate the effect of AuNPs in non-optical bioassay and the mechanisms of AuNPs in improving detection performances are described. Finally, the review summarizes the future prospects of AuNPs in non-optical biosensors.

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Development of Nanomaterials Electrochemical Biosensor and its Applications

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.418-420.2082 ◽

2011 ◽

Vol 418-420 ◽

pp. 2082-2085 ◽

Cited By ~ 1

Author(s):

Qian Xiang ◽

Ying Gao ◽

Jing Qiu Liu ◽

Kun Qi Wang ◽

Juan Tang ◽

...

Keyword(s):

Material Science ◽

Electrochemical Biosensor ◽

High Surface ◽

Volume Ratio ◽

Small Dimension ◽

Biological Detection ◽

Adsorption Ability ◽

Strong Adsorption ◽

Biological Recognition ◽

New Generation

Study of the electrochmeical biosensor has become a new interdisciplinary frontier between biological detection and material science due to their excellent prospects for interfacing biological recognition events with electronic signal transduction. Nanomaterials provided a significant platform for designing a new generation of bioelectronic devices exhibiting novel functions due to their high surface-to-volume ratio, good stability, small dimension effect, good compatibility and strong adsorption ability. In this paper, we review the development of electrochemical biosensors fabricated with various nanoscale materials, also highlight the analytical applications in terms of biochemistry.

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Effect of pH and Salt on Adsorption of Double-Stranded DNA on Graphene Oxide

Journal of Nanoscience and Nanotechnology ◽

10.1166/jnn.2015.11217 ◽

2015 ◽

Vol 15 (10) ◽

pp. 7913-7917 ◽

Cited By ~ 5

Author(s):

Seyeon Kim ◽

Chanoong Park ◽

Jongback Gang

Keyword(s):

Graphene Oxide ◽

Small Molecules ◽

Salt Concentration ◽

Hydrophobic Interactions ◽

Volume Ratio ◽

Optical Biosensors ◽

Effect Of Ph ◽

Double Stranded Dna ◽

Rapid Release ◽

Triton X

Graphene oxide (GO) has a large surface-to-volume ratio and hydrophobic hexagonal rings that can interact with biomolecules. Single-stranded DNA adsorbs strongly to the surface of GO via hydrophobic interactions. GO has been used in optical biosensors and biomedical platforms for the detection of DNA, proteins, and small molecules. This study was designed to measure the adsorption of double-stranded DNA (dsDNA) onto GO according to DNA length, salt concentration, and pH of the reaction. Results showed that dsDNA molecules were adsorbed progressively as the pH changed from 6.0 to 4.0. At high pH, dsDNA adsorption was enhanced by the presence of MgCl2 rather than NaCl. Desorption of DNA from GO, with triton X-100 led to the rapid release of DNA from GO in the presence of MgCl2.

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Review on Gold Nanoparticles-Based Biosensors in Clinical and Non-Clinical Applications

International Journal of Engineering Materials and Manufacture ◽

10.26776/ijemm.07.01.2022.01 ◽

2022 ◽

Vol 7 (1) ◽

pp. 1-12

Author(s):

Nika Momeni ◽

Kayla Javadifar ◽

Maria A. Patrick ◽

Muhammad Hasibul Hasan ◽

Farhana Chowdhury

Keyword(s):

Gold Nanoparticles ◽

High Surface ◽

Volume Ratio ◽

Future Research ◽

Optical Biosensors ◽

Non Invasive ◽

Real World Application ◽

High Resolution Images ◽

Specific Comparison ◽

Research Recommendations

Gold nanoparticles (GNP) acquire unique properties that have made significant contributions to clinical and non-clinical fields, specifically in the application of GNP’s for designing biosensor devices in which exhibit novel functional properties. Many properties of GNP’s are reviewed in this literature including optical properties, biocompatibility, conductivity, catalytic properties, high surface-to-volume ratio, and high density of the GNPs, that make them excellent in the application of constructing GNP-based biosensors. This literature review covers a specific comparison between the optical, electrochemical, and piezoelectric biosensors, as these are the three most common GNP-based biosensors. Optical biosensors are optimal due to their ability to cater to surface modification, which then leads to the ability for selective bonding. Furthermore, with the use of GNP and the sensor's non-invasive and non-toxic method of use, high-resolution images and signals can be formed. The sensitivity and specificity of electrochemical biosensors with the conductivity of GNPs, the electrodes of this stable biosensor can detect tumour markers in the human body. Piezoelectric biosensors are mass sensitive sensors and with the use of GNP, it amplifies the changes in mass. Through this, these sensors progress to be immunosensors which determine microorganisms and macromolecular compounds. As well, this review will conclude with an outline of present and future research recommendations for real-world application of the three GNP-based biosensors discussed.

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