Development of Nanomaterials Electrochemical Biosensor and its Applications

2011 ◽  
Vol 418-420 ◽  
pp. 2082-2085 ◽  
Author(s):  
Qian Xiang ◽  
Ying Gao ◽  
Jing Qiu Liu ◽  
Kun Qi Wang ◽  
Juan Tang ◽  
...  
Keyword(s):  
Material Science ◽  
Electrochemical Biosensor ◽  
High Surface ◽  
Volume Ratio ◽  
Small Dimension ◽  
Biological Detection ◽  
Adsorption Ability ◽  
Strong Adsorption ◽  
Biological Recognition ◽  
New Generation

Study of the electrochmeical biosensor has become a new interdisciplinary frontier between biological detection and material science due to their excellent prospects for interfacing biological recognition events with electronic signal transduction. Nanomaterials provided a significant platform for designing a new generation of bioelectronic devices exhibiting novel functions due to their high surface-to-volume ratio, good stability, small dimension effect, good compatibility and strong adsorption ability. In this paper, we review the development of electrochemical biosensors fabricated with various nanoscale materials, also highlight the analytical applications in terms of biochemistry.

scholarly journals Nanomaterials as Analytical Tools for Genosensors

Sensors ◽  
2010 ◽  
Vol 10 (1) ◽  
pp. 963-993 ◽  
Author(s):  
Khalid Abu-Salah ◽  
Salman A. Alrokyan ◽  
Muhammad Naziruddin Khan ◽  
Anees Ahmad Ansari
Keyword(s):  
Material Science ◽  
Metal Oxide Nanoparticles ◽  
Disease Diagnosis ◽  
Noble Metal Nanoparticles ◽  
Biological Detection ◽  
Dna Biosensors ◽  
The Past ◽  
Biological Recognition ◽  
New Generation ◽  
Analytical Tools

Nanomaterials are being increasingly used for the development of electrochemical DNA biosensors, due to the unique electrocatalytic properties found in nanoscale materials. They offer excellent prospects for interfacing biological recognition events with electronic signal transduction and for designing a new generation of bioelectronic devices exhibiting novel functions. In particular, nanomaterials such as noble metal nanoparticles (Au, Pt), carbon nanotubes (CNTs), magnetic nanoparticles, quantum dots and metal oxide nanoparticles have been actively investigated for their applications in DNA biosensors, which have become a new interdisciplinary frontier between biological detection and material science. In this article, we address some of the main advances in this field over the past few years, discussing the issues and challenges with the aim of stimulating a broader interest in developing nanomaterial-based biosensors and improving their applications in disease diagnosis and food safety examination.

scholarly journals Applications of Gold Nanoparticles in Non-Optical Biosensors

Nanomaterials ◽  
2018 ◽  
Vol 8 (12) ◽  
pp. 977 ◽  
Author(s):  
Pengfei Jiang ◽  
Yulin Wang ◽  
Lan Zhao ◽  
Chenyang Ji ◽  
Dongchu Chen ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Inductively Coupled Plasma ◽  
Electrochemical Biosensor ◽  
High Surface ◽  
Volume Ratio ◽  
Optical Biosensors ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Good Biocompatibility

Due to their unique properties, such as good biocompatibility, excellent conductivity, effective catalysis, high density, and high surface-to-volume ratio, gold nanoparticles (AuNPs) are widely used in the field of bioassay. Mainly, AuNPs used in optical biosensors have been described in some reviews. In this review, we highlight recent advances in AuNP-based non-optical bioassays, including piezoelectric biosensor, electrochemical biosensor, and inductively coupled plasma mass spectrometry (ICP-MS) bio-detection. Some representative examples are presented to illustrate the effect of AuNPs in non-optical bioassay and the mechanisms of AuNPs in improving detection performances are described. Finally, the review summarizes the future prospects of AuNPs in non-optical biosensors.

A Novel Formaldehyde Gas Sensor Based on Ag-LaFeO3 Using Molecular Imprinting Technique

2016 ◽  
Vol 847 ◽  
pp. 287-293
Author(s):  
Yu Min Zhang ◽  
Chang Yi Hu ◽  
Jin Zhang ◽  
Qing Ju Liu ◽  
Qin Zhu ◽  
...  
Keyword(s):  
Gas Sensor ◽  
Molecular Imprinting ◽  
High Selectivity ◽  
High Surface ◽  
Volume Ratio ◽  
Substrate Material ◽  
Small Dimension ◽  
Molecular Imprinting Technique ◽  
First Time

A novel gas sensor for the determination of formaldehyde was developed based on molecular imprinting technique (MIT). MIT was for the first time used to recognize small organic molecule by our group. The molecular imprinting nanoparticles (MINs) with a small dimension which possess extremely high surface-to-volume ratio were synthesized using imprinting polymerization with formaldehyde as template and Ag-LaFeO3 as substrate material. The structure of the MINs is orthogonal perovskite. And then the MINs were printed onto an alumina tube. Subsequently, a high selectivity molecular imprinting gas sensor for detection of formaldehyde was achieved. At 86°C, the response to 0.5 ppm formaldehyde based on the sensor is 16, and the response is lower than 2 for the other test gases. The response time and recovery time are 55 s and 40 s, respectively.

GOLD NANOPARTICLES-BASED BIOSENSORS FOR BIOMEDICAL APPLICATION

Nano LIFE ◽  
2012 ◽  
Vol 02 (04) ◽  
pp. 1230008 ◽  
Author(s):  
JING ZHAO ◽  
BING BO ◽  
YONG-MEI YIN ◽  
GEN-XI LI
Keyword(s):  
Gold Nanoparticles ◽  
Small Molecules ◽  
Catalytic Properties ◽  
Biomedical Application ◽  
Photophysical Properties ◽  
Volume Ratio ◽  
Optical Biosensors ◽  
Electrochemical Biosensors ◽  
Adsorption Ability ◽  
Strong Adsorption

Gold nanoparticles are the most extensively studied nanomaterials for biomedical application due to their unique properties, such as rapid and simple synthesis, large surface area, strong adsorption ability and facile conjugation to various biomolecules. The remarkable photophysical properties of gold nanoparticles have provided plenty of opportunities for the preparation of gold nanoparticles-based optical biosensors, while the excellent biocompatibility, conductivity, catalytic properties and large surface-to-volume ratio have facilitated the application of gold nanoparticles in the construction of electrochemical biosensors. In this review, we mainly detail the gold nanoparticles-based optical and electrochemical biosensors for biomedical application in the recent two years, which have exhibited greatly enhanced analytical performances in the detection of DNA, proteins and some important small molecules.

scholarly journals Preliminary experimental research of metal-organic frameworks (MOFs) for formaldehyde dynamic adsorption

2021 ◽  
Vol 2069 (1) ◽  
pp. 012246
Author(s):  
Shan Chen ◽  
Kan Zu ◽  
Lei Fang ◽  
Menghao Qin
Keyword(s):  
Indoor Air ◽  
High Surface ◽  
Metal Organic Frameworks ◽  
Volume Ratio ◽  
Breakthrough Curves ◽  
Dynamic Adsorption ◽  
Strong Adsorption ◽  
Formaldehyde Removal ◽  
Metal Organic ◽  
Series Of Experiments

Abstract Formaldehyde is a common emission from furniture and indoor decorations. Although the concentration of formaldehyde gas is not too high in the indoor environment, it is highly toxic and carcinogenic. The formaldehyde removal potential of a novel type of green and safe nano-porous materials, Metal-Organic Frameworks (MOFs), with a high surface-to-volume ratio, strong adsorption capacity, and low regeneration temperature was investigated. To date, researchers are mainly focusing on formaldehyde selectivity and detection using MOFs in low moisture circumstances. This study carried out a series of experiments to compare breakthrough curves of formaldehyde dynamic adsorption on MIL-100(Fe), MIL-160(Al), and aluminum fumarate with activated carbon. In experiments, the formaldehyde was evaporated from diluted formalin solution, dried to 30±5 % RH, and driven through different adsorbents by nitrogen. The results indicated that MOFs showed great potential for indoor air formaldehyde removal.

scholarly journals Electrospun Nanofibers for Sensing and Biosensing Applications—A Review

2021 ◽  
Vol 22 (12) ◽  
pp. 6357
Author(s):  
Kinga Halicka ◽  
Joanna Cabaj
Keyword(s):  
High Surface ◽  
High Surface Area ◽  
Toxic Metal ◽  
Volume Ratio ◽  
Electrospun Nanofibers ◽  
Clinical Diagnostics ◽  
Loading Capacity ◽  
Electrospun Nanofiber ◽  
Sensing Platforms ◽  
Different Types

Sensors and biosensors have found applications in many areas, e.g., in medicine and clinical diagnostics, or in environmental monitoring. To expand this field, nanotechnology has been employed in the construction of sensing platforms. Because of their properties, such as high surface area to volume ratio, nanofibers (NFs) have been studied and used to develop sensors with higher loading capacity, better sensitivity, and faster response time. They also allow to miniaturize designed platforms. One of the most commonly used techniques of the fabrication of NFs is electrospinning. Electrospun NFs can be used in different types of sensors and biosensors. This review presents recent studies concerning electrospun nanofiber-based electrochemical and optical sensing platforms for the detection of various medically and environmentally relevant compounds, including glucose, drugs, microorganisms, and toxic metal ions.

scholarly journals Study of the geometry of open channels in a layer-bed-type microfluidic immobilized enzyme reactor

2021 ◽  
Author(s):  
Cynthia Nagy ◽  
Robert Huszank ◽  
Attila Gaspar
Keyword(s):  
Immobilized Enzyme ◽  
High Surface ◽  
Volume Ratio ◽  
Volumetric Flow Rate ◽  
Enzyme Reactor ◽  
Channel Pattern ◽  
Immobilized Enzyme Reactor ◽  
Split Flow ◽  
Parallel Streams ◽  
Enzymatic Microreactors

AbstractThis paper aims at studying open channel geometries in a layer-bed-type immobilized enzyme reactor with computer-aided simulations. The main properties of these reactors are their simple channel pattern, simple immobilization procedure, regenerability, and disposability; all these features make these devices one of the simplest yet efficient enzymatic microreactors. The high surface-to-volume ratio of the reactor was achieved using narrow (25–75 μm wide) channels. The simulation demonstrated that curves support the mixing of solutions in the channel even in strong laminar flow conditions; thus, it is worth including several curves in the channel system. In the three different designs of microreactor proposed, the lengths of the channels were identical, but in two reactors, the liquid flow was split to 8 or 32 parallel streams at the inlet of the reactor. Despite their overall higher volumetric flow rate, the split-flow structures are advantageous due to the increased contact time. Saliva samples were used to test the efficiencies of the digestions in the microreactors. Graphical abstract

scholarly journals A Review on Biosensors and Recent Development of Nanostructured Materials-Enabled Biosensors

Sensors ◽  
2021 ◽  
Vol 21 (4) ◽  
pp. 1109
Author(s):  
Varnakavi. Naresh ◽  
Nohyun Lee
Keyword(s):  
High Surface ◽  
Three Dimensional ◽  
Biological Response ◽  
Volume Ratio ◽  
Recent Decade ◽  
Disease Diagnosis ◽  
Electrical Signal ◽  
Detection Sensitivity ◽  
Wide Range ◽  
Color Tunability

A biosensor is an integrated receptor-transducer device, which can convert a biological response into an electrical signal. The design and development of biosensors have taken a center stage for researchers or scientists in the recent decade owing to the wide range of biosensor applications, such as health care and disease diagnosis, environmental monitoring, water and food quality monitoring, and drug delivery. The main challenges involved in the biosensor progress are (i) the efficient capturing of biorecognition signals and the transformation of these signals into electrochemical, electrical, optical, gravimetric, or acoustic signals (transduction process), (ii) enhancing transducer performance i.e., increasing sensitivity, shorter response time, reproducibility, and low detection limits even to detect individual molecules, and (iii) miniaturization of the biosensing devices using micro-and nano-fabrication technologies. Those challenges can be met through the integration of sensing technology with nanomaterials, which range from zero- to three-dimensional, possessing a high surface-to-volume ratio, good conductivities, shock-bearing abilities, and color tunability. Nanomaterials (NMs) employed in the fabrication and nanobiosensors include nanoparticles (NPs) (high stability and high carrier capacity), nanowires (NWs) and nanorods (NRs) (capable of high detection sensitivity), carbon nanotubes (CNTs) (large surface area, high electrical and thermal conductivity), and quantum dots (QDs) (color tunability). Furthermore, these nanomaterials can themselves act as transduction elements. This review summarizes the evolution of biosensors, the types of biosensors based on their receptors, transducers, and modern approaches employed in biosensors using nanomaterials such as NPs (e.g., noble metal NPs and metal oxide NPs), NWs, NRs, CNTs, QDs, and dendrimers and their recent advancement in biosensing technology with the expansion of nanotechnology.

scholarly journals Water uptake of various electrospun nonwovens

2020 ◽  
Vol 6 (3) ◽  
pp. 155-158
Author(s):  
Katharina Wulf ◽  
Volkmar Senz ◽  
Thomas Eickner ◽  
Sabine Illner
Keyword(s):  
Contact Angle ◽  
Surface Modification ◽  
Water Absorption ◽  
Water Uptake ◽  
Biomedical Applications ◽  
High Surface ◽  
Volume Ratio ◽  
Polymer Composition ◽  
Water Wetting ◽  
Morphology Changes

AbstractIn recent years, nanofiber based materials have emerged as especially interesting for several biomedical applications, regarding their high surface to volume ratio. Due to the superficial nano- and microstructuring and the different wettability compared to nonstructured surfaces, the water absorption is an important parameter with respect to the degradation stability, thermomechanic properties and drug release properties, depending on the type of polymer [1]. In this investigation, the water absorption of different non- and plasma modified biostable nanofiber nonwovens based on polyurethane, polyester and polyamide were analysed and compared. Also, the water absorption by specified water wetting, the contact angle and morphology changes were examined. The results show that the water uptake is highly dependent on the surface modification and the polymer composition itself and can therefore be partially changed.

scholarly journals Solar-blind ultraviolet photodetector based on vertically aligned single-crystalline β-Ga2O3 nanowire arrays

Nanophotonics ◽  
2020 ◽  
Vol 9 (15) ◽  
pp. 4497-4503
Author(s):  
Liying Zhang ◽  
Xiangqian Xiu ◽  
Yuewen Li ◽  
Yuxia Zhu ◽  
Xuemei Hua ◽  
...  
Keyword(s):  
Inductively Coupled Plasma ◽  
Light Trapping ◽  
High Surface ◽  
Volume Ratio ◽  
Average Diameter ◽  
Nanowire Arrays ◽  
Etching Technique ◽  
Inductively Coupled ◽  
Solar Blind ◽  
Vertically Aligned

AbstractVertically aligned nanowire arrays, with high surface-to-volume ratio and efficient light-trapping absorption, have attracted much attention for photoelectric devices. In this paper, vertical β-Ga2O3 nanowire arrays with an average diameter/height of 110/450 nm have been fabricated by the inductively coupled plasma etching technique. Then a metal-semiconductor-metal structured solar-blind photodetector (PD) has been fabricated by depositing interdigital Ti/Au electrodes on the nanowire arrays. The fabricated β-Ga2O3 nanowire PD exhibits ∼10 times higher photocurrent and responsivity than the corresponding film PD. Moreover, it also possesses a high photocurrent to dark current ratio (Ilight/Idark) of ∼104 and a ultraviolet/visible rejection ratio (R260 nm/R400 nm) of 3.5 × 103 along with millisecond-level photoresponse times.

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