scholarly journals Bimolecular Chemistry in the Ultracold Regime

2021 ◽  
Vol 73 (1) ◽  
Author(s):  
Yu Liu ◽  
Kang-Kuen Ni
Keyword(s):  
Physical Chemistry ◽  
Annual Review ◽  
Publication Date ◽  
State Control ◽  
Ion Imaging ◽  
Nuclear Spins ◽  
Ultracold Molecules ◽  
Long Range Interactions ◽  
Recent Developments ◽  
Simple Molecules

Advances in atomic, molecular, and optical physics techniques allowed the cooling of simple molecules down to the ultracold regime ([Formula: see text]1 mK) and opened opportunities to study chemical reactions with unprecedented levels of control. This review covers recent developments in studying bimolecular chemistry at ultralow temperatures. We begin with a brief overview of methods for producing, manipulating, and detecting ultracold molecules. We then survey experimental works that exploit the controllability of ultracold molecules to probe and modify their long-range interactions. Further combining the use of physical chemistry techniques such as mass spectrometry and ion imaging significantly improved the detection of ultracold reactions and enabled explorations of their dynamics in the short range. We discuss a series of studies on the reaction KRb + KRb → K2 + Rb2 initiated below 1 [Formula: see text]K, including the direct observation of a long-lived complex, the demonstration of product rotational state control via conserved nuclear spins, and a test of the statistical model using the complete quantum state distribution of the products. Expected final online publication date for the Annual Review of Physical Chemistry, Volume 73 is April 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Drug Target Identification in Tissues by Thermal Proteome Profiling

2021 ◽  
Vol 62 (1) ◽  
Author(s):  
André Mateus ◽  
Nils Kurzawa ◽  
Jessica Perrin ◽  
Giovanna Bergamini ◽  
Mikhail M. Savitski
Keyword(s):  
Drug Target ◽  
Target Identification ◽  
Annual Review ◽  
Publication Date ◽  
Proteome Profiling ◽  
Biological Phenomena ◽  
Target Deconvolution ◽  
Drug Target Identification ◽  
Recent Developments ◽  
Fundamental Biology

Drug target deconvolution can accelerate the drug discovery process by identifying a drug's targets (facilitating medicinal chemistry efforts) and off-targets (anticipating toxicity effects or adverse drug reactions). Multiple mass spectrometry–based approaches have been developed for this purpose, but thermal proteome profiling (TPP) remains to date the only one that does not require compound modification and can be used to identify intracellular targets in living cells. TPP is based on the principle that the thermal stability of a protein can be affected by its interactions. Recent developments of this approach have expanded its applications beyond drugs and cell cultures to studying protein-drug interactions and biological phenomena in tissues. These developments open up the possibility of studying drug treatment or mechanisms of disease in a holistic fashion, which can result in the design of better drugs and lead to a better understanding of fundamental biology. Expected final online publication date for the Annual Review of Pharmacology and Toxicology, Volume 62 is January 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

In Vivo Dynamics of the Latent Reservoir for HIV-1: New Insights and Implications for Cure

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Janet D. Siliciano ◽  
Robert F. Siliciano
Keyword(s):  
Limit Of Detection ◽  
Latent Reservoir ◽  
Annual Review ◽  
Publication Date ◽  
Viral Rebound ◽  
Major Barrier ◽  
Persons Living With Hiv ◽  
Recent Developments ◽  
Hiv 1

Although antiretroviral therapy (ART) can reduce viremia to below the limit of detection and allow persons living with HIV-1 (PLWH) to lead relatively normal lives, viremia rebounds when treatment is interrupted. Rebound reflects viral persistence in a stable latent reservoir in resting CD4+ T cells. This reservoir is now recognized as the major barrier to cure and is the focus of intense international research efforts. Strategies to cure HIV-1 infection include interventions to eliminate this reservoir, to prevent viral rebound from the reservoir, or to enhance immune responses such that viral replication is effectively controlled. Here we consider recent developments in understanding the composition of the reservoir and how it can be measured in clinical studies. We also discuss exciting new insights into the in vivo dynamics of the reservoir and the reasons for its remarkable stability. Finally we discuss recent discoveries on the complex processes that govern viral rebound. Expected final online publication date for the Annual Review of Pathology: Mechanisms of Disease, Volume 17 is January 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

scholarly journals Translating Basic Research to Animal Agriculture

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
George E. Seidel
Keyword(s):  
Embryo Transfer ◽  
Artificial Insemination ◽  
Companion Animals ◽  
Basic Research ◽  
Annual Review ◽  
Publication Date ◽  
Animal Agriculture ◽  
Vitro Fertilization ◽  
Recent Developments

Procedures to maintain viability of mammalian gametes and embryos in vitro, including cryopreservation, have been exceedingly valuable for my research over the past 55 years. Keeping sperm viable in vitro enables artificial insemination, which, when combined with selective breeding, often is the most effective approach to making rapid genetic change in a population. Superovulation and embryo transfer constitute a parallel approach for amplifying reproduction of female mammals. More recent developments include sexing of semen, in vitro fertilization, cloning by nuclear transfer, and genetic modification of germline cells, tools that are enabled by artificial insemination and/or embryo transfer for implementation. I have been fortunate in being able to contribute to the development of many of the above techniques, and to use them for research and applications for improving animal agriculture. Others have built on this work to circumvent human infertility, assist reproduction of companion animals, and rescue endangered species. It also has been a privilege to teach, mentor, and be mentored in this area. Resulting worldwide friendships have enriched me personally and professionally. Expected final online publication date for the Annual Review of Animal Biosciences, Volume 10 is February 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Quantum-State Control and Manipulation of Paramagnetic Molecules with Magnetic Fields

2021 ◽  
Vol 72 (1) ◽  
Author(s):  
Brianna R. Heazlewood
Keyword(s):  
Magnetic Fields ◽  
Chemical Reactivity ◽  
Paramagnetic Species ◽  
Annual Review ◽  
Publication Date ◽  
State Control ◽  
Magnetic Traps ◽  
Paramagnetic Molecules ◽  
Experimental Approaches ◽  
And Control

Since external magnetic fields were first employed to deflect paramagnetic atoms in 1921, a range of magnetic field–based methods have been introduced to state-selectively manipulate paramagnetic species. These methods include magnetic guides, which selectively filter paramagnetic species from all other components of a beam, and magnetic traps, where paramagnetic species can be spatially confined for extended periods of time. However, many of these techniques were developed for atomic—rather than molecular—paramagnetic species. It has proven challenging to apply some of these experimental methods developed for atoms to paramagnetic molecules. Thanks to the emergence of new experimental approaches and new combinations of existing techniques, the past decade has seen significant progress toward the manipulation and control of paramagnetic molecules. This review identifies the key methods that have been implemented for the state-selective manipulation of paramagnetic molecules—discussing the motivation, state of the art, and future prospects of the field. Key applications include the ability to control chemical interactions, undertake precise spectroscopic measurements, and challenge our understanding of chemical reactivity at a fundamental level. Expected final online publication date for the Annual Review of Physical Chemistry, Volume 72 is April 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

The Science and Practice of Item Response Theory in Organizations

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Jonas W.B. Lang ◽  
Louis Tay
Keyword(s):  
Item Response Theory ◽  
Organizational Behavior ◽  
Item Response ◽  
Ideal Point ◽  
Annual Review ◽  
Publication Date ◽  
Response Theory ◽  
Test Items ◽  
Starting Point ◽  
Recent Developments

Item response theory (IRT) is a modeling approach that links responses to test items with underlying latent constructs through formalized statistical models. This article focuses on how IRT can be used to advance science and practice in organizations. We describe established applications of IRT as a scale development tool and new applications of IRT as a research and theory testing tool that enables organizational researchers to improve their understanding of workers and organizations. We focus on IRT models and their application in four key research and practice areas: testing, questionnaire responding, construct validation, and measurement equivalence of scores. In so doing, we highlight how novel developments in IRT such as explanatory IRT, multidimensional IRT, random item models, and more complex models of response processes such as ideal point models and tree models can potentially advance existing science and practice in these areas. As a starting point for readers interested in learning IRT and applying recent developments in IRT in their research, we provide concrete examples with data and R code. Expected final online publication date for the Annual Review of Organizational Psychology and Organizational Behavior, Volume 8 is January 21, 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

In Situ X-Ray Techniques for Electrochemical Interfaces

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Bruna F. Baggio ◽  
Yvonne Grunder
Keyword(s):  
Annual Review ◽  
Publication Date ◽  
Time Resolved ◽  
X Ray ◽  
X Ray Scattering ◽  
Recent Developments ◽  
In Operando ◽  
Electrochemical Interfaces ◽  
Ray Scattering

This article reviews progress in the study of materials using X-ray-based techniques from an electrochemistry perspective. We focus on in situ/in operando surface X-ray scattering, X-ray absorption spectroscopy, and the combination of both methods. The background of these techniques together with key concepts is introduced. Key examples of in situ and in operando investigation of liquid–solid and liquid–liquid interfaces are presented. X-ray scattering and spectroscopy have helped to develop an understanding of the underlying atomic and molecular processes associated with electrocatalysis, electrodeposition, and battery materials. We highlight recent developments, including resonant surface diffraction and time-resolved studies. Expected final online publication date for the Annual Review of Analytical Chemistry, Volume 14 is June 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Evolution of the Mode of Nutrition in Symbiotic and Saprotrophic Fungi in Forest Ecosystems

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Annie Lebreton ◽  
Qingchao Zeng ◽  
Shingo Miyauchi ◽  
Annegret Kohler ◽  
Yu-Cheng Dai ◽  
...  
Keyword(s):  
Mycorrhizal Fungi ◽  
Large Scale ◽  
Soil Fungi ◽  
Forest Ecosystems ◽  
Annual Review ◽  
Publication Date ◽  
Saprotrophic Fungi ◽  
Recent Developments ◽  
Future Potential

In this review, we highlight the main insights that have been gathered from recent developments using large-scale genomics of fungal saprotrophs and symbiotrophs (including ectomycorrhizal and orchid and ericoid mycorrhizal fungi) inhabiting forest ecosystems. After assessing the goals and motivations underlying our approach, we explore our current understanding of the limits and future potential of using genomics to understand the ecological roles of these forest fungi. Comparative genomics unraveled the molecular machineries involved in lignocellulose decomposition in wood decayers, soil and litter saprotrophs, and mycorrhizal symbionts. They also showed that transitions from saprotrophy to mutualism entailed widespread losses of lignocellulose-degrading enzymes; diversification of novel, lineage-specific symbiosis-induced genes; and convergent evolution of genetic innovations that facilitate the accommodation of mutualistic symbionts within their plant hosts. We also identify the major questions that remain unanswered and propose new avenues of genome-based research to understand the role of soil fungi in sustainable forest ecosystems. Expected final online publication date for the Annual Review of Ecology, Evolution, and Systematics, Volume 52 is November 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Olivine-Hosted Melt Inclusions: A Microscopic Perspective on a Complex Magmatic World

2021 ◽  
Vol 49 (1) ◽  
Author(s):  
Paul J. Wallace ◽  
Terry Plank ◽  
Robert J. Bodnar ◽  
Glenn A. Gaetani ◽  
Thomas Shea
Keyword(s):  
Melt Inclusions ◽  
Melt Inclusion ◽  
Volcanic Eruptions ◽  
Annual Review ◽  
Publication Date ◽  
Basaltic Melt ◽  
Recent Developments ◽  
Magma Crystallization ◽  
Detailed Record ◽  
Kinetics Of

Inclusions of basaltic melt trapped inside of olivine phenocrysts during igneous crystallization provide a rich, crystal-scale record of magmatic processes ranging from mantle melting to ascent, eruption, and quenching of magma during volcanic eruptions. Melt inclusions are particularly valuable for retaining information on volatiles such as H2O and CO2 that are normally lost by vesiculation and degassing as magma ascends and erupts. However, the record preserved in melt inclusions can be variably obscured by postentrapment processes, and thus melt inclusion research requires careful evaluation of the effects of such processes. Here we review processes by which melt inclusions are trapped and modified after trapping, describe new opportunities for studying the rates of magmatic and volcanic processes over a range of timescales using the kinetics of post-trapping processes, and describe recent developments in the use of volatile contents of melt inclusions to improve our understanding of how volcanoes work. ▪ Inclusions of silicate melt (magma) trapped inside of crystals formed by magma crystallization provide a rich, detailed record of what happens beneath volcanoes. ▪ These inclusions record information ranging from how magma forms deep inside Earth to its final hours as it ascends to the surface and erupts. ▪ The melt inclusion record, however, is complex and hazy because of many processes that modify the inclusions after they become trapped in crystals. ▪ Melt inclusions provide a primary archive of dissolved gases in magma, which are the key ingredients that make volcanoes erupt explosively. Expected final online publication date for the Annual Review of Earth and Planetary Sciences, Volume 49 is May 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Recent Developments in Solvent-Based Fluid Separations

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Boelo Schuur ◽  
Thomas Brouwer ◽  
Lisette M.J. Sprakel
Keyword(s):  
Carbon Capture ◽  
Fluid Phase ◽  
Deep Eutectic Solvents ◽  
Annual Review ◽  
Publication Date ◽  
Stimuli Responsive ◽  
Redox Responsive ◽  
Recent Developments ◽  
Application Fields ◽  
Molecular Solvents

The most important developments in solvent-based fluid separations, separations involving at least one fluid phase, are reviewed. After a brief introduction and discussion on general solvent trends observed in all fields of application, several specific fields are discussed. Important solvent trends include replacement of traditional molecular solvents by ionic liquids and deep eutectic solvents and, more recently, increasing discussion around bio-based solvents in some application fields. Furthermore, stimuli-responsive systems are discussed; the most significant developments in this field are seen for CO2-switchable and redox-responsive solvents. Discussed fields of application include hydrocarbons separations, carbon capture, biorefineries, and metals separations. For all but the hydrocarbons separations, newly reported electrochemically mediated separations seem to offer exciting new windows of opportunities. Expected final online publication date for the Annual Review of Chemical and Biomolecular Engineering, Volume 12 is June 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Modeling the Morphodynamics of Coastal Responses to Extreme Events: What Shape Are We In?

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Christopher R. Sherwood ◽  
Ap van Dongeren ◽  
James Doyle ◽  
Christie A. Hegermiller ◽  
Tian-Jian Hsu ◽  
...  
Keyword(s):  
Initial Conditions ◽  
Numerical Models ◽  
Annual Review ◽  
Publication Date ◽  
Impact Scale ◽  
Recent Developments ◽  
Source Models ◽  
Storm Impact ◽  
Wave Models ◽  
The Impact

This review focuses on recent advances in process-based numerical models of the impact of extreme storms on sandy coasts. Driven by larger-scale models of meteorology and hydrodynamics, these models simulate morphodynamics across the Sallenger storm-impact scale, including swash, collision, overwash, and inundation. Models are becoming both wider (as more processes are added) and deeper (as detailed physics replaces earlier parameterizations). Algorithms for wave-induced flows and sediment transport under shoaling waves are among the recent developments. Community and open-source models have become the norm. Observations of initial conditions (topography, land cover, and sediment characteristics) have become more detailed, and improvements in tropical cyclone and wave models provide forcing (winds, waves, surge, and upland flow) that is better resolved and more accurate, yielding commensurate improvements in model skill. We foresee that future storm-impact models will increasingly resolve individual waves, apply data assimilation, and be used in ensemble modeling modes to predict uncertainties. Expected final online publication date for the Annual Review of Marine Science, Volume 14 is January 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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