‘Focusing and Unfocusing’—Cognitive, Evaluative, and Emotional Dynamics in the Relationship with Human Embryos among ART Beneficiaries

This article uses data gathered from a study conducted in Portugal to examine the (plural and composite) conceptions that doctors, embryologists, and beneficiaries of Assisted Reproductive Technology (ART) have of the in vitro human embryo. Taking the sociology of engagements, developed by Thévenot, as its theoretical lens, the article draws on a total of 69 interviews with ART patients to analyse the plurality of fluid meanings produced about this biological entity, whose status is neither static nor universal. ART beneficiaries are likely to produce plural conceptions of the lab-generated embryo within the framework of different regimes of engagement, understood as cognitive and evaluative formats. These various pragmatic regimes, in turn, entail distinct emotional investments. When speaking about their relationship with embryos, beneficiaries therefore express plural emotional experiences, which are articulated using terms such as affection, love, detachment, loss, frustration, hope, mourning, and anguish. Using the theoretical framework of the sociology of engagements, we propose an approach that enables us to produce a detailed record of the connections between the cognitive, evaluative, and emotional dimensions in beneficiaries’ relationship with—and decision-making processes about—the embryos, accounting for the plasticity of emotional states linked to the (re)configuration of attributed meanings.

Temporal Analysis of SARS-CoV-2 Variants during the COVID-19 Pandemic in Nepal

Nepal has suffered two waves of SARS-CoV-2 infections, one in the year 2020 and another in the year 2021. Although the government of Nepal keeps a detailed record of daily coronavirus infections and deaths throughout the country, and publishes the result every day, genomic surveillance of mutants in the country has lagged behind. Sequencing of COVID-19 samples has been conducted sporadically during the pandemic. From the GISAID database, 127 high-quality sequences deposited by different health authorities in Nepal were collected and analyzed. From the analysis, it can be concluded that at least two variants of concern, alpha and delta, and one variant of interest, kappa, were detected in Nepal in 2021. As in other countries, the delta variant outcompeted the kappa and alpha variants and by July 2021 had established itself as the dominant variant. It can be hypothesized that the second wave in Nepal was primarily caused by the delta variant. Further, phylogenetic tree analysis suggests cases of local transmission and global transmission of coronavirus. This analysis reveals the global nature of the disease, where variants arising in one part of the world can quickly spread to other parts of the world and can also spread through individual communities. This paper highlights a need to structure public policy of Nepal to target the delta variant since it has become the predominant variant in Nepal. A further policy suggestion is to appropriately sample and sequence genomes of SARS-CoV-2 at regular intervals to understand the dynamics of variants in the population.

The Map and the Territory

“I didn’t even know that was a question I could ask.” That remark from a student in an introductory philosophy course points to the primary body of knowledge philosophy produces: a detailed record of what we do not know. When we come to view a philosophical question as well-formed and worthwhile, it is a way of providing as specific a description as we can of something we do not know. The creation or discovery of such questions is like noting a landmark in a territory we’re exploring. When we identify reasonable, if conflicting, answers to this question, we are noting routes to and away from that landmark. And since proposed answers to philosophical questions often contain implied answers to other philosophical questions, those routes connect different landmarks. The result is a kind of map: a map of the unknown. Yet when it comes to the unknown, and all the more so to its cartography, might it not make sense to take our orientation from Borges: What’s in question here, with respect to philosophical questions, is an incipient, unlocalizable threshold—a terrain neither subjective, nor entirely objective, one neither of representation, nor finally of simple immediacy—there where the map perceptibly fails to diverge from the territory. Amid Inclemencies of weather and fringed, as per Borges, with ruin and singular figures—with Animals and Beggars—what’s enclosed is an attempt to chart the contours of this curious immanence.

Integrated stratigraphy from a transgressive upper Oligocene section in NW Italy

ABSTRACT: The Oligo-Miocene Transition (OMT) is one of the most important climatic transitions of the last 30 million years. This short period of climate warming coincides with a few biotic turnovers, which are well known in deeper marine settings where stratigraphic successions yield a detailed record; in shallowmarine environments they have been proved difficult to recognize as the occurrence and absence of certain taxa due to ecological preferences hamper the study. This study focuses on the Case Cné section in the late Oligocene of the Tertiary Piedmont Basin (TPB) as it represents a gradual transgressive event, which shows the drowning of a locally developed reef complex and development of a deeper marine sedimentary setting influenced by gravity flow mechanics. Larger foraminifera biostratigraphy was used to date the section to the late Oligocene (SBZ23); preliminary strontium isotope data confirms this result. Using sedimentological, semi-quantitative microfacies and geochemical analysis the sedimentary history of the section was reconstructed and divided into four major phases: the drowning of the reef complex, a short prograding phase of the fluvial system, the onset of gravity flow mechanics and a final transgressive phase with an initial turbiditic influence which continues regionally into the Miocene.

Rock-Paper-Scissors-Hammer: A Tie-Less Decentralized Protocol for IoT Resource Allocation

With the rapid development of the autonomous world, local decision making between devices is becoming important. This article provides a new paradigm (Rock-Paper-Scissors-Hammer: RPSH) that can reduce the number of conflicts or decision draws and thus increase the throughput of autonomous devices while reducing the kept number of records or transactions. The paradigm requires a sealed envelope protocol and sequential message passing between both parties to decide unanimously a winner between the two participants without a third-party mediation. The message passing proposes a detailed record in a blockchain-like format that is not corruptible and is verifiable for conflict resolution. A simulated IoT environment is created to show the advantage of the proposed protocol and it shows significant reduction in mean efforts due to the elimination of draws or undecided situations. Autonomous devices, such as cars, need to maintain meticulous, lightweight, but blockchain-like record keeping for insurance settlements or conflict resolutions; that archival data size is significantly reduced by the RPSH protocol.

Prehistoric earthquakes on the Banning strand of the San Andreas fault, North Palm Springs, California

We studied a paleoseismic trench excavated in 2017 across the Banning strand of the San Andreas fault and herein provide the first detailed record of ground-breaking earthquakes on this important fault in Southern California. The trench exposed an ~40-m-wide fault zone cutting through alluvial sand, gravel, silt, and clay deposits. We evaluated the paleoseismic record using a new metric that combines event indicator quality and stratigraphic uncertainty. The most recent paleoearthquake occurred between 950 and 730 calibrated years B.P. (cal yr B.P.), potentially contemporaneous with the last rupture of the San Gorgonio Pass fault zone. We interpret five surface-rupturing earthquakes since 3.3–2.5 ka and eight earthquakes since 7.1–5.7 ka. It is possible that additional events have occurred but were not recognized, especially in the deeper (older) section of the stratigraphy, which was not fully exposed across the fault zone. We calculated an average recurrence interval of 380–640 yr based on four complete earthquake cycles between earthquakes 1 and 5. The average recurrence interval is thus slightly less than the elapsed time since the most recent event on the Banning strand. The average recurrence interval on the Banning strand is thus intermediate between longer intervals published for the San Gorgonio Pass fault zone (~1600 yr) and shorter intervals on both the Mission Creek strand of the San Andreas fault (~215 yr) and the Coachella section (~125 yr) of the San Andreas fault.

Evolving pattern of fetal movements throughout a healthy pregnancy

A 31-year-old woman with a history of stillbirth due to placental abruption at 29 weeks’ gestation and one first trimester miscarriage documented a continuous record of her perceived fetal movements from 28 to 38 weeks’ gestation. Repeated ultrasound examinations confirmed a viable pregnancy, with normal growth, liquor volume and Doppler profile. She delivered a healthy male infant at 38 weeks and 3 days’ gestation. The data collected give a detailed record of fetal activity in a healthy pregnancy. Perceived fetal activity increased as pregnancy progressed and was greatest in the evenings. We also found that clusters of movements, which have previously been reported as protective against stillbirth, were felt earlier on in pregnancy.

A Common, Categorical Misinterpretation of Bar Graphs: Readout-based Measurement Reveals the Bar-tip Limit Error

Here, we make three contributions to the study of graph cognition. First, we introduce a framework for measuring graph comprehension via the elicitation of a readout: a relatively concrete and detailed record of thought. Second, we create a flexible new readout-based measure, called Draw Datapoints on Graphs (DDoG), to assess the comprehension of graphs that abstract away from their raw, underlying data. Third, using this new measure, we identify a common error in the interpretation of bar graphs of means. The error we identify is an apparent conflation of bar graphs of means with bar graphs of counts. It occurs when the raw underlying data is assumed to be limited by, rather than spread across, the bar-tip. We therefore call it the Bar-Tip Limit Error (BTLE). In a large, demographically diverse sample, we observe BTLE in about one in five persons, across educational levels, ages, and genders, and despite thoughtful responding and relevant foundational knowledge. The identification of BTLE provides a case-in-point that simplification via abstraction can risk severe, high-prevalence misinterpretation. DDoG reveals the nature and likely cognitive mechanisms of BTLE with an ease that speaks both to DDoG’s value as a measure of graph comprehension and, more broadly, to the efficacy of our readout-focused framework. We conclude that bar graphs of means may be misinterpreted by a large proportion of the population, and that readout-focused measurement holds promise for accelerating the study of graph cognition.

A Detailed Record of Deglacial and Early Post-Glacial Fluvial Evolution: The River Ure in North Yorkshire, UK

The lower reaches of the River Ure, on the flanks of the Pennine Hills in northern England, contain sedimentary and erosional landforms that are a record of fluvial activity during deglaciation and valley-glacier retreat at the end of the last (Devensian) glacial period, and in the subsequent post-glacial Holocene. Terraces and channels, most of which are now relict features well above the altitude of the present river, attest to the impacts of massive meltwater discharge and deposition of sand and gravel outwash, and dynamic river regimes with rapid incision. Through field survey, we have created a detailed geomorphological map of these landforms and glacial and fluvioglacial surface deposits, as well as the terraces and palaeochannels that were abandoned by the river due to avulsion and incision-driven course changes. We have recorded the nature of the outwash gravels, now effectively terrace features, from exposed sections in working quarries, one of which we discuss here. The palaeochannels have accumulated sediment fills and we have examined several which lie within the range of 100 and 16 m above present sea level. The results of lithostratigraphic, palynological, and radiocarbon analyses at two main and three subsidiary sites indicate that palaeochannel ages range from almost 14,000 to approximately 4000 calibrated years ago in a clear altitudinal sequence. The oldest are probably caused by rapid incision due to deglaciation-driven isostatic uplift. The similarity in date of the three downstream sites suggests that a late Holocene combination of climatic deterioration and increased human activity in the catchment caused instability and entrenchment. Pollen data from the channel fills provide relative dating, and agree well with pollen records from other regional Lateglacial and Holocene sites. Non-pollen palynomorph (NPP) analysis at one of the sites allows reconstruction of the hydrological history of channel infill. This research shows that the application of an integrated suite of research techniques can yield a highly detailed understanding of fluvial evolution and landscape history.

Human arrival and landscape dynamics in the northern Bahamas

The first Caribbean settlers were Amerindians from South America. Great Abaco and Grand Bahama, the final islands colonized in the northernmost Bahamas, were inhabited by the Lucayans when Europeans arrived. The timing of Lucayan arrival in the northern Bahamas has been uncertain because direct archaeological evidence is limited. We document Lucayan arrival on Great Abaco Island through a detailed record of vegetation, fire, and landscape dynamics based on proxy data from Blackwood Sinkhole. From about 3,000 to 1,000 y ago, forests dominated by hardwoods and palms were resilient to the effects of hurricanes and cooling sea surface temperatures. The arrival of Lucayans by about 830 CE (2σ range: 720 to 920 CE) is demarcated by increased burning and followed by landscape disturbance and a time-transgressive shift from hardwoods and palms to the modern pine forest. Considering that Lucayan settlements in the southern Bahamian archipelago are dated to about 750 CE (2σ range: 600 to 900 CE), these results demonstrate that Lucayans spread rapidly through the archipelago in less than 100 y. Although precontact landscapes would have been influenced by storms and climatic trends, the most pronounced changes follow more directly from landscape burning and ecosystem shifts after Lucayan arrival. The pine forests of Abaco declined substantially between 1500 and 1670 CE, a period of increased regional hurricane activity, coupled with fires on an already human-impacted landscape. Any future intensification of hurricane activity in the tropical North Atlantic Ocean threatens the sustainability of modern pine forests in the northern Bahamas.