Thermogenic effect of thyroid hormones: interactions with epinephrine and insulin.

1990 ◽  
Vol 259 (3) ◽  
pp. E305
Author(s):  
V Piolino ◽  
K J Acheson ◽  
M J Müller ◽  
N Jeanprêtre ◽  
A G Burger ◽  
...  
Keyword(s):  
Energy Expenditure ◽  
Thyroid Hormones ◽  
Basal Insulin ◽  
Plasma Insulin ◽  
Resting Energy Expenditure ◽  
Fat Free Mass ◽  
Short Term ◽  
Epinephrine Infusion ◽  
Before And After ◽  
Basal Plasma

The interactions between thyroid hormones, epinephrine, and insulin in the regulation of energy expenditure were investigated in a group of healthy young men before and after thyroxine (T4) treatment (300 micrograms/day for 14 days) at basal plasma insulin concentrations and during hypoinsulinemia with and without epinephrine infusion (0.05 micrograms.kg fat-free mass-1.min-1). T4 treatment induced moderate hyperthyroidism and increased resting energy expenditure (RMR). The effect was more pronounced during short-term hypoinsulinemia, but hypoinsulinemia by itself did not influence RMR. Epinephrine infusion caused a significant increase in energy expenditure. The effect was most pronounced at hypoinsulinemia and with T4 treatment. Hypoinsulinemia and T4 treatment were not additive in their effects. We conclude that basal insulin concentrations mask some of the thermogenic effects of thyroid hormones and epinephrine. Thus insulin antagonism may suppress some of the thermogenic actions of thyroid hormones and epinephrine.

scholarly journals Resting energy expenditure in obese women: comparison between measured and estimated values

2016 ◽  
Vol 116 (7) ◽  
pp. 1306-1313 ◽  
Author(s):  
Vanessa Fadanelli Schoenardie Poli ◽  
Ricardo Badan Sanches ◽  
Amanda dos Santos Moraes ◽  
João Pedro Novo Fidalgo ◽  
Maythe Amaral Nascimento ◽  
...  
Keyword(s):  
Energy Expenditure ◽  
Indirect Calorimetry ◽  
Intraclass Correlation ◽  
Resting Energy Expenditure ◽  
Fat Free Mass ◽  
Interdisciplinary Therapy ◽  
Obese Women ◽  
Predictive Equations ◽  
Before And After ◽  
Resting Energy

AbstractAssessing energy requirements is a fundamental activity in clinical dietetic practice. The aim of this study was to investigate which resting energy expenditure (REE) predictive equations are the best alternatives to indirect calorimetry before and after an interdisciplinary therapy in Brazilian obese women. In all, twelve equations based on weight, height, sex, age, fat-free mass and fat mass were tested. REE was measured by indirect calorimetry. The interdisciplinary therapy consisted of nutritional, physical exercise, psychological and physiotherapy support during the course of 1 year. The average differences between measured and predicted REE, as well as the accuracy at the ±10 % level, were evaluated. Statistical analysis included paired t tests, intraclass correlation coefficients and Bland–Altman plots. Validation was based on forty obese women (BMI 30–39·9 kg/m2). Our major findings demonstrated a wide variation in the accuracy of REE predictive equations before and after weight loss in non-morbid, obese women. The equations reported by Harris–Benedict and FAO/WHO/United Nations University (UNU) were the only ones that did not show significant differences compared with indirect calorimetry and presented a bias <5 %. The Harris–Benedict equation provided 40 and 47·5 % accurate predictions before and after therapy, respectively. The FAO equation provided 35 and 47·5 % accurate predictions. However, the Bland–Altman analysis did not show good agreement between these equations and indirect calorimetry. Therefore, the Harris–Benedict and FAO/WHO/UNU equations should be used with caution for obese women. The need to critically re-assess REE data and generate regional and more homogeneous REE databases for the target population is reinforced.

scholarly journals The relationship between resting energy expenditure and thyroid hormones in response to short-term weight loss in severe obesity

PLoS ONE ◽  
2018 ◽  
Vol 13 (10) ◽  
pp. e0205293 ◽  
Author(s):  
Paolo Marzullo ◽  
Alessandro Minocci ◽  
Chiara Mele ◽  
Rezene Fessehatsion ◽  
Mariantonella Tagliaferri ◽  
...  
Keyword(s):  
Weight Loss ◽  
Energy Expenditure ◽  
Thyroid Hormones ◽  
Severe Obesity ◽  
Resting Energy Expenditure ◽  
Short Term ◽  
The Relationship ◽  
Resting Energy

scholarly journals Resting energy expenditure adaptation after short-term caloric restriction in morbidly obese women

2015 ◽  
Vol 28 (5) ◽  
pp. 505-511 ◽  
Author(s):  
Andresa Toledo TRIFFONI-MELO ◽  
Vivian Marques Miguel SUEN ◽  
Cristina Maria Mendes RESENDE ◽  
Camila Bitu Moreno BRAGA ◽  
Rosa Wanda DIEZ-GARCIA
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Energy Expenditure ◽  
Resting Energy Expenditure ◽  
Substrate Oxidation ◽  
Fat Free Mass ◽  
Morbidly Obese ◽  
Obese Women ◽  
Short Term ◽  
Resting Energy

Objective:The objective of this study was to describe changes in the resting energy expenditure, substrate oxidation rate, and body composition in morbidly obese women subjected to short-term caloric restriction. Methods:This was a prospective study that included ten obese women with body mass index greater than 40 kg/m2 and aged between 20-50 years. The participants were hospitalized for eight days and received a controlled conventional low-calorie diet, 1200 kcal/day, for seven days. Body weight, body mass index, abdominal circumference, body composition, resting energy expenditure, and substrate oxidation rate were evaluated at the beginning and at the end of the study. Results:A significant reduction in body weight (p=0.005), body mass index (p=0.005), abdominal circumference (p=0.005), fat mass (p=0.005) and fat-free mass (p=0.008) was observed at the end of the study. There was an average reduction in resting energy expenditure of approximately 124 kcal/day (5%). Substrate oxidation rate did not show statistically significant changes. There was a positive correlation only between body weight reduction and fat-free mass reduction (r=0.753; p=0.012). Conclusion:There was an adaptive response of the resting energy expenditure with short-term energy restriction in morbidly obese women with a 5% reduction in resting energy expenditure and a positive correlation between weight loss and the fat-free mass, which indicates the influence of fat-free mass on the decrease in resting energy expenditure. Therefore, short-term caloric restriction in morbidly obese women led to a decrease in resting energy expenditure and fat-free mass, which suggests a rapid adaptation of energy expenditure.

scholarly journals Resistance training increases total energy expenditure and free-living physical activity in older adults

2000 ◽  
Vol 89 (3) ◽  
pp. 977-984 ◽  
Author(s):  
Gary R. Hunter ◽  
Carla J. Wetzstein ◽  
David A. Fields ◽  
Amanda Brown ◽  
Marcas M. Bamman
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Resistance Training ◽  
Energy Expenditure ◽  
Resting Energy Expenditure ◽  
Compartment Model ◽  
Fat Free Mass ◽  
Free Living ◽  
Oxidation Rates ◽  
Before And After

The purpose of this study was to determine what effects 26 wk of resistance training have on resting energy expenditure (REE), total free-living energy expenditure (TEE), activity-related energy expenditure (AEE), engagement in free-living physical activity as measured by the activity-related time equivalent (ARTE) index, and respiratory exchange ratio (RER) in 61- to 77-yr-old men ( n = 8) and women ( n = 7). Before and after training, body composition (four-compartment model), strength, REE, TEE (doubly labeled water), AEE (TEE − REE + thermic response to meals), and ARTE (AEE adjusted for energy cost of standard activities) were evaluated. Strength (36%) and fat-free mass (2 kg) significantly increased, but body weight did not change. REE increased 6.8%, whereas resting RER decreased from 0.86 to 0.83. TEE (12%) and ARTE (38%) increased significantly, and AEE (30%) approached significance ( P = 0.06). The TEE increase remained significant even after adjustment for the energy expenditure of the resistance training. In response to resistance training, TEE increased and RER decreased. The increase in TEE occurred as a result of increases in both REE and physical activity. These results suggest that resistance training may have value in increasing energy expenditure and lipid oxidation rates in older adults, thereby improving their metabolic profiles.

scholarly journals Resting energy expenditure in short-term starvation is increased as a result of an increase in serum norepinephrine

2000 ◽  
Vol 71 (6) ◽  
pp. 1511-1515 ◽  
Author(s):  
Christian Zauner ◽  
Bruno Schneeweiss ◽  
Alexander Kranz ◽  
Christian Madl ◽  
Klaus Ratheiser ◽  
...  
Keyword(s):  
Energy Expenditure ◽  
Resting Energy Expenditure ◽  
Short Term ◽  
Resting Energy

Energy Expenditure and Body Fat Distribution in Mohawk Children

PEDIATRICS ◽  
1995 ◽  
Vol 95 (1) ◽  
pp. 89-95
Author(s):  
Michael I. Goran ◽  
Mary Kaskoun ◽  
Rachel Johnson ◽  
Charlene Martinez ◽  
Benson Kelly ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Composition ◽  
Native Americans ◽  
Energy Expenditure ◽  
Total Energy ◽  
Body Fat ◽  
Resting Energy Expenditure ◽  
Fat Distribution ◽  
Total Energy Expenditure ◽  
Fat Free Mass

Objective. Epidemiologic studies suggest that Native Americans, including the Mohawk people, have a high prevalence of obesity, diabetes, and cardiovascular risk. However, current information on alterations in related variables such as energy metabolism and body composition in Native Americans is almost exclusively limited to already obese Pima adults living in the Southwest. The aim of this study was to characterize energy metabolism and body composition in young Mohawk children (17 girls, 11 boys; aged 4 to 7 years) as compared to Caucasian children (36 girls, 34 boys; aged 4 to 7 years). Total energy expenditure was measured by doubly labeled water, postprandial resting energy expenditure by indirect calorimetry, and activity energy expenditure was derived from the difference between total and resting energy expenditure. Fat and fat free mass were estimated from bioelectrical resistance, and body fat distribution was estimated from skinfolds and circumferences. Results. There were no significant effects of ethnic background or sex on body weight, height, or body mass index. Fat free mass was significantly higher in boys and fat mass was significantly higher in girls, with no effect of ethnic background. Chest skinfold thickness, the ratio of trunk skinfolds:extremity skinfolds, and the waist:hip ratio were significantly higher in Mohawk children by 2.5 mm, 0.09 units, and 0.03 units, respectively, independent of sex and fat mass. Total energy expenditure was significantly higher in Mohawk children compared to Caucasian (100 kcal/day in girls, 150 kcal/day in boys), independent of fat free mass and sex, due to a significantly higher physical activity-related energy expenditure. Conclusion. These data suggest that: 1) body fat is more centrally distributed in Mohawk relative to Caucasian children, and this effect is independent of sex and body fat content; 2) Mohawk children have a greater total energy expenditure than Caucasian children, independent of fat free mass, due to greater physical activity-related energy expenditure.

Effects of acute α2-blockade on insulin action and secretion in humans

1998 ◽  
Vol 274 (1) ◽  
pp. E57-E64 ◽  
Author(s):  
Andrea Natali ◽  
Amalia Gastaldelli ◽  
Alfredo Quiñones Galvan ◽  
Anna Maria Sironi ◽  
Demetrio Ciociaro ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Energy Expenditure ◽  
Plasma Insulin ◽  
Time Course ◽  
Resting Energy Expenditure ◽  
Oral Glucose ◽  
Cardiac Work ◽  
C Peptide ◽  
Glucose Ingestion ◽  
Resting Energy

We tested whether acute α2-blockade affects insulin secretion, glucose and fat metabolism, thermogenesis, and hemodynamics in humans. During a 5-h epinephrine infusion (50 ng ⋅ min−1 ⋅ kg−1) in five volunteers, deriglidole, a selective α2-receptor inhibitor, led to a more sustained rise in plasma insulin and C-peptide levels (+59 ± 14 vs. +28 ± 6, and +273 ± 18 vs. +53 ± 14 pM, P < 0.01 vs. placebo) despite a smaller rise in plasma glucose (+0.90 ± 0.4 vs. +1.5 ± 0.3 mM, P < 0.01). Another 10 subjects were studied in the postabsorptive state and during a 4-h hyperglycemic (+4 mM) clamp, coupled with the ingestion of 75 g of glucose at 2 h. In the postabsorptive state, hepatic glucose production, resting energy expenditure, and plasma insulin, free fatty acid (FFA), and potassium concentrations were not affected by acute α2-blockade. Hyperglycemia elicited a biphasic rise in plasma insulin (to a peak of 140 ± 24 pM), C-peptide levels (1,520 ± 344 pM), and insulin secretion (to 410 ± 22 pmol/min); superimposed glucose ingestion elicited a further twofold rise in insulin and C-peptide levels, and insulin secretion. However, α2-blockade failed to change these secretory responses. Fasting blood β-hydroxybutyrate and glycerol and plasma FFA and potassium concentrations all declined with hyperglycemia; time course and extent of these changes were not affected by α2-blockade. Resting energy expenditure (+25 vs. +16%, P < 0.01) and external cardiac work (+28% vs. +19%, P < 0.01) showed larger increments after α2-blockade. We conclude that acute α2-blockade in humans 1) prevents epinephrine-induced inhibition of insulin secretion, 2) does not potentiate basal or intravenous- or oral glucose-induced insulin release, 3) enhances thermogenesis, and 4) increases cardiac work.

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