A review of the efficacy and safety of nanoparticle-based oral insulin delivery systems

2011 ◽  
Vol 301 (6) ◽  
pp. G956-G967 ◽  
Author(s):  
Jeffrey W. Card ◽  
Bernadene A. Magnuson
Keyword(s):  
Insulin Therapy ◽  
Oral Delivery ◽  
Oral Treatment ◽  
Safety Data ◽  
Experimental Models ◽  
Oral Insulin ◽  
Noninvasive Treatment ◽  
Uptake Pathway ◽  
Treatment Of Diabetes ◽  
Insight Into

Nanotechnology is providing new and innovative means to detect, diagnose, and treat disease. In this regard, numerous nanoparticle-based approaches have been taken in an effort to develop an effective oral insulin therapy for the treatment of diabetes. This review summarizes efficacy data from studies that have evaluated oral insulin therapies in experimental models. Also provided here is an overview of the limited safety data that have been reported in these studies. To date, the most promising approaches for nanoparticle-based oral insulin therapy appear to involve the incorporation of insulin into complex multilayered nanoparticles that are mucoadhesive, biodegradable, biocompatible, and acid protected and into nanoparticles that are designed to take advantage of the vitamin B12 uptake pathway. It is anticipated that the continued investigation and optimization of nanoparticle-based formulations for oral delivery of insulin will lead to a much sought-after noninvasive treatment for diabetes. Such investigations also may provide insight into the use of nanoparticle-based formulations for peptide- and protein-based oral treatment of other diseases and for various food-related purposes.

scholarly journals Oral insulin delivery for treatment of diabetes mellitus

2021 ◽  
pp. 66-70
Author(s):  
Durga Devi K
Keyword(s):  
Diabetes Mellitus ◽  
Oral Delivery ◽  
Proteolytic Enzymes ◽  
Insulin Delivery ◽  
Oral Route ◽  
Intestinal Lumen ◽  
Oral Insulin ◽  
Polymer Microsphere ◽  
Enzyme Degradation ◽  
Treatment Of Diabetes

Diabetes mellitus is characterized by a condition known as hyperglycemia which may be controlled through medication and insulin. Current insulin therapy for diabetes mellitus involves frequent dosing of subcutaneous injections, causing local discomfort, patient incompliance, hypoglycemia, and hyperinsulinemia, among others, one of the approaches to overcoming these issues is to administer insulin through oral route. An oral form of insulin has been the elusive goal for many investigators since the protein initial discovery by Banting and Best in 1922. Oral delivery of insulin is one of the promising and anticipated areas in the treatment of diabetes, primarily because it may significantly improve the quality of life of patients who receives insulin regularly. However, there are several challenges in developing an oral route for insulin delivery; include low bioavailability due to rapid enzyme degradation in the stomach, inactivation, and digestion by proteolytic enzymes in the intestinal lumen, poor permeability, and poor stability. Several companies have developed technology platforms that protect polypeptides and proteins from enzymatic hydrolysis, enable their transport across the epithelial lining, and promote their absorption from the GI tract. Most notably, the use of permeation enhancers, protease inhibitors, enteric coatings, and polymer microsphere formulation will be covered, including commentary on which methods hold more promise towards the successful development of oral insulin. This review, considers the current literature on the advances, methods, needs, and challenges in the development of oral insulin.

scholarly journals Systematic Review on the Effectiveness of Strategies for Increasing Insulin Bioavailability in Oral Route Delivery Systems Based on Manufacturing Techniques and Materials Used

2021 ◽  
Vol 11 (6) ◽  
pp. 194-208
Author(s):  
ADIVA PUJA KRISNA ◽  
Hendri Wahyu Ningrum ◽  
Tamara Laily Fimannuha ◽  
Oktavia Eka Puspita
Keyword(s):  
Insulin Therapy ◽  
Delivery System ◽  
Oral Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Relative Bioavailability ◽  
Oral Route ◽  
Oral Insulin ◽  
Layer By Layer ◽  
Glucose Levels ◽  
Insulin Stability

Diabetes is a metabolic disease characterized by hyperglycemia due to impaired insulin secretion, insulin action, or both. All patients with type 1 diabetes and many type 2 diabetes require insulin therapy to achieve reasonable glycemic control. During this time, insulin is given through the subcutaneous injection route because it can be destroyed by gastric acid when given orally. Until now, many studies have developed oral insulin therapy using various delivery system strategies. This systematic literature review aims to answer several questions about the effect of technique and material on increasing oral insulin bioavailability and the best technique and type of material that can produce the best oral insulin bioavailability. We searched for published articles regarding the development of oral route insulin. Bioavailability parameters were assessed based on plasma insulin levels for relative bioavailability values and/or plasma glucose levels for pharmacological bioavailability values. Conclusion: The manufacturing technique in the delivery system affects insulin stability in maintaining its conformation to provide a therapeutic effect. The type of substance affects insulin bioavailability through its properties in paving the way for insulin across various barriers in the digestive tract. To date, the best results in the development of oral insulin have obtained oral insulin bioavailability of 73.10% achieved by mesoporous silica nanoparticles (MSN) delivery system with layer-by-layer technique coated with [poly (methacrylic acid-co-vinyl triethoxylsilane)] (PMV)]. Keywords: bioavailability, diabetes, insulin, nanoparticles, oral delivery system.

scholarly journals In vivo oral insulin delivery via covalent organic frameworks

2021 ◽  
Author(s):  
Farah Benyettou ◽  
Nawel Kaddour ◽  
Thirumurugan Prakasam ◽  
Gobinda Das ◽  
Sudhir Kumar Sharma ◽  
...  
Keyword(s):  
Oral Delivery ◽  
Insulin Delivery ◽  
Oral Insulin ◽  
Covalent Organic Frameworks ◽  
Covalent Organic Framework ◽  
Organic Framework

We report the successful use of a gastro-resistant covalent organic framework for in vivo oral delivery of insulin.

Oral Treatment of Diabetes

BMJ ◽  
1961 ◽  
Vol 1 (5227) ◽  
pp. 748-749
Author(s):  
W. Oakley
Keyword(s):  
Oral Treatment ◽  
Treatment Of Diabetes

scholarly journals EFEKTIVITAS KERASIONALAN PEMBERIAN ANTIDIABETIK PENGOBATAN ORAL PASIEN DIABETES MELLITUS PADA USIA 30-50 TAHUN TIPE 2 DI RAWAT INAP PENYAKIT DALAM RSUD DELI SERDANG LUBUK PAKAM TAHUN 2020

2021 ◽  
Vol 3 (2) ◽  
pp. 74-80
Author(s):  
Loraetta Brety Sebayang ◽  
Romauli Anna Teresia Marbun ◽  
Dewi Kartika
Keyword(s):  
Diabetes Mellitus ◽  
Oral Treatment ◽  
Type Ii Diabetes Mellitus ◽  
The Body ◽  
Quality Assurance Process ◽  
Experimental Type ◽  
Treatment Of Diabetes ◽  
Assurance Process ◽  
The Right

Background: Diabetes Mellitus is a chronic condition, which occurs because the body cannot produce insulin, normally or insulin cannot work effectively. Objective: To determine the effectiveness of the rational administration of antidiabetic, oral treatment of diabetes mellitus patients at the age of 30-50 years type 2 in Deli Serdang Hospital, lubuk pakam in 2020. Method: This study is a non-experimental type of research using descriptive methods. Results: Shows that from 72 samples of Type II Diabetes Mellitus patients at Deli Serdang General Hospital, April-July Period 2020. With the number (52.8%) of male sex patients and the number (47.2%) of type patients  female genitalia and antidiabetic drugs most widely used by patients, in the period of April-July 2020, namely (20.8%) glycionion + metformin and (20.8%) insulin drugs.  the use of DM drugs with the right rational indication (65.3%), Rational with the right medicine (100%), rational with the right dosage (100%), the right rational patient (100%) and the rational way of administration (100:%). Conclusion: Evaluation of drug use is a structured quality assurance process that is carried out continuously to ensure that the drugs used are appropriate, safe, and efficient.

scholarly journals ORAL DRUG DELIVERY OF INSULIN IN DIABETES MELLITUS: AN ATTRACTIVE ALTERNATE TO OVERCOME INVASIVE ROUTE

2019 ◽  
Author(s):  
Pooja Mathur ◽  
Chandra Kant Mathur ◽  
Kanchan Mathur
Keyword(s):  
Diabetes Mellitus ◽  
Drug Delivery ◽  
Delivery System ◽  
Oral Delivery ◽  
Oral Drug Delivery ◽  
Relevant Information ◽  
Delivery Systems ◽  
Oral Drug ◽  
Oral Insulin ◽  
Human Beings

The subcutaneous injection of insulin for the treatment of diabetes mellitus can lead to patient non-compliance, discomfort, pain and local infection is a chronic metabolic health disease affecting the homeostasis of blood sugar levels in human beings. Oral route of drug delivery system has been the most widely accepted means of drug administration other than invasive drug delivery systems. For the development of an oral insulin delivery system, we have to focus on overcoming the various gastro-intestinal barriers for insulin uptake from the gastrointestinal tract. To overcome these barriers various types of formulations such as insulin conjugates, micro/nanoparticles, liposomes, hydrogel, capsule, and tablets are designed to deliver insulin orally. Various potential ways to administer insulin orally has been explored over years but a fluctuating level of insulin release have been recorded. A number of advancement has taken place in the recent years for understanding the needs of improved oral delivery systems of insulin. This review article concentrates on the challenges for oral drug delivery of insulin as well as various carriers used for the oral drug delivery of insulin and also provides the relevant information about the clinical tested formulations of oral insulin and its patents.

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