A long-term high-protein diet markedly reduces adipose tissue without major side effects in Wistar male rats

2004 ◽  
Vol 287 (4) ◽  
pp. R934-R942 ◽  
Author(s):  
Magali Lacroix ◽  
Claire Gaudichon ◽  
Antoine Martin ◽  
Céline Morens ◽  
Véronique Mathé ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Weight Control ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Male Rats ◽  
Calcium Balance ◽  
Long Term Effects ◽  
Wistar Male Rats

Although there is a considerable interest of high-protein, low-carbohydrate diets to manage weight control, their safety is still the subject of considerable debate. They are suspected to be detrimental to the renal and hepatic functions, calcium balance, and insulin sensitivity. However, the long-term effects of a high-protein diet on a broad range of parameters have not been investigated. We studied the effects of a high-protein diet in rats over a period of 6 mo. Forty-eight Wistar male rats received either a normal-protein (NP: 14% protein) or high-protein (HP: 50% protein) diet. Detailed body composition, plasma hormones and nutrients, liver and kidney histopathology, hepatic markers of oxidative stress and detoxification, and the calcium balance were investigated. No major alterations of the liver and kidneys were found in HP rats, whereas NP rats exhibited massive hepatic steatosis. The calcium balance was unchanged, and detoxification markers (GSH and GST) were enhanced moderately in the HP group. In contrast, HP rats showed a sharp reduction in white adipose tissue and lower basal concentrations of triglycerides, glucose, leptin, and insulin. Our study suggests that the long-term consumption of an HP diet in male rats has no deleterious effects and could prevent metabolic syndrome.

scholarly journals Long-Term Intake of a High-Protein Diet with or without Potassium Citrate Modulates Acid-Base Metabolism, but Not Bone Status, in Male Rats

2008 ◽  
Vol 138 (4) ◽  
pp. 718-724 ◽  
Author(s):  
Julie Mardon ◽  
Véronique Habauzit ◽  
Anna Trzeciakiewicz ◽  
Marie-Jeanne Davicco ◽  
Patrice Lebecque ◽  
...  
Keyword(s):  
High Protein Diet ◽  
Potassium Citrate ◽  
High Protein ◽  
Protein Diet ◽  
Male Rats ◽  
Acid Base ◽  
Bone Status

scholarly journals Does long-term creatine supplementation impair kidney function in resistance-trained individuals consuming a high-protein diet?

2013 ◽  
Vol 10 (1) ◽  
pp. 26 ◽  
Author(s):  
Rebeca Lugaresi ◽  
Marco Leme ◽  
Vítor de Salles Painelli ◽  
Igor Murai ◽  
Hamilton Roschel ◽  
...  
Keyword(s):  
Kidney Function ◽  
Creatine Supplementation ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet

scholarly journals High-Protein Diet Induces Hyperuricemia in a New Animal Model for Studying Human Gout

2020 ◽  
Vol 21 (6) ◽  
pp. 2147 ◽  
Author(s):  
Fan Hong ◽  
Aijuan Zheng ◽  
Pengfei Xu ◽  
Jialin Wang ◽  
Tingting Xue ◽  
...  
Keyword(s):  
Animal Model ◽  
Metabolic Diseases ◽  
High Protein Diet ◽  
Serum Urate ◽  
Dietary Factors ◽  
High Protein ◽  
Protein Diet ◽  
Positive Effects ◽  
Biological Studies

Hyperuricemia is a central risk factor for gout and increases the risk for other chronic diseases, including cardiometabolic disease, kidney disease, and hypertension. Overproduction of urate is one of the main reasons for hyperuricemia, and dietary factors including seafoods, meats, and drinking are contributed to the development of it. However, the lack of a suitable animal model for urate metabolism is one of the main reasons for the delay and limitations of hyperuricemia research. Combining evolutionary biological studies and clinical studies, we conclude that chicken is a preferred animal model for hyperuricemia. Thus, we provided chickens a high-protein diet (HPD) to evaluate the changes in the serum urate levels in chickens. In our study, the HPD increased the serum urate level and maintained it at a long-term high level in chickens. Long-term high serum urate levels induced an abnormal chicken claw morphology and the precipitation of monosodium urate (MSU) in joint synovial fluid. In addition, a long-term HPD also decreased the glomerular filtration rate and induced mild renal injury. Most importantly, allopurinol and probenecid displayed the positive effects in decreasing serum urate and then attenuated hyperuricemia in chicken model. These findings provide a novel model for hyperuricemia and a new opportunity to further investigate the effects of long-term hyperuricemia on other metabolic diseases.

scholarly journals The effects of a combination of high-protein diet and resistance training on short-term weight loss and long-term weight maintenance in overweight and obese Chinese people: a study protocol

2019 ◽  
Author(s):  
Xu Shaoyong ◽  
Juan Zhang ◽  
Yuxiang Dong ◽  
Ruikun Chen ◽  
Wenlei Xu ◽  
...  
Keyword(s):  
Weight Loss ◽  
Resistance Training ◽  
Weight Maintenance ◽  
High Protein Diet ◽  
Diet Group ◽  
High Protein ◽  
Protein Diet ◽  
Short Term ◽  
Low Fat Diet

Abstract Background It is very important for clinicians and dieticians to explore reasonable weight management strategies for obese people that address both short-term weight loss and subsequent weight maintenance. We hypothesized that resistance training combined with a high-protein diet would result in similar short-term weight loss but better long-term weight maintenance than either conventional low-fat diet control or high-protein diet alone.Methods/design This is an 8-week randomized parallel controlled trial followed by a 24-week observational follow-up study. A 48-week supplementary follow-up study will be carried out if necessary. The study will be conducted between June 2019 and October 2020. The 90 overweight or obese participants will be randomly assigned to the conventional low-fat diet group, the high-protein diet group and the high-protein diet and resistance training combination group. Primary outcomes are body weight changes at week 8 and week 24 compared with the baseline level.Discussion High-quality research on the effect of a high-protein diet combined resistance training on weight loss and weight maintenance is limited in Chinese population. Our study will provide a basis for obesity management in China, and promote the development of exercise and diet-related studies.Trials registration ChiCTR1900023841, 14 June 2019

scholarly journals Renal hypertrophy and function in irradiated and nephrectomized rats fed a high protein diet

1962 ◽  
Vol 202 (1) ◽  
pp. 88-90 ◽  
Author(s):  
Frank Konishi ◽  
R. W. Brauer
Keyword(s):  
High Protein Diet ◽  
Compensatory Hypertrophy ◽  
High Protein ◽  
Protein Diet ◽  
Male Rats ◽  
Renal Neoplasm ◽  
Renal Hypertrophy ◽  
X Irradiation ◽  
Renal Clearances ◽  
And Function

Male rats exposed to a total of 740 rad X-irradiation were fed a high protein diet and unilaterally nephrectomized to investigate functional and compensatory regenerative capacity of the kidney as probable indices of residual radiation injury. The extent of compensatory hypertrophy after nephrectomy showed a significantly greater increase due to the high protein diet but no effect due to irradiation. Estimates of maximal tubular excretions of p-aminohippurate (PAH), however, were significantly greater in irradiated groups than in control groups when determined 3 weeks postnephrectomy. Renal clearances of CIn and CPAH were significantly depressed after nephrectomy but not after radiation. Histological studies of the kidneys did not indicate renal damage by radiation except for an isolated instance of a renal neoplasm in an irradiated, nephrectomized rat fed a high protein diet. The results indicate that radiation does not modify compensatory hypertrophy after unilateral nephrectomy but appears to increase the apparent functional capacity of the tubules.

Corrigendum to: IGF-I is not a useful marker for nutritional status in the growing pig under commercial conditions

2001 ◽  
Vol 52 (7) ◽  
pp. 791
Author(s):  
L. Ma ◽  
F. R. Dunshea ◽  
Y. M. Brockwell ◽  
R. L. Inglis ◽  
D. J. Kingston ◽  
...  
Keyword(s):  
Weight Gain ◽  
Nutritional Status ◽  
Dietary Protein ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Low Protein ◽  
Igf I ◽  
Protein Diets

Plasma hormone concentrations were measured in gilts after fasting, long-term protein restriction, or supplementation. In 11-week-old pigs fasted overnight, plasma insulin, glucagon, gastrin, urea, and glucose were increased 30 min after re-feeding (P < 0.05), whereas IGF-I did not change. In 16-week-old gilts fed a standard commercial diet [14.6% crude protein (CP)], or a high-protein diet (16.7% CP) for 4 weeks, the high-protein diet increased weight gain (13%; P < 0.05) and carcass weight (4%; P < 0.05), but did not alter plasma IGF-I, insulin, or glucagon. In 10-week-old gilts fed high-protein diets (19.4% and 18.3% CP), or low-protein diets (15.5% and 13.3% CP) for 12 weeks during the grower and finisher phases, respectively, the low-protein diet decreased weight gain (18%; P < 0.001) and carcass weight (11%; P < 0.01), with a marked increase in plasma glucagon (P < 0.05), no change in insulin, and only a trend towards decreased IGF-I (P = 0.1). The pigs were more sensitive to altered dietary protein at 10 weeks of age than at 16 weeks. Plasma IGF-I was not responsive to the short-term effects of feeding or the long-term effects of dietary protein. Glucagon could provide a useful marker for nutritional status in young pigs, provided that time of feeding is taken into account.

Abstract P129: FTO Genotype and 2-year Change in Body Composition and Fat Distribution in Response to Weight-loss Diets: The Pounds Lost Trial

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Xiaomin Zhang ◽  
Qibin Qi ◽  
Frank Hu ◽  
Frank Sacks ◽  
Lu Qi
Keyword(s):  
Weight Loss ◽  
Body Composition ◽  
Adipose Tissue ◽  
Risk Allele ◽  
High Protein Diet ◽  
Fat Distribution ◽  
High Protein ◽  
Protein Diet ◽  
Tissue Mass ◽  
Adipose Tissue Mass

OBJECTIVE The fat mass and obesity-associated gene (FTO) variant has shown the strongest association with obesity. Recent studies suggest that dietary intake may modify the genetic effects of FTO. We tested the effect of FTO variant on long-term weight loss and change in body composition in a 2-year randomized intervention trial. RESEARCH DESIGN AND METHODS FTO SNP rs1558902 was genotyped in 742 overweight or obese adults who were randomly assigned to one of four diets differing in the percentages of energy derived from fat, protein and carbohydrate (20, 15, and 65%; 20, 25, and 55%; 40, 15, and 45%; and 40, 25, and 35%) in the Pounds Lost Trial for 2 years. Body composition and fat distribution were measured in 424 and 195 participants by Dual-energy X-ray absorptiometry (DXA) and computed tomography (CT), respectively. RESULTS We found significant modification effects for diet intervention varying in protein (low vs high), but not in fat, on 2-year changes in total fat, fat free mass (FFM), fat mass% (FM%), trunk fat%, total adipose tissue mass (TAT), visceral adipose tissue mass (VAT) and superficial adipose tissue mass (SAT) (P for interactions=0.045, 0.036, 0.033, 0.048, 0.001, 0.008 and 0.002, respectively). Carriers of the risk allele (A allele) had a greater loss of weight and regional fat in response to high protein diet, while an opposite genetic effect was observed on changes in TAT and SAT in response to low protein diet at 2 years. Significant gene by diet interventions (low vs high protein) were also observed at 6 months of intervention, when the maximum of weight-loss was achieved, for changes in FFM, TAT, VAT and SAT (P for interactions=0.007, 0.019, 0.036 and 0.041, respectively). Patterns of change in body composition and fat distribution by diet intervention were similar at 6 month and 2 year. CONCLUSIONS Our data suggest that a high-protein diet may be beneficial for weight loss in individuals with the risk allele of the FTO variant rs1558902.

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