scholarly journals Dynamic transcriptomic response to acute hypertension in the nucleus tractus solitarius

2008 ◽  
Vol 295 (1) ◽  
pp. R15-R27 ◽  
Author(s):  
Rishi L. Khan ◽  
Rajanikanth Vadigepalli ◽  
Mary K. McDonald ◽  
Robert F. Rogers ◽  
Guang R. Gao ◽  
...  
Keyword(s):  
Nucleus Tractus Solitarius ◽  
Relevant Literature ◽  
Genomic Analysis ◽  
Large Data ◽  
Acute Hypertension ◽  
Transcriptomic Response ◽  
New Findings ◽  
Gene And Protein Expression ◽  
Functional Context ◽  
Analytical Approaches

Baroreceptor afferents project to the cardiovascular region of the nucleus tractus solitarius (cvNTS), and their cvNTS target neurons may play a role in governing the sensitivity and operating range of the arterial baroreceptor reflex (baroreflexes). Recent studies have shown differential gene and protein expression in the cvNTS in response to changed arterial pressure. However, the extent of these responses is unknown. Therefore, we collected differential global gene expression data in a time series following acute hypertension in awake, freely moving rats. To acquire statistically significant results and place them in functional context, we overcame several quality control requirements and developed novel analytical approaches. The physiologically new findings from the study are that acute hypertension causes very extensive, time-varying gene regulatory changes, many involving neuronal function-specific genes and systems of genes. We use standard genomic analysis methods to manage the large data sets and to develop results such as heat maps to examine patterns and clusters in the gene regulation. We used the Gene Ontology categories to provide functional context. To place our findings in the context of the relevant literature, we developed two graphical representations of the networks implicated, linking receptors and channels to signaling pathways. The results point to the multivariate complexity of the response and implicate a group of receptors as candidates for mediating nucleus tractus solitarius baroreflex function in hypertension by identifying concurrent upregulation of receptor genes. We were able to make transcription factor binding predictions and record dysregulation of heart rate correlated with the transcriptional response.

The anti-osteoporosis effects of Vitamin K in postmenopausal women

2021 ◽  
Vol 16 ◽  
Author(s):  
Yuan Liu ◽  
Yuan He ◽  
Baorong He ◽  
Lingbo Kong
Keyword(s):  
Postmenopausal Women ◽  
Vitamin K ◽  
Relevant Literature ◽  
Osteoporotic Fractures ◽  
Mortality And Morbidity ◽  
Standard Guideline ◽  
Set Up ◽  
Meta Analyses ◽  
Aging People ◽  
Analytical Approaches

Abstract: As a common systemically muscular-skeleton disorder in aging, osteoporosis is characterized by the uninterrupted deconstruction in osseous microarchitecture. Osteoporosis can consequently lead to a significantly high risk of osteoporotic fractures, such as osteoporotic vertebral compressive fractures [OVCF] in the spine and osteoporotic femoral neck fractures, which can significantly increase the numbers of mortality and morbidity in aging people, especially in postmenopausal women. In addition, vitamin K has been demonstrated to play a key role in inhibiting osteoporotic fractures among postmenopausal women, but its long-term benefits, potential harms, and effects of the combination between vitamin K and other anti-osteoporosis medicines such as bisphosphonates or teriparatide were just extensively studied. Therefore, the present review aimed to systematically reviewed published literature on the role of vitamin K in the treatment of osteoporosis. We currently, via multiple queries strategy, searched the relevant literature in Cochrane and PubMed from January 2010 to December 2019. Subsequently, we conducteda systematic review according to the standard guideline of Preferred Reporting Item for Systematic Reviews and Meta-Analyses [PRISMA]. Finally, ten relevant works of literature met our current criteria for inclusion, and then we followed the PRISMA guideline and systematically reviewed each study by the categorized data sources and analytical approaches in each study, meanwhile set up variables and defined each study outcomes.

scholarly journals Anesthesia and Intensive Care Management in a Pregnant Woman with PRES: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Ismail Demirel ◽  
Ayse Belin Ozer ◽  
Mustafa K. Bayar ◽  
Salih Burcin Kavak
Keyword(s):  
Intensive Care ◽  
Pregnant Woman ◽  
Visual Impairment ◽  
Care Management ◽  
Relevant Literature ◽  
Immunosuppressive Treatment ◽  
Acute Hypertension ◽  
Cortical Visual Impairment ◽  
The Right ◽  
Reversible Encephalopathy

Posterior reversible encephalopathy syndrome (PRES) is a temporary condition that is diagnosed clinically, neurologically, and radiologically. Its symptoms vary, and nonspecific headaches, confusion, impairment of consciousness, nausea, vomiting, and visual impairment may occur. Acute hypertension often accompanies these symptoms. Patients can also suffer from convulsions, cortical visual impairment, and coma. Diagnosis can be difficult due to focal neurologic signs. Nevertheless, knowing the clinical risk factors can lead to the right diagnosis. It has been reported that this condition may also occur during organ transplantation, immunosuppressive treatment, and autoimmune diseases and chemotherapy, and also patients with eclampsia. In this paper, a 21-year-old, 31-week pregnant woman, who had been diagnosed with PRES and thanks to early diagnosis and treatment had fully recovered and discharged from the intensive care unit, is presented, and the relevant literature is discussed.

scholarly journals Bioinformatics workflows for genomic analysis of tumors from Patient Derived Xenografts (PDX): challenges and guidelines

2018 ◽  
Author(s):  
Xing Yi Woo ◽  
Anuj Srivastava ◽  
Joel H. Graber ◽  
Vinod Yadav ◽  
Vishal Kumar Sarsani ◽  
...  
Keyword(s):  
Copy Number ◽  
Somatic Mutations ◽  
Simulated Data ◽  
Genomic Analysis ◽  
Human Tumors ◽  
The Cancer Genome Atlas ◽  
Accurate Identification ◽  
Human Sequence ◽  
Analytical Approaches ◽  
Bioinformatics Workflows

AbstractBioinformatics workflows for analyzing genomic data obtained from xenografted tumor (e.g., human tumors engrafted in a mouse host) must address several challenges, including separating mouse and human sequence reads and accurate identification of somatic mutations and copy number aberrations when paired normal DNA from the patient is not available. We report here data analysis workflows that address these challenges and result in reliable identification of somatic mutations, copy number alterations, and transcriptomic profiles of tumors from patient derived xenograft models. We validated our analytical approaches using simulated data and by assessing concordance of the genomic properties of xenograft tumors with data from primary human tumors in The Cancer Genome Atlas (TCGA). The commands and parameters for the workflows are available at https://github.com/TheJacksonLaboratory/PDX-Analysis-Workflows.

scholarly journals Analisa Maraknya Pemanfaatan Platform dalam Pengumpulan Zakat Melalui Prespektif Strukturasi Ala Giddens

2021 ◽  
Vol 18 (1) ◽  
pp. 1-12
Author(s):  
Dwiki Faiz
Keyword(s):  
Descriptive Analysis ◽  
Relevant Literature ◽  
Digital Tools ◽  
Literature Study ◽  
Individual Level ◽  
Digital Devices ◽  
New Findings ◽  
Study Techniques ◽  
The Individual ◽  
Two Sides

The potential and realization of zakat reported by BAZNAS as a government agency are still far from expectations. One indication that appears significantly as a cause of digital sociology is the increasing number of actors using platforms to collect zakat. This then needs to be explored further about its attention, considering the digitization will not be stopped as well. This review is analyzed using a qualitative approach with descriptive analysis through relevant literature study techniques in order to form conceptual/ new findings. The results of the review suggest that it’s easy to find support in the digital age for activism through the use of digital tools. Thus, it’s able to encourage other actors to be involved in seeking and collecting zakat. Like the two sides of the coin, the ease for muzaki in distributing zakat certainly occurs thanks to digitization. On the other hand, the supervision of related stakeholders down to the individual level as zakat/ alms collectors must be considered, especially from BAZNAS. If this is not the case, the distribution of zakat can be misused due to its own interests. In the future, because they can’t cut off the development of digital devices and actors, juggernaut symptoms will occur.

Discussion and Conclusion

2020 ◽  
pp. 237-252
Author(s):  
Ulrich Frey
Keyword(s):  
Forest Management ◽  
Influencing Factors ◽  
Goodness Of Fit ◽  
Success Factors ◽  
Large Data ◽  
Large Data Sets ◽  
Data Sets ◽  
Irrigation Systems ◽  
New Findings ◽  
Ecological Success

This chapter tries to give an overall summary of the book. For this purpose, the success factors in their overall importance are discussed across all models. After the discussion of the limitations of this work, the new findings are summarized for a quick overview of the most important advancements of this study. These include a synthesis of influencing factors for ecological success, their operationalization and application to large data sets. Robust models with a high goodness-of-fit are now available for fisheries, forest management, and irrigation systems. Some factors, like monitoring, have to be re-evaluated in their relevance for ecological success. The book concludes with a summary and an outlook on future fields of research.

scholarly journals Semianalytical Correlations for NOx, CO, and UHC Emissions

1992 ◽  
Author(s):  
N. K. Rizk ◽  
H. C. Mongia
Keyword(s):  
Kinetic Scheme ◽  
Large Data ◽  
Chemical Kinetic ◽  
Reaction Scheme ◽  
Emission Model ◽  
Future Goals ◽  
Unburned Hydrocarbon ◽  
Annular Combustor ◽  
Analytical Approaches ◽  
Detailed Chemical

To meet the future goals of reduced emissions produced by gas turbine combustors, a better understanding of the process of formation of various pollutants is required. Both empirical and analytical approaches are used to provide the exhaust concentrations of pollutants of interest such as NOx, CO, and unburned hydrocarbon with varying degrees of success. In the present investigation, an emission model that simulates the combustor by a number of reactors representing various combustion zones is proposed. A detailed chemical kinetic scheme was used to provide a fundamental basis for the derivation of a number of expressions that simulate the reaction scheme. The model addresses the combined effects of spray evaporation and mixing in the reaction zone. The model validation included the utilization of a large data base obtained for an annular combustor of a modern turbopropulsion engine. In addition to the satisfactory agreement with the measurements, the model provided insight into the regions within the combustor that could be responsible for the excessive formation of emissions. Methods to reduce the emissions may be implemented in light of such information.

Semianalytical Correlations for NOx, CO, and UHC Emissions

1993 ◽  
Vol 115 (3) ◽  
pp. 612-619 ◽  
Author(s):  
N. K. Rizk ◽  
H. C. Mongia
Keyword(s):  
Kinetic Scheme ◽  
Large Data ◽  
Chemical Kinetic ◽  
Reaction Scheme ◽  
Emission Model ◽  
Future Goals ◽  
Unburned Hydrocarbon ◽  
Annular Combustor ◽  
Analytical Approaches ◽  
Detailed Chemical

To meet the future goals of reduced emissions produced by gas turbine combustors, a better understanding of the process of formation of various pollutants is required. Both empirical and analytical approaches are used to provide the exhaust concentrations of pollutants of interest such as NOx, CO, and unburned hydrocarbon with varying degrees of success. In the present investigation, an emission model that simulates the combustor by a number of reactors representing various combustion zones is proposed. A detailed chemical kinetic scheme was used to provide a fundamental basis for the derivation of a number of expressions that simulate the reaction scheme. The model addresses the combined effects of spray evaporation and mixing in the reaction zone. The model validation included the utilization of a large data base obtained for an annular combustor of a modern turbopropulsion engine. In addition to the satisfactory agreement with the measurements, the model provided insight into the regions within the combustor that could be responsible for the excessive formation of emissions. Methods to reduce the emissions may be implemented in light of such information.

scholarly journals E-lectra: A Bibliography for the Study and Practice of Legal, Court and Official Translation and Interpreting

2010 ◽  
Vol 55 (2) ◽  
pp. 355-373 ◽  
Author(s):  
Esther Monzó
Keyword(s):  
Reference Material ◽  
Relevant Literature ◽  
Translation Studies ◽  
The Other ◽  
Scientific Development ◽  
Bibliographic Database ◽  
Legal Translation ◽  
New Findings ◽  
Efficient Communication ◽  
Electronic Bibliographic Database

Scientific development presupposes the efficient communication of new findings. The increase in the number of academic journals and publications worldwide burdens scholars, also translation scholars, with the responsibility of keeping up to date with ever increasingly scattered relevant literature. On the other hand, legal translation professionals need to select and find specialised documentation and reference material, which the market addresses not to translators or interpreters but to law specialists. E-lectra is an electronic bibliographic database whose purpose is to help legal translation scholars and practitioners select and find relevant literature and documentation resources, and further help researchers to present their work by providing a powerful pool of formats and styles incorporated in an easy-to-use system for citing references in their works and adapting them to the conventions of different journals from the field of translation studies.

scholarly journals “During the interview, the interpreter will provide a faithful translation.” The potentials and pitfalls of researchinginterpreting in immigration, asylum, and police settings: methodology and research paradigms

2021 ◽  
Vol 5 ◽  
Author(s):  
Sonja Pöllabauer
Keyword(s):  
Relevant Literature ◽  
Research Paradigms ◽  
Disciplinary Background ◽  
Analytical Approaches

This article presents a bibliometrical survey of an extensive corpus of research on interpreting in immigration, asylum andpolice settings. The article takes stock ofpast research andpoints towards questionsforfurther research. The corpus of relevant literature is grouped according to the authors’ disciplinary background, and examined on the basis of a bibliometrical analysis with respect to the authors’ affiliation, type(s) ofpublication, date(s) of publication, methodology, and predominant paradigms and topics. The survey also investigates the different analytical (mainly discourse analytical) approaches that have been used to analyse these kind of interpreter-mediated interviews

scholarly journals Mesh repairing using topology graphs

2020 ◽  
Author(s):  
Jerome Charton ◽  
Stephen Baek ◽  
Youngjun Kim
Keyword(s):  
Relevant Literature ◽  
Large Data ◽  
Triangular Meshes ◽  
Oriented Manifold ◽  
Geometry Processing ◽  
Data Set ◽  
Large Data Set ◽  
Final Output ◽  
Local Pairing ◽  
Topology Graph

Abstract Geometrical and topological inconsistencies, such as self-intersections and non-manifold elements, are common in triangular meshes, causing various problems across all stages of geometry processing. In this paper, we propose a method to resolve these inconsistencies using a graph-based approach. We first convert geometrical inconsistencies into topological inconsistencies and construct a topology graph. We then define local pairing operations on the topology graph, which is guaranteed not to introduce new inconsistencies. The final output of our method is an oriented manifold with all geometrical and topological inconsistencies fixed. Validated against a large data set, our method overcomes chronic problems in the relevant literature. First, our method preserves the original geometry and it does not introduce a negative volume or false new data, as we do not impose any heuristic assumption (e.g. watertight mesh). Moreover, our method does not introduce new geometric inconsistencies, guaranteeing inconsistency-free outcome.

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