Measuring leg muscle and fat mass in humans: comparison of CT and dual-energy X-ray absorptiometry

2000 ◽  
Vol 88 (2) ◽  
pp. 452-456 ◽  
Author(s):  
James A. Levine ◽  
Lana Abboud ◽  
Mitchel Barry ◽  
Judd E. Reed ◽  
Patrick F. Sheedy ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Soft Tissue ◽  
Fat Mass ◽  
Multislice Ct ◽  
Dual Energy ◽  
Fat Free Mass ◽  
Thigh Muscle ◽  
Muscle Area ◽  
X Ray ◽  
Leg Muscle

Dual-energy X-ray absorptiometry (DEXA) is reported to be inferior to computed tomography (CT) to measure changes in appendicular soft tissue composition. We compared CT- and DEXA-measured thigh muscle and fat mass to evaluate the random and systematic discrepancies between these two methods. Thigh skeletal muscle area (single-slice CT) was suboptimally ( r 2= 0.74, P < 0.0001) related to DEXA-measured thigh fat-free mass (FFM). In contrast, thigh muscle and adipose tissue volumes (multislice CT) were highly related to DEXA-measured thigh FFM and fat (both r 2 = 0.96, P < 0.0001). DEXA-measured leg fat was significantly less than multislice-CT-measured leg adipose tissue volume, whereas multislice-CT-measured leg muscle mass was less ( P < 0.0001) than DEXA-measured leg FFM. The systematic discrepancies between the two approaches were consistent with the 10–15% nonfat components of adipose tissue. In conclusion, CT and DEXA measures of appendicular soft tissue are highly related. Systematic differences between DEXA and CT likely relate to the underlying principles of the techniques.

Fat-free mass and fat mass reference values by dual-energy X-ray absorptiometry (DEXA) in a 20–80 year-old Italian population

2008 ◽  
Vol 27 (1) ◽  
pp. 87-94 ◽  
Author(s):  
Alessandra Coin ◽  
Giuseppe Sergi ◽  
Nadia Minicuci ◽  
Sandro Giannini ◽  
Elisa Barbiero ◽  
...  
Keyword(s):  
Fat Mass ◽  
Reference Values ◽  
Dual Energy ◽  
Fat Free Mass ◽  
Italian Population ◽  
X Ray

scholarly journals Fat and Fat-Free Mass of Preterm and Term Infants from Birth to Six Months: A Review of Current Evidence

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 288 ◽  
Author(s):  
Constanze Hamatschek ◽  
Efrah I. Yousuf ◽  
Lea Sophie Möllers ◽  
Hon Yiu So ◽  
Katherine M. Morrison ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Fat Mass ◽  
Infant Nutrition ◽  
Dual Energy ◽  
Fat Free Mass ◽  
Current Evidence ◽  
Term Infants ◽  
Air Displacement Plethysmography ◽  
X Ray ◽  
Postmenstrual Age

To optimize infant nutrition, the nature of weight gain must be analyzed. This study aims to review publications and develop growth charts for fat and fat-free mass for preterm and term infants. Body composition data measured by air displacement plethysmography (ADP) and dual energy X-ray absorptiometry (DXA) in preterm and term infants until six months corrected age were abstracted from publications (31 December 1990 to 30 April 2019). Age-specific percentiles were calculated. ADP measurements were used in 110 studies (2855 preterm and 22,410 term infants), and DXA was used in 28 studies (1147 preterm and 3542 term infants). At term age, preterm infants had higher percent-fat than term-born infants (16% vs. 11%, p < 0.001). At 52 weeks postmenstrual age (PMA), both reached similar percent-fat (24% vs. 25%). In contrast, at term age, preterm infants had less fat-free mass (2500 g vs. 2900 g) by 400 g. This difference decreased to 250 g by 52 weeks, and to 100 g at 60 weeks PMA (5000 g vs. 5100 g). DXA fat-free mass data were comparable with ADP. However, median percent-fat was up to 5% higher with DXA measurements compared with ADP with PMA > 50 weeks. There are methodological differences between ADP and DXA measures for infants with higher fat mass. The cause of higher fat mass in preterm infants at term age needs further investigation.

scholarly journals Body composition in older community-dwelling adults with hip fracture: portable field methods validated by dual-energy X-ray absorptiometry

2012 ◽  
Vol 109 (7) ◽  
pp. 1219-1229 ◽  
Author(s):  
Anthony M. Villani ◽  
Michelle Miller ◽  
Ian D. Cameron ◽  
Susan Kurrle ◽  
Craig Whitehead ◽  
...  
Keyword(s):  
Body Composition ◽  
Hip Fracture ◽  
Dual Energy ◽  
Community Dwelling ◽  
Fat Free Mass ◽  
Muscle Area ◽  
Field Methods ◽  
Predictive Equations ◽  
X Ray ◽  
Post Surgery

Ageing is associated with weight loss and subsequently poor health outcomes. The present study assessed agreement between two field methods, bioelectrical impedance spectroscopy (BIS) and corrected arm muscle area (CAMA) for assessment of body composition against dual-energy X-ray absorptiometry (DXA), the reference technique. Agreement between two predictive equations estimating skeletal muscle mass (SMM) from BIS against SMM from DXA was also determined. Assessments occurred at baseline < 14 d post-surgery (n 79), and at 6 months (6M; n 75) and 12 months (12M; n 63) in community-living older adults after surgical treatment for hip fracture. The 95 % limits of agreement (LOA) between BIS and DXA, CAMA and DXA and the equations and DXA were assessed using Bland–Altman analyses. Mean bias and LOA for fat-free mass (FFM) between BIS and DXA were: baseline, 0·7 ( − 10·9, 12·4) kg; 6M, − 0·5 ( − 20·7, 19·8) kg; 12M, 0·1 ( − 8·7, 8·9) kg and for SMM between CAMA and DXA were: baseline, 0·3 ( − 11·7, 12·3) kg; 6M, 1·3 ( − 4·5, 7·1) kg; 12M, 0·9 ( − 5·4, 7·2) kg. Equivalent data for predictive equations against DXA were: equation 1: baseline, 15·1 ( − 9·5, 20·6) kg; 6M, 17·1 ( − 12·0, 22·2) kg; 12M, 17·5 ( − 13·0, 22·0) kg; equation 2: baseline, 12·6 ( − 7·3, 19·9) kg; 6M, 14·4 ( − 9·7, 19·1) kg; 12M, 14·8 ( − 10·7, 18·9) kg. Proportional bias (BIS: β = − 0·337, P< 0·001; CAMA: β = − 0·294, P< 0·001) was present at baseline but not at 6M or 12M. Clinicians should be cautious in using these field methods to predict FFM and SMM, particularly in the acute care setting. New predictive equations would be beneficial.

scholarly journals Comparison of Dual-Energy X-Ray Absorptiometry (DXA) versus a Multi-frequency Bioelectrical Impedance (InBody 770) Device for Body Composition Assessment after a 4-Week Hypoenergetic Diet

2019 ◽  
Vol 4 (2) ◽  
pp. 23 ◽  
Author(s):  
Antonio ◽  
Kenyon ◽  
Ellerbroek ◽  
Carson ◽  
Burgess ◽  
...  
Keyword(s):  
Body Composition ◽  
Energy Intake ◽  
Body Fat ◽  
Fat Mass ◽  
Bioelectrical Impedance ◽  
Dual Energy ◽  
Fat Free Mass ◽  
Percent Body Fat ◽  
Men And Women ◽  
X Ray

The purpose of this investigation was to compare two different methods of assessing body composition (i.e., a multi-frequency bioelectrical impedance analysis (MF-BIA) and dual-energy x-ray absorptiometry (DXA)) over a four-week treatment period in exercise-trained men and women. Subjects were instructed to reduce their energy intake while maintaining the same exercise regimen for a period of four weeks. Pre and post assessments for body composition (i.e., fat-free mass, fat mass, percent body fat) were determined via the MF-BIA and DXA. On average, subjects reduced their energy intake by ~18 percent. The MF-BIA underestimated fat mass and percentage body fat and overestimated fat-free mass in comparison to the DXA. However, when assessing the change in fat mass, fat-free mass or percent body fat, there were no statistically significant differences between the MF-BIA vs. DXA. Overall, the change in percent body fat using the DXA vs. the MF-BIA was −1.3 ± 0.9 and −1.4 ± 1.8, respectively. Our data suggest that when tracking body composition over a period of four weeks, the MF-BIA may be a viable alternative to the DXA in exercise-trained men and women.

scholarly journals Identification of and Associations among Low, Middle, and High Body Composition Trajectories from Age 5- to 17-Years

Children ◽  
2020 ◽  
Vol 7 (10) ◽  
pp. 192
Author(s):  
Teresa A. Marshall ◽  
Alexandra M. Curtis ◽  
Joseph E. Cavanaugh ◽  
John J. Warren ◽  
Steven M. Levy
Keyword(s):  
Body Composition ◽  
Body Fat ◽  
Fat Mass ◽  
Dual Energy ◽  
Fat Free Mass ◽  
Clinical Settings ◽  
Fat Mass Index ◽  
X Ray ◽  
Body Composition Measure ◽  
Dxa Scans

Our objective was to identify sex-specific age 5- to 17-year body composition (body mass index (BMI), % body fat, fat mass index, fat-free mass index) trajectories, compare trajectories assigned using age 5 (AGE5) data to those assigned using all available (ALL) data, and compare BMI assignments to other body composition assignments. Cluster analysis was used to identify low, medium, and high trajectories from body composition measures obtained from dual energy x-ray absorptiometry (DXA) scans at 5, 9, 11, 13, 15, and 17 years in a birth cohort followed longitudinally (n = 469). Moderate agreement was observed for comparisons between AGE5 data and ALL data cluster assignments for each body composition measure. Agreement between cluster assignments for BMI and other body composition measures was stronger using ALL data than using AGE5 data. Our results suggest that BMI, % body fat, fat mass index, and fat free mass index trajectories are established during early childhood, and that BMI is a reasonable predictor of body composition appropriate to track obesity in public health and clinical settings.

Limb fat-free mass and fat mass reference values by dual-energy X-ray absorptiometry (DEXA) in a 20–80 year-old italian population

2012 ◽  
Vol 31 (4) ◽  
pp. 506-511 ◽  
Author(s):  
Alessandra Coin ◽  
Sandro Giannini ◽  
Nadia Minicuci ◽  
Giulia Rinaldi ◽  
Mario Pedrazzoni ◽  
...  
Keyword(s):  
Fat Mass ◽  
Reference Values ◽  
Dual Energy ◽  
Fat Free Mass ◽  
Italian Population ◽  
X Ray

scholarly journals Validation of foot-to-foot bioelectrical impedance analysis with dual-energy X-ray absorptiometry in the assessment of body composition in young children: the EarlyBird cohort

2006 ◽  
Vol 96 (6) ◽  
pp. 1163-1168 ◽  
Author(s):  
Joanne Hosking ◽  
Brad S. Metcalf ◽  
Alison N. Jeffery ◽  
Linda D. Voss ◽  
Terence J. Wilkin
Keyword(s):  
Body Composition ◽  
Young Children ◽  
Fat Mass ◽  
Bioelectrical Impedance Analysis ◽  
Large Scale ◽  
Bioelectrical Impedance ◽  
Impedance Analysis ◽  
Dual Energy ◽  
Fat Free Mass ◽  
X Ray

Foot-to-foot bioelectrical impedance analysis (BIA) is simple and non-invasive, making it particularly suitable for use in children. There is insufficient evidence of the validity of foot-to-foot BIA compared with dual-energy X-ray absorptiometry (DEXA) as the criterion method in healthy young children. Our objective was to assess the validity of foot-to-foot BIA against DEXA in a large cohort of healthy young children. Body composition was measured by foot-to-foot BIA and DEXA in 203 children (mean age 8·9 (sd0·3) years). Bland–Altman and simple linear regression analyses were used to determine agreement between methods. BIA overestimated fat-free mass by a mean of 2·4 % in boys and 5·7 % in girls, while fat mass was underestimated by 6·5 % in boys and 10·3 % in girls. The percentage fat recorded by BIA was, accordingly, also lower than by DEXA (boys 4·8 %; girls 12·8 %). In boys, however, there were correlations between the size of the difference between methods and the size of the measure under consideration such that in smaller boys fat-free mass was underestimated (r − 0·57;P < 0·001) while fat mass and percentage fat were overestimated (r0·74 for fat mass;r0·69 for percentage fat; bothP < 0·001) with the reverse in bigger boys. Mean differences between techniques were greater in the girls than in the boys but in boys only, the direction of the differences was dependent upon the size of the child. Therefore, BIA may be useful for large-scale studies but is not interchangeable with DEXA and should be interpreted with caution in individuals.

Acute Feeding Has Minimal Effect on the Validity of Body Composition and Metabolic Measures: Dual Energy X-ray Absorptiometry and a Multi-compartment Model

2021 ◽  
pp. 1-39
Author(s):  
Abbie E. Smith-Ryan ◽  
Gabrielle J. Brewer ◽  
Lacey M. Gould ◽  
Malia N.M. Blue ◽  
Katie R. Hirsch ◽  
...  
Keyword(s):  
Body Composition ◽  
Measurement Error ◽  
Fat Mass ◽  
Total Error ◽  
Resting Metabolic Rate ◽  
Compartment Model ◽  
Total Sample ◽  
Dual Energy ◽  
Fat Free Mass ◽  
X Ray

Abstract Understanding the effects of acute feeding on body composition and metabolic measures is essential to the translational component and practical application of measurement and clinical use. To investigate the influence of acute feeding on the validity of dual energy x-ray absorptiometry (DXA), a four-compartment model (4C), and indirect calorimetry metabolic outcomes, 39 healthy young adults (n=19 females; age: 21.8± 3.1 yrs, weight; 71.5 ± 10.0 kg) participated in a randomized cross-over study. Subjects were provided one of four randomized meals on separate occasions (high carbohydrate, high protein, ad libitum or fasted baseline) prior to body composition and metabolic assessments. Regardless of macronutrient content, acute feeding increased DXA percent body fat (%fat) for the total sample and females [average constant error (CE):-0.30%; total error (TE): 2.34%), although not significant (p=0.062); the error in males was minimal (CE: 0.11%; TE: 0.86%). DXA fat mass (CE: 0.26 kg; TE: 0.75 kg), lean mass (CE: 0.83 kg; TE: 1.23 kg) were not altered beyond measurement error for the total sample. 4C %fat was significantly impacted from all acute feedings (avg CE: 0.46%; TE: 3.7%). 4C fat mass (CE: 0.71 kg; TE: 3.38 kg) and fat-free mass (CE: 0.55 kg; TE: 3.05 kg) exceeded measurement error for the total sample. Resting metabolic rate was increased for each feeding condition (TE: 398.4 kcal/d). Standard pre-testing fasting guidelines may be important when evaluating DXA and 4C %fat, whereas additional DXA variables (FM, LM) may not be significantly impacted by an acute meal. Measuring body composition via DXA under less stringent pre-testing guidelines may be valid and increase feasibility of testing in clinical settings.

scholarly journals Comparisons of a Multi-Frequency Bioelectrical Impedance Analysis to the Dual-Energy X-Ray Absorptiometry Scan in Healthy Young Adults Depending on their Physical Activity Level

2015 ◽  
Vol 47 (1) ◽  
pp. 73-80 ◽  
Author(s):  
Julien Verney ◽  
Chloé Schwartz ◽  
Saliha Amiche ◽  
Bruno Pereira ◽  
David Thivel
Keyword(s):  
Physical Activity ◽  
Young Adults ◽  
Body Composition ◽  
Fat Mass ◽  
Physical Activity Level ◽  
Bioelectrical Impedance ◽  
Dual Energy ◽  
Activity Level ◽  
Fat Free Mass ◽  
X Ray

AbstractThis study aimed at comparing BIA and DXA results in assessing body composition in young adults depending on their physical activity level. Eighty healthy 19-30 years old subjects were enrolled and their body composition (Fat Mass and Fat-Free Mass) was assessed by dual-energy X-ray absorptiometry (DXA) and by a newly developed Bioelectrical Impedance Analyzer (BIA - Tanita MC780). A seven-day physical activity level was assessed using a 3-axial accelerometer. DXA-FM% and BIA-FM% were correlated (p<0.001; r= 0.852; ICC [IC95%]: 0.84 [0.75 – 0.90]; concordance coefficient: 0.844). DXA-FFM and BIA FFM were correlated (p<0.001; r=0.976; ICC [IC95%]: 0.95 [0.93 – 0.97], concordance coefficient: 0.955). DXA and BIA measurements of FM% and FFM were highly correlated in both boys and girls regardless of the physical activity level. Compared with DXA scans, newly developed bioelectrical impedance analyzers provide satisfactory fat mass and lean mass measures in healthy young women and men, despite their physical activity level.

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