Circulating angiogenic cell population responses to 10 days of reduced physical activity

Circulating angiogenic cells (CACs) are a diverse group that have been identified as predictors of cardiovascular health and are inversely proportional to cardiovascular disease (CVD) outcomes. Inactivity is a growing concern in industrialized nations and is an independent risk factor for CVD. There is limited evidence regarding the impact of reduced physical activity (rPA) on different CAC populations. The purpose of this study was to evaluate the effect of objectively monitored rPA with maintained energy balance on two CAC populations (CFU and CD34+cells), intracellular nitric oxide (NOi), and genes related to NO production in active, healthy men. Participants (age 25 ± 2.9 yr) refrained from structured physical activity for 10 days, which was reflected by a significant reduction in time in vigorous + very vigorous intensity activity ( P = 0.03). Sedentary time tended to increase ( P = 0.06) with rPA. CFU CACs have been characterized as mainly monocytic and lymphocytic cells. We found significant reductions in both the number of CFU CACs (−35.69%, P = 0.01) and CFU CAC NOi (−33.84%, P = 0.03). Neither NOi nor the number of CD34+cells, which are hematopoietic and endothelial progenitors, changed with rPA. We found no significant differences in NO-related gene expression or oxidative stress-related gene expression with rPA in either CAC type. Therefore, we conclude that although various CAC populations have been related to vascular health, regular physical activity is necessary to maintain CAC NOi and the vulnerability of CACs to short-term reductions in physical activity is population specific.

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The Impact of Long‐Term Physical Activity on Age‐Related Changes in Protein and Gene Expression

The FASEB Journal ◽

10.1096/fasebj.22.1_supplement.1163.21 ◽

2008 ◽

Vol 22 (S1) ◽

Author(s):

Ian R Lanza ◽

Daniel K Short ◽

Kevin R Short ◽

Yan W Asmann ◽

Sreekumar Raghavakaimal ◽

...

Keyword(s):

Gene Expression ◽

Physical Activity ◽

Age Related ◽

The Impact ◽

Age Related Changes

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The Impact of the COVID-19 Pandemic on Psychological Distress, Physical Activity, and Symptom Severity in Parkinson’s Disease

Journal of Parkinson s Disease ◽

10.3233/jpd-202251 ◽

2020 ◽

Vol 10 (4) ◽

pp. 1355-1364 ◽

Cited By ~ 1

Author(s):

Anouk van der Heide ◽

Marjan J. Meinders ◽

Bastiaan R. Bloem ◽

Rick C. Helmich

Keyword(s):

Physical Activity ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Psychological Distress ◽

Symptom Severity ◽

Neuropsychiatric Symptoms ◽

Lifestyle Changes ◽

Personality Factors ◽

Reduced Physical Activity ◽

The Impact

Background: The ongoing COVID-19 pandemic has many consequences for people with Parkinson’s disease (PD). Social distancing measures complicate regular care and result in lifestyle changes, which may indirectly cause psychological stress and worsening of PD symptoms. Objective: To assess whether the COVID-19 pandemic was associated with increased psychological distress and decreased physical activity in PD, how these changes related to PD motor and non-motor symptom severity, and what frequency and burden of COVID-related stressors were. Methods: We sent an online survey to the Personalized Parkinson Project (PPP) cohort (n = 498 PD patients) in the Netherlands. In the survey, we distinguished between COVID-related stressor load, psychological distress, PD symptom severity, and physical activity. We related inter-individual differences to personality factors and clinical factors collected before the pandemic occurred. Results: 358 PD patients completed the survey between April 21 and May 25, 2020 (response rate 71.9%). Patients with higher COVID-related stressor load experienced more PD symptoms, and this effect was mediated by the degree of psychological distress. 46.6% of PD patients were less physically active since the COVID-19 pandemic, and reduced physical activity correlated with worse PD symptoms. Symptoms that worsened most were rigidity, fatigue, tremor, pain and concentration. Presence of neuropsychiatric symptoms (anxiety, depression) before the pandemic, as well as cognitive dysfunction and several personality traits predicted increased psychological distress during the COVID-19 pandemic. Conclusion: Our findings show how an external stressor (the COVID-19 pandemic) leads to a worsening of PD symptoms by evoking psychological distress as well as lifestyle changes (reduced physical activity).

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Effects of Exercise Training on the Paracrine Function of Circulating Angiogenic Cells

International Journal of Sports Medicine ◽

10.1055/a-1273-8390 ◽

2020 ◽

Author(s):

William S. Evans ◽

Ryan M. Sapp ◽

Katherine I. Kim ◽

James M. Heilman ◽

James Hagberg ◽

...

Keyword(s):

Exercise Training ◽

Cardiovascular Health ◽

Aerobic Exercise Training ◽

Angiogenic Potential ◽

Circulating Angiogenic Cells ◽

Secreted Factors ◽

Circulating Angiogenic Cell ◽

Heterogenous Population ◽

Future Work

AbstractExercise training has various benefits on cardiovascular health, and circulating angiogenic cells have been proposed as executing these changes. Work from the late 1990s supported an important role of these circulating post-natal cells in contributing to the maintenance and repair of the endothelium and vasculature. It was later found that circulating angiogenic cells were a heterogenous population of cells and primarily functioned in a paracrine manner by adhering to damaged endothelium and releasing growth factors. Many studies have discovered novel circulating angiogenic cell secreted proteins, microRNA and extracellular vesicles that mediate their angiogenic potential, and some studies have shown that both acute and chronic aerobic exercise training have distinct benefits. This review highlights work establishing an essential role of secreted factors from circulating angiogenic cells and summarizes studies regarding the effects of exercise training on these factors. Finally, we highlight the various gaps in the literature in hopes of guiding future work.

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β-Carotene-9′,10′-Oxygenase Status Modulates the Impact of Dietary Tomato and Lycopene on Hepatic Nuclear Receptor–, Stress-, and Metabolism-Related Gene Expression in Mice

Journal of Nutrition ◽

10.3945/jn.113.186676 ◽

2014 ◽

Vol 144 (4) ◽

pp. 431-439 ◽

Cited By ~ 24

Author(s):

Hsueh-Li Tan ◽

Nancy E. Moran ◽

Morgan J. Cichon ◽

Ken M. Riedl ◽

Steven J. Schwartz ◽

...

Keyword(s):

Gene Expression ◽

Nuclear Receptor ◽

Related Gene ◽

The Impact ◽

Β Carotene

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Placenta nutrient transport-related gene expression: the impact of maternal obesity and excessive gestational weight gain

The Journal of Maternal-Fetal & Neonatal Medicine ◽

10.3109/14767058.2015.1049522 ◽

2015 ◽

Vol 29 (9) ◽

pp. 1399-1405 ◽

Cited By ~ 12

Author(s):

Kendra Elizabeth Brett ◽

Zachary Michael Ferraro ◽

Martin Holcik ◽

Kristi Bree Adamo

Keyword(s):

Gene Expression ◽

Weight Gain ◽

Gestational Weight Gain ◽

Maternal Obesity ◽

Nutrient Transport ◽

Related Gene ◽

Gestational Weight ◽

Excessive Gestational Weight Gain ◽

The Impact

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The Impact of Web-Based Feedback on Physical Activity and Cardiovascular Health of Nurses Working in a Cardiovascular Setting: A Randomized Trial

Frontiers in Physiology ◽

10.3389/fphys.2018.00142 ◽

2018 ◽

Vol 9 ◽

Cited By ~ 10

Author(s):

Jennifer L. Reed ◽

Christie A. Cole ◽

Madeleine C. Ziss ◽

Heather E. Tulloch ◽

Jennifer Brunet ◽

...

Keyword(s):

Physical Activity ◽

Randomized Trial ◽

Cardiovascular Health ◽

Web Based ◽

The Impact

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P095 The impact of COVID-19 lockdown on clinical care, self-management, and mental health in patients with inflammatory arthritis

Rheumatology ◽

10.1093/rheumatology/keab247.093 ◽

2021 ◽

Vol 60 (Supplement_1) ◽

Author(s):

Melissa Sweeney ◽

Lewis Carpenter ◽

Savia de Souza ◽

Hema Chaplin ◽

Hsiu Tung ◽

...

Keyword(s):

Mental Health ◽

Physical Activity ◽

Emotional Distress ◽

Inflammatory Arthritis ◽

Clinical Care ◽

Self Management ◽

Disease Outcomes ◽

Reduced Physical Activity ◽

Vas Scores ◽

The Impact

Abstract Background/Aims COVID-19 lockdown affected access to clinical care for many vulnerable patients, including those with inflammatory arthritis (IA). It also had the potential to alter self-management behaviours. These changes could in turn impact mental health, especially given that IA patients are already at higher risk of mental health disorders. Thus, the aims of this study were to determine how IA care and self-management were affected by lockdown and assess the impact of these changes on disease outcomes and mental health. Methods Online questionnaires were completed by 338 participants between June and July 2020. The questionnaires assessed demographics, IA condition, IA self-management, COVID-19 clinical information, quality of life, and mental health. Visual analogue scale (VAS) scores for patient global assessment (PGA) of disease activity, pain, fatigue, and emotional distress were completed relating to the previous week and retrospectively for pre-lockdown (March) and early-lockdown (April). Improvement/worsening in each VAS was considered as a change of 10 points or more from pre-lockdown to the current rating. Linear regressions were conducted to determine factors associated with worse outcomes, controlling for potential confounders including self-reported pre-lockdown status. Results Mean VAS scores worsened during lockdown for all outcome measures, with over half reporting a more than 10-point worsening (Table 1). Changes to clinical care affected 87% of patients. The most commonly affected services were hospital outpatient appointments (77%), GP appointments (59%), and blood tests (53%). Changes to clinical care were significantly associated with worse PGA (b = 8.95, p=0.01), pain (b = 7.13, p=0.05), fatigue (b = 17.01, p<0.00) and emotional distress (b = 12.78, p<0.01). Regarding self-management, 64% of patients reported changes to diet while 51% reduced physical activity. Change in diet was not significantly associated with any of the outcomes, whereas physical activity was associated with PGA (b=-2.42, p<0.01), pain (b=-2.43, p<0.01), fatigue (b=-2.5, p < 0.01), and emotional distress (b=-2.41, p<0.01). Conclusion Most patients (87%) had at least one area of clinical care affected by the lockdown. These changes in IA clinical care were associated with worse disease outcomes across all measures and greater emotional distress. In self-management, reduced physical activity was associated with worse outcomes in all physical and mental health measures. P095 Table 1:Mean VAS (0-100) scores and percent changesPGAMarch April June/JulyMean (SD) 44.51 (23.70) 53.18 (24.67) 57.69 (25.29)Better Same WorsePercent 7.9936.6855.33[95% CI] [5.33-11.41][31.54-42.07][49.85-60.71]PainMarch April June/July42.60 (25.60) 51.11 (26.01) 56.66 (26.40)Better Same Worse7.6937.8754.44[5.09-11.07] [32.68-43.28][48.96-59.84]FatigueMarch April June/July46.86 (26.17) 57.11 (25.83) 61.35 (26.51)Better Same Worse10.0634.0255.92[7.07-13.77] [28.98-39.35][50.44-61.29]Emotional DistressMarch April June/July30.96 (26.28) 49.06 (29.09) 48.75 (29.15)Better Same Worse8.2833.14 58.58[5.58-11.75] [28.14-38.43][53.12-63.88] Disclosure M. Sweeney: None. L. Carpenter: None. S. de Souza: None. H. Chaplin: None. H. Tung: None. E. Caton: None. J. Galloway: None. A. Cope: None. M. Yates: None. S. Norton: None.

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Examining the impact of a community-based exercise intervention on cardiorespiratory fitness, cardiovascular health, strength, flexibility and physical activity among adults living with HIV: A three-phased intervention study

PLoS ONE ◽

10.1371/journal.pone.0257639 ◽

2021 ◽

Vol 16 (9) ◽

pp. e0257639

Author(s):

Kelly K. O’Brien ◽

Aileen M. Davis ◽

Soo Chan Carusone ◽

Lisa Avery ◽

Ada Tang ◽

...

Keyword(s):

Physical Activity ◽

Blood Pressure ◽

Cardiovascular Health ◽

Intervention Study ◽

Phase 1 ◽

Community Based ◽

Phase 3 ◽

Living With Hiv ◽

The Impact

Purpose Our aim was to examine the impact of a community-based exercise (CBE) intervention on cardiorespiratory fitness, cardiovascular health, strength, flexibility, and physical activity outcomes among adults living with HIV. Methods We conducted a longitudinal intervention study with community-dwelling adults living with HIV in Toronto, Canada. We measured cardiopulmonary fitness (V̇O2peak (primary outcome), heart rate, blood pressure), strength (grip strength, vertical jump, back extension, push-ups, curl ups), flexibility (sit and reach test), and self-reported physical activity bimonthly across three phases. Phase 1 included baseline monitoring (8 months); Phase 2 included the CBE Intervention (6 months): participants were asked to exercise (aerobic, strength, balance and flexibility training) for 90 minutes, 3 times/week, with weekly supervised coaching at a community-based fitness centre; and Phase 3 included follow-up (8 months) where participants were expected to continue with thrice weekly exercise independently. We used segmented regression (adjusted for baseline age and sex) to assess the change in trend (slope) among phases. Our main estimates of effect were the estimated change in slope, relative to baseline values, over the 6 month CBE intervention. Results Of the 108 participants who initiated Phase 1, 80 (74%) started and 67/80 (84%) completed the intervention and 52/67 (77%) completed the study. Most participants were males (87%), with median age of 51 years (interquartile range (IQR): 45, 59). Participants reported a median of 4 concurrent health conditions in addition to HIV (IQR: 2,7). Participants attended a median of 18/25 (72%) weekly supervised sessions. Change in V̇O2peak attributed to the six-month Phase 2 CBE intervention was 0.56 ml/kg/min (95% Confidence Interval (CI): -1.27, 2.39). Significant effects of the intervention were observed for systolic blood pressure (-5.18 mmHg; 95% CI: -9.66, -0.71), push-ups (2.30 additional push-ups; 95% CI: 0.69, 3.91), curl ups (2.89 additional curl ups; 95% CI: 0.61, 5.17), and sit and reach test (1.74 cm; 95% CI: 0.21, 3.28). More participants engaged in self-reported strength (p<0.001) and flexibility (p = 0.02) physical activity at the end of intervention. During Phase 3 follow-up, there was a significant reduction in trend of benefits observed during the intervention phase for systolic blood pressure (1.52 mmHg/month; 95% CI: 0.67, 2.37) and sit and reach test (-0.42 cm/month; 95% CI: -0.68, -0.16). Conclusion Adults living with HIV who engaged in this six-month CBE intervention demonstrated inconclusive results in relation to V̇O2peak, and potential improvements in other outcomes of cardiovascular health, strength, flexibility and self-reported physical activity. Future research should consider features tailored to promote uptake and sustained engagement in independent exercise among adults living with HIV. ClinicalTrials.gov Identifier NCT02794415. https://clinicaltrials.gov/ct2/show/record/NCT02794415.

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