Biliary Sludge: A Risk Factor for ‘Idiopathic’ Pancreatitis?

Idiopathic acute pancreatitis is common. Recent evidence suggests that biliary sludge may be the etiology in many patients with this disorder. In this case-control study, admission ultrasound examinations of patients with idiopathic pancreatitis, patients with acute alcohol-associated pancreatitis and a control group were compared. Biliary sludge was found in seven of 21 patients (33%) with idiopathic pancreatitis, two of 25 (8%) with acute alcohol-associated pancreatitis and one of 63 controls (1.6%). Comparison of idiopathic pancreatitis patients with both acute alcohol-associated pancreatitis patients and controls for the presence of sludge revealed odds ratios of 31.0 (95% CI 3.5 to 273) and 5.8 (95% CI 1.1 to 32.0), respectively. Also observed was a trend towards higher levels of liver enzymes, bilirubin and amylase in patients with idiopathic pancreatitis who had sludge identified. This study provides further evidence linking biliary sludge with a significant proportion of patients with idiopathic acute pancreatitis.

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Familial, Social and Environmental Risk Factors in Autism: A Case-Control Study

Bangladesh Medical Research Council Bulletin ◽

10.3329/bmrcb.v40i3.25233 ◽

2015 ◽

Vol 40 (3) ◽

pp. 113-117 ◽

Cited By ~ 2

Author(s):

A Jahan ◽

SZR Rezina Parvin ◽

D Bugum

Keyword(s):

Risk Factors ◽

Environmental Risk ◽

Case Control Study ◽

Significant Proportion ◽

Case Control ◽

Delay Group ◽

Environmental Risk Factors ◽

Control Group ◽

Autism Group ◽

Control Study

This case-control study was done to identify the correlation between the familial, social and environmental risk factors and autism. This hospital and specialized centre based study done from January 2002 to November, 2004. Thirty two children from the autism group and 14 children from the control group were enrolled. Mean age were 3.75 yrs. and 2.83 yrs. respectively. Significant proportion of children were in the highest birth orders, 68.8% in autism and 78.6% in the control group. Full term children were 96.9% and 92.9% respectively. 53.1% children in the autism and 57.1% in the normal speech delay group were born by cesarean sections. Higher education of parents in autism group was statistically significant (p<0.05). Too much watching TV, inadequate opportunity to mix with peers and inadequate interactive relationship with the family members in the early childhood were significantly (p= 0.001) related to the development of autism.Bangladesh Med Res Counc Bull 2014; 40 (3): 113-117

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Metabolic Syndrome Components and Acute pancreatitis: A Case-Control Study in China

10.21203/rs.3.rs-45027/v1 ◽

2020 ◽

Author(s):

zhemin Shen ◽

Xueqiao Wang ◽

Zili Zhen ◽

Yao Wang ◽

Peilong Sun

Keyword(s):

Metabolic Syndrome ◽

Acute Pancreatitis ◽

Incidence Rate ◽

Case Control Study ◽

Case Control ◽

Control Group ◽

Inflammatory Disorder ◽

The Metabolic Syndrome ◽

Metabolic Syndrome Components ◽

Control Study

Abstract Background: Acute pancreatitis (AP) is a common inflammatory disorder of pancreas. Recent evidence has shown that metabolic syndrome was positively correlated with the severity of AP. However, only few studies have revealed the relationship between metabolic syndrome and the occurrence of AP. We therefore elucidated the association between the metabolic syndrome components and the incidence rate of AP. Methods: A hospital-based case-control study was conducted. 705 patients admitted to our hospital from January 2016 to December 2018 were included in the study. Subjects were divided into case and control group according to their diagnosis: (1) According to the revised Atlanta classification from 2012, patients diagnosed as AP were enrolled into case group. (2) Patients without history of AP or any disease related to metabolic syndrome were allocated into control group. Controls were matched to cases individually by sex and age (control/case ratio=1). Risk factors were determined by univariate and multivariate logistic regression analyses. Results: The incidence rate of metabolic syndrome with AP patients was 30.9%, which was more frequent than controls (13.2%) (OR=2.975; 95%CI 1.947-4.548, p<0.001). In multivariate regression analysis, histories of smoking or alcohol drinking, biliary stone were important predictors of AP. Besides, occurrence of AP was significantly associated with total cholesterol (TC) (OR=1.831; 95%CI 1.137-2.948, p=0.013), triglyceride (TG) (OR=2.058; 95%CI 1.332-3.179, p=0.001), fasting plasma glucose (FPG) (OR =2.345; 95%CI 1.395-3.940, p=0.001), as well as low values of apolipoprotein A (Apo A) (OR =0.247; 95%CI 0.146-0.416, p<0.001). Conclusion: Metabolic syndrome and its components portend high risks of occurrence of AP.

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Metabolic Syndrome Components and Acute Pancreatitis: A Case-Control Study in China

10.21203/rs.3.rs-45027/v3 ◽

2020 ◽

Author(s):

Zhemin Shen ◽

Xueqiao Wang ◽

Zili Zhen ◽

Yao Wang ◽

Peilong Sun

Keyword(s):

Metabolic Syndrome ◽

Acute Pancreatitis ◽

Case Control Study ◽

Case Control ◽

Control Group ◽

Case Group ◽

Inflammatory Disorder ◽

Biliary Stones ◽

History Of ◽

Control Study

Abstract Background: Acute pancreatitis (AP) is a common inflammatory disorder of the pancreas. Recent evidence has shown that metabolic syndrome is positively correlated with the severity of AP. However, only a few studies have revealed the relationship between metabolic syndrome and the occurrence of AP. We therefore elucidated the association between metabolic syndrome and the occurrence of AP. Methods: A hospital-based case-control study was conducted. A total of 705 patients admitted to our hospital from January 2016 to December 2018 were included in the study. Subjects were divided into case and control groups according to their diagnosis: (1) According to the revised Atlanta classification from 2012, patients diagnosed with AP were enrolled in the case group. (2) Patients without a history of AP or any disease related to metabolic syndrome were allocated into the control group. Controls were matched to cases individually by sex and age (control/case ratio=1). Results: The incidence rate of metabolic syndrome in AP patients was 30.9%, which was more frequent than that in controls (13.2%) (OR=2.837; 95% CI 1.873-4.298, p<0.001). In the multivariate regression analysis, a history of smoking or alcohol consumption and biliary stones were significantly associated with AP (OR=2.441; 95% CI 1.865-5.172, p<0.001; OR=1.777; 95% CI 1.060-2.977, p=0.029; OR=28.995; 95% CI 13.253-63.435, p<0.001). In addition, the occurrence of AP was significantly associated with total cholesterol (TC) (OR=1.992; 95% CI 1.246-3.183, p=0.004), triglyceride (TG) (OR=2.134; 95% CI 1.403-3.245, p<0.001), hyperglycaemia (OR=2.261; 95% CI 1.367-3.742, p=0.001), and apolipoprotein A (Apo A) (OR=0.270; 95% CI 0.163-0.447, p<0.001). Conclusions: Metabolic syndrome and its components were associated with AP occurrence.

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LIFEStyle, Prevention and Risk of Acute PaNcreatitis (LIFESPAN): protocol of a multicentre and multinational observational case–control study

BMJ Open ◽

10.1136/bmjopen-2019-029660 ◽

2020 ◽

Vol 10 (1) ◽

pp. e029660 ◽

Cited By ~ 1

Author(s):

Balázs Koncz ◽

Erika Darvasi ◽

Dalma Erdősi ◽

Andrea Szentesi ◽

Katalin Márta ◽

...

Keyword(s):

Acute Pancreatitis ◽

Case Control Study ◽

Dietary Habits ◽

Case Control ◽

Medical Community ◽

Control Group ◽

Case Group ◽

Control Groups ◽

Link Type ◽

Control Study

IntroductionAcute pancreatitis (AP) is a life-threatening inflammatory disease of the exocrine pancreas which needs acute hospitalisation. Despite its importance, we have significant lack of knowledge whether the lifestyle factors elevate or decrease the risk of AP or influence the disease outcome. So far, no synthetising study has been carried out examining associations between socioeconomic factors, dietary habits, physical activity, chronic stress, sleep quality and AP. Accordingly, LIFESPAN identifies risk factors of acute pancreatitis and helps to prepare preventive recommendations for lifestyle elements.Methods and analysisLIFESPAN is an observational, multicentre international case–control study. Participating subjects will create case and control groups. The study protocol was designed according to the SPIRIT guideline. Patients in the case group (n=1700) have suffered from AP (alcohol-induced, n=500; biliary, n=500; hypertriglyceridemiainduced, n=200; other, n=500); the control group subjects have no AP in their medical history. Our study will have three major control groups (n=2200): hospital-based (n=500), population-based (n=500) and aetiology-based (alcohol, n=500; biliary, n=500 and hypertriglyceridemia, n=200). All of them will be matched to the case group individually by gender, age and location of residence. Aggregately, 3900 subjects will be enrolled into the study. The study participants will complete a complex questionnaire with the help of a clinical research administrator/study nurse. Analysis methods include analysis of the continuous and categorical values.Ethics and disseminationThe study has obtained the relevant ethical approval (54175-2/2018/EKU) and also internationally registered (ISRCTN25940508). After obtaining the final conclusions, we will publish the data to the medical community and will also disseminate our results via open access.Trial registration numberISRCTN25940508; Pre-results.

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A STUDY ON ROLE OF OCTREOTIDE ON OUTCOME OF PATIENTS WITH ACUTE PANCREATITIS

10.36106/gjra/4303162 ◽

2020 ◽

pp. 22-24

Author(s):

Vishal Lodha ◽

Rajesh Sonsale ◽

Sandip Jadhav

Keyword(s):

Acute Pancreatitis ◽

Hospital Stay ◽

Case Control Study ◽

Case Control ◽

Control Group ◽

Care Hospital ◽

Group A ◽

Group B ◽

Control Study

Introduction: Mild pancreatitis is a self limiting disease, while morbidity and mortality is considerably high in cases of severe necrotizing pancreatitis. Octreotide reduces secretion, release and activation of exocrine hormones; there is collection of pancreatic hormones in duct which in return causes irreversible destruction of the exocrine and endocrine pancreatic parenchyma leading to mal-digestion and diabetes. There are lot of controversies in the treatment of acute pancreatitis, so through this study we tried to evaluate whether there is a beneficial role of octreotide or not. Materials and Method: This case control study was done on patients admitted for the treatment of acute pancreatitis at a tertiary care hospital in Central India. This is retrospective study. The data of inpatient records were taken from the medical records department (MRD) of the hospital. The diagnosis of patients was established on basis of biochemical and radiological investigations. The patients were divided into two groups; cases and control, cases had received octreotide along with fluids (group A) controls received fluids without octreotide (group B). Symptomatic treatment was given in both the groups. Ages of the cases and controls were matched (±3 years). The statistical analysis of data was done and results were obtained. Results: In this retrospective case control study the records of fifty two patients were selected. The mean age in Group A was 35 ±16.45 years and in Group B 40±17.51 years in Group B (tA/B1.061; p ˂0.294). There were 22 males and 4 females in group A, while 20 males and 6 females in group B. Both the groups were comparable. All the patients in octreotide group survived while there were three deaths in control group. As far as mean hospital stay is was 10 days ± 7.10 in group A while it was 7 days ±3.65 in group B. All the p values for the criteria of study are non-significant. But when we talk about percentage, 11.53% patient died in control group. Conclusion: In our study we found that octreotide does not affect the final outcome of patients with acute pancreatitis. There is no effect on hospital stay and reduced need of analgesics in patients with acute pancreatitis. Keywords: Acute Pancreatitis; Octreotide; Hospital Stay; Mortality

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Metabolic Syndrome Components and Acute Pancreatitis: A Case-Control Study in China

10.21203/rs.3.rs-45027/v2 ◽

2020 ◽

Author(s):

zhemin Shen ◽

Xueqiao Wang ◽

Zili Zhen ◽

Yao Wang ◽

Peilong Sun

Keyword(s):

Metabolic Syndrome ◽

Acute Pancreatitis ◽

Case Control Study ◽

Case Control ◽

Control Group ◽

Case Group ◽

Inflammatory Disorder ◽

Biliary Stones ◽

History Of ◽

Control Study

Abstract Background: Acute pancreatitis (AP) is a common inflammatory disorder of the pancreas. Recent evidence has shown that metabolic syndrome is positively correlated with the severity of AP. However, only a few studies have revealed the relationship between metabolic syndrome and the occurrence of AP. We therefore elucidated the association between the components of metabolic syndrome and the occurrence of AP. Methods: A hospital-based case-control study was conducted. A total of 705 patients admitted to our hospital from January 2016 to December 2018 were included in the study. Subjects were divided into case and control groups according to their diagnosis: (1) According to the revised Atlanta classification from 2012, patients diagnosed with AP were enrolled in the case group. (2) Patients without a history of AP or any disease related to metabolic syndrome were allocated into the control group. Controls were matched to cases individually by sex and age (control/case ratio=1). Results: The incidence rate of metabolic syndrome in AP patients was 30.9%, which was more frequent than that in controls (13.2%) (OR=2.837; 95% CI 1.873-4.298, p<0.001). In the multivariate regression analysis, a history of smoking or alcohol consumption and biliary stones were significantly associated with AP (OR=2.441; 95% CI 1.865-5.172, p<0.001; OR=1.777; 95% CI 1.060-2.977, p=0.029; OR=28.995; 95% CI 13.253-63.435, p<0.001). In addition, the occurrence of AP was significantly associated with total cholesterol (TC) (OR=1.992; 95% CI 1.246-3.183, p=0.004), triglyceride (TG) (OR=2.134; 95% CI 1.403-3.245, p<0.001), hyperglycaemia (OR=2.261; 95% CI 1.367-3.742, p=0.001), and low values of apolipoprotein A (Apo A) (OR=0.270; 95% CI 0.163-0.447, p<0.001). Conclusions: Metabolic syndrome and its components were associated with AP occurrence.

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Metabolic syndrome components and acute pancreatitis: a case–control study in China

BMC Gastroenterology ◽

10.1186/s12876-020-01579-3 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Zhemin Shen ◽

Xueqiao Wang ◽

Zili Zhen ◽

Yao Wang ◽

Peilong Sun

Keyword(s):

Metabolic Syndrome ◽

Acute Pancreatitis ◽

Case Control Study ◽

Case Control ◽

Control Group ◽

Case Group ◽

Inflammatory Disorder ◽

Biliary Stones ◽

History Of ◽

Control Study

Abstract Background Acute pancreatitis (AP) is a common inflammatory disorder of the pancreas. Recent evidence has shown that metabolic syndrome is positively correlated with the severity of AP. However, only a few studies have revealed the relationship between metabolic syndrome and the occurrence of AP. We therefore elucidated the association between metabolic syndrome and the occurrence of AP. Methods A hospital-based case–control study was conducted. A total of 705 patients admitted to our hospital from January 2016 to December 2018 were included in the study. Subjects were divided into case and control groups according to their diagnosis: (1) According to the revised Atlanta classification from 2012, patients diagnosed with AP were enrolled in the case group. (2) Patients without a history of AP or any disease related to metabolic syndrome were allocated into the control group. Controls were matched to cases individually by sex and age (control/case ratio = 1). Results The incidence rate of metabolic syndrome in AP patients was 30.9%, which was more frequent than that in controls (13.2%) (OR 2.837; 95% CI 1.873–4.298, p < 0.001). In the multivariate regression analysis, a history of smoking or alcohol consumption and biliary stones were significantly associated with AP (OR 2.441; 95% CI 1.865–5.172, p < 0.001; OR 1.777; 95% CI 1.060–2.977, p = 0.029; OR 28.995; 95% CI 13.253–63.435, p < 0.001). In addition, the occurrence of AP was significantly associated with total cholesterol (TC) (OR 1.992; 95% CI 1.246–3.183, p = 0.004), triglyceride (TG) (OR 2.134; 95% CI 1.403–3.245, p < 0.001), hyperglycaemia (OR 2.261; 95% CI 1.367–3.742, p = 0.001), and apolipoprotein A (Apo A) (OR 0.270; 95% CI 0.163–0.447, p < 0.001). Conclusions Metabolic syndrome and its components were associated with AP occurrence.

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Assessment of Craniofacial Morphology in Mouth Breathing Children. A retrospective case-control study

Revista de Chimie ◽

10.37358/rc.19.10.7614 ◽

2019 ◽

Vol 70 (10) ◽

pp. 3649-3653

Author(s):

David Angelescu ◽

Teodora Angelescu ◽

Meda Romana Simu ◽

Alexandrina Muntean ◽

Anca Stefania Mesaros ◽

...

Keyword(s):

Case Control Study ◽

Case Control ◽

Craniofacial Morphology ◽

Respiratory Pattern ◽

Control Group ◽

Upper Lip ◽

Retrospective Case ◽

Oral Breathing ◽

Facial Height ◽

Control Study

The aim of this retrospective case-control study is to determine a possible correlation between breathing mode and craniofacial morphology. The study was carried out in the Department of Pedodontics,Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. The sample comprised 80 patients, age between 6 and 13 years, which were divided in two groups based on respiratory pattern: control group composed of 38 nasal breathing children and case group composed of 42 oral breathing children. Three quantitative craniofacial parameters were measured from the frontal and lateral photos: facial index, lower facial height ratio and upper lip ratio. The statistical analysis showed a significant higher facial index (p=0.006*) and an increase lower facial height (p=0.033*) for the oral breathers group. No differences in facial morphology were found between genders and age groups, when comparing the data between the same type of respiratory pattern children. Spearman�s rho Correlation show a significant positive correlation (p=0.002*) between facial index and lower facial height and a significant negative correlation between facial index and upper lip (p=0,005*). Long faces children are more likely to develop oral breathing in certain conditions, which subsequently have a negative effect on increasing the lower facial height by altering the postural behavior of mandible and tongue.

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Association of Serum Homocysteine Level and Interstitial Lung Disease in Systemic Sclerosis: A Case-control Study

Current Rheumatology Reviews ◽

10.2174/1573397114666180628162907 ◽

2018 ◽

Vol 15 (1) ◽

pp. 74-78

Author(s):

Mohammadali Nazarinia ◽

Asghar Zare ◽

Mohammad javad Fallahi ◽

Mesbah Shams

Keyword(s):

Systemic Sclerosis ◽

Healthy Subjects ◽

Case Control Study ◽

Homocysteine Level ◽

Case Control ◽

Control Group ◽

Lung Involvement ◽

Serum Homocysteine ◽

The Mean ◽

Control Study

Background:Systemic sclerosis is a disorder of connective tissue with unknown cause, affecting the skin and internal organs, characterized by fibrotic changes.Objective:To determine the correlation between serum homocysteine level and interstitial lung involvement in systemic sclerosis. </P><P> Materials and Methods: In this case – control study, 59 patients who fulfilled the ACR/EULAR classification criteria for systemic sclerosis and were referred to Hafez Hospital of Shiraz, Iran, were included as the case group. Fifty nine healthy subjects were involved as the control group. Patients were divided into two groups based on interstitial lung involvement and two subtypes, diffuse and limited type. Serum homocysteine, vitamin B12, and folate levels compared between the controls, and cases groups.Results:Of 59 case and control group, 53 (%89.8) were female and the mean age did not differ in both groups (P=0.929). Thirty five (%59.3) patients had interstitial lung involvement and 38(%64.4) had diffuse cutaneous systemic sclerosis. The mean serum homocysteine level was 13.9±6.3 µmol/L in the case and 13.7±9.2 µmol/L in the control group (P=0.86). The mean serum homocysteine level did not differ between the patients with and without interstitial lung involvement (P=0.52). The patients with lung involvement was older than those without lung involvement (P=0.004). Lung disease was more common in diffuse type (P=0.014).Conclusion:In our study, serum homocysteine level did not differ between the patients and healthy subjects. Also, there was no correlation between serum homocysteine level and lung involvement, but lung involvement was more common in older patients and also diffuse subtype.

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Study of cognitive impairment and genetic polymorphism of SLC41A1 (rs11240569 allele) in Parkinson’s disease in Upper Egypt: case-control study

The Egyptian Journal of Neurology Psychiatry and Neurosurgery ◽

10.1186/s41983-021-00341-0 ◽

2021 ◽

Vol 57 (1) ◽

Author(s):

Hamdy N. El-Tallawy ◽

Tahia H. Saleem ◽

Wafaa M. Farghaly ◽

Heba Mohamed Saad Eldien ◽

Ashraf Khodaery ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Cognitive Impairment ◽

Case Control Study ◽

Case Control ◽

Control Group ◽

Motor Symptoms ◽

And Control ◽

Non Motor Symptoms ◽

Control Study

Abstract Background Parkinson’s disease is one of the neurodegenerative disorders that is caused by genetic and environmental factors or interaction between them. Solute carrier family 41 member 1 within the PARK16 locus has been reported to be associated with Parkinson’s disease. Cognitive impairment is one of the non-motor symptoms that is considered a challenge in Parkinson’s disease patients. This study aimed to investigate the association of rs11240569 polymorphism; a synonymous coding variant in SLC41A1 in Parkinson’s disease patients in addition to the assessment of cognitive impairment in those patients. Results In a case -control study, rs11240569 single nucleotide polymorphisms in SLC41A1, genes were genotyped in 48 Parkinson’s disease patients and 48 controls. Motor and non-motor performance in Parkinson's disease patients were assessed by using the Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS). The genotype and allele frequencies were compared between the two groups and revealed no significant differences between case and control groups for rs11240569 in SLC41A1 gene with P value .523 and .54, respectively. Cognition was evaluated and showed the mean ± standard deviation (SD) of WAIS score of PD patients 80.4 ± 9.13 and the range was from 61 to 105, in addition to MMSE that showed mean ± SD 21.96 ± 3.8. Conclusion Genetic testing of the present study showed that rs11240569 polymorphism of SLC41A1 gene has no significant differences in distributions of alleles and genotypes between cases and control group, in addition to cognitive impairment that is present in a large proportion of PD patients and in addition to the strong correlation between cognitive impairment and motor and non-motor symptoms progression.

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