scholarly journals Phosphotyrosine-Protein-Phosphatases and Human Reproduction: An Association between Low Molecular Weight Acid Phosphatase (ACPl) and Spontaneous Abortion

1996 ◽  
Vol 12 (4) ◽  
pp. 261-269 ◽  
Author(s):  
F. Gloria-Bottini ◽  
M. Nicotra ◽  
N. Lucarini ◽  
P. Borgiani ◽  
M. La Torre ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Acid Phosphatase ◽  
Pregnant Women ◽  
Spontaneous Abortion ◽  
Human Reproduction ◽  
Low Molecular Weight ◽  
High Concentration ◽  
Control Groups ◽  
Significant Difference ◽  
History Of

ACP1 (low molecular weight acid phosphatase) genetic polymorphism has been studied in 173 women with a history of two or more consecutive spontaneous abortions and in 1508 control subjects, including 482 normal pregnant women. The proportion of carriers of ACP1 *C allele (* A/ *C, *B/*C) in women with a history of repeated spontaneous abortion is lower than in normal pregnant women and other control groups, Women with repeated spontaneous abortion show a specific decrease of ACPI S isoform concentration as compared to normal pregnant women, The other component of ACP I activity, the F isoform, does not show a significant difference between the two groups. The data suggest that women with ACP1 genotypes showing a high concentration of S isoform are relatively 'protected' against spontaneous abortion, Preliminary analysis of a sample of 352 normal puerperae along with their newborn babies supports this hypothesis,

The Relationship between Use of Low Molecular Weight Heparin during Pregnancy and Risk of Peripartum Adverse Events: A Meta-Analysis

2021 ◽  
Vol 8 (11) ◽  
Author(s):  
Xiaorong Y ◽  
◽  
Shan L ◽  
Shengji S ◽  
Tao S ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Adverse Events ◽  
Pregnant Women ◽  
Low Molecular Weight Heparin ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Premature Delivery ◽  
Low Molecular Weight ◽  
Significant Difference ◽  
Fetal Complications

Introduction: To summarize the trials investigated on relationship between low molecular weight heparin use during pregnancy and peripartum adverse events. Meta-analysis was performed to evaluate the effect of Low Molecular Weight Heparin (LMWH) on maternal and fetal complications. Methods: Electronic research was performed in Cochrane Library, MEDLINE and EMBASE through October 2020. The primary outcome was the incidence of maternal and fetal complications during peripartum period. RevMan 5.3 was used for data analysis. Results: 11 articles were finally included. Meta-analysis showed there was no significant difference in abortion, premature delivery, stillbirth, preeclampsia and postpartum hemorrhage events between pregnant women who used LMWH and those who not. Conclusion: Using LMWH in pregnant women does not increase pregnancy related maternal and fetal complications.

Cost-effectiveness of prophylactic low molecular weight heparin in pregnant women with a prior history of venous thromboembolism

2005 ◽  
Vol 118 (5) ◽  
pp. 503-514 ◽  
Author(s):  
Joseph A. Johnston ◽  
Patrick Brill-Edwards ◽  
Jeffrey S. Ginsberg ◽  
Stephen G. Pauker ◽  
Mark H. Eckman
Keyword(s):  
Molecular Weight ◽  
Venous Thromboembolism ◽  
Cost Effectiveness ◽  
Pregnant Women ◽  
Low Molecular Weight Heparin ◽  
Prior History ◽  
Low Molecular Weight ◽  
History Of

scholarly journals Gut Microbiota Composition and Functional Prediction in Recurrent Spontaneous Abortion

2021 ◽  
Author(s):  
Ying Cui ◽  
Li Zou ◽  
Qian Ye ◽  
Dandan Li ◽  
Huiming Wu ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Spontaneous Abortion ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Recurrent Spontaneous Abortion ◽  
Microbiota Composition ◽  
Functional Prediction ◽  
Significant Difference ◽  
History Of ◽  
Gut Microbiota Composition

Abstract Objective The changes of microbial community in pregnant women, let alone those of patients with recurrent spontaneous abortion (RSA), remain unclear. We analyzed the differences of gut mircobiota (GM) between RSA patients and pregnant women to find the possible mechanism of RSA. MethodsWe enrolled 30 RSA patients (RSA group) and 30 pregnant women who terminated their pregnancy and did not have a history of spontaneous abortion (NR group) in our hospital from June 2020 to August 2020, and fecal samples were obtained to analyze the GM using 16S rDNA V3–V4 sequencing.ResultsAt the phylum level, we found that there is no significant difference in composition of GM between RSA and NR. But at the genus level, compared with NR, Roseburia significantly decreased (P<0.01), and Ruminococcus significantly increased in RSA patients (P<0.05). Further analysis indicated that Klebsiella (P<0.05) was significantly increased, Prevotella.9 (P<0.05) and Roseburia (P<0.05) were significantly decreased in RSA2 group (BMI>23.9 in RSA). Moreover, Agathobacter (P<0.01) was significantly increased in NR2 group (no delivery in NR). Functional prediction indicated that GM may interfere with RSA through membrane transport, carbohydrate metabolism, amino acid metabolism and other pathways.ConclusionDecreased Roseburia in GM of pregnant women maybe related to RSA. Our results provide the basis for in-depth studies of the composition of gut microbial communities in RSA.

Angiogenic Factor Profiles in Pregnant Women With a History of Early-Onset Severe Preeclampsia Receiving Low-Molecular-Weight Heparin Prophylaxis

2018 ◽  
Vol 131 (1) ◽  
pp. 63-69 ◽  
Author(s):  
Edouard Lecarpentier ◽  
Jean Christophe Gris ◽  
Eva Cochery-Nouvellon ◽  
Erick Mercier ◽  
Cyril Touboul ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Pregnant Women ◽  
Early Onset ◽  
Low Molecular Weight Heparin ◽  
Severe Preeclampsia ◽  
Angiogenic Factor ◽  
Low Molecular Weight ◽  
History Of ◽  
Heparin Prophylaxis

Reducing Anxiety of Pregnant Women with a History of Pregnancy Loss-A Randomize Clinical Trial

2020 ◽  
Vol 16 (2) ◽  
pp. 160-166
Author(s):  
Hoda Zaraj ◽  
Katayon Vakilian ◽  
Fatemeh Mehrabi Rezveh
Keyword(s):  
Clinical Trial ◽  
Cognitive Behavioral Therapy ◽  
Pregnant Women ◽  
Spontaneous Abortion ◽  
Behavioral Therapy ◽  
T Test ◽  
Cognitive Behavioral ◽  
Significant Difference ◽  
History Of ◽  
And Control

Background: Spontaneous abortion is the most common complication of pregnancy which is considered an unfavorable experience both physically and psychologically. Objective: This study was conducted to investigate the effect of group counseling through cognitive behavioral therapy (CBT) on the anxiety of pregnant women with a history of spontaneous abortion. Methods: This study was randomized clinical trial type, in which convenient sampling was performed to select 64 subjects from healthcare centers in Arak province. After receiving written consent from the participants, the sampling was performed and the subjects were categorized randomly into two 32-subject groups as intervention and control. The intervention was performed as six 60- min sessions through cognitive behavioral therapy (CBT). Control group, however, only routine cares of pregnancy were provided. For data collection, The Spielberger State-Trait Anxiety Inventory was utilized at the beginning and end of the study. Then, the collected information was analyzed by SPSS 21 through paired t-test, independent t-test. Results: The mean anxiety after the intervention in the intervention and control groups was 65.13±8.11 and 75.91±5.56, respectively, whereby a significant difference was observed between the two groups (p≤0.05). Conclusion: It seems that women with a previous history of abortion require psychological support during pregnancy. It is recommended that the skills of midwives also be improved to psychologically support these women.

scholarly journals Phosphotyrosine-Protein-Phosphatase and Diabetic Disorders. Further Studies on the Relationship between Low Molecular Weight Acid Phosphatase Genotype and Degree of Glycemic Control

1998 ◽  
Vol 14 (2) ◽  
pp. 121-125 ◽  
Author(s):  
N. Lucarini ◽  
E. Antonacci ◽  
N. Bottini ◽  
P. Borgiani ◽  
G. Faggioni ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Acid Phosphatase ◽  
Glycemic Control ◽  
Mean Value ◽  
Diabetic Patients ◽  
Low Molecular Weight ◽  
Glycemic Level ◽  
Significant Difference ◽  
Obese Subjects ◽  
The Relationship

We have studied a new sample of 276 NIDDM patients from the population of Penne (Italy). Comparison of the new data with those of 214 diabetic pregnant women from the population of Rome reported in a previous paper has shown that the pattern of association between low molecular weight acid phosphatase genotype and degree of glycemic control is similar in the two classes of diabetic patients.Among nonobese subjects the proportion of ACP1*A (the allele showing the lowest enzymatic activity) is lower in diabetic patients with high glycemic levels (mean value greater than 8.9 mmol/l) than in diabetic patients with a low glycemic level (mean value less than 8.9 mmol/l). Among obese subjects no significant association is observed between glycemic levels and ACP1. Among nonobese subjects the concentration of f isoform of ACP1 is higher in patients showing a high glycemic level than in patients showing a low glycemic level. No significant difference is observed for s isoform.

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