scholarly journals Emotional Processing following Cortical and Subcortical Brain Damage: Contribution of the Fronto-Striatal Circuitry

1998 ◽  
Vol 11 (1) ◽  
pp. 29-42 ◽  
Author(s):  
Caterina Breitenstein ◽  
Irene Daum ◽  
Hermann Ackermann
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Emotional Processing ◽  
Brain Structures ◽  
Emotional Perception ◽  
Subcortical Brain ◽  
Subcortical Brain Structures ◽  
Advanced Stages ◽  
Standardized Measure ◽  
The Right

The present study examined the differential contribution of cortical and subcortical brain structures in emotional processing by comparing patients with focal cortical lesions (n= 32) to those with primarily subcortical dysregulation of the basal ganglia (Parkinson’s diseasen= 14). A standardized measure of emotional perception (Tübingen Affect Battery) was used. Only patients in the more advanced stages of Parkinson’s disease and patients with focal damage to the (right) frontal lobe differed significantly from controls in both facial expression and affective prosody recognition. The findings imply involvement of the fronto-striatal circuitry in emotional processing.

scholarly journals Magnetic resonance morphometry of the brain in the advanced stages of Parkinson's disease and vascular parkinsonism

2021 ◽  
Vol 11 (4) ◽  
pp. 16-22
Author(s):  
E. V. Iskhakova ◽  
A. G. Trufanov ◽  
A. Yu. Efimtsev ◽  
A. A. Yurin ◽  
A. S. Lepekhina ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Differential Diagnosis ◽  
Magnetic Resonance ◽  
Brain Structures ◽  
Pathological Process ◽  
Vascular Parkinsonism ◽  
Stage 4 ◽  
Advanced Stages ◽  
The Brain

Introduction. MR-morphometry is a method of image processing independent of the researcher, which allows you to get the results of measuring the volume of the brain structures and the thickness of various areas of the cortex and helps in the differential diagnosis in assessing the results of MRI. Our study used MR-morphometry to identify structural markers in the differential diagnosis of vascular parkinsonism in the examination of patients with Parkinson's symptoms. Purpose of research. Visualization of the distribution of atrophic changes in brain structures in vascular parkinsonism and in the advanced stages of Parkinson's disease, as well as the identification of characteristic parts of the brain that undergo a pathological process to increase the accuracy of differential diagnosis. Materials and methods. The results of magnetic resonance morphometry of patients using the postprocessing of native MR images using Freesurfer software are analyzed. We examined 29 patients with vascular parkinsonism and 19 patients with Parknison disease, at stage 4 according to Hyun and Yar. Summary. The application of the method of postprocessing data processing of MR-morphometry allows instrumental confirmation of the clinical diagnosis, as well as to clarify the pathogenesis of neurological syndromes observed in progressive supranuclear paralysis.

scholarly journals Emotional Processing Impairments in Apathetic Patients with Parkinson’s Disease: An ERP Study in Early Time Windows

2019 ◽  
Vol 2019 ◽  
pp. 1-9
Author(s):  
Wei Wei ◽  
Jianghai Ruan ◽  
Xiaodong Duan ◽  
Hua Luo
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Emotional Processing ◽  
Right Hemisphere ◽  
Digit Span ◽  
Time Windows ◽  
Early Time ◽  
Event Related Potentials ◽  
Related Potentials ◽  
The Right

We investigated emotional processing in apathetic patients with Parkinson’s disease (PD) by observing components of event-related potentials (ERPs) in early time windows. Forty PD patients and 21 healthy controls (HCs) were enrolled. The Starkstein Apathy Scale (SAS) was used to divide the PD patients into apathetic and nonapathetic groups. Cognitive function was evaluated by the forward and backward Digit Span tests, Trail Making Test (TMT), and Word Fluency Test. The participants were required to recognize positive, neutral, and negative emotional faces and engage in an emotion categorization task while EEG was recorded. The time to completion for the TMT (Part A and Part B) from highest to lowest was in the order of apathetic group > nonapathetic group > HC group. Compared with the nonapathetic and HC groups, in the apathetic group, P100 amplitudes were smaller for positive expressions in the right hemisphere and latencies were longer for positive expressions in the left hemisphere, while latencies were longer for neutral expressions bilaterally. Compared with the nonapathetic group, in the apathetic group, N170 amplitudes were attenuated and latencies were delayed for neutral and negative expressions in the right hemisphere. A trend towards larger N170 amplitudes in the right hemisphere than in the left was observed in the nonapathetic and HC groups, but this difference was not significant in the apathetic group. In the apathetic group, bilateral P100 amplitudes elicited by negative expressions were negatively correlated with SAS scores, and SAS scores were positively correlated with Part B of the TMT. N170 amplitudes elicited by negative expressions in the right hemisphere were negatively correlated with SAS in the apathetic group and with Part B of TMT in both PD groups. Our findings suggested that emotional processing was impaired in apathetic PD patients and that the right hemisphere was more sensitive to reflecting this impairment in the early time windows of ERPs.

Functional Role of the Cerebellum in Parkinson Disease: A PET Study

Neurology ◽  
2021 ◽  
pp. 10.1212/WNL.0000000000012036
Author(s):  
Audrey Riou ◽  
Jean-François Houvenaghel ◽  
Thibaut Dondaine ◽  
Sophie Drapier ◽  
Paul Sauleau ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Multiple Testing ◽  
Principal Component ◽  
Brain Structures ◽  
Cognitive Domain ◽  
Metabolic Imaging ◽  
Crus I ◽  
The Right

OBJECTIVES:To test for cerebellar involvement in motor and nonmotor impairments in Parkinson’s disease (PD), and to determine patterns of metabolic correlations with supratentorial brain structures, we correlated clinical motor, cognitive and psychiatric scales with cerebellar metabolism.METHODS:We included 90 patients with PD. Motor, cognitive and psychiatric domains were assessed, and resting-state 18FDG-PET metabolic imaging was performed. The motor, cognitive and psychiatric scores were entered separately in a principal component analysis. We looked for correlations between these three principal components and cerebellar metabolism. Furthermore, we extracted the mean glucose metabolism value for each significant cerebellar cluster and looked for patterns of cerebrum-cerebellum metabolic correlations.RESULTS:Severity of impairment was correlated with increased metabolism in the anterior lobes and vermis (motor domain), and the right Crus I, Crus II, and declive (cognitive domain), and the right Crus I and Crus II (psychiatric domain). There were no results surviving multiple testing corrections regarding the psychiatric domain. Moreover, we found distributed and overlapping - but not identical- patterns of metabolic correlations for motor and cognitive domains. Specific supratentorial structures (cortical structures, basal ganglia, and thalamus) were strongly correlated with each of the cerebellar clusters.CONCLUSIONS:These results confirm the role of the cerebellum in nonmotor domains of Parkinson’s disease, with differential but overlapping patterns of metabolic correlations suggesting the involvement of cerebello-thalamo-striatal-cortical loops.

Emotional processing in Parkinson's disease: a reaction time study

2007 ◽  
Vol 34 (S 2) ◽  
Author(s):  
TD Hälbig ◽  
S Assuras ◽  
J Barry ◽  
JC Borod ◽  
JM Gracies ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Reaction Time ◽  
Emotional Processing ◽  
Time Study ◽  
Reaction Time Study

Current Therapeutic Strategies and Perspectives for Neuroprotection in Parkinson’s Disease

2020 ◽  
Vol 26 (37) ◽  
pp. 4738-4746
Author(s):  
Mohan K. Ghanta ◽  
P. Elango ◽  
Bhaskar L. V. K. S.
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Early Diagnosis ◽  
Neurodegenerative Disorder ◽  
Therapeutic Strategies ◽  
Neuroprotective Agents ◽  
Striatal Neurons ◽  
The Status ◽  
Advanced Stages ◽  
Dopaminergic Pathways

Parkinson’s disease is a progressive neurodegenerative disorder of dopaminergic striatal neurons in basal ganglia. Treatment of Parkinson’s disease (PD) through dopamine replacement strategies may provide improvement in early stages and this treatment response is related to dopaminergic neuronal mass which decreases in advanced stages. This treatment failure was revealed by many studies and levodopa treatment became ineffective or toxic in chronic stages of PD. Early diagnosis and neuroprotective agents may be a suitable approach for the treatment of PD. The essentials required for early diagnosis are biomarkers. Characterising the striatal neurons, understanding the status of dopaminergic pathways in different PD stages may reveal the effects of the drugs used in the treatment. This review updates on characterisation of striatal neurons, electrophysiology of dopaminergic pathways in PD, biomarkers of PD, approaches for success of neuroprotective agents in clinical trials. The literature was collected from the articles in database of PubMed, MedLine and other available literature resources.

scholarly journals Present and Future of Parkinson’s Disease in Spain: PARKINSON-2030 Delphi Project

2021 ◽  
Vol 11 (8) ◽  
pp. 1027
Author(s):  
Diego Santos García ◽  
Marta Blázquez-Estrada ◽  
Matilde Calopa ◽  
Francisco Escamilla-Sevilla ◽  
Eric Freire ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
New Technologies ◽  
Management Strategies ◽  
Multidisciplinary Teams ◽  
Modified Delphi ◽  
Advanced Stages ◽  
Diagnostic Capacity ◽  
Socio Economic Impact

Parkinson’s disease (PD) is a chronic progressive and irreversible disease and the second most common neurodegenerative disease worldwide. In Spain, it affects around 120.000–150.000 individuals, and its prevalence is estimated to increase in the future. PD has a great impact on patients’ and caregivers’ lives and also entails a substantial socioeconomic burden. The aim of the present study was to examine the current situation and the 10-year PD forecast for Spain in order to optimize and design future management strategies. This study was performed using the modified Delphi method to try to obtain a consensus among a panel of movement disorders experts. According to the panel, future PD management will improve diagnostic capacity and follow-up, it will include multidisciplinary teams, and innovative treatments will be developed. The expansion of new technologies and studies on biomarkers will have an impact on future PD management, leading to more accurate diagnoses, prognoses, and individualized therapies. However, the socio-economic impact of the disease will continue to be significant by 2030, especially for patients in advanced stages. This study highlighted the unmet needs in diagnosis and treatment and how crucial it is to establish recommendations for future diagnostic and therapeutic management of PD.

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