PPAR-γ: Therapeutic Potential for Multiple Sclerosis
Keyword(s):
Ppar Γ
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The role of peroxisome proliferator-activated receptors (PPARs) in altering lipid and glucose metabolism is well established. More recent studies indicate that PPARs also play critical roles in controlling immune responses. We and others have previously demonstrated that PPAR-γagonists modulate the development of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). This review will discuss the cellular and molecular mechanisms by which these agonists are believed to modulate disease. The therapeutic potential of PPAR-γagonists in the treatment of multiple sclerosis will also be considered.
2010 ◽
Vol 2010
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pp. 1-10
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2013 ◽
Vol 256
(1-2)
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pp. 7-12
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2016 ◽
Vol 52
(3)
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pp. 436-445
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