scholarly journals Impact of HPV in Oropharyngeal Cancer

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Linda Marklund ◽  
Lalle Hammarstedt

The incidence of oropharyngeal cancers has increased in the western world and Human Papilloma Virus (HPV) has been recognised as a risk factor in the last decades. During the same period the prevalence of HPV in oropharyngeal tumours has increased and HPV has been suggested responsible for the increase. The HPV-positive tumours are today recognized as a distinct subset of head and neck cancers with its own clinopathological and risk profile and have a significantly improved prognosis regardless of treatment strategy. This review summarizes current knowledge regarding human papillomavirus biology, oncogenic mechanisms, risk factors, and impact of treatment.

2018 ◽  
Vol 3 (2) ◽  
pp. 96
Author(s):  
Suzana Devi ◽  
Yufri Aldy ◽  
Andani Eka Putra

<em>Human Papillomavirus (HPV) berkaitan dengan penyebab terjadinya kanker  serviks. Salah satu HPV yang beresiko tinggi adalah tipe 16. Protein virus yang beresiko tinggi yang menyebabkan karsinogen salah satunya gen E7. Dikarenakan tingginya tingkat kematian yang di sebabkan oleh kanker servik, salah satu cara untuk mengatasinya adalah dengan cara vaksinasi. Protein E7 merupakan target ideal untuk dapat dijadikan sebagai dasar dalam pembuatan vaksin. Dimana hasil ekspresi gen E7 HPV tipe 16 yang selanjutnya dapat dimanfaatkan dalam membuat antigen spesifik dari gen E7. Proses kloning gen E7 HPV tipe 16 dari peneliti sebelumnya, Isolasi plasmid menggunakan kit (Geneaid®), kultur bakteri yang telah ditumbuhkan pada plat yang mengandung antibiotik. Bakteri yang tumbuh merupakan bakteri yang telah mengandung gen sisipan. Selanjutnya lakukan over ekspresi. Hasil over ekspresi di tambah IPTG kemudian hasilnya di visualisasikan dengan SDS PAGE. Over ekspresi dari gen E7 HPV tipe 16 berhasil dilakukan dengan terdapatnya pita dari protein dari gen E7 HPV tipe 16 dari hasil SDS-PAGE. Dari penelitian yang telah dilakukan di dapat  hasil over ekspresi gen E7 HPV tipe 16 pada ukuran protein dengan kisaran 11,0 kDa. Pita yang didapat terlihat tipis dan samar-samar</em>


2017 ◽  
Vol 13 (6) ◽  
pp. 1404-1411 ◽  
Author(s):  
Nianmin Shi ◽  
Qiang Lu ◽  
Jiao Zhang ◽  
Li Li ◽  
Junnan Zhang ◽  
...  

2018 ◽  
Vol 11 (12) ◽  
pp. 1-6
Author(s):  
Meryene Barrios ◽  
Liliana Rodr�guez ◽  
Claudia Pach�n ◽  
◽  
◽  
...  

2014 ◽  
Vol 66 (4) ◽  
pp. 1653-1658
Author(s):  
Gordana Mijovic ◽  
Tatjana Jovanovic ◽  
Nada Kuljic-Kapulica ◽  
Nebojsa Jokmanovic ◽  
Marina Bujko ◽  
...  

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Luca Fiorillo ◽  
Gabriele Cervino ◽  
Giovanni Surace ◽  
Rosa De Stefano ◽  
Luigi Laino ◽  
...  

The human papilloma virus (HPV) is responsible for different pathological manifestations in humans. This agent gives rise to lesions of different types and in different areas of the organism, including the oral cavity. The aim of this study is to show which are the main diseases for which HPV is responsible and to bring to light some of the interceptive and therapeutic strategies. The analysis was conducted by consulting the major scientific databases with the aim of obtaining information on the characteristics of oral HPV and its management; furthermore, the literature was supported by some clinical cases proposed by the authors. The role of dentistry is essential in the early diagnosis of this type of pathologies and above all in knowing how to direct patients towards a path that can lead to patient management, especially in the event that these lesions have a malignant potential. Enhancing the knowledge and role of dentistry can lead to early diagnosis of this type of injury, intercepting a pathology that could have multiorgan implications.


2016 ◽  
Vol 2 (3_suppl) ◽  
pp. 72s-73s
Author(s):  
Sean Parkinson ◽  
Ian Bambury ◽  
Carole Rattray

Abstract 51 Background: Cervical cancer is the second most common cancer in Jamaica with an incidence of 17.4/100,000. (1). Cervical cancer is acquired sexually, with the human papilloma virus (HPV) being the most important causative agent (2,3). HPV infection is associated with the development of other cancers such as anogenital, vaginal, vulvar and anal cancers in women, and penile and anal cancers in men.(2) It is also responsible for genital warts and oropharyngeal cancer in both men and women. Two vaccines were approved for the prevention of cervical cancer by the Food and Drug Administration (FDA) and are available in Jamaica (4,5). This study assessed the knowledge and attitudes in a male cohort towards HPV and HPV vaccine. Methods: This was a cross-sectional study in which two hundred male students were recruited. Information for this study was gathered from responses given in a self-administered questionnaire. Data was analyzed using the statistical package for social sciences (SPSS) version 20. Results: The mean age of the respondents was 22.6 years. 50.5% stated that they had heard of HPV. Of those who knew of the HPV, only 37.6% vs 39.6% of respondents reported that sexual intercourse was a requirement for HPV transmission, while 22.8% did not know. 43% reported knowing that HPV causes genital warts and 42% knew of an association with cervical cancer. 16.5% of the respondents knew of the HPV vaccine. Only 21.2% knew that the HPV vaccine protects against cervical cancer while the remaining 78.8% either said that it didn't provide protection or did not know. 15.3% knew that the vaccine is approved for both males and females while 84.7% did not know. Conclusion: There was significant knowledge deficit in the awareness of HPV and the HPV vaccine in our male university students. Gibson, T.N., et al., Age-specific incidence of cancer in Kingston and St. Andrew, Jamaica, 2003-2007. West Indian Med J, 2010. 59(5): p. 456-64. Centers for Disease Control and Prevention. Basic information about HPV –associated cancers. Available at: http://www.cdc.gov/cancer/hpv/basic_info . 2013. Bosch, F.X. and S. de Sanjose, Chapter 1: Human papillomavirus and cervical cancer-- burden and assessment of causality. J Natl Cancer Inst Monogr, 2003(31): p. 3-13. FDA licensure of bivalent Human Papillomavirus vaccine (HPV2,Cervarix) for use in females and updated vaccination recommendations from the Advisory Committee on Immunization Practices (ACIP) .Centers For Disease Control and Prevention (CDC). MMWR Morb Mort Wkly Rep, 2010(59): p. 626-9. FDA, “FDA Approves New Vaccine Indication for Gardasil to Prevent Genital Warts in Men and Boys,” Bethesda, Md, USA. 2009. AUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST: No COIs from the authors.


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