Cystatin C-Based Evaluation of Kidney Function of HIV-Infected Children in Benin City, Southern Nigeria

Background. Human immunodeficiency virus (HIV) is now a confirmed risk factor for kidney disease with an increased burden in persons of African descent.Method. We measured the serum cystatin C levels of 205 ART-naive, HIV-infected children by an ELISA technique and compared them with the levels of apparently healthy children.Result. The mean ± SD serum cystatin C level of children with HIV infection was 1.01 ± 0.44 mg/L, significantly higher than the mean value in the control group, that is, 0.72 ± 0.20 mg/L (P=0.000). The mean ± SD cystatin C-based estimated GFR of children with HIV infection was 102.7 ± 31.0 mL/min/1.73 m2, significantly lower than 126.9 ± 28.5 mL/min/1.73 m2in the control group, (P=0.014). A significantly higher proportion of HIV-infected children compared to controls had eGFR < 90 mL/min/1.73 m2(21.5% versus 5.4%;P=0.00). The prevalence of chronic kidney disease (CKD) among the HIV-infected children was 10.7%. The cystatin C-based eGFR of the HIV-infected children ≥5 years old correlated positively with their CD4 count (r=0.23; P=0.022).Conclusion. There is a high prevalence of CKD among HIV-infected children, requiring regular monitoring of their kidney function using a cystatin C-based method.

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Assessment of Subclinical Renal Glomerular and Tubular Dysfunction in Children with Beta Thalassemia Major

Children ◽

10.3390/children8020100 ◽

2021 ◽

Vol 8 (2) ◽

pp. 100

Author(s):

Asmaa A. Mahmoud ◽

Doaa M. Elian ◽

Nahla MS. Abd El Hady ◽

Heba M. Abdallah ◽

Shimaa Abdelsattar ◽

...

Keyword(s):

Cystatin C ◽

Kidney Injury ◽

Thalassemia Major ◽

Beta Thalassemia ◽

Good Survival ◽

Control Group ◽

Healthy Children ◽

Serum Cystatin C ◽

Serum Cystatin ◽

Beta Thalassemia Major

Background: A good survival rate among patients with beta thalassemia major (beta-TM) has led to the appearance of an unrecognized renal disease. Therefore, we aimed to assess the role of serum cystatin-C as a promising marker for the detection of renal glomerular dysfunction and N-acetyl beta-D-glucosaminidase (NAG) and kidney injury molecule 1 (KIM-1) as potential markers for the detection of renal tubular injury in beta-TM children. Methods: This case-control study was implemented on 100 beta-TM children receiving regular blood transfusions and undergoing iron chelation therapy and 100 healthy children as a control group. Detailed histories of complete physical and clinical examinations were recorded. All subjected children underwent blood and urinary investigations. Results: There was a significant increase in serum cystatin-C (p < 0.001) and a significant decrease in eGFR in patients with beta-TM compared with controls (p = 0.01). There was a significant increase in urinary NAG, KIM-1, UNAG/Cr, and UKIM-1/Cr (p < 0.001) among thalassemic children, with a significant positive correlation between serum cystatin-C, NAG and KIM-1 as regards serum ferritin, creatinine, and urea among thalassemic patients. A negative correlation between serum cystatin-C and urinary markers with eGFR was noted. Conclusion: Serum cystatin-C is a good marker for detection of glomerular dysfunction. NAG and KIM-1 may have a predictive role in the detection of kidney injury in beta-TM children.

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Association of Serum Cystatin C with Pre-eclampsia: A Case Control Study

Bangladesh Journal of Obstetrics & Gynaecology ◽

10.3329/bjog.v32i1.56731 ◽

2017 ◽

Vol 32 (1) ◽

pp. 29-32

Author(s):

Nasima Akhter ◽

Farzana Deeba ◽

Begum Nasrin ◽

Saleha Begum Chowdhury

Keyword(s):

Cystatin C ◽

Case Control Study ◽

Case Control ◽

Control Group ◽

P Value ◽

Serum Cystatin C ◽

Serum Cystatin ◽

Control Serum ◽

The Mean ◽

Control Study

Background: Cystatin C, an endogenous marker of renal function, which increases in pregnancy as more so in pre-eclampsia, studies show it may be marker of pre-eclampsia. Objective (s): The objective of the present work was to investigate the association between serum cystatin C levels in normal and pre-eclamptic pregnancy. Methods and material: This case control study was conducted in the department of obstetrics and gynaecology in three tertiary care hospitals of Dhaka city (BSMMU, DMC, BIRDEM ) during the period from January 2009 to December 2010. A total 240 women of 20-40 wks of pregnancy were enrolled in the study. One hundred and twenty four women of pre-eclampsia were recruited as case and 116 healthy pregnant women were enrolled as control. Serum cystatin C was measured in both case and control by a fully automated particle-enhanced immune-turbidimetric assay for cystatin C in undiluted samples. Serum cystatin C level was compared between the groups. P value reached from unpaired student t-test and chi square test by analyzing the data. P value less than 0.05 was considered to be significant. Results: The mean (±SD) serum cystatin C levels in case group was 1.17±0.34 mg/lranged from 0.1-2.2 mg/l. In control groups the mean (±SD) serum cystatin C level was 0.87±0.31 mg/l, ranged from 0.24-1.98 mg/l, which was significantly higher (p<0.001) in case. There was statistically significant association between serum cystatin C and pre-eclampsia. Serum Cystatin C level >1mg/l was found in more than half (69%) of the cases compared to 25% of the control group (p<0.001). Computation of odds ratio reveals that the cases had 6.79 times higher risk of having pre-eclampsia than that of the control group (p<0.001). Conclusion: There is significant association between pre-eclampsia and serum cystatin C Bangladesh J Obstet Gynaecol, 2017; Vol. 32(1): 29-32

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Serum cystatin C as a marker for early detection of chronic kidney disease and grade 2 nephropathy in Japanese patients with type 2 diabetes

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm-2011-0777 ◽

2012 ◽

Vol 50 (10) ◽

Cited By ~ 7

Author(s):

Yoshitake Suzuki ◽

Kazuyuki Matsushita ◽

Masanori Seimiya ◽

Toshihiko Yoshida ◽

Yuji Sawabe ◽

...

Keyword(s):

Type 2 Diabetes ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Early Detection ◽

Cystatin C ◽

Japanese Patients ◽

Serum Cystatin C ◽

Serum Cystatin

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Population Pharmacokinetic Analysis of Vancomycin Using Serum Cystatin C as a Marker of Renal Function

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.00661-09 ◽

2009 ◽

Vol 54 (2) ◽

pp. 778-782 ◽

Cited By ~ 33

Author(s):

Akihiro Tanaka ◽

Tetsuya Aiba ◽

Takashi Otsuka ◽

Katsuya Suemaru ◽

Tatsuya Nishimiya ◽

...

Keyword(s):

Renal Function ◽

Cystatin C ◽

Predictive Performance ◽

Pharmacokinetic Analysis ◽

Pharmacokinetic Parameters ◽

Population Pharmacokinetic ◽

Serum Cystatin C ◽

Serum Cystatin ◽

New Model ◽

The Mean

ABSTRACT We determined the population pharmacokinetics of vancomycin (VAN) using the glomerular filtration rate (GFR) estimated from the serum cystatin C concentration. We examined the predictive performance of the trough serum VAN concentration for determination of the initial dose by using a new model for the analysis of the population pharmacokinetic parameters. Data for 86 patients were used to estimate the values of the population pharmacokinetic parameters. Analysis with a nonlinear mixed-effects modeling program was done by using a one-compartment model. Data for 78 patients were used to evaluate the predictive performance of the new model for the analysis of population pharmacokinetic parameters. The estimated GFR values determined by using Hoek's formula correlated linearly with VAN clearance (VAN clearance [ml/min] = 0.825 × GFR). The mean volume of distribution was 0.864 (liters/kg). The interindividual variability of VAN clearance was 19.8%. The accuracy of the prediction determined by use of the new model was statistically better than that determined by use of the Japanese nomogram-based model because the 95% confidence interval (−3.45 to −1.38) of the difference in each value of the mean absolute error (−2.41) did not include 0. Use of the serum cystatin C concentration as a marker of renal function for prediction of serum VAN concentrations may be useful.

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Activity of Proteolytic Enzymes and Level of Cystatin C in the Peripartum Period

BioMed Research International ◽

10.1155/2016/7065821 ◽

2016 ◽

Vol 2016 ◽

pp. 1-5

Author(s):

Anna Cyganek ◽

Aleksandra Wyczalkowska-Tomasik ◽

Patrycja Jarmuzek ◽

Barbara Grzechocinska ◽

Zoulikha Jabiry-Zieniewicz ◽

...

Keyword(s):

Cystatin C ◽

Cathepsin B ◽

Proteolytic Enzymes ◽

Late Pregnancy ◽

Control Group ◽

Study Group ◽

Serum Cystatin C ◽

Serum Cystatin ◽

Peripartum Period

Objectives. The aim of the study was to evaluate the activity of cathepsin B, collagenases, trypsin, and plasmin and concentration of cystatin C in serum of healthy pregnant women in peripartum period.Study Design. The study group included 45 women in uncomplicated pregnancies. Blood samples were collected in four time points. Enzyme activity was measured by spectrofluorometric method. The level of cystatin C was measured using immunonephelometric method.Results. Mean activity of cathepsin B and the level of serum cystatin C were significantly higher in the study group. Collagenase activity was significantly lower in the study group than the control group. No differences in collagenase, plasmin, and trypsin activity on each day of the peripartum period were found.Conclusion. High activity of cathepsin B and increased level of cystatin C are typical for women in late pregnancy. Those levels significantly decrease after delivery which can be associated with potential role of those markers in placental separation. The insignificant changes of cystatin C level in the peripartum period seem to exclude the possibility of using cystatin C as a marker for renal insufficiency in the peripartum period but additional research is necessary to investigate the matter further.

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Gestational and age-specific cystatin C reference intervals for newborns in China

10.21203/rs.2.19480/v1 ◽

2019 ◽

Author(s):

Chao Tong ◽

Yalan Liu ◽

Yanqiu Wu ◽

Qiong Li ◽

Yipin Wu ◽

...

Keyword(s):

Cystatin C ◽

Newborn Infants ◽

Reference Intervals ◽

Reference Level ◽

Reference Ranges ◽

Perinatal Factors ◽

Blood Cell Count ◽

Serum Cystatin C ◽

Serum Cystatin ◽

The Mean

Abstract Backgroud : To establish reference values of serum cystatin C (CysC) in Chinese newborn infants. Methods: Serum CysC levels were measured in 1919 blood samples from 1044 newborns during their first 28 days of life. CysC levels were analyzed for association between subgroups dichotomized by postnatal age (PA) and gestational age (GA). Reference intervals of serum CysC were determined according to the PA and GA. The association between serum CysC level and other biochemical parameters as well as perinatal factors were also analyzed. Results: In this study, the mean GA was 35.75±2.90 weeks and birth weight was 2613.77±696.72 g. Reference ranges of serum CysC were determined and a general decreasing trend of CysC levels was observed as GA increased. CysC levels differed significantly among the PA and GA groups (P＜0.001). Serum CysC levels were relatively stable throughout GA, except being impacted by white blood cell count within postnatal 24 hours. Moreover, their levels always correlated positively with serum creatinine concentrations (P<0.001). Conclusion: The reference level of serum CysC should be determined according to PA and GA. In contrast to creatinine, serum CysC is a dependable index for assessing renal function in neonate, for there are rare factors influencing it.

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