scholarly journals Microfabricated Engineered Particle Systems for Respiratory Drug Delivery and Other Pharmaceutical Applications

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Andres Garcia ◽  
Peter Mack ◽  
Stuart Williams ◽  
Catherine Fromen ◽  
Tammy Shen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Small Molecule ◽  
Pulmonary Delivery ◽  
Respiratory Drug Delivery ◽  
Dry Powder ◽  
Powder Characteristics ◽  
Powder Particles ◽  
Microelectronics Industry ◽  
Delivery Technology ◽  
Microfabrication Techniques

Particle Replication in Non-Wetting Templates (PRINT®) is a platform particle drug delivery technology that coopts the precision and nanoscale spatial resolution inherently afforded by lithographic techniques derived from the microelectronics industry to produce precisely engineered particles. We describe the utility of PRINT technology as a strategy for formulation and delivery of small molecule and biologic therapeutics, highlighting previous studies where particle size, shape, and chemistry have been used to enhance systemic particle distribution properties. In addition, we introduce the application of PRINT technology towards respiratory drug delivery, a particular interest due to the pharmaceutical need for increased control over dry powder characteristics to improve drug delivery and therapeutic indices. To this end, we have produced dry powder particles with micro- and nanoscale geometric features and composed of small molecule and protein therapeutics. Aerosols generated from these particles show attractive properties for efficient pulmonary delivery and differential respiratory deposition characteristics based on particle geometry. This work highlights the advantages of adopting proven microfabrication techniques in achieving unprecedented control over particle geometric design for drug delivery.

Novel Pulmonary Delivery of Antiviral Drugs for Treating COVID-19 in Patients with Parkinson’s Disease

2021 ◽  
Vol 18 ◽  
Author(s):  
Nazrul Islam ◽  
Shafiqur Rahman
Keyword(s):  
Public Health ◽  
Drug Delivery ◽  
Antiviral Drug ◽  
Pulmonary Delivery ◽  
Therapeutic Benefit ◽  
Antiviral Drugs ◽  
Effective Strategy ◽  
Delivery Methods ◽  
Significant Burden ◽  
Delivery Technology

: The COVID-19 pandemic has caused a significant burden on public health worldwide. Currently, there are limited medications for the treatment of COVID-19 in patients with Parkinson’s disorder (PD). Several antiviral drugs and other pharmacotherapies have shown promise and are used by various delivery methods. Among the antiviral drugs, amantadine alone was reported to provide therapeutic benefit against COVID-19 in patients with PD. Here we propose novel strategies for pulmonary drug delivery technology of antiviral drug amantadine. As such pulmonary delivery of this drug or combination with the additional antiviral drugs could be a more effective strategy for the treatment of COVID-19-related complications in patients with PD. Furthermore, the important benefits and limitations of this novel delivery technology will be discussed.

Effervescent dry powder for respiratory drug delivery

2007 ◽  
Vol 65 (3) ◽  
pp. 346-353 ◽  
Author(s):  
Leticia Ely ◽  
Wilson Roa ◽  
Warren H. Finlay ◽  
Raimar Löbenberg
Keyword(s):  
Drug Delivery ◽  
Respiratory Drug Delivery ◽  
Dry Powder

Use of a Fundamental Approach to Spray-Drying Formulation Design to Facilitate the Development of Multi-Component Dry Powder Aerosols for Respiratory Drug Delivery

2013 ◽  
Vol 31 (2) ◽  
pp. 449-465 ◽  
Author(s):  
Susan Hoe ◽  
James W. Ivey ◽  
Mohammed A. Boraey ◽  
Abouzar Shamsaddini-Shahrbabak ◽  
Emadeddin Javaheri ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Spray Drying ◽  
Respiratory Drug Delivery ◽  
Dry Powder ◽  
Formulation Design ◽  
Dry Powder Aerosols ◽  
Powder Aerosols

Recent Advances in Gastric Floating Drug Delivery Technology: A Review

2013 ◽  
Vol 10 (3) ◽  
pp. 286-298 ◽  
Author(s):  
Rakesh Pahwa ◽  
Seema Bisht ◽  
Vipin Kumar ◽  
Kanchan Kohli
Keyword(s):  
Drug Delivery ◽  
Recent Advances ◽  
Floating Drug Delivery ◽  
Delivery Technology

scholarly journals Flexible Polymeric Nanosized Micelle for Ophthalmic Drug Delivery: Research Progress in Recent Three Years

2021 ◽  
Author(s):  
Zhiguo Li ◽  
Mingting Liu ◽  
Lingjie Ke ◽  
Li-Juan Wang ◽  
Caisheng Wu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Complex Structure ◽  
Research Progress ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug ◽  
Delivery Technology

The eye is a complex structure with a variety of anatomical barriers and clearance mechanisms, so the provision of safe and effective ophthalmic drug delivery technology is a major challenge....

scholarly journals Advanced and Innovative Nano-Systems for Anticancer Targeted Drug Delivery

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1151
Author(s):  
Lu Tang ◽  
Jing Li ◽  
Qingqing Zhao ◽  
Ting Pan ◽  
Hui Zhong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Small Molecule ◽  
Anticancer Agents ◽  
Targeted Drug Delivery ◽  
Treatment Modalities ◽  
Biological Macromolecules ◽  
Passive Targeting ◽  
Efficient Delivery ◽  
Targeted Drug

The encapsulation of therapeutic agents into nano-based drug delivery system for cancer treatment has received considerable attention in recent years. Advancements in nanotechnology provide an opportunity for efficient delivery of anticancer drugs. The unique properties of nanoparticles not only allow cancer-specific drug delivery by inherent passive targeting phenomena and adopting active targeting strategies, but also improve the pharmacokinetics and bioavailability of the loaded drugs, leading to enhanced therapeutic efficacy and safety compared to conventional treatment modalities. Small molecule drugs are the most widely used anticancer agents at present, while biological macromolecules, such as therapeutic antibodies, peptides and genes, have gained increasing attention. Therefore, this review focuses on the recent achievements of novel nano-encapsulation in targeted drug delivery. A comprehensive introduction of intelligent delivery strategies based on various nanocarriers to encapsulate small molecule chemotherapeutic drugs and biological macromolecule drugs in cancer treatment will also be highlighted.

Computational Study of Atomization Models and Optimal Design of a Pressurized Inhaler

2021 ◽  
Vol 50 ◽  
pp. 123-134
Author(s):  
Anurag Tiwari ◽  
Siddharth Sharma ◽  
Vivek Kumar Srivastav ◽  
Anuj Jain ◽  
Akshoy Ranjan Paul
Keyword(s):  
Drug Delivery ◽  
Particle Production ◽  
Computational Study ◽  
Nozzle Diameter ◽  
Inhalation Therapy ◽  
Respiratory Drug Delivery ◽  
Minimum Diameter ◽  
Inhaler Device ◽  
Swirl Atomizer ◽  
Pressure Swirl

Respiratory drug delivery has been under the spotlight of research for the past few decades, mainly due to rapid increase of pulmonary diseases. This type of drug delivery offers the highest efficiency for treatment. Despite its numerous benefits, there are some drawbacks in the method of respiratory drug delivery-the most important being poor delivery efficiency and high drug deposition in undesirable regions, such as the oropharynx. This study is focused on improving pressurized inhaler device, which is one of the most used devices for inhalation therapy throughout the world using the results and findings obtained from numerical analysis. In this study, three atomizer models are investigated and found that pressure swirl atomizer model closely represents the atomization phenomenon from a pressurized inhaler device. Parametric study is carried out using three parameters: nozzle diameter, dispersion angle and sheet constant to optimize the performance of the device. It is revealed that a reduction in nozzle diameter and dispersion angle help in generating fine (smaller diameter) particles, whereas increase in sheet constant is responsible for fine particle production. The values of nozzle diameter, dispersion angle and sheet constant are tuned to get the particles with minimum diameter as output which is desirable for the drug particles to get deposited in the smaller airways of lungs and increase the efficiency of drug delivery and improve the device performance.

Company News

2003 ◽  
Vol 07 (10) ◽  
pp. 496-502
Keyword(s):  
Drug Delivery ◽  
Japanese Firm ◽  
Inflammatory Drug ◽  
Synthetic Dna ◽  
Business News ◽  
Medical Standard ◽  
Anti Inflammatory ◽  
Delivery Technology

Prima Subsidiary Breakthrough in Malaria Experiments. Biota Achieves HIV Drug Breakthrough. China Business News. Sino-French Collaboration. US to Export Synthetic DNA to Japanese Firm. Genesis and EvoGenix Collaborates to Discover Anti-Inflammatory Drug. Biomedical Strategy Consultants Marches into Europe. Athelas and MerLion to Work Together on Anti-Infectives. BioPhotoFullerenes to Open HQ in Taiwan. Kiotek to Produce Medical-Standard Chitosan. TaiGen to Buy Microbubble Drug Delivery Technology. Intel Launches Itanium2 Server to Address Bioinformatics Market.

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