scholarly journals Cut-Off Values of Visceral Adiposity to Predict NAFLD in Brazilian Obese Adolescents

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Ana Paula Grotti Clemente ◽  
Bárbara Dal Molin Netto ◽  
Aline di Piano Ganen ◽  
Lian Tock ◽  
Danielle Arisa Caranti ◽  
...  
Keyword(s):  
Visceral Fat ◽  
Subcutaneous Fat ◽  
Treatment Strategies ◽  
Roc Curves ◽  
Visceral Adiposity ◽  
Safe Alternative ◽  
Abdominal Ultrasonography ◽  
Cross Sectional ◽  
Obese Adolescents ◽  
Total Fat

Objectives.The present study aimed at determining cut-off points of visceral fat to predict NAFLD and analyzed metabolic disorders of obese adolescents.Methods.Cross-sectional study involved 165 obese adolescents ranged in age from 15 to 19 years. Glycemia, hepatic transaminases, lipid profile, and insulin resistance were analyzed. Visceral and subcutaneous fat were measured by ultrasound and body composition by plesthysmography.Results.The NAFLD adolescents had significantly higher values for body mass, BMI-for-age, BMI, total fat, waist circumference, and visceral fat when compared with non-NAFLD obese adolescents in both genders. Moreover, there were significant positive correlations between visceral fat with the variables BMI-for-age (r=0.325,), TG (r=0.277), AST (r=0.509), ALT (r=0.519), WC (r=0.390), and visceral/subcutaneous ratio (r=0.790) for NAFLD group. Total fat, triglycerides, and visceral fat were the independent predictors to NAFLD. Analysis of the ROC curves revealed cut-off points of visceral fat of 4.47 cm for girls and 4.21 cm for boys.Conclusions.The results may suggest that abdominal ultrasonography procedure may be a safe alternative method of assessing visceral adiposity aiming to be considered to the development of preventive and treatment strategies in obese individuals. This clinial trial is registered with ClinicalTrial.gov (NCT01358773).

scholarly journals Metabolic syndrome and visceral fat thickness in obese adolescents

2007 ◽  
Vol 47 (3) ◽  
pp. 124
Author(s):  
Lanny C. Gultom ◽  
Damayanti R. Sjarif ◽  
Evita K. B. Ifran ◽  
Partini P. Trihono ◽  
Jose R. L. Batubara
Keyword(s):  
Metabolic Syndrome ◽  
Visceral Fat ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Abdominal Ultrasonography ◽  
Cross Sectional ◽  
Obese Adolescent ◽  
Obese Adolescents ◽  
Visceral Fat Accumulation ◽  
Fat Thickness

Background Metabolic syndrome (MS) is one of the long-termconsequences of obesity which can be found in adolescents. MS iscaused by excessive visceral fat accumulation. The visceral fatthickness (VFT) itself can be measured by using waist circumference(WC) measurement and abdominal ultrasonography. Until now,there are no WC and VFT cut-off points to predict MS in childrenand adolescents. This study used MS criteria based on NationalCholesterol Education Program – Adult Treatment Panel III(NCEP-ATP III) which specifically modified.Objective The objectives of this study are (a) to determine the MSocurrence based on modified NCEP-ATP III in obese adolescents;(b) to measure the VFT by using abdominal ultrasonography in obeseadolescent with MS and obese adolescent without MS.Methods We conducted a cross-sectional study from March toMay 2006. Fifty obese adolescents were recruited from severaljunior and senior high schools in Jakarta.Results Of those 50 obese adolescents, there were 34 subjects withWC>P 80  and 16 subjects with WC <P 80 . Of those 34 subjectswith WC>P 80 , 17 subjects had MS and the others had no MS. Allthe 16 subjects with WC <P 80 did not have MS. The VFT in 17subjects with WC>P 80  who had MS was 5.19 cm (SD 2.07 cm).The VFT in 17 subjects with WC>P 80 who had no MS was 3.94cm (SD 1.62 cm). The VFT in all 16 subjects with WC <P 80 whodid not have MS was 3.54 cm (SD 0.92 cm). All obese adolescentswith MS had WC>P 80  and they also had visceral fat which wasthicker than obese adolescents without MS.Conclusions All obese adolescents with MS have WC>P 80  andthicker visceral fat than obese adolescents without MS; the VFTof obese adolescents without MS, who had WC>P 80 was 3.94cm (SD 1.62 cm), and the VFT of obese adolescents without MS,who had WC <P 80 was 3.54 cm (SD 0.92 cm).

scholarly journals HELICAL COMPUTERIZED TOMOGRAPHY CAN MEASURE SUBCUTANEOUS, VISCERAL AND TOTAL FAT AREAS?

2021 ◽  
Vol 34 (3) ◽  
Author(s):  
Guilherme WENDLER ◽  
Paulo Afonso Nunes NASSIF ◽  
Osvaldo MALAFAIA ◽  
Eduardo WENDLER ◽  
Ilana Barrichello Torres WENDLER ◽  
...  
Keyword(s):  
Visceral Fat ◽  
Medical Image ◽  
Statistical Significance ◽  
Subcutaneous Fat ◽  
Visceral Fat Area ◽  
Cross Sectional ◽  
Visualization Software ◽  
Grade Ii ◽  
Total Fat ◽  
Umbilical Scar

ABSTRACT Background: Abdominal obesity or android obesity, that is, the increase in adipose tissue in the abdominal region, is considered a risk factor for several morbidities. Different ways of quantifying it have been proposed, one method is the measurement of the abdominal fat area by computed tomography. Aim: To establish correspondence between the groups defined by degree of obesity in relation to the total, subcutaneous and visceral fat area. Methods: Cross-sectional observational study carried out through the analysis of tomographic examinations. Horos v3.3.5 medical image visualization software was used, with abdominal tomography in a single cut including the L4 vertebral body and the umbilical scar, to obtain the areas of total, visceral and subcutaneous fat. Results: Of the 40 patients, 10 had grade II obesity, 23 grade III and 7 superobese. The amount of total fat showed an increase in relation to the degree of obesity. Visceral fat did not show significant differences between the degrees of obesity, but the data showed a lower average in the group of obesity grade II. The area of subcutaneous fat, as well as total fat, showed an increase in its measurements, according to the progression of the patients’ BMI, but there was no statistical significance in this difference between the groups of grade II and super-obese individuals. Conclusion: The area of total and subcutaneous fat showed an increase in its measurements according to the progression of the BMI groups, which did not happen with visceral fat.

scholarly journals Visceral fat obesity is the key risk factor for the development of reflux erosive esophagitis in 40–69-years subjects

Esophagus ◽  
2021 ◽  
Author(s):  
Shinya Ohashi ◽  
Takahisa Maruno ◽  
Keita Fukuyama ◽  
Osamu Kikuchi ◽  
Tomohiko Sunami ◽  
...  
Keyword(s):  
Risk Factor ◽  
Visceral Fat ◽  
Subcutaneous Fat ◽  
Erosive Esophagitis ◽  
Smoking History ◽  
Related Factors ◽  
Visceral Fat Area ◽  
Daily Alcohol Intake ◽  
Gastrointestinal Reflux ◽  
Total Fat

Abstract Background Visceral fat obesity can be defined quantitatively by abdominal computed tomography, however, the usefulness of measuring visceral fat area to assess the etiology of gastrointestinal reflux disease has not been fully elucidated. Methods A total of 433 healthy subjects aged 40–69 years (234 men, 199 women) were included in the study. The relationship between obesity-related factors (total fat area, visceral fat area, subcutaneous fat area, waist circumference, and body mass index) and the incidence of reflux erosive esophagitis was investigated. Lifestyle factors and stomach conditions relevant to the onset of erosive esophagitis were also analyzed. Results The prevalence of reflux erosive esophagitis was 27.2% (118/433; 106 men, 12 women). Visceral fat area was higher in subjects with erosive esophagitis than in those without (116.6 cm2 vs. 64.9 cm2, respectively). The incidence of erosive esophagitis was higher in subjects with visceral fat obesity (visceral fat area ≥ 100 cm2) than in those without (61.2% vs. 12.8%, respectively). Visceral fat obesity had the highest odds ratio (OR) among obesity-related factors. Multivariate analysis showed that visceral fat area was associated with the incidence of erosive esophagitis (OR = 2.18), indicating that it is an independent risk factor for erosive esophagitis. In addition, daily alcohol intake (OR = 1.54), gastric atrophy open type (OR = 0.29), and never-smoking history (OR = 0.49) were also independently associated with the development of erosive esophagitis. Conclusions Visceral fat obesity is the key risk factor for the development of reflux erosive esophagitis in subjects aged 40–69 years.

scholarly journals Systemic Inflammation Characterizes Lack of Metabolic Health in Nonobese HIV-Infected Men

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Ana N. Monczor ◽  
Xiuhong Li ◽  
Frank J. Palella ◽  
Kristine M. Erlandson ◽  
Dorothy Wiley ◽  
...  
Keyword(s):  
Systemic Inflammation ◽  
Visceral Fat ◽  
Subcutaneous Fat ◽  
Normal Weight ◽  
Metabolic Health ◽  
Model Assessment ◽  
Cross Sectional ◽  
Inflammatory Biomarker ◽  
Hiv Serostatus ◽  
Metabolically Healthy

Background. Increasing body mass index (BMI) is generally associated with loss of metabolic health, although some obese individuals remain metabolically healthy. Among nonobese men, HIV infection has been associated with a lower prevalence of metabolic health. Methods. We conducted a cross-sectional analysis of 470 HIV-infected and 368 HIV-uninfected men enrolled in the Multicenter AIDS Cohort Study Cardiovascular substudy. Circulating biomarker levels were compared by BMI category and by HIV serostatus. Poisson regression with robust variance determined associations between metabolic health and circulating inflammatory biomarker levels after adjusting for factors previously associated with metabolic health. Results. HIV-infected men were younger and less likely to be obese. Among HIV-infected, normal weight metabolically healthy men (compared to unhealthy) had significantly lower circulating levels of interleukin- (IL-) 6, soluble tumor necrosis factor receptors (sTNFR) I and II, and homeostatic model assessment of insulin resistance (HOMA-IR), higher adiponectin, less visceral fat, and more subcutaneous fat. Among HIV-uninfected normal weight men and obese men (regardless of HIV serostatus), metabolic health was associated only with higher levels of adiponectin, less visceral fat, and lower HOMA-IR values. In multivariate analyses restricted to HIV-infected men, lower hs-CRP, sTNFRI, sTNFRII, and HOMA-IR and higher adiponectin levels were associated with metabolic health. Additional adjustment for visceral adiposity did not alter results. Conclusions. Among HIV-infected normal weight men, metabolic health was associated with less systemic inflammation, a relationship that, among normal weight men, was unique to HIV+ men and did not exist among obese men of either HIV serostatus.

Subcutaneous fat: A better marker than visceral fat for insulin resistance in obese adolescents

2013 ◽  
Vol 8 (6) ◽  
pp. e251-e255 ◽  
Author(s):  
Matteo Baldisserotto ◽  
Durval Damiani ◽  
Louise Cominato ◽  
Ruth Franco ◽  
Arthur Lazaretti ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Visceral Fat ◽  
Subcutaneous Fat ◽  
Obese Adolescents

scholarly journals Evaluating Relationships between Visceral Fat Measures and Adipokines Concentrations among Women with a History of Preeclampsia

2019 ◽  
Vol 37 (11) ◽  
pp. 1140-1145
Author(s):  
Suchitra Chandrasekaran ◽  
Darcy Barry ◽  
Susan Melhorn ◽  
Thomas Easterling ◽  
Hilary Gammill ◽  
...  
Keyword(s):  
Visceral Fat ◽  
Subcutaneous Fat ◽  
Secondary Analysis ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Anthropometric Data ◽  
Cross Sectional ◽  
Blood Samples ◽  
Plasma Adiponectin ◽  
History Of

Abstract Objective We sought to evaluate associations between postpartum plasma adipokine concentrations among women with a history of preeclampsia (PE) without severe features (MPE), PE with severe features (SPE), and no PE (NPE). We also investigated relationships between adipokines and computed tomography (CT)-quantified measures of visceral fat (VF) area (VFA) and subcutaneous fat area (SCFA). Study Design We performed a secondary analysis of data collected as part of a previously performed cross-sectional study at our institution. Women with and without a history of PE were recruited in 10 years after delivery. VFA and SCFA measures were performed by CT scan. Anthropometric data and peripheral blood samples from subjects were collected concurrently. Results Plasma adiponectin concentrations (µg/mL) were significantly lower among MPE (18.5 ± 7.1) compared with NPE (27.3 ± 13.8) and SPE (25.7 ± 9.6). Leptin (p = 0.32) and resistin (p = 0.93) concentrations were similar among the groups. Adiponectin concentrations more closely aligned with VFA (β = −0.001, p = 0.03), while resistin concentrations trended toward correlating with SCFA (β = 0.02, p = 0.05). Leptin was not preferential to VFA or SCFA. Conclusion VF distribution may contribute to the variation in PE phenotype. Adiponectin specifically may be a promising marker representing VFA.

scholarly journals Does a “Cushion Effect” Really Exist? A Morphomic Analysis of Vulnerable Road Users with Serious Blunt Abdominal Injury

Healthcare ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 1006
Author(s):  
Yu-San Tee ◽  
Chi-Tung Cheng ◽  
Chi-Hsun Hsieh ◽  
Shih-Ching Kang ◽  
Chih-Yuan Fu ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Visceral Fat ◽  
Motor Vehicle ◽  
Subcutaneous Fat ◽  
Abdominal Injury ◽  
Visceral Fat Area ◽  
Cross Sectional ◽  
Road Users ◽  
Severity Of Injury ◽  
Vulnerable Road Users

Introduction: The severity of injury from motor vehicle crashes (MVCs) depends on complex biomechanical factors, and the bodily features of the injured person account for some of these factors. By assuming that vulnerable road users (VRUs) have limited protection resulting from vehicles and safety equipment, the current study analyzed the characteristics of fat distribution measured by computed tomography (CT) imaging and investigated the existence of a “cushion effect” in VRUs. Materials and Methods: This retrospective study enrolled 592 VRUs involved in MVCs who underwent CT scans. Visceral fat area and subcutaneous fat cross-sectional area were measured and adjusted according to total body area (TBA) and are presented as the visceral fat ratio and the subQ fat ratio (subcutaneous fat ratio). Risk factors for serious abdominal injury (maximum abbreviated injury scale (MAISabd ≥ 3)) resulting from MVCs were determined by univariate and multivariate analysis. Results: MAISabd ≥ 3 was observed in 104 (17.6%) of the patients. The subQ fat ratio at the L4 vertebral level was significantly lower in the MAISabd ≥ 3 group than in the MAISabd < 3 group (24.9 ± 12.0 vs. 28.1 ± 11.9%; p = 0.015). A decreased L4 subQ fat ratio was associated with a higher risk for MAISabd ≥ 3 in multivariate analysis (odds ratio 0.063; 95% CI 0.008–0.509; p = 0.009). Conclusion: The current study supported the “cushion effect” theory, and protection was apparently provided by subcutaneous fat tissue. This concept may further improve vehicle and safety designation in the future.

Visceral adiposity as a predictor of survival in patients with epithelial ovarian cancer receiving platinum and taxane-based chemotherapy.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e17031-e17031
Author(s):  
Stuart-Allison Moffat Staley ◽  
Katherine Tucker ◽  
Jorge Oldan ◽  
Dominic T. Moore ◽  
Meredith Newton ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Visceral Fat ◽  
Cox Regression ◽  
Subcutaneous Fat ◽  
Progression Free Survival ◽  
Visceral Adiposity ◽  
Oncologic Outcomes ◽  
The Impact ◽  
Fat Volume

e17031 Background: Obesity has been linked to worse outcomes in epithelial ovarian cancer (EOC), due to underlying metabolic dysfunction. Visceral fat (i.e. central obesity) compared to subcutaneous fat is more metabolically active and has been linked to higher rates of obesity-related comorbidities such as hypertension and diabetes, but less is known of the impact of increased visceral adiposity on EOC outcomes. Thus, our goal was to evaluate if visceral adiposity, as determined by computed tomography (CT) morphometric measurements, was associated with worse outcomes in EOC patients undergoing platinum and taxane-based chemotherapy. Methods: EOC patients diagnosed between 12/2004 and 5/2016 who received neoadjuvant or adjuvant treatment with platinum and taxane-based chemotherapy were included. Data on age, stage, grade, histology, BMI, comorbidities, treatment approaches and outcomes were collected. CT images closest to the time of diagnosis were retrospectively evaluated for mid-waist visceral fat volume (VFV), mid-waist subcutaneous fat volume (SFV) and the ratio of mid-waist VFV/SFV. Visceral adiposity is commonly defined as a VFV/SFV ≥ 0.4. Cox regression models were used to analyze time-to-event outcomes. Results: Two hundred fifty-eight EOC patients were evaluated. Seventy-five percent of patients were diagnosed with Stage III or IV disease, with high grade serous as the most common histology (72%). Median age at diagnosis was 62.4 years. Approximately 65% were obese; the median BMI was 26.8 (IQR 23.1 – 32.6). The median VFV/SFV ratio was 0.46 (IQR 0.32 – 0.70). Patients were categorized into those with a VFV/SFV ratio greater than 0.4 or a ratio less than 0.4. When comparing these two groups, there was no difference in progression free survival (PFS) for women with a VFV/SFV ratio greater or less than 0.4 (p = 0.22). However, a VFV/SFV ratio of greater than 0.4 was associated with worse overall survival (OS) (p = 0.01). Conclusions: We found that visceral adiposity, defined as a VFV/SFV ratio greater than 0.4, appeared to be associated with decreased OS, but not PFS. These findings suggest that body fat distribution may be an important prognostic factor for EOC and should be further explored as we expect the obesity epidemic to continue and influence EOC oncologic outcomes.

scholarly journals Association Between Visceral Fat and Brain Cortical Thickness in the Elderly: A Neuroimaging Study

2021 ◽  
Vol 13 ◽  
Author(s):  
Jaelim Cho ◽  
Seongho Seo ◽  
Woo-Ram Kim ◽  
Changsoo Kim ◽  
Young Noh
Keyword(s):  
Cortical Thickness ◽  
Visceral Fat ◽  
Reference Group ◽  
Subcutaneous Fat ◽  
Additive Model ◽  
The Elderly ◽  
Brain Regions ◽  
Magnetic Resonance Images ◽  
Visceral Fat Area ◽  
Cross Sectional

BackgroundDespite emerging evidence suggesting that visceral fat may play a major role in obesity-induced neurodegeneration, little evidence exists on the association between visceral fat and brain cortical thickness in the elderly.PurposeWe aimed to examine the association between abdominal fat and brain cortical thickness in a Korean elderly population.MethodsThis cross-sectional study included elderly individuals without dementia (n = 316). Areas of visceral fat and subcutaneous fat (cm2) were estimated from computed tomography scans. Regional cortical thicknesses (mm) were obtained by analyzing brain magnetic resonance images. Given the inverted U-shaped relationship between visceral fat area and global cortical thickness (examined using a generalized additive model), visceral fat area was categorized into quintiles, with the middle quintile being the reference group. A generalized linear model was built to explore brain regions associated with visceral fat. The same approach was used for subcutaneous fat.ResultsThe mean (standard deviation) age was 67.6 (5.0) years. The highest quintile (vs. the middle quintile) group of visceral fat area had reduced cortical thicknesses in the global [β = –0.04 mm, standard error (SE) = 0.02 mm, p = 0.004], parietal (β = –0.04 mm, SE = 0.02 mm, p = 0.01), temporal (β = –0.05 mm, SE = 0.02 mm, p = 0.002), cingulate (β = –0.06 mm, SE = 0.02 mm, p = 0.01), and insula lobes (β = –0.06 mm, SE = 0.03 mm, p = 0.02). None of the regional cortical thicknesses significantly differed between the highest and the middle quintile groups of subcutaneous fat area.ConclusionThe findings suggest that a high level of visceral fat, but not subcutaneous fat, is associated with a reduced cortical thickness in the elderly.

Targeting FFA1 and FFA4 receptors in cancer-induced cachexia

2020 ◽  
Vol 319 (5) ◽  
pp. E877-E892
Author(s):  
Raquel D. S. Freitas ◽  
Thaís C. Muradás ◽  
Ana Paula A. Dagnino ◽  
Fernanda L. Rost ◽  
Kesiane M. Costa ◽  
...  
Keyword(s):  
Visceral Fat ◽  
Cancer Cachexia ◽  
Motor Coordination ◽  
Metabolic Diseases ◽  
Uncoupling Protein ◽  
Subcutaneous Fat ◽  
Body Weight Loss ◽  
Brain Regions ◽  
Omega 3 ◽  
Cross Sectional

Free fatty acid (FFA) receptors FFA1 and FFA4 are omega-3 molecular targets in metabolic diseases; however, their function in cancer cachexia remains unraveled. We assessed the role of FFA1 and FFA4 receptors in the mouse model of cachexia induced by Lewis lung carcinoma (LLC) cell implantation. Naturally occurring ligands such as α-linolenic acid (ALA) and docosahexaenoic acid (DHA), the synthetic FFA1/FFA4 agonists GW9508 and TUG891, or the selective FFA1 GW1100 or FFA4 AH7614 antagonists were tested. FFA1 and FFA4 expression and other cachexia-related parameters were evaluated. GW9508 and TUG891 decreased tumor weight in LLC-bearing mice. Regarding cachexia-related end points, ALA, DHA, and the preferential FFA1 agonist GW9508 rescued body weight loss. Skeletal muscle mass was reestablished by ALA treatment, but this was not reflected in the fiber cross-sectional areas (CSA) measurement. Otherwise, TUG891, GW1100, or AH7614 reduced the muscle fiber CSA. Treatments with ALA, GW9508, GW1100, or AH7614 restored white adipose tissue (WAT) depletion. As for inflammatory outcomes, ALA improved anemia, whereas GW9508 reduced splenomegaly. Concerning behavioral impairments, ALA and GW9508 rescued locomotor activity, whereas ALA improved motor coordination. Additionally, DHA improved grip strength. Notably, GW9508 restored abnormal brain glucose metabolism in different brain regions. The GW9508 treatment increased leptin levels, without altering uncoupling protein-1 downregulation in visceral fat. LLC-cachectic mice displayed FFA1 upregulation in subcutaneous fat, but not in visceral fat or gastrocnemius muscle, whereas FFA4 was unaltered. Overall, the present study shed new light on FFA1 and FFA4 receptors’ role in metabolic disorders, indicating FFA1 receptor agonism as a promising strategy in mitigating cancer cachexia.

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