scholarly journals Vascularized Bone Tissue Formation Induced by Fiber-Reinforced Scaffolds Cultured with Osteoblasts and Endothelial Cells

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Xinhui Liu ◽  
Guoping Zhang ◽  
Chuanyong Hou ◽  
Hua Wang ◽  
Yelin Yang ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Bone Tissue ◽  
Bone Repair ◽  
Composite Scaffold ◽  
Tissue Formation ◽  
General Observation ◽  
Repair Materials ◽  
Bone Tissue Formation ◽  
Vascularized Bone

The repair of the damaged bone tissue caused by damage or bone disease was still a problem. Current strategies including the use of autografts and allografts have the disadvantages, namely, diseases transmission, tissue availability and donor morbidity. Bone tissue engineering has been developed and regarded as a new way of regenerating bone tissues to repair or substitute damaged or diseased ones. The main limitation in engineering in vitro tissues is the lack of a sufficient blood vessel system, the vascularization. In this paper, a new-typed hydroxyapatite/collagen composite scaffold which was reinforced by chitosan fibers and cultured with osteoblasts and endothelial cells was fabricated. General observation, histological observation, detection of the degree of vascularization, and X-ray examination had been done to learn the effect of vascularized bone repair materials on the regeneration of bone. The results show that new vessel and bone formed using implant cultured with osteoblasts and endothelial cells. Nanofiber-reinforced scaffold cultured with osteoblasts and endothelial cells can induce vascularized bone tissue formation.

Bioactive and Biocompatible Silica/Pseudowollastonite Aerogels

2014 ◽  
Vol 96 ◽  
pp. 21-26 ◽  
Author(s):  
P.J. Reséndiz-Hernández ◽  
D.A. Cortés-Hernández ◽  
Juan Méndez Nonell ◽  
J.C. Escobedo-Bocardo
Keyword(s):  
Bone Tissue ◽  
Ambient Pressure ◽  
Sol Gel ◽  
Ambient Pressure Drying ◽  
Bone Tissue Regeneration ◽  
Tissue Formation ◽  
Potential Applications ◽  
Ft Ir ◽  
Bone Tissue Formation

Silica aerogels have attracted increasingly more attention due to their extraordinary properties and their existing and potential applications in a wide variety of technological areas. Materials that promote bone-tissue formation at their surface and bond to osseous tissues when implanted are called bioactive, such as pseudowollastonite particles. In this work, the synthesis of aerogels with pseudowollastonite particles was performed. The synthesis involved the preparation of an alcogel by a two step sol-gel route followed by ambient pressure drying. To promote a higher bioactivity the obtained aerogels were then biomimetically treated using simulated body fluids, SBF and 1.5 SBF. A high bioactivity was demonstrated by FT-IR, SEM, EDS, and XRD. The in vitro biocompatibility was assessed by testing cytotoxicity using rat osteoblasts cultures. The results obtained indicate that these materials are highly potential aerogels for bone tissue regeneration.

Carbon Nanotube Reinforced Collagen/Hydroxyapatite Scaffolds Improve Bone Tissue Formation In Vitro and In Vivo

2017 ◽  
Vol 45 (9) ◽  
pp. 2075-2087 ◽  
Author(s):  
Zheng Jing ◽  
Yeke Wu ◽  
Wen Su ◽  
Mi Tian ◽  
Wenlu Jiang ◽  
...  
Keyword(s):  
Carbon Nanotube ◽  
Bone Tissue ◽  
Tissue Formation ◽  
Bone Tissue Formation

scholarly journals Carboxyl-modified single-wall carbon nanotubes improve bone tissue formation in vitro and repair in an in vivo rat model

2014 ◽  
pp. 4277 ◽  
Author(s):  
Antonio Barrientos-Duran ◽  
Ellen M. Carpenter ◽  
Nicole I. zur Nieden ◽  
Theodore I. Malinin ◽  
Juan Carlos Rodriguez-Manzaneque ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Bone Tissue ◽  
Rat Model ◽  
Single Wall Carbon Nanotubes ◽  
Tissue Formation ◽  
Single Wall Carbon ◽  
Bone Tissue Formation

Bioinspired inorganic nanoparticles and vascular factor microenvironment directed neo-bone formation

2020 ◽  
Vol 8 (9) ◽  
pp. 2627-2637
Author(s):  
Hwan D. Kim ◽  
Jungha Park ◽  
Sivashanmugam Amirthalingam ◽  
R. Jayakumar ◽  
Nathaniel S. Hwang
Keyword(s):  
Stem Cells ◽  
Bone Formation ◽  
Bone Tissue ◽  
Inorganic Nanoparticles ◽  
Tissue Formation ◽  
Human Tonsil ◽  
Polymeric Scaffolds ◽  
Vascular Factor ◽  
Bone Tissue Formation ◽  
Vascularized Bone

VEGF-overexpressing human tonsil-derived stem cells (VEGF-hTMSCs) and a whitlockite microenvironment induce vascularized bone tissue formation in biodegradable polymeric scaffolds.

An experiment on in vitro bone tissue formation by HMS0014 human mesenchymal cells cultured on surface modified titanium plates

Bone ◽  
2012 ◽  
Vol 51 (6) ◽  
pp. S17
Author(s):  
M. Nakatsuka ◽  
S. Kumabe ◽  
Y. Hashimoto ◽  
A. Hosoya ◽  
C. An ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Mesenchymal Cells ◽  
Tissue Formation ◽  
Surface Modified ◽  
Bone Tissue Formation ◽  
Cells Cultured

55S® Bioglass Stimulates in Vitro Osteoblast Differentiation and Creates a Favorable Template for Bone Tissue Formation

2000 ◽  
Vol 192-195 ◽  
pp. 605-608
Author(s):  
S. Loty ◽  
J.M. Sautier ◽  
C. Loty ◽  
M.T. Tan ◽  
D.C. Greenspan ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Osteoblast Differentiation ◽  
Tissue Formation ◽  
Bone Tissue Formation

scholarly journals The action of demineralized bovine bone matrix on bone neoformation in rats submitted to experimental alcoholism

2013 ◽  
Vol 65 (3) ◽  
pp. 715-721 ◽  
Author(s):  
R.L. Buchaim ◽  
J.C. Andreo ◽  
A. C. Rodrigues ◽  
D.V. Buchaim ◽  
D.V. Dias ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Bone Repair ◽  
Blood Clot ◽  
Bone Matrix ◽  
Male Rats ◽  
Bovine Bone ◽  
Filling Material ◽  
Tissue Formation ◽  
Bone Trabeculae ◽  
Bone Tissue Formation

The objective of this study was to evaluate whether demineralized bovine bone (Gen-ox®) alters bone neoformation in rats submitted to alcoholism. Forty male rats were separated into two groups of 20 rats and distributed as follows: Group E1, which received 25% ethanol and a surgical cavity filled only by a blood clot, and Group E2, which received 25% ethanol and a surgical cavity filled with Gen-ox®. The animals were euthanized at 10, 20, 40 and 60 days after surgery and necropsy was performed. The histomorphological and histometric analyses of the area of connective tissue and bone neoformation showed that the reorganization of the bone marrow and full repair of the surgical cavity in Group E1 occurred more quickly than in Group E2. It was also noted that in the final period the animals in Group E2 showed areas of connective tissue and thick bone trabeculae around the particles of the implant. It can be concluded that the use of Gen-ox® delayed the process of bone repair in alcoholic rats, although it can be used as filling material because it shows osteoconductive activity, as evidenced by bone tissue formation around the graft particles.

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