Evaluating the inherent osteogenic and angiogenic potential of mesoporous silica nanoparticles to augment vascularized bone tissue formation

2021 ◽  
Vol 311 ◽  
pp. 110687
Author(s):  
Hemalatha Kanniyappan ◽  
Manigandan Venkatesan ◽  
Jay Panji ◽  
Megala Ramasamy ◽  
Vignesh Muthuvijayan
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Bone Tissue ◽  
Mesoporous Silica Nanoparticles ◽  
Tissue Formation ◽  
Angiogenic Potential ◽  
Bone Tissue Formation ◽  
Vascularized Bone

Bioinspired inorganic nanoparticles and vascular factor microenvironment directed neo-bone formation

2020 ◽  
Vol 8 (9) ◽  
pp. 2627-2637
Author(s):  
Hwan D. Kim ◽  
Jungha Park ◽  
Sivashanmugam Amirthalingam ◽  
R. Jayakumar ◽  
Nathaniel S. Hwang
Keyword(s):  
Stem Cells ◽  
Bone Formation ◽  
Bone Tissue ◽  
Inorganic Nanoparticles ◽  
Tissue Formation ◽  
Human Tonsil ◽  
Polymeric Scaffolds ◽  
Vascular Factor ◽  
Bone Tissue Formation ◽  
Vascularized Bone

VEGF-overexpressing human tonsil-derived stem cells (VEGF-hTMSCs) and a whitlockite microenvironment induce vascularized bone tissue formation in biodegradable polymeric scaffolds.

scholarly journals Vascularized Bone Tissue Formation Induced by Fiber-Reinforced Scaffolds Cultured with Osteoblasts and Endothelial Cells

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Xinhui Liu ◽  
Guoping Zhang ◽  
Chuanyong Hou ◽  
Hua Wang ◽  
Yelin Yang ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Bone Tissue ◽  
Bone Repair ◽  
Composite Scaffold ◽  
Tissue Formation ◽  
General Observation ◽  
Repair Materials ◽  
Bone Tissue Formation ◽  
Vascularized Bone

The repair of the damaged bone tissue caused by damage or bone disease was still a problem. Current strategies including the use of autografts and allografts have the disadvantages, namely, diseases transmission, tissue availability and donor morbidity. Bone tissue engineering has been developed and regarded as a new way of regenerating bone tissues to repair or substitute damaged or diseased ones. The main limitation in engineering in vitro tissues is the lack of a sufficient blood vessel system, the vascularization. In this paper, a new-typed hydroxyapatite/collagen composite scaffold which was reinforced by chitosan fibers and cultured with osteoblasts and endothelial cells was fabricated. General observation, histological observation, detection of the degree of vascularization, and X-ray examination had been done to learn the effect of vascularized bone repair materials on the regeneration of bone. The results show that new vessel and bone formed using implant cultured with osteoblasts and endothelial cells. Nanofiber-reinforced scaffold cultured with osteoblasts and endothelial cells can induce vascularized bone tissue formation.

Recent Advances in Application of Azobenzenes Grafted on Mesoporous Silica Nanoparticles in Controlled Drug Delivery Systems Using Light as External Stimulus

2020 ◽  
Vol 20 (11) ◽  
pp. 1001-1016
Author(s):  
Sandra Ramírez-Rave ◽  
María Josefa Bernad-Bernad ◽  
Jesús Gracia-Mora ◽  
Anatoly K. Yatsimirsky
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
Delivery Systems ◽  
Surface Reactivity ◽  
External Stimulus ◽  
Recent Advances

Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is the use of external stimuli for drug release. In this context, light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and a large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last years with an emphasis on usually overlooked underlying chemistry, photophysical properties, and supramolecular complexation of azobenzenes.

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