scholarly journals Innovations and Challenges by Applying Sublingual Laser Blood Irradiation in Juvenile Idiopathic Arthritis

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Laura Marinela Ailioaie ◽  
Gerhard Litscher ◽  
Michael Weber ◽  
Constantin Ailioaie ◽  
Daniela Litscher ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Maximum Output Power ◽  
Controlled Study ◽  
Maximum Output ◽  
Group Iii ◽  
American College Of Rheumatology ◽  
Group I ◽  
Blood Irradiation ◽  
Group Ii ◽  
Laser Blood Irradiation

Sublingual laser blood irradiation (SLBI) was applied into a randomized, single-blind, placebo-controlled study in juvenile idiopathic arthritis (JIA), aimed at inducing disease remission. 105 children with JIA, without an adequate response to classical treatment, were administrated a disease modifying drug (Methotrexate) and were randomly assigned to three groups. Group I (36 patients) received SLBI with the Weberneedle Lasershower Mouth Applicator with three wavelengths (635 nm, 536 nm, and 405 nm), 5 mW maximum output power each, in continuous mode, simultaneously, for 20 minutes daily, 7 successive sessions per month, repeated every 7 weeks, for three times. Group II (36 patients) received placebo SLBI. Group III (33 patients) received only treatment with Methotrexate. Evaluation was performed using American College of Rheumatology Pediatric criteria (ACR Pedi) at study enrollment and at 8, 16, 24, and 48 weeks. At the end of study, there was an improvement of the ACR Pedi 30 by 86.11% in SLBI group compared to only 61.11% in Group II, respectively, and 60.6% in Group III (P=0.001), with significant statistical differences. SLBI has reduced the pain, lowered the number of articulations with movement limitation, increased the quality of life, and made it possible to avoid the administration of biological agents.

scholarly journals Intravenous Laser Blood Irradiation Increases Efficacy of Etanercept in Selected Subtypes of Juvenile Idiopathic Arthritis: An Innovative Clinical Research Approach

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Dragos Andrei Chiran ◽  
Gerhard Litscher ◽  
Michael Weber ◽  
Laura Marinela Ailioaie ◽  
Constantin Ailioaie ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Blocking Agent ◽  
Controlled Study ◽  
Research Approach ◽  
Necrosis Factor Alpha ◽  
American College Of Rheumatology ◽  
Group I ◽  
Blood Irradiation ◽  
Group Ii ◽  
Laser Blood Irradiation

This single-blind, placebo-controlled study assesses the efficacy of synergic administration of intravenous laser blood irradiation (ILBI) and etanercept in selected subtypes of juvenile idiopathic arthritis (JIA). Etanercept is a tumor necrosis factor alpha blocking agent with recognized importance in JIA. Laser radiation has immunomodulatory effects in animal and human studies. Fourteen patients (Group I) received ILBI and 9 patients (Group II) received placebo laser. ILBI was performed in addition to ongoing JIA medication, including etanercept. ILBI was administrated in 3 sets of 5 consecutive daily sessions, with a 7-week interval between every set of sessions. Evaluation was performed using ACR (American College of Rheumatology) Pediatric Criteria (ACR Pedi) at study enrollment and at 10 and 20 weeks, respectively. After 10 weeks, 85.7% of the patients in Group I fulfilled Pedi 30 criteria, compared to only 55.6% of the patients in Group II. After 20 weeks, all patients in both groups had a Pedi 30 response. In Group I, 92.8% of the subjects met the Pedi 50 response, compared to only 55.6% in the placebo group. One patient in Group I responded best, fulfilling Pedi 70 criteria. If applied synergistically, ILBI and etanercept would have an increased efficacy in promoting JIA remission.

scholarly journals Pharmacodynamics of Rocuronium in Cholestatic Patients with or without Hepatocellular Injury : Normal Onset Time of Initial Dose and Prolonged Duration Time After Repeated Doses

2008 ◽  
Vol 11 (3) ◽  
pp. 15 ◽  
Author(s):  
Jian-jun Yang ◽  
Yong-guang Wang ◽  
Zhuan Zhang ◽  
Zhi-jie Zhang ◽  
Jin Liu ◽  
...  
Keyword(s):  
Initial Dose ◽  
Onset Time ◽  
Controlled Study ◽  
Hepatocellular Injury ◽  
Group Iii ◽  
Recovery Index ◽  
Duration Time ◽  
Group I ◽  
Repeated Doses ◽  
Group Ii

Purpose. A prospective controlled study was designed to observe the pharmacodynamics of rocuronium in cholestatic patients with or without hepatocellular injury. Methods. Sixty patients undergoing abdominal surgery were allocated into three groups: group I had 20 cholestatic patients with hepatocellular injury; group II had 20 cholestatic patients without hepatocellular injury, and group III (control group) had 20 patients without hepatic disease. Anesthetized with propofol and fentanyl, all patients received rocuronium 0.6 mg/kg for initial dose followed by intermittent repeated administration of rocuronium 0.15 mg/kg. The twitch high of adductor pollicis muscle was monitored by acceleromyography. The onset time of the initial dose, the duration time of the initial and the repeated doses, and the recovery index were observed. Results. The onset and the duration time of the initial dose had no significant difference among the three groups (P>0.05). After administration of the 5th dose, the duration time of the repeated doses was significantly prolonged than that of the 2nd dose in group I (31±8 versus 22±4 min) and group II (28±5 versus 21±4 min) (P0.05). The recovery index of rocuronium was longer in group I (48±13 min) and group II (46±9 min) than that in group III (24±5 min) (P

Effects of different polyvinylpyrrolidone iodine concentrations on trismus and swelling following third molar surgery

2020 ◽  
pp. 1-16
Author(s):  
Esra Yüce ◽  
Omur Dereci ◽  
Nazli Altin ◽  
Cansugul Efeoglu Koca ◽  
Murude Yazan
Keyword(s):  
Povidone Iodine ◽  
Maxillofacial Surgery ◽  
Third Molar ◽  
Group Iv ◽  
Controlled Study ◽  
Third Molar Surgery ◽  
Group Iii ◽  
Group I ◽  
Facial Swelling ◽  
Group Ii

Abstract Objective: To compare the clinical efficacy of different povidone iodine concentrations for the management of postoperative pain and swelling following mandibular third molar surgery. Methods: The randomised, prospective, double-blind and controlled study was conducted from October 2016 to January 2018 at the Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Biruni University, Istanbul, Turkey, and comprised individuals aged 18-30 years who underwent surgical removal of pathology-free completely unerrupted mandibular lower third molars. The participants were randomly assigned to four groups: Group I had saline-only controls, Group II was given 0.5% concentration of povidone iodine, Group III had 1% concentration of povidone iodine, and Group IV had 3% concentration of povidone iodine. Facial swelling and trismus were assessed on the 2nd and 7th postoperative days. Data was analysed using SPSS 22. Results: Of the 80 patients, 34(42.5%) were males and 46(57.5%) were females with an overall mean age of 24.6±3.68 years. Each group had 20(25%) subjects. All three concentrations of povidone iodine provided significant reduction in postoperative trismus compared to the controls. Trismus was less in Group III and Group IV compared to Group II up to 7 days after surgery. Conclusion: Irrigation with 3% povidone iodine concentration was found to be more effective in reducing the level of facial swelling after impacted third molar surgery. (Clinical Trials.gov Identifier: NCT03894722) Key Words: Maxillofacial surgery, Third molar, Povidone-Iodine, Swelling, Tismus

scholarly journals Accident risk in patients with epilepsy

2008 ◽  
Vol 66 (2a) ◽  
pp. 175-178 ◽  
Author(s):  
Karla Teixeira Souza ◽  
Marilisa M. Guerreiro ◽  
Carlos A.M. Guerreiro
Keyword(s):  
Epileptic Seizures ◽  
Outpatient Clinics ◽  
Controlled Study ◽  
Accident Risk ◽  
Group Iii ◽  
Group I ◽  
Group Ii ◽  
Patients With Epilepsy ◽  
Prospective Longitudinal ◽  
Structured Questionnaire

OBJECTIVE: To compare the risk of accidents in patients with uncontrolled seizures, in seizure-free patients, and in patients with chronic headache. METHOD: This was a prospective longitudinal case-controlled study with interviews. A semi-structured questionnaire was used in the epilepsy and headache outpatient clinics of the Hospital das Clínicas of UNICAMP. RESULTS: Group I was composed of 48 patients with uncontrolled seizures, group II was composed of 24 seizure-free patients and group III was composed of 32 patients with headache. Thirty-nine patients (81%) in group I, 13 (54%) in group II, and 19 (59%) in group III reported accidents in the last two years. In the first group, 649 accidents (89%) were related to epileptic seizures and the average number of accidents not related to seizures was 1.7. The average number of accidents in groups II and III were both 2.4. CONCLUSION: Epileptic seizure was the most important factor determining the occurrence of accidents in people with epilepsy.

scholarly journals Comparative Study between the Effect of Dexmedetomidine or Magnesium Sulphate Infusion on the Recovery Profile and Postoperative Analgesia in Patients Undergoing Laparoscopic Bariatric Surgery

2021 ◽  
pp. 42-52
Author(s):  
Doaa Kelany Ibrahim ◽  
Sameh Abd EL Khalik Ahmed ◽  
Ashraf Elsayed El Zeftawy ◽  
Sabry Mohamed Amin
Keyword(s):  
Bariatric Surgery ◽  
Magnesium Sulphate ◽  
Controlled Study ◽  
Laparoscopic Bariatric Surgery ◽  
Early Recovery ◽  
Group Iii ◽  
Arterial Blood ◽  
Group I ◽  
Recovery Profile ◽  
Group Ii

Background: The increasing incidence of morbid obesity is a crisis in national healthcare which has precipitated an increase in bariatric surgery. Bariatric surgery is an effective treatment for obesity, with a mean percentage of weight loss after 2 years of 68.2% for laparoscopic bariatric surgery. Methods: This prospective randomized controlled study was carried out in Tanta University Hospitals in General Surgery Department on patients scheduled for elective laparoscopic bariatric surgery from July 2019 to June 2020. The study has been approved by the Institutional ethical committee at Faculty of Medicine, Tanta University with approval number (33161/05/19) Results: There was a significant decrease in heart rate, at T2 to T9, in group II (Dexmedetomidine group) and group III (Mg sulphate group) compared to group I (Control group). There was a significant decrease in mean arterial blood pressure, at T2 to T9,  in group II and group III compared to group I. Visual analog scale for pain (VAS) was decreased significantly in group II and group III compared to group I. There was a negative increase in nausea and vomiting in group I than group II and group III. Bradycardia, hypotension and postoperative hypoxemia were insignificantly different among the three groups. Conclusions: In patients undergoing laparoscopic bariatric surgeries, both dexmedetomidine and magnesium sulphate were safe and effective as regards early recovery profile, delayed time for the first request of analgesia and less opioid consumption.

Polydrug- and Methadone-Addicted Newborns: A Continuum of Impairment?

PEDIATRICS ◽  
1982 ◽  
Vol 70 (2) ◽  
pp. 210-213 ◽  
Author(s):  
Ira J. Chasnoff ◽  
Roger Hatcher ◽  
William J. Burns
Keyword(s):  
Methadone Maintenance ◽  
Behavioral Assessment ◽  
Controlled Study ◽  
Control Group ◽  
Group Iii ◽  
Group I ◽  
Outcome Group ◽  
Group Ii ◽  
Prospective Controlled Study ◽  
Control Group Group

Two groups of infants born to drug-addicted mothers were evaluated in a prospective controlled study and compared with a third control group. Group I infants (N = 39) were born to mothers on well-controlled low-dose methadone maintenance. Group II infants (N = 19) were born to polydrug-abusing mothers, and group III infants (N = 27) were born to control mothers who had no history or evidence of drug abuse. All three groups were matched for maternal factors that might affect neonatal outcome. Group I infants were significantly smaller than control infants for all growth measurements and had a significantly smaller head circumference than group II infants. Utilizing the Brazelton Neonatal Behavioral Assessment Scale, group I infants showed more depression of interactive behaviors and state controls than group II infants, who in turn were more depressed than group III infants. The effects of nonnarcotic drugs on intrauterine growth and neonatal behavior appear to place the polydrug-addicted newborn in an intermediate zone of deficit between normal and opiate-addicted newborns.

scholarly journals Silodosin versus Tamsulosin as Medical Expulsive Therapy for Children with Lower-Third Ureteric Stones: Prospective Randomized Placebo-Controlled Study

2021 ◽  
pp. 1-6
Author(s):  
Mohamed G. Soliman ◽  
Osama El-Gamal ◽  
Samir El-Gamal ◽  
Ali Abdel Raheem ◽  
Ahmed Abou-Ramadan ◽  
...  
Keyword(s):  
Randomized Study ◽  
Study Groups ◽  
Controlled Study ◽  
Expulsion Rate ◽  
Medical Expulsive Therapy ◽  
Group Iii ◽  
Group I ◽  
Younger Age ◽  
Significant Difference ◽  
Group Ii

<b><i>Aim:</i></b> To compare the efficacy and safety of silodosin versus tamsulosin as medical expulsive therapy for stones of lower-third ureter in children. <b><i>Patients and Methods:</i></b> This prospective single-blind placebo-controlled randomized study included 167 pediatric patients who presented with distal ureteric stone (DUS) less than 1 cm. Patients were randomized into 3 groups; group I received silodosin 4 mg once daily, and group II received tamsulosin 0.4 mg while those in group III had placebo. The side effects of the used drugs, both rate and time of stone expulsion, and number of pain episodes were compared among the study groups for a maximum of 4 weeks. <b><i>Results:</i></b> Follow-up data of our patients after treatment revealed that the stone expulsion rate was significantly higher and the time to stone expulsion was significantly shorter in group I (89.3%, 12.4 ± 2.3 days) and group II (74.5%, 16.2 ± 4.2 days) compared to group III (51.8%, 21.2 ± 5.6). However, a statistically significant difference between silodosin and tamsulosin groups in favor of the former one was reported regarding the 2 studied items. Meanwhile, pain episodes requiring analgesia were statistically fewer in group I and II in contrast to placebo group. Adverse events were comparable among all groups. <b><i>Conclusion:</i></b> Silodosin provides significantly better stone expulsion rate and shorter expulsion time than tamsulosin for treatment of DUS. Both medications showed good safety profiles in children. However, further studies are required on a larger scale to confirm our results. Assessment of drug safety on younger age-group is still needed.

scholarly journals Long-Term Effects of Articular and Extra-Articular Damage in Adult Patients with Juvenile Idiopathic Arthritis and Different Immunogenic Markers

2017 ◽  
Vol 24 (3) ◽  
Author(s):  
M. Dzhus ◽  
H. Mostbauer ◽  
T Karasevska ◽  
O. Ivashkivsky
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Rheumatoid Factor ◽  
Damage Index ◽  
Juvenile Arthritis ◽  
Long Term Effects ◽  
Group Iii ◽  
Group I ◽  
Group Ii ◽  
Citrullinated Peptide

To assess the long-term effects of juvenile idiopathic arthritis in adulthood, unified diagnostic methods for articular and extra-articular lesions should be used which depend on the juvenile idiopathic arthritis variants, the disease activity and treatment. The objective of the research was to compare the clinical manifestations in adult patients with different juvenile idiopathic arthritis-specific immunogenic markers and to evaluate their impact on the long-term articular and extra-articular damage.Materials and methods. We observed 132 young patients with different juvenile idiopathic arthritis variants. According to genetic/immunological markers the following groups were formed:  Group I - 38 positive human leukocyte antigen B27 patients; Group II - 13 positive antinuclear antibody patients; Group III - 26 positive rheumatoid factor/anti-cyclic citrullinated peptide patients and Group IV - 55 patients with all negative markers. Long-term effects of juvenile idiopathic arthritis were estimated by the articular juvenile arthritis damage index (JADI-A) and the extra-articular juvenile arthritis damage index (JADI-E). Descriptive statistics, the Student’s T-test, the Fisher’s exact test and Mann-Whitney U-test were performed.Results. 70 women and 62 men with the disease duration of 13.6±9.3 years at the age of 24.3±8.3 years were included into the study: 12 (9.1%) patients with positive rheumatoid factor polyarthritis, 30 (22.7%) patients - with negative rheumatoid factor polyarthritis, 32 (24.2%) patients with persistent oligoarthritis, 19 (14.4%) patients with extendent oligoarthritis, 20 (15.2%) patients with entesitis-related arthritis and 19 (14.4%) patients with systemic arthritis; there were no patients with psoriatic arthritis. There were no differences between groups in age, disease-modifying antirheumatic drug cumulative dose, mean dose of prednisolone and quality of life according to the SF-36. In Group I, the delay in the diagnosis was more than one year (18.6±24.2 months). In this group, less painful (p<0.005) and deformed (p<0.01) joints as compared to Group ІІІ, and higher levels of the ESR and C-reactive protein as compared to Group ІV were found, although the Juvenile Arthritis Disease Activity Score index in childhood was lower (p<0.005) as compared to Group ІІ. They received a lower cumulative dose of the glucocorticoids as compared to Group II (p<0.01), respectively. They had lower (p<0.01) JADI-E as compared to Group II (1.31 ± 1.49) and lower (p <0.01) JADI-A as compared to Group III. In Group III, the diagnosis was made the fastest in comparison with other groups (6.4±8.4 months, p<0.05); more painful joints (p <0.05) and ankylosis (p<0.05) were observed as compared to Group I, JADI-A was significantly higher (p<0.05) in Group III as compared to Group I. The most pronounced JADI-A was found in Group III, while in Group I and Group II, this index was the lowest. JADI-E was the most pronounced in Group II, and the most favorable course was found in Group І and Group ІІІ (p<0.05).Conclusions. Presence of anti-cyclic citrullinated peptide/rheumatoid factor in adults with juvenile idiopathic arthritis has negative impact on joint damage (JADI-A) indicating the need for aggressive therapy in both childhood and adulthood. Presences of antinuclear antibodies are associated with more often extra-articular damages in adulthood as compared to other groups.

scholarly journals Clinical Comparison of Epidural Clonidine and Verapamil with Ropivacaine in Abdominal Hysterectomy; A Prospective, Randomized, Controlled Study.

2020 ◽  
Vol 5 (1) ◽  
pp. 91-95
Author(s):  
Suraj Kumar ◽  
Manoj Tripathi ◽  
Deepak Malviya ◽  
Sujeet Rai ◽  
Sumit Kumar ◽  
...  
Keyword(s):  
Postoperative Analgesia ◽  
Motor Block ◽  
Sensory Block ◽  
Local Anaesthetics ◽  
Epidural Block ◽  
Controlled Study ◽  
Analgesic Requirement ◽  
Group Iii ◽  
Group I ◽  
Group Ii

Background: Adjuvants, when combined with local anaesthetics, increase duration of block, improve quality of blockade and accelerate onset of block. The aim of this study is to assess the analgesic properties and postoperative analgesia of Clonidine and verapamil in the epidural block for abdominal hysterectomy.Subjects and Methods:Ninety patients were divided into three groups Group l- patient were given ropivacaine (0.75%) in the dose of 20 ml, Group II -0.75% ropivacaine 20 ml with verapamil in the dose of 2.5 ml, Group III -0.75% ropivacaine 20 ml with Clonidine in the dose of 1mcg/kg body weight. Patients were assessed for onset, degree, level, duration of sensory and motor block, duration of complete analgesia and postoperative analgesia, rescue analgesic requirement, sedation score and adverse effects.Results:When groups I and II were compared, onset of sensory and motor block was found to be statistically insignificant (p>0.05), while it was early in group III in comparison to groups I and II and statistically significant ( p<0.05). The duration of sensory block in group III was more in comparison to groups I and II  and were statistically significant ( p<0.05). The mean duration of analgesia in group I was 184.03 + 5.20 mins, in group II was 300.46 + 5.80 mins and in groups, III was 538 + 12.80 mins.Conclusion:Verapamil does not enhance the onset, duration of the sensory and motor block, though Clonidine in the dose of 1ug/kg enhances the onset of sensory block. The duration of postoperative analgesia with verapamil was more and much higher compared to Clonidine.

Ultrastructural Lesions Produced by Alcohol and Sucrose in the Heart and Liver of C57BL Mice

1970 ◽  
Vol 28 ◽  
pp. 208-209
Author(s):  
K.K. SEKHRI ◽  
C.S. ALEXANDER ◽  
H.T. NAGASAWA
Keyword(s):  
Osmium Tetroxide ◽  
Male Mice ◽  
Alcohol Group ◽  
Group Iii ◽  
Group I ◽  
C57bl Mice ◽  
Group Ii

C57BL male mice (Jackson Lab., Bar Harbor, Maine) weighing about 18 gms were randomly divided into three groups: group I was fed sweetened liquid alcohol diet (modified Schenkl) in which 36% of the calories were derived from alcohol; group II was maintained on a similar diet but alcohol was isocalorically substituted by sucrose; group III was fed regular mouse chow ad lib for five months. Liver and heart tissues were fixed in 2.5% cacodylate buffered glutaraldehyde, post-fixed in 2% osmium tetroxide and embedded in Epon-araldite.

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