scholarly journals Treatment Outcome of Tuberculosis Patients Registered at DOTS Centre in Ogbomoso, Southwestern Nigeria: A 4-Year Retrospective Study

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Olarewaju Sunday ◽  
Olanrewaju Oladimeji ◽  
Folorunso Ebenezer ◽  
Babatunde Akintunde ◽  
Temitayo-Oboh Abiola ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Success Rate ◽  
Treatment Success ◽  
Tuberculosis Treatment ◽  
Treatment Success Rate ◽  
Health Concern ◽  
Tuberculosis Control ◽  
Southwestern Nigeria ◽  
Tuberculosis Patients ◽  
Unsuccessful Treatment

Background Information. Monitoring outcome of tuberculosis treatment and understanding the specific reasons for unsuccessful treatment outcome are important in evaluating the effectiveness of tuberculosis control program. This study investigated tuberculosis treatment outcomes and predictors for unsuccessful treatment outcome in Ogbomoso town, Southwestern Nigeria.Methodology. Medical records of all tuberculosis patients registered from January 2008 to December 2011 in 5 Local Government areas, Ogbomoso, Southwestern Nigeria, were reviewed. Treatment outcome and tuberculosis type were categorized according to the national tuberculosis control guideline. Bivariate analysis was used to analyse the association between treatment outcome and potential predictor variables.Results. Out of the 965 total TB patients (579 males and 386 females) with mean age 42.4 ± 1.9 years, 866 (89.74%) were categorized as pulmonary tuberculosis and 109 (11.30%) as extrapulmonary tuberculosis. Treatment outcome among total 914 subjects was as follows: 304 (33.26%) patients got cured, 477 (52.19%) completed treatment, 87 (9.52%) died, 9 (0.98%) defaulted, and 1 (0.11%) failed treatment while 36 (3.94%) were transferred out. Higher treatment success rate was associated with those on Category 1 treatment (P<0.05).Conclusion. The treatment success rate of tuberculosis patients was high (85.45%) compared to national target. However, certain proportion of patients died (9.52%) and defaulted (0.98%), which is a serious public health concern that needs to be addressed urgently.

scholarly journals Treatment Outcomes and Associated Factors in Tuberculosis Patients at Atwima Nwabiagya District, Ashanti Region, Ghana: A Ten-Year Retrospective Study

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Sadick Ahmed Agyare ◽  
Francis Adjei Osei ◽  
Samuel Frimpong Odoom ◽  
Nicholas Karikari Mensah ◽  
Ernest Amanor ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Success Rate ◽  
Treatment Outcomes ◽  
Successful Treatment ◽  
Treatment Success ◽  
Treatment Success Rate ◽  
Directly Observed Therapy ◽  
Active Monitoring ◽  
Successful Treatment Outcome ◽  
Unsuccessful Treatment

Introduction. Tuberculosis poses a great threat to public health around the globe and affects persons mostly in their productive age, notwithstanding; everyone is susceptible to tuberculosis (TB) infection. To assess the effectiveness and performance of the tuberculosis control program activities, the percentage of cases with treatment success outcome is key. To control tuberculosis, interrupting transmission through effective treatment cannot be overemphasized. The study was conducted to determine factors associated with TB treatment outcome, in the Atwima Nwabiagya District from 2007–2017. Method. A Retrospective review of routine/standard TB registers was carried out in five directly observed therapy short-course (DOTS) centres at the Atwima Nwabiagya District from January 2007 to December 2017. Demographic characteristics, clinical characteristics, and treatment outcomes were assessed. Bivariate and multivariate logistic regression was conducted to determine the predictors of successful treatment outcome. Results. Of the 891 TB client’s data that was assessed in the district, the treatment success rate was 68.46%. Patients, aged ≤ 20 years (adjusted odds ratio aOR = 4.74 , 95 % CI = 1.75 − 12.83 ) and 51-60 years ( aOR = 1.94 , 95 % CI = 1.12 − 3.39 ), having a pretreatment weight of 35-45 kg ( aOR = 2.54 , 95 % CI = 1.32 − 4.87 ), 46-55 kg ( aOR = 2.75 , 95 % CI = 1.44 − 5.27 ) and 56-65 kg ( aOR = 3.04 , 95 % CI = 1.50 − 6.14 ) were associated with treatment success. However, retreatment patients ( aOR = 0.31 , 95 % CI = 0.11 − 0.84 ) resulted in unsuccessful treatment outcome. Conclusion. Successful treatment outcome among TB patients was about 20.00% and 30.00% lower compared to the national average treatment success rate and WHO target, respectively. Active monitoring, motivation, and counselling of retreatment patients and patients with advanced age are key to treatment success.

scholarly journals Treatment outcome of tuberculosis patients at Debretabor General Hospital, Amhara, Northwest Ethiopia

2019 ◽  
Author(s):  
Tesfaye Andualem ◽  
Wubet Taklual
Keyword(s):  
Treatment Outcome ◽  
Pulmonary Tuberculosis ◽  
Success Rate ◽  
General Hospital ◽  
Treatment Success ◽  
Control Program ◽  
Northwest Ethiopia ◽  
Treatment Success Rate ◽  
Tuberculosis Patients ◽  
Good Treatment Outcome

Abstract Introduction Tuberculosis is still a global health problem. Especially, in developing countries where overcrowded and lack of awareness is existed. According to WHO, to monitor the effectiveness of tuberculosis prevention and control program, assessing tuberculosis outcome is important. The aim of this study was to determine treatment outcome of tuberculosis patients in Debretabor General Hospital, Debretabor, Northwest Ethiopia, 2019. Materials and methods A retrospective study was carried out between December 2016 to December 2018 from TB patients attending the health institutions of Debretabor General Hospital. All tuberculosis cases reported between 2016-2018 were reviewed carefully and analyzed. A total of 455 Tb patients were enrolled in this study and data were coded and entered in to the computer for statistical analysis using SPSS version 20 and Epi-info soft wares. Result and Discussion Within the study period a total of 455 study participants were requireted. Tuberculosis type was categorized as 88(18.0%) were smear positive pulmonary tuberculosis, 192(42.2%) were smear negative pulmonary tuberculosis and 181(39.8%) were extra pulmonary tuberculosis. Among the study subjects 86(18.9%) were HIV seropositive. Of the total study subjects, treatment completed (357)78.5%, cured (57)12.%, death (16)3.5%, treatment failure(4)0.9%, transfer out (21)4.6%. Good proportion of TB treatment success rate was in 15-44 yrs 310/326(95.0%) where as poor treatment success rate was in 0-14 years 26/42 (61.9%). Being an urban also has a high treatment success rate310/325(95.4%). 408(89.7%) were successfully treated. Conclusion The treatment success rate of tuberculosis patients was satisfactory 89.7%. In the study, treatment of HIV-TB co-infection need a better attention for good treatment outcome.

scholarly journals Treatment outcome in tuberculosis patients under DOTS treatment, tuberculosis unit, Nahan, Himachal Pradesh, 2013-2015: a record based descriptive study

2018 ◽  
Vol 5 (7) ◽  
pp. 2894 ◽  
Author(s):  
Rashmi Kashyap ◽  
Kamaljit Singh
Keyword(s):  
Treatment Outcome ◽  
Success Rate ◽  
Health Workers ◽  
Treatment Success ◽  
Descriptive Study ◽  
Treatment Success Rate ◽  
Chi Square ◽  
Tuberculosis Patients ◽  
Chi Square Test ◽  
Poor Treatment Outcome

Background: Tuberculosis (TB) has existed for millennia and remains a major global health problem. There has been significant progress in cure rates achieved in revised national tuberculosis programme (RNTCP), however concerns regarding effectiveness of RNTCP regimens, still exist. These concerns could be addressed through an assessment of treatment outcome. The present study was conducted to ascertain the treatment outcome in tuberculosis patients under DOTS treatment.Methods: A record based descriptive study was conducted in patients enrolled under directly observed treatment strategy (DOTS). The data included the summary of case findings as new smear positive, new smear negative, new extrapulmonary, new others, relapse, failure, treatment after default, category II. Treatment outcome was assessed as cured, treatment completed, died, loss to follow up, failure and transferred out. Different variables were represented as frequency distribution and percentages. Chi square test was used to observe the association of different variables with the outcome of the disease.Results: A total of 899 patients were enrolled under DOTs treatment for tuberculosis. Sputum positivity was present in 481 (72.8%) patients. Outcome showed 384 (79.8%) patients as cured, treatment completed in 414 (81.8%) patients and treatment success rate of 798 (89.7%). Treatment failure was observed 9 (1.9%) patients.Conclusions: Treatment success rate of TB patients in this study was encouraging for TB control through DOTS strategy. However, to reduce poor treatment outcome, patients should be strictly followed by health workers or ASHAs. 

scholarly journals Pulmonary Tuberculosis: Treatment Outcomes and Factors Associated with Poor Treatment Outcome in Pahang, Malaysia

2018 ◽  
Vol 17 (1) ◽  
Author(s):  
Zafirah Amalina binti Zulkipli ◽  
Muhammad Amir Hafiz bin Mohd Salleh ◽  
Musaab Nassereldeen Ahmed
Keyword(s):  
Logistic Regression ◽  
Treatment Outcome ◽  
Pulmonary Tuberculosis ◽  
Success Rate ◽  
Treatment Outcomes ◽  
Treatment Success ◽  
Treatment Success Rate ◽  
Health Concern ◽  
Multiple Logistic Regression ◽  
Factors Associated

Introduction: Tuberculosis (TB) remains a formidable public health concern in Malaysia. Malaysia’s national treatment success rate is still below the ideal 90% positive outcome recommended by the End TB Strategy (2015-2035). In this study, we evaluated the treatment outcomes and associated predictors of smear or culture positive pulmonary tuberculosis (PTB) patients. Materials and Methods: This is a retrospective cohort study conducted in chest clinic of Hospital Tengku Ampuan Afzan (HTAA), Pahang from January 2012 to December 2016. PTB cases in HTAA were crosschecked with TB registry and patients who fulfilled the inclusion criteria were selected. Data was collected using a standardized clinical report form and analyzed using multiple logistic regression. Results: There were a total of 342 patients recruited. Majority were Malaysian (94.2%), male (67.8%) and Malay (80.0%). The treatment success rate was 55.26%, with a cure rate of 42.98%. The high portion of defaulters (21.05%) in our study population was amongst the most striking findings. Multiple logistic regression analysis revealed that the factors associated with unfavourable treatment outcome were time in treatment, case after treatment interruption or failure and poor compliance. Univariate analysis revealed that male, hepatitis, smoking and intravenous drug user were found to be significant factors associated with poorer treatment outcomes. Conclusion: Achieving a higher patient retention rate is a significant factor in increasing effectiveness of treatment services. Thus, our study recommends stricter Directly Observed Treatment, Short Course (DOTS) and an enhanced understanding of the real barriers to patients’ treatment regimen adherence in order to overcome them.

scholarly journals Trends of Tuberculosis Treatment Outcomes of Notified Cases in Three Refugee Camps in Sudan: A Four-year Retrospective Analysis, 2014–2017

2021 ◽  
Author(s):  
Tsegay Legesse ◽  
Mohammed Hussein Elduma ◽  
Nagi Masoud Awad ◽  
Mousab Siddig Elhag ◽  
Israa Abushama ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Success Rate ◽  
Treatment Outcomes ◽  
Treatment Success ◽  
Treatment Success Rate ◽  
Refugee Camps ◽  
Historical Cohort ◽  
Tb Treatment ◽  
Unsuccessful Treatment ◽  
Lost To Follow Up

Background: Refugees are vulnerable to tuberculosis (TB) infection. Tracking of program performance is needed to improve TB care and prevention. The objective of this study was to assess the trends of TB treatment outcomes of notified cases in three refugee camps in Sudan from 2014 to 2017. Methods: This study was a historical cohort study. Sex, age, type of TB, TB patient category, and treatment outcome of all TB cases registered in three refugee camps (Al Kashafa, Shagarab, Wadsherify) from January 1, 2014 to December 31, 2017 were collected from the TB register. Multivariable logistic regression was performed to explore factors for unsuccessful TB treatment. Results: A total of 710 TB cases of which 53.4% were men, 22.1% children (<15 years), and 36.2% extrapulmonary TB (EPTB) were registered. Overall, the TB treatment success rate was 75.7% with a declining trend from 86.2% in 2015 to 63.5% in 2017. On average, 11.4% were lost to follow-up (LTFU), 6.6% died, 5.9% were not evaluated, and in 0.3% the treatment failed. Being 15–24 years old and having EPTB were significantly associated with unsuccessful treatment outcome. Conclusion: The treatment success rate in the refugee camp in 2017 (63.5%) was far lower than the national treatment success rate (78%) and the End TB global target (≥90%) that needs to be improved. LTFU, died, and not evaluated outcomes were high which indicated the necessity to improve the TB treatment program.

scholarly journals Outcome of Tuberculosis patients under directly observed short course treatment in western Ethiopia

2015 ◽  
Vol 9 (07) ◽  
pp. 752-759 ◽  
Author(s):  
Eyasu Ejeta ◽  
Muda Chala ◽  
Gebeyaw Arega ◽  
Kassahu Ayalsew ◽  
Lensa Tesfaye ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Success Rate ◽  
Treatment Success ◽  
World Health ◽  
Treatment Success Rate ◽  
Important Indicator ◽  
Tuberculosis Patients ◽  
Study Participants ◽  
Western Ethiopia

Introduction: Treatment outcome is an important indicator of tuberculosis control programs, as suggested by the World Health Organization. However, this has not been well documented in the study area. This work contributes to a better understanding this issue. Methodology: A five-year (2009–2013) retrospective cohort study was conducted between April and May 2014, in six randomly selected health institutions providing tuberculosis treatment in western Ethiopia. Bivariate and multivariate logistic regression analyses were used to assess the association between treatment outcomes and predictor variables. Results: A total of 1,175 tuberculosis patients with a mean (standard deviation) age of 29.91 (13.99) were involved in the study. The majority of the study participants had smear-negative pulmonary tuberculosis (39.7%) and extrapulmonary tuberculosis (39.7%). Of all the study participants, 14.5% were cured, 56.3% completed treatment, 0.2% had treatment failure, 8.1% died during follow-up, 7.1% were reported as defaulters, and 13.8% were transferred out to another health institution. The overall treatment success rate was 70.8% and show progressive increases over the course of the study. The associated predictors were enrollment years, HIV co-infection, and sputum smear follow-up in the second, fifth, and seven months. Conclusions: The treatment success rate was unsatisfactory in spite of improvement seen over the study period. Thus, continued follow-up of patients, with frequent supportive supervision during the course of treatment, and provision of early detection and follow-up for HIV infection need to be strengthened to achieve an effective treatment outcome.

scholarly journals Treatment outcome of tuberculosis at Dilla Referral Hospital, Gedeo Zone, southern Ethiopia: A retrospective study

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0249369
Author(s):  
Endrias Markos Woldesemayat ◽  
Zewtir Azeze
Keyword(s):  
Risk Factors ◽  
Treatment Outcome ◽  
Success Rate ◽  
Treatment Success ◽  
Referral Hospital ◽  
Treatment Success Rate ◽  
Southern Ethiopia ◽  
Hiv Status ◽  
Hospital Data ◽  
Tb Treatment

Background Tuberculosis (TB) is one of the major public health problems in Ethiopia. Determining treatment outcome of TB cases could help to understand the effectiveness of TB control efforts. The objective of this study was to assess TB treatment outcome and associated factors and determine the risk factors of death among TB cases who were on Directly Observed Treatment Short course (DOTS). Methodology We analyzed a retrospective data for TB cases who were on DOTS at Dilla Referral Hospital from July 2011- June 2016. The study population was TB cases with known HIV status and whose treatment outcome was evaluated at the Hospital. Data were entered, cleaned and analyzed using statistical package SPSS for windows, version 20. Result Out of 899 registered TB cases, 731 included in this analysis. Of these cases, 424 (58.0%) were male and 334 (45.7%) were in the age group of below 25 years. Treatment success rate of TB was 675 (92.3%) and death rate was 18 (2.5%). Treatment outcome showed statistically significant variation by HIV status (P < 0.001). HIV status of the TB cases and pretreatment weight were associated with TB treatment outcome. HIV status of the TB cases was associated with death of the TB cases (Adjusted Odds Ratio (AOR) 5.0; CI 95%: 1.8–13.5). Conclusion TB treatment success rate found in this study was high. Patient’s weight and HIV status were associated with treatment outcome. Moreover, HIV status predicted death of TB cases. Cautious treatment follow-up and defaulter tracing mechanisms for TB cases with these risk factors were suggested.

Treatment outcomes among multidrug-resistant TB patients in Bahawal Victoria Hospital, Bahawalpur, Pakistan: a retrospective record review

2020 ◽  
Vol 114 (10) ◽  
pp. 733-741
Author(s):  
Muhammad Atif ◽  
Wajiha Ahmad ◽  
Nafees Ahmad ◽  
Iram Malik ◽  
Sajjad Sarwar
Keyword(s):  
Success Rate ◽  
Treatment Outcomes ◽  
Treatment Success ◽  
Binary Logistic Regression ◽  
Multidrug Resistant ◽  
Treatment Success Rate ◽  
Binary Logistic Regression Analysis ◽  
Factors Associated ◽  
Unsuccessful Treatment ◽  
Mdr Tb

Abstract Background This study aims to evaluate the treatment outcomes and factors associated with unsuccessful treatment outcomes among multidrug-resistant TB (MDR-TB) patients. Method This was a retrospective observational study conducted at the Bahawal Victoria Hospital, Bahawalpur, Pakistan. The sociodemographic, clinical and treatment-related data of MDR-TB patients registered at the study site between June 2014 and December 2016 were retrospectively collected. Patients’ treatment outcomes were categorized on the basis of WHO-recommended criteria. Multivariate binary logistic regression analysis was used to find the independent factors associated with unsuccessful treatment outcomes. Results Out of 179 MDR-TB patients, 106 (59.2%) completed their treatment successfully. The remaining 73 patients (40.8%) had unsuccessful treatment outcomes, among whom 45 (25.1%) died, while 18 (10.1%) were lost to follow-up. Factors associated with unsuccessful treatment outcomes included age ≥40 y (AOR 4.310; p = 0.006), unsuccessful interim treatment outcomes (AOR 5.810; p = 0.032), occurrence of adverse events (AOR 0.290; p = 0.029) and ofloxacin resistance (AOR 2.952; p = 0.042). Conclusion The treatment success rate among the selected cohort of MDR-TB patients was less than the target of ≥75% set by the WHO in the End TB Strategy. The lower treatment success rate at the study site requires urgent attention from clinicians and program managers.

scholarly journals Treatment outcomes of patients with tuberculosis in war affected region of Khyber Pakhtunkhwa, Pakistan

2020 ◽  
Author(s):  
TAUSEEF AHMAD ◽  
Muhammad Ayub Jadoon ◽  
Muhammad Khan ◽  
Haroon ◽  
Muhammad Mumtaz Khan ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Success Rate ◽  
Treatment Outcomes ◽  
Successful Treatment ◽  
Treatment Success ◽  
Control Program ◽  
Treatment Success Rate ◽  
Khyber Pakhtunkhwa ◽  
Tb Treatment ◽  
Treatment Category

Abstract Background: Globally, tuberculosis (TB) remains the leading cause of death from a single infectious disease. TB treatment outcome is an indicator for the effectiveness of a national TB control program. This study aimed to assess treatment outcomes of TB patients and its determinants in Batkhela, Khyber Pakhtunkhwa, Pakistan. Methods: A retrospective cohort study was designed using all TB patients who were enrolled at District Head Quarter (DHQ) Hospital Batkhela, Pakistan, from January 2011 to December 2014. A binary logistic regression models were used to identify factors associated with successful TB treatment outcomes defined as the sum of cure and completed treatment. Results: A total of 515 TB patients were registered, of which 237 (46%) were males and 278 (53.98%) females. Of all patients, 234 (45.44%) were cured and 210 (40.77%) completed treatment. The overall treatment success rate was 444 (86.21%). Age 0-20 years (adjusted odds ratio, AOR= 3.47; 95% confidence interval, CI)= 1.54-7.81; P= 0.003), smear-positive pulmonary TB (AOR)= 3.58; 95% CI= 1.89-6.78; P= <0.001), treatment category (AOR= 4.71; 95% CI= 1.17-18.97; P= 0.029), and year of enrollment 2012 (AOR= 6.26; 95% CI= 2.52-15.59; P= <0.001) were significantly associated with successful treatment outcome. Conclusions: The overall treatment success rate is satisfactory but still need to be improved to achieve the international targeted treatment outcome. Type of TB, age, treatment category, and year of enrollment were significantly associated with successful treatment outcomes.

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