scholarly journals Observations of TCRVβGene Expression in Rats with Dampness Syndrome

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Yan Chen ◽  
Bao-Guo Sun ◽  
Shi-Jun Zhang ◽  
Ze-Xiong Chen ◽  
Carlini Fan Hardi ◽  
...  
Keyword(s):  
T Cell ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Molecular Mechanism ◽  
Human Body ◽  
Humid Environment ◽  
Pathogenic Factors ◽  
Immunological Recognition ◽  
Recognition Function ◽  
Human Immune

Environmental dampness is one factor which can cause human diseases. The effects of exposure to humidity on human immune function are diverse and numerous. In the theory of traditional Chinese medicine (TCM), dampness is defined as one of the major pathogenic factors in the human body. It is divided into “external dampness” and “internal dampness.” However the molecular mechanism leading to humidity-induced immunosuppression is obscure. In the present study, we investigated the expression of the T-cell antigen receptor variableβ(TCRVβ) subfamilies in rats which were fed in different humid environment. And the expression levels of the TCRVβsubfamilies were detected using FQ-PCR. We found that the dampness might reduce the immunological recognition function of rats. And the obstruction of the immunological recognition function might be caused by internal dampness rather than external dampness.

Opening up a New Field of Modern Medical Research 1

2020 ◽  
Author(s):  
Xiaoguang Li
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Human Body ◽  
Low Cost ◽  
Acupuncture Point ◽  
Modern Medicine ◽  
Body Structure ◽  
Special Effect ◽  
Special Knowledge ◽  
Opening Up

Modern medicine tells us that the human body is an organism composed of heart, lung, liver, kidney, spleen, stomach, brain, nerves, muscles, bones, blood vessels, blood and so on, while traditional Chinese medicine believes that besides these tissues and organs, the human body still has another part of the structure, traditional Chinese medicine calls them Jing Luo and Shu Xue. Jing Luo means the longitudinal line of the human body and the accompanying net, translated into English Meridians and Collaterals. Shu Xue means holes distributed on Jing Luo and outside Jing Luo, because stimulating Shu Xue's position by acupuncture, massage and other methods can cure diseases, so Shu Xue is translated into English acupuncture point, abbreviated as acupoint or point. Meridians and acupoints are the special knowledge of human body structure in traditional Chinese medicine. Traditional Chinese medicine not only draws the distribution map of the meridians and acupoints in the human body, but also has been using them to treat diseases for thousands of years. There are hundreds of these acupoints, stimulating each one by acupuncture, massage or other methods will have a special effect on the human body and can treat various diseases. But what effect does stimulating every acupoint have on the human body so that it can treat various diseases? The discussion of traditional Chinese medicine is vague and incomprehensible, and can not be proved by experiments. According to the author's research for more than 30 years, this paper makes a clear and accurate exposition of the effects on the human body and diseases that can be treated with acupoint massage. These statements can be proved by experiments, so they are believed to be reliable. It is hoped that meridians, acupoints and massage therapy can be incorporated into modern medicine and become a part of modern medicine after being proved by others through experiments. Massaging acupoints can not only treat many diseases that are difficult to be treated with drugs, but also have simple methods and low cost.

Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCγ1- and Ca2+-dependent apoptosis

Blood ◽  
2008 ◽  
Vol 111 (4) ◽  
pp. 2354-2363 ◽  
Author(s):  
Sven Baumann ◽  
Stefanie C. Fas ◽  
Marco Giaisi ◽  
Wolfgang W. Müller ◽  
Anette Merling ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Therapeutic Potential ◽  
Human T Cell ◽  
Voltage Dependent ◽  
Ca2 Channels ◽  
Malignant T Cells

Herbs have successfully been used in traditional Chinese medicine for centuries. However, their curative mechanisms remain largely unknown. In this study, we show that Wogonin, derived from the traditional Chinese medicine Huang-Qin (Scutellaria baicalensis Georgi), induces apoptosis in malignant T cells in vitro and suppresses growth of human T-cell leukemia xenografts in vivo. Importantly, Wogonin shows almost no toxicity on T lymphocytes from healthy donors. Wogonin induces prolonged activation of PLCγ1 via H2O2 signaling in malignant T cells, which leads to sustained elevation of cytosolic Ca2+ in malignant but not normal T cells. Subsequently, a Ca2+ overload leads to disruption of the mitochondrial membrane. The selective effect of Wogonin is due to its differential regulation of the redox status of malignant versus normal T cells. In addition, we show that the L-type voltage-dependent Ca2+ channels are involved in the intracellular Ca2+ mobilization in T cells. Furthermore, we show that malignant T cells possess elevated amounts of voltage-dependent Ca2+ channels compared with normal T cells, which further enhance the cytotoxicity of Wogonin for malignant T cells. Taken together, our data show a therapeutic potential of Wogonin for the treatment of hematologic malignancies.

scholarly journals Theoretical Study of the anti-NCP Molecular Mechanism of Traditional Chinese Medicine Lianhua-Qingwen Formula (LQF)

2020 ◽  
Author(s):  
Chenghao Ye ◽  
Meina Gao ◽  
Wangqiang Lin ◽  
Kunqian Yu ◽  
Peng Li ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Molecular Mechanism ◽  
Hydrophobic Interactions ◽  
Killer Cell ◽  
Cell Receptor ◽  
The United States ◽  
Mapk Signaling ◽  
Binding Modes ◽  
Pathway Network

<div>Due to the good clinical efficacy in treating Novel Coronavirus Pneumonia (NCP) resulted from </div><div> </div><div>SARS-CoV-2, as the traditional Chinese medicine(TCM) prescription, Lianhua Qingwen Formula </div><div>(LQF) was composed into the Diagnosis and Treatment Programs of 2019 New Coronavirus<br></div><div> </div><div>Pneumonia (from fourth to seventh editions) formulated by the National Health Commission of China. </div><div> </div><div>Aiming to prevent and treat viral influenza, LQF was patented from 2003 in China, and passed the </div><div> </div><div>Phase II clinical trial by FDA in the United States in 2015. However, the molecular mechanism of LQF </div><div> </div><div>anti SARS-CoV-2 pneumonia is still not clear. It is shown that the docking scores of three components </div><div> </div><div>in LQF including Rutin, Forsythoside E, and Hyperoside to main protease of SARS-CoV-2 are very </div><div>large as -9.1, -9.0 and -8.7 kcal/mol, respectively, which are even better than those of Lopinavir at -7.3<br></div><div> </div><div>kcal/mol. Importantly, the binding modes between active compounds and protein were verified via </div><div> </div><div>molecular dynamics (MD) simulation and calculation all the binding free energies at MM-PBSA level. </div><div> </div><div>Note that these donor-acceptor systems were stabilized by non-polar interactions including hydrogen </div><div> </div><div>bonds and hydrophobic interactions. At last, from the constructed component-target-pathway network, </div><div> </div><div>it is shown that the components in LQF are related important pathways to improve the human immunity </div><div> </div><div>such as T cell, B cell receptor signaling, natural killer cell mediated cytotoxicity, as well as anti</div><div> </div><div>inflammatory pathways including Fc epsilon RI, ErbB, MAPK signaling and so on. The present </div><div> </div><div>investigation represents the first report on the molecular mechanism of LQF as NCP inhibitor</div>

Comprehension of the Unique Characteristics of Traditional Chinese Medicine

2012 ◽  
Vol 40 (02) ◽  
pp. 231-244 ◽  
Author(s):  
Stevenson Xutian ◽  
Dongyi Cao ◽  
JoAnn Wozniak ◽  
John Junion ◽  
Johanne Boisvert
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Human Body ◽  
Western Medicine ◽  
Turning Points ◽  
Theory And Practice ◽  
Human History ◽  
Medical Systems ◽  
Paper Briefly ◽  
Methodological Aspects

Traditional Chinese Medicine (TCM) has made great contributions to human history, especially in China, as has been recorded for thousands of years. The characteristics of TCM in both theory and practice make it different from Conventional Western Medicine (CWM). The characteristics of TCM include phenomenological, philosophical, and methodological aspects. This paper briefly discusses some historical turning points and innovations in TCM development in China, explores human body enigmas such as the heart, compares different aspects of TCM and CWM, and identifies the unique characteristics of TCM treatment, as compared to other medical systems.

Modulation of Antigen-Induced Anaphylaxis in Mice by a Traditional Chinese Medicine Formula, Guo Min Kang

2009 ◽  
Vol 37 (01) ◽  
pp. 113-125 ◽  
Author(s):  
Xiu-Min Li ◽  
Qian-Fei Wang ◽  
Brian Schofield ◽  
Jie Lin ◽  
Shau-Ku Huang ◽  
...  
Keyword(s):  
T Cell ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Symptom Score ◽  
T Cell Responses ◽  
T Cell Response ◽  
Type I ◽  
Plasma Histamine ◽  
Immediate Hypersensitivity ◽  
Cell Responses

A traditional Chinese Medicine (TCM) formula, Guo Min Kang (GMK), has been used in clinics in China for allergic diseases, including type I immediate hypersensitivity, a potentially fatal disease, but its modulatory mechanism remains elusive. The aim of this study was to investigate the modulatory mechanisms of GMK in a mouse model of Ag-induced anaphylaxis. Ag (conalbumin) sensitized mice were treated with either PBS (sham) or GMK before (schedule A) or during (schedule B) sensitization, and various anaphylactic parameters were measured following Ag challenge, including symptom score, cutaneous hypersensitivity response, mast cell degranulation, plasma histamine levels and the levels of specific IgE and T-cell responses. Systemic anaphylaxis was investigated in mice immediately following Ag challenge, and the results showed that GMK-treated mice from both treatment schedules A and B showed significantly reduced symptom scores when compared with the sham-treated group. The reduction in symptom score was associated with a significant reduction in the level of Ag-induced cutaneous immediate hypersensitivity. Also, GMK was able to suppress Ag-induced IgE production and T-cell responses, while it spares mitogen (Con A)-induced T-cell response. Further, treatment of mice with GMK abrogated the levels of Ag-induced histamine release and significantly reduced the number of degranulated mast cells. No effect of GMK was observed on the levels of total IgE and plasma histamine in naive mice. These results provide a basis for the modulation effect of GMK and suggest a potential utility of GMK as a prophylactic and therapeutic agent.

scholarly journals Traditional Chinese Medicine TN-01 Reconstitutes T Cells in SIV–infected Rhesus Monkeys

2021 ◽  
Author(s):  
Qiaoli Wang ◽  
Qiongzhen Zeng ◽  
Zhe Ren ◽  
Yuefeng Li ◽  
Rongze Wang ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Rhesus Monkeys ◽  
Clinical Trial Data ◽  
Hiv Treatment ◽  
T Cell Subsets ◽  
Antiviral Immune Response ◽  
Cell Counts

Abstract Background: Long-term antiretroviral therapy (ART) cannot recover the T cell counts in a substantial proportion of AIDS patients and viral loads rapidly rebound after ART suspension. Therefore, exploring novel alternative and adjuvant ART has become a priority in HIV treatment. Traditional Chinese medicine (TCM) have beneficial effects in regulating T cells and our previous clinical trial data have shown that TCM TN-01 maintains good health of patients with AIDS with an unclear mechanism. Herein, we preliminary investigated whether TN-01 influences immune reconstruction to enhance the antiviral immune response in simian immunodeficiency virus (SIV)-infected rhesus monkeys. Methods: The SIV-infected animals were firstly administered with TN-01 alone (5 ml/kg; twice a day, i.g.). More than 2 months later, these 2 SIV-infected rhesus monkeys were intraperitoneally injected with PMPA (30 mg/kg; once a day) and FTC (20 mg/kg; once a day) for about 3 months. Moreover, SIV-infected rhesus monkeys were also administered with TN-01 each 2 weeks from week 23 to week 35 during ART. Flow cytometer were used to assess the phenotype of T cell and plasma was isolated from whole blood for viral load detection. Results: The flow cytometry analysis revealed that treatment with TN-01 alone or combined with ART significantly upregulated T cells counts and the proportions of T cell subsets. TN-01 treatment also delayed viral rebound after ART suspension. Conclusions: Our data indicate that TN-01 could enhance the efficacy of ART and promote immune reconstruction, suggesting TN-01 treatment as a potent strategy in immune functional cure of HIV infection.

scholarly journals Integrating Data Mining, Network Pharmacology, and Molecular Docking Verification to Investigate the Molecular Mechanism of Traditional Chinese Medicine Prescriptions for Treating Male Infertility

2021 ◽  
Author(s):  
Xue Bai ◽  
Yibo Tang ◽  
Qiang Li ◽  
Guimin Liu ◽  
Dan Liu ◽  
...  
Keyword(s):  
Data Mining ◽  
Molecular Docking ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Male Infertility ◽  
Signaling Pathway ◽  
Molecular Mechanism ◽  
Oxidant Stress ◽  
Estrogen Signaling ◽  
Network Pharmacology

Abstract Background: Male infertility (MI) affects almost 5% adult men worldwide, and 75% of these cases are unexplained idiopathic. There are limitations in the current treatment due to the unclear mechanism of MI, which highlight the urgent need for a more effective strategy or drug. Traditional Chinese Medicine (TCM) prescriptions have been used to treat MI for thousands of years, but their molecular mechanism is not well defined. Methods: Aiming at revealing the molecular mechanism of TCM prescriptions on MI, a comprehensive strategy integrating data mining, network pharmacology, and molecular docking verification was performed. Firstly, we collected 289 TCM prescriptions for treating MI from National Institute of TCM Constitution and Preventive Medicine for 6 years. Then, Core Chinese Materia Medica (CCMM), the crucial combination of TCM prescriptions, was obtained by the TCM Inheritance Support System from China Academy of Chinese Medical Sciences. Next, the components and targets of CCMM in TCM prescriptions and MI-related targets were collected and analyzed through network pharmacology approach.Results: The results showed that the molecular mechanism of TCM prescriptions for treating MI are regulating hormone, inhibiting apoptosis, oxidant stress and inflammatory. Estrogen signaling pathway, PI3K-Akt signaling pathway, HIF-1 signaling pathway, and TNF signaling pathway are the most important signaling pathways. Molecular docking experiments were used to further validate network pharmacology results. Conclusions: This study not only discovers CCMM and the molecular mechanism of TCM prescriptions for treating MI, but may be helpful for the popularization and application of TCM treatment.

scholarly journals Analysis of Zhang Hongxing's Clinical Experience in Treating Chronic Cough

2021 ◽  
Vol 5 (3) ◽  
Author(s):  
Wenguang Zheng ◽  
Hongxing Zhang
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Clinical Experience ◽  
Human Body ◽  
Chronic Cough ◽  
Treatment Effects ◽  
Shandong Province ◽  
Clinical Treatment ◽  
Considerable Experience

Director Zhang Hongxing is a famous traditional Chinese medicine (TCM) doctor in Shandong province and a teacher in the Famous TCM Expert Studio in Dezhou city. He has rich clinical experience and considerable experience in the treatment of common clinical chronic coughs. Director Zhang Hongxing believes that chronic cough belongs to the category of "wind cough" and "long-term cough" according to TCM. TCM diagnosis should start from the four aspects of "wind evil residing in lung", "liver", "spleen and stomach", and "yang deficiency". Starting from viewing the human body as an organic whole, distinguish between deficiency or excess in cold and heat, and clinical treatment for cough should focus on dispelling "wind", regulating the functions of liver, spleen, and stomach, and supplementing the body's yang. Formulate treatment based on different categorization, and modify prescription according to the symptoms, and the treatment effects are remarkable.

Sign in / Sign up

Export Citation Format

Share Document