Synthesis and Antibacterial Screening of Some 1-Aroyl-3-aryl Thiourea Derivatives
Keyword(s):
A series of 1-aroyl-3-aryl thioureas derivatives were synthesized and evaluated for antibacterial activity. The results indicated that the compounds possessed higher activity against gram-negative bacteria than gram-positive bacteria. Amongst all these compounds, C18 (89.4%) exhibited the greatest antibacterial activity against gram-negative bacteria while C5 (85.6%) displayed maximum antibacterial activity against gram-positive bacteria. Preliminary study of the structure-activity relationship revealed that an electronic factor on aryl rings had a great effect on the antibacterial activity of these compounds.
2019 ◽
Vol 10
(03)
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2012 ◽
Vol 7
(5)
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pp. 1934578X1200700
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2019 ◽
Vol 18
(5)
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pp. 1147-1155
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2013 ◽
Vol 650
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pp. 249-252
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