Medium-/Long-Term Effects of a Specific Exercise Protocol Combined with Patient Education on Spine Mobility, Chronic Fatigue, Pain, Aerobic Fitness and Level of Disability in Fibromyalgia

Objective. To propose a rehabilitation protocol able to produce immediate and long-term beneficial effects on level of disability and overall performance in ADLs.Materials and Methods. Forty-one FM patients were randomized to an exercise and educational-behavioral programme group (experimental group, EG = 21) or to a control group (CG = 20). Each subject was evaluated before, at the end (T1), and after 6 months (T6) from the conclusion of the rehabilitation treatment using the Fibromyalgia Impact Questionnaire (FIQ), the visual analogue scale (VAS), the Health Assessment Questionnaire (HAQ), the fatigue severity scale (FSS), the 6-minute walking test (6MWT), tender points count (TPC), and spinal active range of motion. The exercise protocol included 20 sessions consisting in self-awareness, stretching, strengthening, spine flexibility, and aerobic exercises, which patients were subsequently educated to perform at home.Results. The two groups were comparable at baseline. At T1, the EG showed a positive trend in FIQ, VAS, HAQ, and FSS scales and significant improvement in 6MWT and in most spinal active range of motion measurements (Pbetween 0.001 and 0.04). The positive results were maintained at the follow-up.Conclusion. The proposed programme was well tolerated and produced immediate and medium-term beneficial effects improving function and strain endurance. This trial is registered withDRKS00005071on DRKS.

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Dexamethasone as Adjuvant Therapy to Moxifloxacin Attenuates Valve Destruction in Experimental Aortic Valve Endocarditis Due to Staphylococcus aureus

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.01376-06 ◽

2007 ◽

Vol 51 (8) ◽

pp. 2848-2854 ◽

Cited By ~ 3

Author(s):

Ioannis Skiadas ◽

Angelos Pefanis ◽

Apostolos Papalois ◽

Aspasia Kyroudi ◽

Helen Triantafyllidi ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Aortic Valve ◽

Cardiac Function ◽

Control Group ◽

Long Term Effects ◽

Inflammatory Infiltration ◽

Beneficial Effects ◽

Group B ◽

Group D

ABSTRACT Although the beneficial effects of dexamethasone have frequently been investigated in various serious-infection settings, insufficient data on valve histology and cardiac function for infective endocarditis are available. The efficacy of moxifloxacin for the treatment of experimental aortic valve endocarditis due to methicillin-susceptible Staphylococcus aureus and the long-term effects of dexamethasone were evaluated in the current study. Sixty-eight rabbits were randomly assigned to four groups: A, B, C, and D. Group A consisted of 18 animals and functioned as a control group. Groups B and C consisted of 11 and 23 subjects, respectively, which received moxifloxacin for 5 days in a human-like pharmacokinetic simulation. Group D consisted of 16 animals that were administered moxifloxacin plus dexamethasone (0.25 mg/kg of body weight twice a day intravenously). The group B animals were sacrificed a day after the completion of treatment, and group C and D animals were sacrificed after 12 days in order to monitor any possible relapse and allow microbiological, histopathological, and echocardiographic evaluation of the long-term effects of glucocorticoids. No differences in survival, sterilization rates, or inflammatory infiltration and calcification of valve tissue were observed among the treated groups. However, the degrees of valve damage and collagenization were significantly worse, the fibroblast content was higher, and fractional shortening of the left ventricle fluctuated significantly in group C compared to group D (all groups, P < 0.05). We concluded that dexamethasone treatment for experimental S. aureus endocarditis attenuates valve destruction and preserves overall cardiac function without impeding the efficacy of moxifloxacin.

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Follow-Up of the Cues and Care Trial

Journal of Early Intervention ◽

10.1177/1053815112453767 ◽

2012 ◽

Vol 34 (2) ◽

pp. 65-81 ◽

Cited By ~ 10

Author(s):

Nancy Feeley ◽

Phyllis Zelkowitz ◽

Ian Shrier ◽

Robyn Stremler ◽

Ruta Westreich ◽

...

Keyword(s):

Infant Development ◽

Very Low Birth Weight ◽

Control Group ◽

Maternal Outcomes ◽

Long Term Effects ◽

Beneficial Effects ◽

Interactive Behavior ◽

Bayley Scales

The long-term effects of the Cues intervention to reduce anxiety and enhance the interactive behavior of mothers of very low birth weight (VLBW) infants were investigated. A randomized trial comparing the Cues intervention to an attention control condition was conducted. A total of 122 mothers of newborns weighing < 1,500 g were randomized, and 96 participated in a follow-up assessment when the infants were 6 months corrected age. Maternal outcomes included anxiety, posttraumatic stress and depression, and mother–infant interaction. The Bayley Scales were used to assess infant development. Mother’s anxiety was not significantly lower in the Cues group (27.8 [ SD = 7.9]) compared with the control group (30.5 [ SD = 10.0]; p = 0.14). Mothers in the Cues group were not more sensitive in interactions with their infants. There were no differences between groups with respect to infant development. Thus, there was no evidence of any differential beneficial effects of the Cues program.

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The response of skin perfusion and of rheological and immunological variables to intravenous prostanoid administration in Raynaud’s phenomenon secondary to collagenosis

VASA ◽

10.1024/0301-1526.34.4.243 ◽

2005 ◽

Vol 34 (4) ◽

pp. 243-249 ◽

Cited By ~ 2

Author(s):

Drinda ◽

Neumann ◽

Pöhlmann ◽

Vogelsang ◽

Stein ◽

...

Keyword(s):

Laser Doppler Flowmetry ◽

Raynaud’S Phenomenon ◽

Raynaud's Phenomenon ◽

Plasma Viscosity ◽

Laser Doppler ◽

Erythrocyte Aggregation ◽

Control Group ◽

Long Term Effects ◽

Doppler Flowmetry

Background: Prostanoids are used in the treatment of Raynaud’s phenomenon and acral perfusion disorders secondary to collagenosis. In subjective terms, intravenous administration of these agents produces success in more than 50% of patients. The therapeutic outcome of clinical administration of alprostadil or iloprost may vary from individual to individual. Patients and methods: The following variables were analysed in a cross-over study in 27 patients with collagenosis and Raynaud’s phenomenon: plasma viscosity and erythrocyte aggregation (rheological variables), partial pressure of oxygen and laser Doppler flowmetry in the finger region, and lymphocyte phenotyping and interleukin (IL) determinations (immunological variables). Results: Laser Doppler flowmetry revealed significant differences between patients with secondary Raynaud’s phenomenon and a control group of 25 healthy subjects. Laser Doppler readings did not change significantly as a result of the treatments. Therapy with iloprost produced a reduction in IL-1beta, L-selectin (CD 62 L) and IL-6. Conclusion: The change in immunological variables due to iloprost may explain the long-term effects of prostaglandins in the treatment of Raynaud’s phenomenon. From our results it is not possible to infer any preference for iloprost or alprostadil.

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A Clinical Study of Platelet-Rich Fibrin Combined With Autologous High-Density Fat Transplantation in Augmentation Rhinoplasty

Ear Nose & Throat Journal ◽

10.1177/01455613211016902 ◽

2021 ◽

pp. 014556132110169

Author(s):

Dan Yan ◽

Shuai-Hua Li ◽

An-Li Zhang ◽

Yao Xiao ◽

Ze-Chun Huang

Keyword(s):

Retention Rate ◽

Statistical Significance ◽

High Density ◽

Control Group ◽

Long Term Effects ◽

Fat Transplantation ◽

Augmentation Rhinoplasty ◽

Platelet Rich Fibrin ◽

Autologous Fat

Objective: This study was designed to analyze the clinical effect of autologous fat-granule transplantation in augmentation rhinoplasty and explore methods to improve the fat retention rate. Methods: A total of 70 enrolled patients were randomly divided into 2 groups: the platelet-rich fibrin (PRF) combined with high-density fat transplantation group (combined group) and the conventional fat-granule transplantation group (control group; n = 35 in each group). In the combined group, an appropriate amount of autologous fat was extracted and centrifuged, and the lower layer of high-density fat was taken and mixed with PRF isolated from whole blood for autotransplantation. In the control group, only fat was extracted and centrifuged for transplantation. The patients were followed up with for more than one year to observe the short- and long-term effects, complications, safety, and patient satisfaction. Results: Six months after the operation, the nasal shape was stable, the contour was higher and more stereoscopic than before, the average increase of nasal height was 3.0 mm in the combined group and 2.0 mm in the control group. No complications, such as fat embolism, infection, or necrosis occurred during the 1-year follow-up. The satisfaction rate between the 2 groups has statistical significance ( P < .05). Conclusion: Overall, PRF combined with autologous high-density fat transplantation is simple to perform, has a significantly increased fat-retention rate than the control group, and has stable long-term effects without obvious adverse reactions. A sufficient amount of fat and PRF transplantation can achieve a good orthopedic effect. Thus, this method can be widely used in clinical augmentation rhinoplasty.

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Antibiotics at birth and later antibiotic courses: effects on gut microbiota

Pediatric Research ◽

10.1038/s41390-021-01494-7 ◽

2021 ◽

Author(s):

Sofia Ainonen ◽

Mysore V Tejesvi ◽

Md. Rayhan Mahmud ◽

Niko Paalanne ◽

Tytti Pokka ◽

...

Keyword(s):

Gut Microbiota ◽

Control Group ◽

List Type ◽

Antibiotic Exposure ◽

Microbiota Composition ◽

Long Term Effects ◽

The Impact ◽

Antibiotic Courses ◽

Gut Microbiota Composition

Abstract Background Intrapartum antibiotic prophylaxis (IAP) is widely used, but the evidence of the long-term effects on the gut microbiota and subsequent health of children is limited. Here, we compared the impacts of perinatal antibiotic exposure and later courses of antibiotic courses on gut microbiota. Methods This was a prospective, controlled cohort study among 100 vaginally delivered infants with different perinatal antibiotic exposures: control (27), IAP (27), postnatal antibiotics (24), and IAP and postnatal antibiotics (22). At 1 year of age, we performed next-generation sequencing of the bacterial 16S ribosomal RNA gene of fecal samples. Results Exposure to the perinatal antibiotics had a clear impact on the gut microbiota. The abundance of the Bacteroidetes phylum was significantly higher in the control group, whereas the relative abundance of Escherichia coli was significantly lower in the control group. The impact of the perinatal antibiotics on the gut microbiota composition was greater than exposure to later courses of antibiotics (28% of participants). Conclusions Perinatal antibiotic exposure had a marked impact on the gut microbiota at the age of 1 year. The timing of the antibiotic exposure appears to be the critical factor for the changes observed in the gut microbiota. Impact Infants are commonly exposed to IAP and postnatal antibiotics, and later to courses of antibiotics during the first year of life. Perinatal antibiotics have been associated with an altered gut microbiota during the first months of life, whereas the evidence regarding the long-term impact is more limited. Perinatal antibiotic exposure had a marked impact on the infant’s gut microbiota at 1 year of age. Impact of the perinatal antibiotics on the gut microbiota composition was greater than that of the later courses of antibiotics at the age of 1 year.

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Long Term Effects of the Latham Presurgical Maxillary Orthopedic Appliance, Including Effects on Tooth Growth

Canadian Journal of Plastic Surgery ◽

10.1177/229255030000800105 ◽

2000 ◽

Vol 8 (1) ◽

pp. 15-20 ◽

Cited By ~ 1

Author(s):

Michel C Samson ◽

Donald H Lalonde ◽

Donald Fitzpatrick ◽

Gerald L Sparkes

Keyword(s):

Bone Grafting ◽

Cleft Lip ◽

Alveolar Bone ◽

Consistent Difference ◽

Long Term Effects ◽

Beneficial Effects ◽

Alar Base ◽

Alveolar Bone Grafting ◽

Base Elevation

Reported beneficial effects of presurgical maxillary orthopedics in cleft lip include reduction of the cleft width, alignment of the maxillary segments, elevation of the alar base on the cleft side, diminished need for alveolar bone grafting and lip closure without tension. Possible adverse effects of presurgical maxillary orthopedics include tooth root damage and inability of periosteoplasty to make bone over the cleft. A series of wide cleft lip patients (n=15) treated with the Latham appliance at the time of lip closure were retrospectively compared with a similar group treated without the Latham appliance. The Latham appliance group (seven unilateral clefts, eight bilateral clefts; mean follow-up 9.5 years; range four to 18 years) was treated between the years 1980 and 1994. None of the 15 patients treated with the appliance had any tooth loss or damage attributable to the pins, and bone formation in the alveolar cleft was observed radiographically in all 13 of the patients who had a periosteoplasty at the time of lip repair, possibly obviating the need for secondary bone grafting. Five of these Latham group patients demonstrated clinical and radiographic evidence of tooth eruption into the periosteoplasty-formed bone. There was no consistent difference in the level of nasal alar base elevation in the two groups.

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Dynamic CT Scan of the Normal Scapholunate Joint in a Clenched Fist and Radial and Ulnar Deviation

Hand ◽

10.1177/1558944717726372 ◽

2017 ◽

Vol 13 (6) ◽

pp. 666-670 ◽

Cited By ~ 3

Author(s):

Paul M. Kelly ◽

John G. Hopkins ◽

Andrew J. Furey ◽

Daniel S. Squire

Keyword(s):

Ct Scan ◽

Range Of Motion ◽

Ct Imaging ◽

Dynamic Ct ◽

Long Term Effects ◽

Ulnar Deviation ◽

Left Wrist ◽

The Right ◽

User Friendly

Background: Injuries to the scapholunate can have severe long-term effects on the wrist. Early detection of these injuries can help identify pathology. The purpose of this study was to evaluate the motions of the scapholunate joint in normal wrists in a clenched fist and through radial and ulnar deviation using novel dynamic computed tomography (CT) imaging. Methods: Fifteen participants below 40 years of age consented to have their wrist scanned. Eight participants were randomized to have the right wrist scanned and 7 the left wrist. Volunteers were positioned at the back of the gantry with the wrist placed on the table, palmar side down. Participants began with the hand in a relaxed fist position and then proceeded through an established range of motion protocol. Dynamic CT imaging was captured throughout the range of motion. Results: The movement in the healthy scapholunate joint through a clenched fist and radial and ulnar deviation is minimal. The averages were 1.19, 1.01, and 0.95 mm, representing the middle, dorsal, and volar measurements, respectively. Conclusions: This novel dynamic CT scan of the wrist is a user-friendly way of measuring of the scapholunate distance, which is minimal in the normal wrist below 40 years of age.

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Effects of 1 y of free school fruit on intake of fruits, vegetables, and unhealthy snacks: 14 y later

American Journal of Clinical Nutrition ◽

10.1093/ajcn/nqy243 ◽

2018 ◽

Vol 108 (6) ◽

pp. 1309-1315 ◽

Cited By ~ 1

Author(s):

Tonje Holte Stea ◽

Ingrid Marie Hovdenak ◽

Jannike Rønnestad ◽

Kjersti Rennestraum ◽

Frøydis Nordgård Vik ◽

...

Keyword(s):

Fruits And Vegetables ◽

Intervention Group ◽

Baseline Survey ◽

Control Group ◽

Intervention Period ◽

Long Term Effects ◽

Intervention Effects ◽

Sample Mean ◽

Unhealthy Snacks

ABSTRACT Background There are not many studies evaluating the long-term effects of fruit and vegetable interventions. Objective We examined the effects of 1 y of free fruit in elementary school on long-term consumption of fruit, vegetables, and unhealthy snacks, according to sex and educational attainment, 14 y after the intervention period. Design In 2001, the baseline survey of the longitudinal cohort, Fruits and Vegetables Make the Marks (FVMM), included 1950 children (mean age: 11.8 y) attending 38 randomly drawn elementary schools from 2 counties in Norway. In the following 10 mo, 9 schools served as intervention schools by participating in the Norwegian School Fruit Program for free, whereas 29 schools served as control schools. A follow-up survey conducted in 2016 included 982 participants (50%) from the original study sample (mean age: 26.5 y). The consumption of fruit and vegetables was measured by a 24-h recall (portions per day), and the consumption of unhealthy snacks was measured by food-frequency questions (portions per week). Linear mixed models were performed to test possible intervention effects on the consumption of fruit, vegetables, and unhealthy snacks 14 y after the intervention period. Results No overall intervention effects after 14 y due to the free-fruit scheme on the consumption of fruit, vegetables, and unhealthy snacks were observed, but significant interactions showed a sustained higher frequency of fruit consumption among females in the intervention group compared with the control group [mean difference (MD): 0.38 portions/d; P = 0.023] and that this effect was only significant among less-educated females (MD: 0.73 portions/d; P = 0.043). No significant long-term intervention effects were observed in the consumption of fruit among highly educated females and males nor in the consumption of vegetables or unhealthy snacks. Conclusion Results from the present study indicate that receiving free fruit at school for 1 y may have positive long-term effects for females without higher education.

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Catheter Patency and Peritoneal Morphology and Function in a Rat Model of Citrate-Buffered Peritoneal Dialysis

Peritoneal Dialysis International ◽

10.3747/pdi.2009.00132 ◽

2010 ◽

Vol 30 (6) ◽

pp. 602-610 ◽

Cited By ~ 1

Author(s):

Nicola Cavallini ◽

Magnus Braide

Keyword(s):

Peritoneal Dialysis ◽

Rat Model ◽

Fluid Transport ◽

Separate Experiment ◽

Control Group ◽

Vascular Density ◽

Long Term Effects ◽

Catheter Patency ◽

Peritoneal Morphology

BackgroundSingle-dwell studies in rats and humans have shown that supplementing citrate for lactate in peritoneal dialysis (PD) fluids improves ultrafiltration (UF).MethodsThe long-term effects of citrate-substituted PD fluids on PD catheter patency, UF, and peritoneal morphology were evaluated in a rat model over 5 weeks of daily PD fluid exposure. A standard 2.5% glucose 40 mmol/L lactate PD fluid and a corresponding 10/30 mmol/L citrate/lactate PD fluid were compared. In a control group, rats with catheters received no PD fluid.ResultsThe average patency time (% of 36 days) of silicone rubber PD catheters was significantly longer in the citrate PD group (98.8% ± 1.2%) and the control group (100% ± 0%) compared to the lactate PD group (54.7% ± 9.5%). In a separate experiment, heparin-coated polyurethane catheters were used to study peritoneal morphology and fluid transport. The citrate group had a higher net UF than the lactate group at the beginning and at the end of the 5 weeks. During the experiment, both fluid-treated groups suffered from UF loss; the control group showed the highest net UF at the end of the 5 weeks. Peritoneal vascular density and submesothelial thickness, indicators of angiogenesis and fibrosis, were not significantly different among the groups. Fibrosis was significantly negatively correlated to osmotic UF.ConclusionA positive acute effect of citrate on UF was confirmed and conserved over time. Citrate PD strongly improved PD catheter patency time compared with lactate. Both citrate PD and lactate PD induced negative long-term effects on UF compared with control animals.

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Low Mortality of Larval Lampreys from Electrofishing, Suction-pumping, Anesthesia, and Handling

Journal of Fish and Wildlife Management ◽

10.3996/052017-jfwm-046 ◽

2017 ◽

Vol 8 (2) ◽

pp. 640-647 ◽

Cited By ~ 2

Author(s):

Jeffrey C. Jolley ◽

Christina T. Uh ◽

Gregory S. Silver ◽

Timothy A. Whitesel

Keyword(s):

Pacific Northwest ◽

Control Group ◽

Long Term Effects ◽

Negative Effects ◽

Short Term ◽

Important Species ◽

Pacific Lamprey ◽

The Pacific ◽

Delayed Mortality

Abstract Native lamprey populations are declining worldwide. In the Pacific Northwest focus on conservation and management of these ecologically and culturally important species has increased. Concern has emerged regarding the effects of sampling and handling of lamprey, with little to no attention given to the larval lifestage. We monitored the survival of larval Pacific Lamprey Entosphenus tridentatus and Lampetra spp. after backpack electrofishing, deepwater electrofishing and suction-pumping, anesthesia, and handling. We performed survival trials on wild-caught lamprey (n = 15 larvae in each trial) collected from the Clackamas River drainage in Oregon, USA, coupled with control group trials from lamprey sourced from a hatchery (n = 10 larvae). Short-term (96 h) survival was >98% with only one observed mortality. Delayed mortality (1 wk) was observed for four individuals that had fungus; two of those were positive for the bacteria Aeromonas hyrdrophila. We recorded blood hematocrit as a secondary measure of stress. The baseline, nonstressed larvae hematocrit levels did not differ from those of fish that had undergone stress through electrofishing, suction-pumping, and handling without anesthesia. Electrofishing, suction-pumping, and anesthesia showed no short-term negative effects on larval lamprey although potential long-term effects remain unstudied. These techniques appear to provide efficient and relatively safe methods for collecting and surveying larval lamprey.

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