scholarly journals Synthesis and Characterization of Novel Copolymeric Resveratrol Conjugates

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Yan-Jing Ng ◽  
Heather A. E. Benson ◽  
David H. Brown ◽  
Yan Chen
Keyword(s):  
Micelle Formation ◽  
Rat Plasma ◽  
The Body ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
The Stability ◽  
Chain Lengths ◽  
Cardioprotective Drug

Resveratrol (RSV), naturally found in plants, is known to have health benefits and has been proposed as a potential anticancer and cardioprotective drug. However, due to its molecular structure, it undergoes rapid metabolism in the body resulting in low bioavailability. Novel polymeric methoxy-poly(ethylene glycol)-block-poly(ε-caprolactone) (mPEG-PCL) RSV conjugates with varying PCL chain lengths have been synthesised and formulated into micelles and/or nanoparticles for preliminaryin vitrostability studies. RSV conjugated with mPEG2000-PCL9500 was found to have improved solubility and stability of RSV as compared to RSV alone. The length of the PCL chain was found to affect the micelle formation, hence the stability in physiological buffers and rat plasma.

Study on the Synthesis and Characterization of Polylactic Acid/Maleic Anhydride Copolymer

2011 ◽  
Vol 335-336 ◽  
pp. 165-171
Author(s):  
You Ning Chen ◽  
Jun Cai Zhang
Keyword(s):  
Orthogonal Design ◽  
Acid Anhydride ◽  
Mass Ratio ◽  
Poly Ethylene Glycol ◽  
Mechanics Performance ◽  
Water Affinity ◽  
Poly Ethylene ◽  
Maleic Anhydride Copolymer

Hydroxyl terminated lactic acid prepolymer was synthesized with poly ethylene glycol (PEG).The malaya acid anhydride modified PLA by fuse polymerization, and the different technological conditions (temperature, reaction time and so on) were discussed by the orthogonal design approach. The result of the orthogonal test indicated that, the product molecular weight had enhanced greatly with the Malaya acid anhydride and the PLEG mass ratio 1:15, at 130°C for 15h. The products were characterized by DSC, IR and SEM, Mechanics performance and water affinity performance of the products was determined, and the degradation behavior in vitro simulated bioenvironmental condition was studied. Mechanics performance was improved, and the good water affinity performance biodegradability was maintained.

scholarly journals Synthesis and Characterization of Polymer-Based Coatings Modified with Bioactive Ceramic and Bovine Serum Albumin

2021 ◽  
Vol 12 (2) ◽  
pp. 21
Author(s):  
Wioletta Florkiewicz ◽  
Dagmara Słota ◽  
Angelika Placek ◽  
Klaudia Pluta ◽  
Bożena Tyliszczak ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Ftir Spectroscopy ◽  
Bovine Serum ◽  
Poly Ethylene Glycol ◽  
Sem Imaging ◽  
Poly Ethylene

This study involves the synthesis of hydroxyapatite and describes the preparation and characterization of polymer coatings based on poly(ethylene glycol) diacrylate and poly(ethylene glycol) and modified with bovine serum albumin and hydroxyapatite. Hydroxyapatite was obtained by wet chemical synthesis and characterized by X-ray diffraction and FTIR spectroscopy, and its Ca/P molar ratio was determined (1.69 ± 0.08). The ceramic and bovine serum albumin were used in the preparation of composite materials with the polymeric matrix. The chemical composition of coatings was characterized with FTIR spectroscopy, and their morphology was recorded with SEM imaging. Moreover, the measurements of surface roughness parameters and stereometric research were performed. The prepared coatings were subjected to in vitro studies in simulated body fluid and artificial saliva. Changes in chemical composition and morphology after immersion were examined with FTIR spectroscopy and SEM imaging. Based on the conducted research, it can be stated that applied modifiers promote the biomineralization process. The roughness analysis confirmed prepared materials were characterized by the micrometer-scale topography. The materials morphology and roughness, and the morphology of the newly formed apatite deposit, were dependent on the type of the used modifier, and the artificial fluid used in in vitro studies.

scholarly journals Influence of Poly(Ethylene Glycol) End Groups on Poly(Ethylene Glycol)-Albumin System Properties as a Potential Degradable Tissue Scaffold

2018 ◽  
Vol 10 (1) ◽  
pp. 1 ◽  
Author(s):  
Robyn Overby ◽  
Dale Feldman
Keyword(s):  
Ethylene Glycol ◽  
Crosslinking Agent ◽  
Poly Ethylene Glycol ◽  
In Vivo Evaluation ◽  
Tissue Scaffold ◽  
Handling Characteristics ◽  
Poly Ethylene ◽  
The Stability

Chronic dermal lesions, such as pressure ulcers, are difficult to heal. Degradable tissue scaffold systems can be employed to serve as a provisional matrix for cellular ingrowth and facilitate regenerative healing during degradation. Degradable regenerative tissue scaffold matrices can be created by crosslinking albumin with functionalized poly(ethylene glycol) (PEG) polymers. The purpose of this study was to evaluate the stability of PEG-albumin scaffold systems formed using PEG polymers with three different functionalized end chemistries by quantifying in vitro system swellability to determine the most promising PEG crosslinking polymer for wound healing applications. Of the three polymers evaluated, PEG-succinimidyl glutarate (SG) exhibited consistent gelation and handling characteristics when used as the crosslinking agent with albumin. PEG-SG polymers were identified as an appropriate synthetic crosslinking moiety in a PEG-albumin scaffold system, and further in vitro and in vivo evaluation of this scaffold system is merited.

scholarly journals A GelMA-PEGDA-nHA Composite Hydrogel for Bone Tissue Engineering

Materials ◽  
2020 ◽  
Vol 13 (17) ◽  
pp. 3735
Author(s):  
Yihu Wang ◽  
Xiaofeng Cao ◽  
Ming Ma ◽  
Weipeng Lu ◽  
Bing Zhang ◽  
...  
Keyword(s):  
Bone Repair ◽  
Composite Hydrogel ◽  
Hydroxyl Group ◽  
Poly Ethylene Glycol ◽  
Hydrogel Scaffold ◽  
Glycol Diacrylate ◽  
3D Printed ◽  
Poly Ethylene ◽  
The Stability

A new gelatin methacrylamine (GelMA)-poly (ethylene glycol) diacrylate (PEGDA)-nano hydroxyapatite (nHA) composite hydrogel scaffold was developed using UV photo-crosslinking technology. The Ca2+ from nHA can form a [HO]Ca2+ [OH] bridging structure with the hydroxyl group in GelMA, thereby enhancing the stability. Compared with GelMA-PEGDA hydrogel, the addition of nHA can control the mechanical properties of the composite hydrogel and reduce the degradation rate. In vitro cell culture showed that osteoblast can adhere and proliferate on the surface of the hydrogel, indicating that the GelMA-PEGDA-nHA hydrogel had good cell viability and biocompatibility. Furthermore, GelMA-PEGDA-nHA has excellent injectability and rapid prototyping properties and is a promising 3D printed bone repair scaffold material.

Characterization of DNA release from composites of oligo(poly(ethylene glycol) fumarate) and cationized gelatin microspheres in vitro

2006 ◽  
Vol 78A (4) ◽  
pp. 823-835 ◽  
Author(s):  
F. Kurtis Kasper ◽  
Erin Jerkins ◽  
Kazuhiro Tanahashi ◽  
Michael A. Barry ◽  
Yasuhiko Tabata ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Gelatin Microspheres ◽  
Dna Release ◽  
Poly Ethylene
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