The Forgotten Complication of Recurrent Nephrolithiasis: “Squamous Cell Carcinoma of the Renal Pelvis”—A Case and Review of the Literature

Squamous cell carcinoma (SCC) of the renal pelvis is an aggressive tumor with insidious onset of unspecific symptoms and advanced stages at diagnosis. It is a rare entity, accounting for 0.5–8% of renal tumors. In this paper, we describe the case of a patient with a history of recurrent nephrolithiasis that presented with an aggressive form of SCC of the renal pelvis with rapid relapse after resection.

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Incidentally Detected Squamous Cell Carcinoma of Renal Pelvis in Patients with Staghorn Calculi: Case Series with Review of the Literature

ISRN Oncology ◽

10.5402/2011/620574 ◽

2011 ◽

Vol 2011 ◽

pp. 1-6 ◽

Cited By ~ 7

Author(s):

Ayushi Jain ◽

Deepti Mittal ◽

Arpita Jindal ◽

Ranjana Solanki ◽

Suman Khatri ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Renal Pelvis ◽

Relevant Literature ◽

Case Series ◽

Advanced Stages ◽

One Year ◽

Suspicious Nodule ◽

Gross Examination

Squamous cell carcinoma of the renal pelvis is a rare neoplasm, often unsuspected clinically due to its rarity and ambiguous clinical and radiological features, and hence patients present at advanced stages resulting in poor prognosis. We report here four cases of incidentally diagnosed primary renal squamous cell carcinoma, treated at our hospital over a short span of one year, and review the relevant literature. Mean age of the patients (3 males, 1 female) was 60 years. All suffered from staghorn stones. Interestingly, renal carcinoma was unsuspected clinically in all patients. In one case, a computerised tomography scan showed a suspicious nodule. All underwent nephrectomy for nonfunctioning kidney. In just two cases, tumor was identified on gross examination, while the other two only showed thickened pelvis. Our series emphasises the need for pelvicalyceal biopsy during treatment for long-standing nephrolithiasis, and thorough sampling of the renal pelvis in nephrectomy specimen of such patients.

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The potential of molecular markers to improve interventions through the natural history of oesophageal squamous cell carcinoma

Bioscience Reports ◽

10.1042/bsr20130063 ◽

2013 ◽

Vol 33 (4) ◽

Cited By ~ 12

Author(s):

Nathalia Meireles da Costa ◽

Sheila Coelho Soares Lima ◽

Tatiana de Almeida Simão ◽

Luis Felipe Ribeiro Pinto

Keyword(s):

Squamous Cell Carcinoma ◽

Natural History ◽

Cell Carcinoma ◽

Squamous Cell ◽

Current Knowledge ◽

Oesophageal Squamous Cell Carcinoma ◽

Comprehensive Knowledge ◽

High Incidence ◽

History Of ◽

Advanced Stages

EC (oesophageal cancer) is one of the ten most frequent and fatal tumours worldwide and ESCC (oesophageal squamous cell carcinoma) accounts for about 80% of the cases. The first symptoms of ESCC arise late during the progression of the disease and, therefore, the diagnosis is usually done in advanced stages. This leads to an inefficient treatment and consequently to a poor prognosis. Thus, a comprehensive knowledge of ESCC biology is of major importance to identify risk factors, especially in high-incidence areas and biomarkers which could enable ESCC prevention and interventions throughout the natural history of the disease. In this review, we present the current knowledge regarding ESCC aetiology as well as the different genetic and epigenetic alterations already described in this tumour. We also discuss how these alterations could be used to anticipate ESCC diagnosis as well as how they can help improving treatment. A molecular natural history of the disease is proposed pointing out potential markers that may improve interventions at different points of ESCC development. Only when the different layers of complexity behind this tumour are elucidated, it will be possible to successfully perform prevention at different levels.

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Renal calculus complicated with squamous cell carcinoma of renal pelvis: Report of two cases

Canadian Urological Association Journal ◽

10.5489/cuaj.2441 ◽

2015 ◽

Vol 9 (5-6) ◽

pp. 310

Author(s):

Jiantao Xiao ◽

Jun Lei ◽

Leye He ◽

Guangming Yin

Keyword(s):

Squamous Cell Carcinoma ◽

Risk Factor ◽

Early Diagnosis ◽

Cell Carcinoma ◽

Squamous Cell ◽

Renal Pelvis ◽

Kidney Stone ◽

Poor Prognosis ◽

Renal Calculus ◽

Advanced Stages

Longstanding renal calculus is a risk factor of squamous cell carcinoma (SCC) of the renal pelvis. It is highly aggressive and usually diagnosed at advanced stages with a poor prognosis. We present two cases of kidney stone complications with renal pelvic SCC. These two patients had a radical nephrectomy and the dissected tissues were renal pelvic SCC. Our cases further emphasize that renal pelvic SCC should be considered in patients with longstanding renal calculus. These cases contribute greatly to an early diagnosis and early treatment, both of which will significantly minimize the damage of, and markedly improve the prognosis of, renal pelvic SCC.

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Management of a recurrence of a squamous cell carcinoma of the scalp with extension to the brain: A case report and literature review

Surgical Neurology International ◽

10.25259/sni_356_2020 ◽

2020 ◽

Vol 11 ◽

pp. 347

Author(s):

Mohamed Chabaane ◽

Khalil Ayadi ◽

Mouna Rkhami ◽

Cyrine Drissi ◽

Sarra Houimli ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Multidisciplinary Treatment ◽

Brain Invasion ◽

Initial Surgery ◽

History Of ◽

Advanced Stages ◽

Challenging Situation ◽

The Brain

Background: Squamous cell carcinoma (SCC) is the most common form of nonmelanoma skin cancer after basal cell carcinoma. Simple excision can be the treatment at early stages of diagnosis. However, at late stages, treatment is more complex due to extension to the skull and the dura. In extremely rare cases, it can invade the brain making it a challenging situation for treatment. Case Description: We present the case of a 54-year-old man with a history of cutaneous SCC who presented an invasive left frontal recurrence with brain invasion 19 years after initial surgery. The patient underwent surgery which consisted in tumor removal and bone and skin reconstruction. Immediate and late outcomes were favorable. Conclusion: Multidisciplinary treatment for SCC diagnosed in advanced stages is the best way to obtain encouraging results. Although significant advancements have been made, further study is needed for cases with advanced disease.

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Incidental squamous cell carcinoma of renal pelvis presenting as skin invasion: a case report

Journal of Medical Case Reports ◽

10.1186/s13256-020-02530-6 ◽

2020 ◽

Vol 14 (1) ◽

Author(s):

Xinghui Sun ◽

Yongqing Li

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Renal Pelvis ◽

Renal Tumors ◽

Pathological Examination ◽

Low Back ◽

Middle Portion ◽

Skin Invasion ◽

The Right

Abstract Introduction Squamous cell carcinoma of the renal pelvis is a rare neoplasm, accounting for less than 0.8% of malignant renal tumors. Chronic irritation is believed to be the primary pathogenic cause for squamous cell carcinoma of the renal pelvis. The most frequently reported cases of squamous cell carcinoma of the renal pelvis generally present with hydronephrosis, pyelonephritis, or nephrolithiasis. The skin of the flank is a very uncommon site of clinical presentation. Here, we report an exceedingly rare case of squamous cell carcinoma of the renal pelvis presenting as skin invasion of the flank. Case presentation A 66-year-old Han Chinese man consulted our hospital because of a right lumbar skin lesion lasting more than 3 months. His physical examination revealed that he had a palpable mass about 6.0 cm × 5.0 cm in size at the posterior axillary line in the right low back with skin ulceration 3 mm in diameter and exudation on it. Magnetic resonance imaging showed hydronephrosis of the right kidney and plaque-like abnormal signal in the middle portion of the kidney. The patient underwent a right nephrectomy. The sinus tract formation between the ulcerative skin in the right low back and the middle portion of the right kidney could be found. The distended kidney could not be excised entirely for tight adhesion. Pathological examination showed moderately differentiated renal squamous cell carcinoma with invasion of the renal parenchyma and perirenal adipose tissue. Conclusion It is extremely rare for renal squamous cell carcinoma to present as skin invasion. Recurrent percutaneous nephrolithotomy may be a risk factor for squamous cell carcinoma of the renal pelvis. The possibility of renal squamous cell carcinoma should be kept in mind in patients who have hydronephrosis, nephrolithiasis, or chronic pyelonephritis for a long time or with renal anomalies. More radiological examinations are suggested for such patients.

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Primary Squamous Cell Carcinoma (SCC) of the renal pelvis: A retrospective study of 14 cases

10.26226/morressier.578f37ffd462b8028d8905c0 ◽

2016 ◽

Author(s):

Ines Saguem

Keyword(s):

Squamous Cell Carcinoma ◽

Retrospective Study ◽

Cell Carcinoma ◽

Squamous Cell ◽

Renal Pelvis ◽

Primary Squamous Cell Carcinoma

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Primary squamous cell carcinoma of the ampulla of Vater: management and review of the literature

BMJ Case Reports ◽

10.1136/bcr-2020-236477 ◽

2021 ◽

Vol 14 (1) ◽

pp. e236477

Author(s):

Subhash Soni ◽

Poonam Elhence ◽

Vaibhav Kumar Varshney ◽

Sunita Suman

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Survival Rates ◽

Ampulla Of Vater ◽

Metallic Stent ◽

Biological Behaviour ◽

Curative Intent ◽

Term Survival ◽

History Of

Squamous cell carcinoma (SCC) of the ampulla of Vater is a rare pathology and only few cases are reported in the literature. With limited experience of primary SCC in the ampulla of Vater, its biological behaviour, prognosis and long-term survival rates are not well known. A 38-year-old woman presented with a history of painless progressive jaundice for which self-expending metallic stent was placed 3 years back. She was evaluated and initially diagnosed as probably periampullary adenocarcinoma. She underwent pancreaticoduodenectomy and histopathology with immunohistochemistry was suggestive of SCC of ampulla of Vater. She received adjuvant chemotherapy and doing well with no recurrence after 1 year of follow-up. In conclusion, SCC of the ampulla is an unusual pathology that should be kept as a differential diagnosis for periampullary tumours. Surgical treatment with curative intent should be performed whenever feasible even in the setting of bulky tumour to improve the outcome.

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Leiomyosarcoma of the Tracheostomy Site in a Patient with History of Laryngeal Squamous Cell Carcinoma

Case Reports in Oncology ◽

10.1159/000516797 ◽

2021 ◽

pp. 912-917

Author(s):

Zainub Ajmal ◽

Abdul Moiz Khan ◽

Lezah McCarthy ◽

Allison Lupinetti ◽

Syed Mehdi

Keyword(s):

Risk Factors ◽

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

English Literature ◽

Neck Region ◽

Multiple Risk Factors ◽

History Of ◽

Rare Malignancy

Leiomyosarcoma (LMS) of the trachea is an extremely rare malignancy with only a few reported cases in English literature. As such the diagnosis can be frequently missed or delayed. We present a case of a 69-year-old male who underwent tracheostomy for airway obstruction secondary to glottic squamous cell carcinoma and treated definitely with radiation therapy. Subsequently, the patient developed LMS of the tracheostomy site. The case further details multiple risk factors that could contribute to development of LMS including radiation exposure, prior malignancy, and chronic inflammation. These risk factors have been well established for LMS in other sites but less so in the head and neck region, which is the subject of our discussion. We also review the current guidelines for head and neck as well as limb sarcomas and discussed role of surgery or radiation and their accompanying challenges in management of this rare malignancy.

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Oral findings during follow-up of nasopharyngeal squamous cell carcinoma treatment: A case report

SAGE Open Medical Case Reports ◽

10.1177/2050313x211033037 ◽

2021 ◽

Vol 9 ◽

pp. 2050313X2110330

Author(s):

Atsushi Musha ◽

Nobuteru Kubo ◽

Naoko Okano ◽

Hidemasa Kawamura ◽

Yuhei Miyasaka ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Concurrent Chemoradiotherapy ◽

Nasopharyngeal Cancer ◽

Inflammatory Conditions ◽

Positron Emission ◽

History Of ◽

Oral Area

A 50-year-old woman with a long history of nasopharyngeal cancer (T2N2M0, squamous cell carcinoma) underwent chemoradiotherapy and surgery. In the past, to prevent tumor recurrence or metastasis, she underwent concurrent chemoradiotherapy or neck dissection. However, during a follow-up 10 years after the surgery, intense F-18 fluorodeoxyglucose uptake was detected in the oral area (SUVmax 6.0). A biopsy of the area with F-18 fluorodeoxyglucose uptake revealed pathological inflammation. Radiography showed the presence of a wisdom tooth, located at the F-18 fluorodeoxyglucose accumulation site, and pericoronitis of this tooth was detected. Our findings indicate the importance of considering the effect of inflammatory conditions, such as periodontal disease, in using F-18 fluorodeoxyglucose positron emission tomography/computed tomography during follow-up after head and neck cancer treatment.

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