scholarly journals Ferrocene-Based Bioactive Bimetallic Thiourea Complexes: Synthesis and Spectroscopic Studies

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Shafqat Ali ◽  
Ghulam Yasin ◽  
Zareen Zuhra ◽  
Zhanpeng Wu ◽  
Ian S. Butler ◽  
...  
Keyword(s):  
Double Helix ◽  
Spectroscopic Studies ◽  
Cyclic Voltammetric ◽  
Binding Model ◽  
Elemental Analyses ◽  
Ft Ir ◽  
Relative Potential ◽  
Double Helix Structure ◽  
Enzyme Alkaline Phosphatase ◽  
C Nmr

Bioactive 1,1′-(4,4′-di-ferrocenyl)di-phenyl thiourea and various metal complexes of this ligand have been successfully synthesized and characterized by using physicoanalytical techniques such as FT-IR and multinuclear (1H and13C) NMR spectroscopy along with melting point and elemental analyses. The interaction of the synthesized compounds with DNA has been investigated by using cyclic voltammetric and viscometric measurements. The intercalation of the complexes into the double helix structure of DNA is presumably occurring. Viscosity measurements of the complexes have shown that there is a change in length and this is regarded as the least ambiguous and the most critical test of the binding model in solution. The relative potential of the complexes as anti-bacterial, antifungal, and inhibition agents against the enzyme, alkaline phosphatase EC 3.1.3.1, has also been assessed and the complexes were found to be active inhibitors.

Semirigid Homo- and Copoly(Imide-Carbonate)s Based on 3,4,3″,4″ -p-Terphenyltetracarboxdiimide

1998 ◽  
Vol 10 (1) ◽  
pp. 155-162 ◽  
Author(s):  
Moriyuki Sato ◽  
Seiji Ujiie ◽  
Yuji Tada ◽  
Takashi Kato
Keyword(s):  
Nematic Phase ◽  
Liquid Crystalline ◽  
Molar Ratio ◽  
Temperature Dependent ◽  
X Ray ◽  
Melt Polycondensation ◽  
Elemental Analyses ◽  
Temperature Ranges ◽  
Ft Ir ◽  
C Nmr

Novel thermotropic liquid crystalline (LC) semirigid homo- and copoly(imidecarbonate)s composed of a 3, 4, 3″, 4″- p-terphenyltetracarboxdiimide ring and aliphatic chains were prepared by melt polycondensation of a dihexanol derivative of 3, 4, 3″, 4″- p-terphenyltetracarboxdiimide and/or a dioxydihexanol of biphenyl taken in a definite molar ratio with hexamethylene diphenyl dicarbonate in the presence of zinc acetate, and their thermal and mesogenic properties were evaluated. The assigned structures of polymers were characterized by FT-IR and 13C NMR spectroscopy, and elemental analyses. DSC and TG-DTA measurements, polarizing microscope observations of textures and temperature-dependent x-ray analyses demonstrated that the polymers have wider LC temperature ranges (nematic phase) than analogous semirigid poly(ester-imide)s and are thermally stable up to 300 °C in air.

scholarly journals Theoretical and Spectroscopic Studies of SN Donor Thiosemicarbazone Ligand and Its Pt(II) Complex

2021 ◽  
Vol 20 (1) ◽  
pp. 113-117
Author(s):  
Amna Qasem Ali ◽  
Boubaker Hosouna ◽  
Khadija Abdusslam Ahmida ◽  
Abdulasalam Amhamed Mohamed Alshreef
Keyword(s):  
Schiff Base ◽  
Schiff Base Ligand ◽  
Spectroscopic Studies ◽  
Azomethine Nitrogen ◽  
Nmr Analysis ◽  
Thiosemicarbazone Ligand ◽  
Elemental Analyses ◽  
Ft Ir ◽  
Theoretical Results ◽  
Good Agreement

Sulphur-nitrogen(SN) donor thiosemicarbazone ligand [(Z)-N-ethyl-2-(5-methyl-2-oxoindolin-3-ylidene)hydrazinecarbothioamide] and its Pt(II) complex were synthesized by condensation method. The compounds were structurally characterized by elemental analysis CHNS, FT-IR, and NMR analysis. The elemental analyses data for the compounds were in good agreement with the theoretical values.  The melting point of the complex was higher than the ligand, as expected. The FT-IR spectral data reflect a bidentate bonding of thiosemicarbazone ligand to Pt(II) ion through thioketo sulfur and azomethine nitrogen. The docking results (theoretical results) of these compounds show that the binding energy between DNA and Pt(II) complex was found to be less than that of the Schiff base ligand (L) in the sense that it has higher stability at various stages and angles. The strength of docking between DNA and Pt(II) complex was also found to be that stronger than the Schiff base ligand (L).

scholarly journals Synthesis and Characterization of β-Diketimine Schiff Base Complexes with Ni(II) and Zn(II) Ions: Experimental and Theoretical Study

2019 ◽  
Vol 2019 ◽  
pp. 1-9
Author(s):  
Ibrahim A. M. Saraireh ◽  
Mohammednoor Altarawneh ◽  
Jibril Alhawarin ◽  
Mahmoud Salman ◽  
Abdel Aziz Abu-Yamin ◽  
...  
Keyword(s):  
Schiff Base ◽  
Schiff Base Complexes ◽  
H Nmr ◽  
Square Planar ◽  
Basic Set ◽  
Vis Spectroscopy ◽  
Elemental Analyses ◽  
Ft Ir ◽  
C Nmr

Schiff base diethyl 4,4-(pentane-2,4-diylidenebis(azanylylidene))benzoate (1) as a new ligand (L) was prepared by the reaction of acetylacetone with benzocaine in the ratio of 1 : 1. Two transition-metal complexes, [Ni(II)(LCl(HOEt))] (2) and [Zn(II)(LCl(HOEt))] (3), have been synthesized from metal salts with didentate Schiff base ligand (L) and characterized by elemental analyses, FT-IR, 1H NMR, 13C NMR UV-Vis spectroscopy, and magnetic susceptibility. The biological activity of the complexes was studied. In addition, the M06-2x density function theory method and the 6-31G(d) basic set were applied to determine the optimized structures of 1–3 and to determine their IR and 1H NMR, 13C NMR spectra theoretically. The data are in good agreement with the experimental results. The geometries of complexes 2 and 3 were determined to be square-planar for 2 and tetrahedral for 3.

Novel Schiff Bases with Oxime Groups and Their Homo- and Heteronuclear Copper(II) Complexes

2007 ◽  
Vol 72 (10) ◽  
pp. 1383-1397 ◽  
Author(s):  
Bülent Dede ◽  
Fatma Karipcin ◽  
Mustafa Cengiz
Keyword(s):  
Schiff Bases ◽  
Inductively Coupled Plasma ◽  
Thermal Analyses ◽  
Optical Emission ◽  
Schiff Base Ligands ◽  
Inductively Coupled ◽  
Imine Nitrogen ◽  
Elemental Analyses ◽  
Ft Ir ◽  
C Nmr

Two novel tetradentate Schiff bases containing oxime groups and their homodinuclear, homotrinuclear Cu(II) and heterodinuclear Cu(II)-Mn(II) and Cu(II)-Co(II) complexes were synthesized. The Schiff base ligands (H2L1 and H2L2) were prepared by condensing of diethylenetriamine with 2-(biphenyl-4-yl)-N-(4-chlorophenyl)-N'-hydroxy-2-oxoacetimidamide (HL1) and 2-(biphenyl-4-yl)-N'-hydroxy-N-(4-methylphenyl)-2-oxoacetimidamide (HL2). Structure assignments are supported by a combination of FT-IR, elemental analyses, inductively coupled plasma optical emission spectroscopy (ICP-OES), magnetic susceptibility, molar conductivity and thermal analyses studies. The free ligands were also characterized by 1H and 13C NMR spectra. Elemental analyses, stoichiometric and spectroscopic data indicated that the metal:ligand ratio is 2:1 for the dinuclear copper(II) complexes and 3:2 for the trinuclear copper(II) complexes. The copper(II) ions are coordinated to the oxime and imine nitrogen atoms. Pyrolytic decomposition occurred in melting the metal complexes and metal oxides were the ultimate products.

Synthesis, characterization, and aggregation properties of functionalized polyfluorinated metallo-phthalocyanines

2013 ◽  
Vol 17 (10) ◽  
pp. 972-979 ◽  
Author(s):  
Mukaddes Özçeşmeci ◽  
Ebru Özkan ◽  
Esin Hamuryudan
Keyword(s):  
Substitution Reaction ◽  
Electronic Spectroscopy ◽  
H Nmr ◽  
Regioselective Substitution ◽  
Elemental Analyses ◽  
Ft Ir ◽  
Manganese Salts ◽  
Influence Of Solvent ◽  
C Nmr ◽  
Cobalt Copper

The reaction of 4-(2′,3′,4′,5′,6′-pentafluorobenzyloxy)phthalonitrile with 2,2,3,3,4,4,5,5-octafluoropentanol leads to the formation of 4-[2′,3′,5′,6′-tetrafluoro-4′-(octafluoropentoxy) benzyloxy]-phthalonitrile. The reaction was achieved by regioselective substitution reaction of the p-fluorine atoms of pentafluorobenzyloxy group by perfluoroalkoxy group. The tetramerization of the new dinitrile derivative in the presence of zinc, cobalt, copper or manganese salts results in the corresponding phthalocyanines. The prepared compounds have been characterized by elemental analyses, FT-IR, UV-vis, 1 H NMR, 13 C NMR, 19 F NMR and mass spectroscopies, consistent with the proposed structures. The influence of solvent and concentrations on the aggregation of the phthalocyanine complexes was studied by electronic spectroscopy.

N,N-Diethylamine appended binuclear Zn(ii) complexes: highly selective and sensitive fluorescent chemosensors for picric acid

2016 ◽  
Vol 45 (20) ◽  
pp. 8475-8484 ◽  
Author(s):  
Amit Kumar ◽  
Ashish Kumar ◽  
Daya Shankar Pandey
Keyword(s):  
Picric Acid ◽  
Fluorescent Chemosensors ◽  
Esi Ms ◽  
Elemental Analyses ◽  
Ft Ir ◽  
C Nmr

Novel binuclear Zn(ii) complexes (1–2) derived from bis-chelating salen type ligands (H2L1 and H2L2) possessing N,N-diethylamine moieties on the periphery of the molecules have been synthesized and thoroughly characterized by satisfactory elemental analyses and spectral (FT-IR, 1H, 13C NMR, UV-vis, fluorescence and ESI-MS) studies.

scholarly journals Conventional versus ultrasound and microwave assisted synthesis: Some new environmentally friendly functionalized picolinium-based ionic liquids with potential antibacterial activity

2015 ◽  
Vol 65 (3) ◽  
pp. 253-270 ◽  
Author(s):  
Mouslim Messali
Keyword(s):  
Ionic Liquids ◽  
Mass Spectra ◽  
Microwave Assisted Synthesis ◽  
The Novel ◽  
Human Pathogens ◽  
Thermal Heating ◽  
H Nmr ◽  
Elemental Analyses ◽  
Ft Ir ◽  
C Nmr

Abstract A green chemistry approach has been adopted for the synthesis of thirty-four new picolinium-based ionic liquids using microwave (MW) and ultrasound (US) irradiation as well as conventional thermal heating. Their structures were confirmed by FT-IR, 1H NMR, 13C NMR, 11B NMR, 19F NMR, 31P NMR, mass spectra and elemental analyses. The antimicrobial profile of the novel ionic liquids was evaluated and the minimum inhibitory concentration (MIC) showed their moderate to low antimicrobial activity against eight types of human pathogens.

DNA Inspirited Rational Construction of Nonconventional Luminophores with Efficient and Color-Tunable Afterglow

2020 ◽  
Author(s):  
Yunzhong Wang ◽  
Saixing Tang ◽  
Yating Wen ◽  
Shuyuan Zheng ◽  
Bing Yang ◽  
...  
Keyword(s):  
Rational Design ◽  
Room Temperature ◽  
Double Helix ◽  
Mechanical Grinding ◽  
Room Temperature Phosphorescence ◽  
Color Tunable ◽  
Potential Applications ◽  
Rational Construction ◽  
Double Helix Structure ◽  
Made In

<div>Persistent room-temperature phosphorescence (p-RTP) from pure organics is attractive </div><div>due to its fundamental importance and potential applications in molecular imaging, </div><div>sensing, encryption, anticounterfeiting, etc.1-4 Recently, efforts have been also made in </div><div>obtaining color-tunable p-RTP in aromatic phosphors5 and nonconjugated polymers6,7. </div><div>The origin of color-tunable p-RTP and the rational design of such luminogens, </div><div>particularly those with explicit structure and molecular packing, remain challenging. </div><div>Noteworthily, nonconventional luminophores without significant conjugations generally </div><div>possess excitation-dependent photoluminescence (PL) because of the coexistence of </div><div>diverse clustered chromophores6,8, which strongly implicates the possibility to achieve </div><div>color-tunable p-RTP from their molecular crystals assisted by effective intermolecular </div><div>interactions. Here, inspirited by the highly stable double-helix structure and multiple </div><div>hydrogen bonds in DNA, we reported a series of nonconventional luminophores based on </div><div>hydantoin (HA), which demonstrate excitation-dependent PL and color-tunable p-RTP </div><div>from sky-blue to yellowish-green, accompanying unprecedentedly high PL and p-RTP </div><div>efficiencies of up to 87.5% and 21.8%, respectively. Meanwhile, the p-RTP emissions are </div><div>resistant to vigorous mechanical grinding, with lifetimes of up to 1.74 s. Such robust, </div><div>color-tunable and highly efficient p-RTP render the luminophores promising for varying </div><div>applications. These findings provide mechanism insights into the origin of color-tunable </div><div>p-RTP, and surely advance the exploitation of efficient nonconventional luminophores.</div>

Syntheses and Cytotoxicity Screening of some Novel 1,2,4-Triazine Derivatives against Liver Carcinoma Cell Lines

2020 ◽  
Vol 17 ◽  
Author(s):  
W. Abd El-Fattah
Keyword(s):  
Acetic Anhydride ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Aromatic Aldehydes ◽  
Liver Carcinoma ◽  
Anticancer Activities ◽  
Carcinoma Cell Lines ◽  
Elemental Analyses ◽  
Triazine Derivatives ◽  
C Nmr

: In this work, 1,2,4-triazine derivatives were synthesized and evaluated for anticancer activities. Series of 1,2,4-triazine derivatives (4a, b) were prepared via the reaction of N-benzoyl glycine (1) with aromatic aldehydes in presence of fused sodium acetate and acetic anhydride to give 1,3-oxazolinone derivatives (2a, b), followed by condensation with 1-(ethoxycarbonyl) hydrazine (3) in glacial acetic acid. Compounds (4a, b) then reacted with acetic anhydride, ethyl chloroacetate and 2,4-dinitrophenyl hydrazine yielded the corresponding to N-acetyl derivatives (5a, b), N-(ethoxycarbonyl) methyl derivative (6) and 1,2-disubstituted hydrazine (7), respectively. The structures of the 1,2,4-triazine derivatives were confirmed by IR, 1H, 13C NMR, MS and elemental analyses. Anticancer activity of some 1,2,4-triazine derivatives (4-7) have been investigated. The results revealed that compounds 4a (IC50= 2.7μM), 5a (IC50= 1.5μM), and 5b (IC50= 3.9μM) show promising inhibitory growth efficacy compared to a standard antitumor drug (IC50= 4.6μM). These three compounds can be considered as potential agents against human hepatocellular carcinoma cell lines (HepG-2).

Ultrasound-assisted aqua-mediated synthesis of multi-substituted tetrahydropyridine-3-carboxylates using N-carboxymethyl-3-pyridinium hydrogensulfate ([N-CH2CO2H-3-pic]+HSO4−) as a new efficient ionic liquid catalyst

2021 ◽  
Vol 3 (6) ◽  
Author(s):  
Kobra Nikoofar ◽  
Fatemeh Shahriyari
Keyword(s):  
Ionic Liquid ◽  
Reaction Times ◽  
Aromatic Aldehydes ◽  
Environmentally Benign ◽  
H Nmr ◽  
Sonic Waves ◽  
Ft Ir ◽  
High Yields ◽  
Work Up ◽  
C Nmr

AbstractA simple, straightforward, and ultrasound-promoted method for the preparation of some highly functionalized tetrahydropyridines reported via pseudo five-component reaction of (hetero)aromatic aldehydes, different anilines, and alkyl acetoacetates in the presence of [N-CH2CO2H-3-pic]+HSO4−, as a novel ionic liquid, in green aqueous medium. The IL was synthesized utilizing simple and easily-handled substrates and characterized by FT-IR, 1H NMR, 13C NMR, GC-MASS, FESEM, EDX, and TGA/DTG techniques. The procedure contains some highlighted aspects which are: (a) performing the MCR in the presence of aqua and sonic waves, as two main important and environmentally benign indexes in green and economic chemistry, (b) high yields of products within short reaction times, (c) convenient work-up procedure, (d) preparing the new IL via simple substrates and procedure.

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