scholarly journals Femoral Metastasis from Penile Carcinoma: Report of 2 Cases

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Laura Braumann ◽  
Panagiotis Tsagozis ◽  
Rikard Wedin ◽  
Otte Brosjö
Keyword(s):  
Pain Relief ◽  
Bone Metastases ◽  
Penile Cancer ◽  
Pathological Fracture ◽  
Squamous Carcinoma ◽  
Skeletal Metastasis ◽  
Skeletal Metastases ◽  
Endoprosthetic Reconstruction ◽  
Pathological Fractures ◽  
Femoral Metastasis

Purpose. Penile cancer rarely gives symptomatic skeletal metastases.Methods. We present 2 patients with squamous carcinoma of the penis who were surgically treated for metastases in the femur.Results. Both patients had pathological fractures and were operated on. In one case, the skeletal metastasis preceded any lymphatic spread of the disease, suggesting early haematogenous dissemination.Conclusions. Endoprosthetic reconstruction resulted in pain relief and restored the ambulatory capacity. Clinicians should be aware of the possibility for symptomatic bone metastases with a risk for pathological fracture in patients with penile cancer.

scholarly journals PATHOLOGICAL FRACTURES DUE TO BONE METASTASES FROM LUNG CANCER: RISK FACTORS AND SURVIVAL

2018 ◽  
Vol 26 (6) ◽  
pp. 388-393 ◽  
Author(s):  
Marcelo Bragança dos Reis Oliveira ◽  
Bruno de Carvalho Marques ◽  
Rosa Aurílio Matos ◽  
César Rubens da Costa Fontenelle ◽  
Fernanda Carvalho de Queiroz Mello ◽  
...  
Keyword(s):  
Risk Factors ◽  
Lung Cancer ◽  
Overall Survival ◽  
Bone Metastases ◽  
Pathological Fracture ◽  
Case Series ◽  
Rank Test ◽  
High Morbidity ◽  
Pathological Fractures ◽  
Diagnosis Of Lung Cancer

ABSTRACT Introduction: Pathological fractures are frequent skeletal-related events among lung cancer patients, which result in high morbidity and decreased overall survival and make operative treatment decisions challenging. Objectives: To identify risk factors associated with the occurrence of pathological fractures in patients with lung cancer and to determine survival. Methods: We conducted a retrospective cohort study with 407 lung carcinoma patients diagnosed between 2006 and 2015. The prevalence of bone metastases and pathological fractures was calculated. Statistical analysis was conducted using a chi-squared test, and the odds ratio and 95% confidence interval were calculated. Overall survival was determined using the Kaplan-Meier method and differences were compared using the log-rank test. Results: The prevalence of bone metastases and pathological fractures was 28.2% (n = 115) and 19.1% (n = 22), respectively. Pathological fractures were more frequent among patients with bone metastases at the time of diagnosis of lung cancer (24.7% [n = 20] vs. 5.9% [n = 2]; p < 0.05). The median overall survival following the diagnosis of lung cancer, bone metastases, and pathological fracture was 6, 4, and 2 months, respectively. Conclusions: Pathological fracture was associated with synchronous bone metastases and overall survival times were considerably reduced. Level of Evidence IV, Case Series.

Skeletal metastases in advanced pancreatic ductal adenocarcinoma (PDAC): A retrospective analysis.

2018 ◽  
Vol 36 (4_suppl) ◽  
pp. 245-245
Author(s):  
Akshjot Puri ◽  
John Chang ◽  
Tomislav Dragovich ◽  
Patricia Lucente ◽  
Madappa N. Kundranda
Keyword(s):  
Retrospective Analysis ◽  
Cervical Vertebrae ◽  
Lumbar Vertebrae ◽  
Skeletal Metastasis ◽  
Ductal Adenocarcinoma ◽  
Skeletal Metastases ◽  
Initial Symptom ◽  
Intractable Pain ◽  
Thoracic Vertebrae ◽  
Pathological Fractures

245 Background: Skeletal metastasis (SM) in advanced PDAC is an infrequent occurrence and has been previously reported to be < 2.5%. However; pathological fractures in these patients can result in intractable pain, immobilization and a significant deterioration in quality of life. Methods: A retrospective analysis was conducted of patients (pts) with advanced PDAC receiving palliative chemotherapy. Data collection included age, gender, ECOG, sites of disease, and overall survival (OS). Statistical analysis included Kaplan Meier survival analysis. Results: The 135 pts included had a median age of 65.8 years (range: 53.7–91.3); 5 (31.2%) were women and 11 (68.7%) had an ECOG performance status of 0 or 1. A majority of patients received combination therapy that was either gemcitabine or 5-flurouracil based. Sixteen pts (11.8%) had skeletal metastasis with the primary tumor located in the pancreatic body/tail (11 pts - 68.7%).The sites of SM included thoracic vertebrae (8), lumbar vertebrae (5), pelvis (5), ribs (4), sacrum (4), scapula (3), acetabulum (2), cervical vertebrae (2), femoral head (2), sternum (1) and humerus head (1). A majority of the lesions were osteolytic (62.5%) with a median time of diagnosis of SM from initial diagnosis being 1.25 months (range 0-33). Bone pain was observed as the initial symptom in 5 pts (32%), 1 pt (6.2%) had a pathological fracture. The mOS for patients with SM was 6.5 months (range 0-38) when compared to 8 months (range 0-147) without SM.The mOS for pts treated with gemcitabine based regimen was 5.75 months (range 2.5-14), and patients who received multiple lines of therapy including gemcitabine and 5-FU based regimens was 15 months (range 5-38). Survival from onset of skeletal metastases ranged from 0-14 months (mOS: 4 months). Conclusions: More effective systemic therapies which improve mOS are likely to result in increased incidence of SM. The most common sites observed were the thoracic and lumbar vertebrae and pathological fractures in these sites can be catastrophic. Therefore careful evaluation of skeletal signs and symptoms, early detection and intervention will be important to prevent morbidity and mortality from pathological fractures.

scholarly journals SURVIVAL IMPACT OF SKELETAL METASTASIS ON BONE SCINTIGRAPHY IN PATIENTS WITH GERM CELL TUMOURS

2016 ◽  
Vol 2 (4) ◽  
Author(s):  
Maimoona Siddique ◽  
Aamna Hassan ◽  
Saadiya J Khan
Keyword(s):  
Germ Cell ◽  
Bone Metastases ◽  
Bone Scintigraphy ◽  
Bone Scan ◽  
Disease Free Survival ◽  
Skeletal Metastasis ◽  
Whole Body ◽  
Skeletal Metastases ◽  
Germ Cell Tumours ◽  
Visceral Metastases

Objective: Our aim was to determine the frequency of skeletal metastasis in germ cell tumours (GCT) at baseline and relapse on conventional technetium-99m methylene diphosphonate (Tc-99m MDP) whole body bone scan (bone scan) and to evaluate the effect of bone metastases on survival. Materials and Methods: Electronic medical records of histologically proven GCT over 64 months were retrospectively analysed. Basic demographic and histologic information were correlated with the presence of osseous and visceral metastases. 5-year disease-free survival (DFS) and overall survival (OS) were calculated in presence, the absence of bone metastases at baseline and at relapse. Results: A total of 130 gonadal and extragonadal GCT patients underwent Tc-99m MDP bone scans; four with insuf cient data were excluded from the study. 47% were females and 53% were males with the age range of 1 month – 72 years. 105 (83%) were under 18 years of age. Osseous metastasis was detected in 12 (9.5%). Two (17%) had solitary and 10 (83%) had multifocal skeletal metastases. Clinically, 83% had localised bone pain. Osseous metastases were more frequently associated with mixed GCT and yolk sac tumour. 50% of mediastinal GCT developed bone metastases. 42% died within 4–18 months. There was a statistically signi cant impact of visceral metastases on DFS and OS. OS at 5 years in patients without bone metastases, with bone metastases at baseline and bone metastases at relapse, was 77%, 38% and 75%, respectively. 5-year DFS for the same cohort groups was 63%, 38% and 20%, respectively. Conclusion: Osseous involvement was found in 9.5% of GCT patients undergoing diagnostic Tc-99m MDP bone scan. Baseline skeletal evaluation for metastases should be done, particularly in the case of bone pains or known systemic metastases. Although skeletal relapses are rare, they have a grim outcome. Key words: Bone scintigraphy, germ cell tumours, skeletal metastases 

Intercalary endoprosthetic reconstruction for impending pathological fractures in patients with femoral diaphyseal bone metastases

2009 ◽  
Vol 19 (8) ◽  
pp. 547-551 ◽  
Author(s):  
Kenichiro Hamada ◽  
Norifumi Naka ◽  
Hironari Tamiya ◽  
Ritsuro Ozaki ◽  
Hidetatsu Outani ◽  
...  
Keyword(s):  
Bone Metastases ◽  
Endoprosthetic Reconstruction ◽  
Pathological Fractures ◽  
Diaphyseal Bone

scholarly journals Pattern of Skeletal Metastasis in Breast Cancer Patients Attending INMAS, Rajshahi

2019 ◽  
Vol 21 (1) ◽  
pp. 21-25
Author(s):  
Munshi Md Arif Hosen ◽  
Nasrin Begum ◽  
Pervez Ahmed ◽  
Mosharrof Hossain ◽  
Shefaly Khatun ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cervical Spine ◽  
Lumbar Spine ◽  
Bone Metastases ◽  
Cancer Patients ◽  
Bone Scan ◽  
Skeletal Metastasis ◽  
Skeletal Metastases ◽  
Breast Cancer Patients ◽  
Common Site

Breast cancer is the most common malignant tumor of females, the incidence increases with age. Bone is the most common site to which breast cancer metastasizes. Between 30% to 85% of patients with metastatic breast cancer develop bone metastases during the course of the disease. Bone scan is the most commonly used means of detecting bone metastasis; it visualizes increases in osteoblastic activity and skeletal vascularity. Many radio-pharmaceuticals (radionuclides) have been used in bone scan including technetium-99m bound to methylene diphosphonate (MDP). Published sensitivity and specificity rates of bone scan for diagnosis varies, with sensitivity ranging from 62% to 100% and specificity from 78% to 100%. However, bone scan is generally considered sensitive for detecting bone metastases on whole-body images.The aim of this study was to evaluate the pattern of distribution of skeletal metastases in patients with breast carcinoma by using Tc-99m MDP bone scan. A retrospective study was conducted on 245 consecutive female breast carcinoma patients irrespective of clinical staging, menopausal status and pre-operative / post- mastectomy status, referred for bone scan to Institute of Nuclear Medicine and Allied Sciences, Rajshahi from July 2015 to June 2017.  The mean age of the patients was 43.4 ± 13.8 years (mean ± SD) with range from 29 to 66 years. Bone scan was performed by an intravenous bolus injection of 20 mCi Tc99m-MDP. Bone phase images were taken at three hours after injection of the radiotracer. Out of 245 studied patients, 163 patients (66.53%) were negative for skeletal metastasis and 82 patients (33.47%) were positive for skeletal metastasis. Out of 82 patients with positive skeletal metastasis, 68 (82.93%) patients had multiple sites (two or more) and 14 (17.07%) patients had solitary site of bony involvement. Out of 68 patients with multiple sites of skeletal metastasis, highest number was noted in thoraco-lumbar spine (80.89%), followed by ribs including sternum and clavicle (57.35%), pelvic bones (47.06%), upper extremities including scapula (41.18%), lower extremities (33.82%), cervical spine (23.53%) and skull bone (8.82%). Among 14 patients with solitary skeletal metastasis, maximum number was noted in thoraco-lumbar spine (64.29%), followed by cervical spine (14.29%), pelvic bone (07.14%), ribs (07.14%) and sternum (07.14%). Skeletal metastases were  much more common in multiple sites than solitary lesion in breast cancer patients. Thoraco-lumbar spine was the most common site of involvement in both solitary and multiple lesions in our study. Axial skeleton was more commonly involved than the appendicular skeleton. Bone scan may pick up bone metastases up to 18 months earlier than conventional radiology, with an average lead of four months. 99m Tc- MDP bone scan is very cost effective in comparison to other imaging modalities (CT, MRI, and PET) and play a major role in early detection of skeletal metastasis in breast cancer patients. Bangladesh J. Nuclear Med. 21(1): 21-25, January 2018

scholarly journals Unplanned surgery increases the morbidity of patients with solitary plasmacytoma of femoral bone: a case report

2018 ◽  
Vol 6 (11) ◽  
pp. 3765
Author(s):  
I. Gde Eka Wiratnaya ◽  
Ida Bagus Gede Arimbawa ◽  
I. Made Tusan Sidharta
Keyword(s):  
Pain Relief ◽  
Internal Fixation ◽  
Pathological Fracture ◽  
Modular System ◽  
Solitary Plasmacytoma ◽  
Femoral Bone ◽  
Pathological Fractures ◽  
Prosthetic Reconstruction ◽  
Modular Prosthesis ◽  
Pathologic Fractures

Solitary skeletal plasmacytoma is a malignant plasma cell tumour that accounts for 3-5% of all monoclonal gammopathies. Lytic bone disease is a hallmark, and a substantial percentage of patients develop pathologic fractures. For lesions involving the femur, internal fixation frequently fails; therefore, prosthetic reconstruction may be the optimal choice for treatment. A 52-year-old male patient with pathological fracture of right femoral bone. Patient was undergone surgery with internal fixation. The pain had been continuing for several months and giant masses has developed on affected side. Further test was done and showed solitary plasmacytoma of proximal femur. The patient was treated with cemented modular prosthesis following tumor excision. Treatment of pathological fracture often challenging. Unplanned surgery could be devastating for the patient. Compare to internal fixation, cemented modular prosthesis is designed as a modular system that can be used to replace diseased or deficient bone in the femur following wide excision. Treatment of pathological fractures in solitary plasmacytoma with modular prosthesis appears to be a feasible option. They were able to mobilize early with good pain relief and had a useful functional limb. Further diagnostic test should be done for fracture of proximal femoral bone that considered pathologic. Limb salvage surgery with modular prosthesis can be considered as a viable option for treating painful pathological fractures in solitary plasmacytoma. It provides pain relief, early mobilization, and good functional outcome with improved quality of life.

Skeletal metastasis in feline mammary carcinoma: case report and literature review

1998 ◽  
Vol 34 (2) ◽  
pp. 103-108 ◽  
Author(s):  
DJ Waters ◽  
A Honeckman ◽  
DM Cooley ◽  
D DeNicola
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Bone Metastases ◽  
Mammary Carcinoma ◽  
Skeletal Metastasis ◽  
Skeletal Metastases ◽  
Distal Limb ◽  
Pertinent Literature ◽  
Distal Extremity ◽  
Feline Mammary Carcinoma

Despite the highly malignant nature of feline mammary carcinoma, few cases of skeletal metastasis have been reported. In this paper, a case of feline mammary carcinoma with skeletal metastasis to a distal limb is presented. The pertinent literature on feline mammary carcinoma and bone metastases is reviewed. Although the metastases of carcinomas in dogs and humans usually exhibit a proximal skeletal distribution, cats are more likely to develop distal extremity lesions. Clinicians need to have an index of suspicion that skeletal metastases may be responsible for lameness in elderly cats. Further investigation of the comparative aspects of bone metastases in cats and other species may elucidate the factors that regulate the development of skeletal metastases.

Radiotherapy plus either transdermal fentanyl or paracetamol and codeine for painful bone metastases: a randomised study of pain relief and quality of life

2004 ◽  
Vol 20 (2) ◽  
pp. 159-163 ◽  
Author(s):  
Kyriaki Pistevou-Gompaki ◽  
Vassilis E. Kouloulias ◽  
Charalambos Varveris ◽  
Kyriaki Mystakidou ◽  
Grigoris Georgakopoulos ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Pain Relief ◽  
Bone Metastases ◽  
Transdermal Fentanyl ◽  
Randomised Study ◽  
Painful Bone Metastases

scholarly journals Impact of radiofrequency ablation (RFA) on bone quality in a murine model of bone metastases

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0256076
Author(s):  
Soroush Ghomashchi ◽  
Cari M. Whyne ◽  
Tricia Chinnery ◽  
Fayez Habach ◽  
Margarete K. Akens
Keyword(s):  
Radiofrequency Ablation ◽  
Bone Metastases ◽  
Tumor Cells ◽  
Bone Quality ◽  
Second Harmonic ◽  
Local Treatment ◽  
Skeletal Metastases ◽  
The Impact ◽  
Surrounding Bone

Thermal therapies such as radiofrequency ablation (RFA) are gaining widespread clinical adoption in the local treatment of skeletal metastases. RFA has been shown to successfully destroy tumor cells, yet the impact of RFA on the quality of the surrounding bone has not been well characterized. RFA treatment was performed on femora of rats with bone metastases (osteolytic and osteoblastic) and healthy age matched rats. Histopathology, second harmonic generation imaging and backscatter electron imaging were used to characterize changes in the structure, organic and mineral components of the bone after RFA. RFA treatment was shown to be effective in targeting tumor cells and promoting subsequent new bone formation without impacting the surrounding bone negatively. Mineralization profiles of metastatic models were significantly improved post-RFA treatment with respect to mineral content and homogeneity, suggesting a positive impact of RFA treatment on the quality of cancer involved bone. Evaluating the impact of RFA on bone quality is important in directing the growth of this minimally invasive therapeutic approach with respect to fracture risk assessment, patient selection, and multimodal treatment planning.

scholarly journals Detection and Segmentation of Pelvic Bones Metastases in MRI Images for Patients With Prostate Cancer Based on Deep Learning

2021 ◽  
Vol 11 ◽  
Author(s):  
Xiang Liu ◽  
Chao Han ◽  
Yingpu Cui ◽  
Tingting Xie ◽  
Xiaodong Zhang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Deep Learning ◽  
Bone Metastases ◽  
Model Development ◽  
Whole Body ◽  
Pelvic Bone ◽  
Skeletal Metastases ◽  
Dice Similarity Coefficient ◽  
Patient Level ◽  
Lesion Level

ObjectiveTo establish and evaluate the 3D U-Net model for automated segmentation and detection of pelvic bone metastases in patients with prostate cancer (PCa) using diffusion-weighted imaging (DWI) and T1 weighted imaging (T1WI) images.MethodsThe model consisted of two 3D U-Net algorithms. A total of 859 patients with clinically suspected or confirmed PCa between January 2017 and December 2020 were enrolled for the first 3D U-Net development of pelvic bony structure segmentation. Then, 334 PCa patients were selected for the model development of bone metastases segmentation. Additionally, 63 patients from January to May 2021 were recruited for the external evaluation of the network. The network was developed using DWI and T1WI images as input. Dice similarity coefficient (DSC), volumetric similarity (VS), and Hausdorff distance (HD) were used to evaluate the segmentation performance. Sensitivity, specificity, and area under the curve (AUC) were used to evaluate the detection performance at the patient level; recall, precision, and F1-score were assessed at the lesion level.ResultsThe pelvic bony structures segmentation on DWI and T1WI images had mean DSC and VS values above 0.85, and the HD values were &lt;15 mm. In the testing set, the AUC of the metastases detection at the patient level were 0.85 and 0.80 on DWI and T1WI images. At the lesion level, the F1-score achieved 87.6% and 87.8% concerning metastases detection on DWI and T1WI images, respectively. In the external dataset, the AUC of the model for M-staging was 0.94 and 0.89 on DWI and T1WI images.ConclusionThe deep learning-based 3D U-Net network yields accurate detection and segmentation of pelvic bone metastases for PCa patients on DWI and T1WI images, which lays a foundation for the whole-body skeletal metastases assessment.

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