scholarly journals Adjuvant Chemoradiation Therapy in Gastric Cancer: Critically Reviewing the Past and Visualizing the Next Step Forward

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Konstantinos Papadimitriou ◽  
Georgios Antoniou ◽  
Christian Rolfo ◽  
Antonio Russo ◽  
Giuseppe Bronte ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Surgical Treatment ◽  
Literature Review ◽  
Combined Therapy ◽  
Chemoradiation Therapy ◽  
Potential Bias ◽  
Adjuvant Chemoradiation ◽  
The Past ◽  
Pros And Cons ◽  
Chemoradiation Treatment

Gastric cancer remains one of the most common malignancies worldwide. Despite the significant advances in surgical treatment and multimodality strategies, prognosis has modestly improved over the last two decades. Locoregional relapse remains one of the main issues and the combined chemoradiation treatment seems to be one of the preferred approaches. However, more than ten years after the hallmark INT-0116 trial, minimal progress has been made both in terms of effectiveness and toxicity. Moreover, new regimens added to combined therapy failed to prove favourable results. Herein, we attempt a thorough literature review comparing pros and cons of all relative studies and potential bias, targeting well-designed future approaches.

Cost-effectiveness analysis of gastric cancer management using perioperative chemotherapy versus adjuvant chemoradiation therapy.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e16079-e16079
Author(s):  
Vishnu Prasath ◽  
Patrick L. Quinn ◽  
Joseph B. Oliver ◽  
Omar Mahmoud ◽  
Mohammed Jaloudi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cost Effectiveness ◽  
Treatment Strategy ◽  
Chemoradiation Therapy ◽  
Adjuvant Chemoradiotherapy ◽  
Complication Rates ◽  
Perioperative Chemotherapy ◽  
Adjuvant Chemoradiation ◽  
Cancer Management ◽  
Life Years

e16079 Background: The most commonly used treatment options for gastric cancer include complete resection with adequate margins with either perioperative chemotherapy (PCT) or adjuvant chemoradiotherapy (CRT). While both treatment strategies have shown superiority over surgical resection alone, it is not clear which treatment strategy is more optimal. Methods: Our decision tree model was built to analyze the survival and costs associated with the two major management methods: perioperative chemotherapy and adjuvant chemoradiation therapy. Costs were obtained from Medicare reimbursement rates using a third-party payer perspective. Our model’s effectiveness was represented using quality-adjusted life years (QALYs). Our analysis tested the robustness of our conclusions by utilizing one-way, two-way, and probabilistic sensitivity analyses. Results: PCT was the preferred treatment strategy for diagnosed gastric cancer over CRT, with a cost of $54,326.10 and 4.08 QALYs. CRT was the costliest economic strategy with a cost of $77,987.52 and 4.28 QALYs and an ICER of 115,907.48. We set a threshold of $100,000 per QALYs gained which CRT surpassed making PCT the preferred treatment modality. Over 100,000 simulations, 51.4% of simulations favored PCT. CRT became favored when CRT non-curative procedure rates rose 3% higher than PCT non-curative procedure rates and when PCT complication rates rose 15% higher than CRT complication rates. Conclusions: In our simulated patients with diagnosed gastric cancer, the most cost-effective treatment strategy was PCT. We see cost-effectiveness alternating to favor CRT with changes in non-curative procedure rates and adjuvant therapy complication rates.[Table: see text]

scholarly journals Pengaruh Sosiologis Komunitas Lesbian Gay Biseksual Dan Transgender Ditinjau Dalam Etika Kristen

2021 ◽  
Vol 8 (1) ◽  
pp. 331-356
Author(s):  
Ekker Saogo
Keyword(s):  
Literature Review ◽  
Economic Factors ◽  
Natural Behavior ◽  
Male And Female ◽  
Clear Separation ◽  
The Past ◽  
Lgbt Community ◽  
Bisexual And Transgender ◽  
Pros And Cons ◽  
Lgbt People

The Lesbian, Gay, Bisexual, and Transgender (LGBT) in the past was something deviant, but nowadays it has become a trend that is even considered natural by many people. This of course has a sociological impact. There is a view that says that the behavior of LGBT people is a biological natural behavior, so it needs to be accepted as something that cannot be changed. Some theories agree that LGBT behavior is influenced by environmental, parenting, and economic factors so that there are pros and cons for LGBT people. This study aims to see the sociological influence of the LGBT community by using a literature review. The results of the study show that LGBT is contrary to the truth of God's creation, namely the clear separation of sex, namely male and female. Also, this is contrary to the design of marriage that God built, namely heterosexuality and monogamy.

Impact of Adjuvant Chemoradiation Therapy on the Postoperative 5-year Survival Rates for Stage-II Gastric Cancer

2005 ◽  
Vol 5 (4) ◽  
pp. 281
Author(s):  
Seong Kweon Hong ◽  
Min Gew Choi ◽  
Yong Hae Baik ◽  
Jae Hyung Noh ◽  
Tae Sung Sohn ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Survival Rates ◽  
Chemoradiation Therapy ◽  
Stage Ii ◽  
Adjuvant Chemoradiation

Adjuvant chemoradiation therapy (CRT) for resected gastric cancer (GC): A population-based study.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e15569-e15569
Author(s):  
Albert Y. Lin ◽  
Brice Jabo ◽  
Liang Ji ◽  
John S. Macdonald ◽  
Peter Ravdin ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Population Based ◽  
Chemoradiation Therapy ◽  
Adjuvant Chemoradiation ◽  
Population Based Study ◽  
Resected Gastric Cancer

scholarly journals Neoadjuvant Chemotherapy and Adjuvant Chemoradiation Therapy in the Treatment of Resected Gastric Adenocarcinoma: A Case Series

2017 ◽  
Vol 10 (1) ◽  
pp. 308-315 ◽  
Author(s):  
Christina Hadzitheodorou ◽  
Rebecca A. Moss ◽  
Timothy J. Kennedy ◽  
Salma K. Jabbour
Keyword(s):  
Gastric Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Gastric Adenocarcinoma ◽  
Case Series ◽  
The United States ◽  
Distant Recurrence ◽  
Chemoradiation Therapy ◽  
Optimal Timing ◽  
Multimodal Approach ◽  
Adjuvant Chemoradiation

The treatment of gastric cancer requires a multimodal approach to decrease the risk of locoregional and distant recurrence. The optimal timing of chemotherapy, surgery, and radiation therapy continues to be explored in ongoing trials. In the United States, surgical resection is often followed by adjuvant chemoradiation therapy or by a combination of neoadjuvant and adjuvant chemotherapy. Here we report on 4 patients with resected gastric adenocarcinoma who were treated with a combination of these 2 approaches, receiving neoadjuvant chemotherapy followed by adjuvant chemoradiation therapy.

Efficacy of Neo- and Adjuvant Treatment Modalities in Gastrointestinal Cancer Patients

Swiss Surgery ◽  
2001 ◽  
Vol 7 (6) ◽  
pp. 239-242
Author(s):  
Mayer
Keyword(s):  
Gastric Cancer ◽  
Rectal Cancer ◽  
Randomized Clinical Trials ◽  
Neoadjuvant Chemoradiation ◽  
Complete Resection ◽  
Chemoradiation Therapy ◽  
Treatment Modalities ◽  
Adjuvant Chemoradiation ◽  
Neoadjuvant Chemoradiation Therapy ◽  
Stage Ii Colon Cancer

Data which have emerged from randomized clinical trials are inconclusive regarding the efficacy of neoadjuvant chemoradiation therapy for patients with esophageal cancer. In 2001, available data appear to support the use of adjuvant chemoradiation therapy following the complete resection of a gastric cancer, adjuvant chemotherapy following the resection of a stage III (and - probably - "high-risk" stage II) colon cancer, and the use of adjuvant (and most likely neoadjuvant) chemoradiation therapy for stages II and III rectal cancer.

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